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Analysis of sister-chromatid exchanges and micronuclei in cultured human lymphocytes treated with insulin
(Charles Univ Prague, First Faculty Medicine, Prague 6, 2001)
Insulin is an anabolic hormone that may facilitate development of malignant diseases in various susceptible tissues due to stimulation of mitotic divisions. In this work, an evaluation of mitogenic and genotoxic effects ...
Enhanced sister-chromatid exchange rate in human lymphocytes exposed to 17 beta estradiol in vitro
(Elsevier Science Inc, New York, 2002)
Background. Epidemiologic data and animal experiments strongly implicate that steroid hormones are involved in the process of malignant transformation due to their capability to stimulate mitotic division and/or elevate ...
Mutagenic activity of estradiol evaluated by an in vitro micronucleus assay - Short communication
(Akademiai Kiado, Budapest, 2005)
The objective of the present study was to evaluate possible genetic changes in cultured human lymphocytes treated with estradiol, using the cytokinesis block micronucleus assay. Eight experimental concentrations of estradiol ...