Prikaz osnovnih podataka o dokumentu
Synthesis, structural and spectroscopic characterization, in vitro cytotoxicity and in vivo activity as free radical scavengers of chlorido(p-cymene) complexes of ruthenium(II) containing N-alkylphenothiazines
dc.creator | Krstić, Milena | |
dc.creator | Sovilj, Sofija P. | |
dc.creator | Grgurić-Šipka, Sanja | |
dc.creator | Radosavljevic-Evans, Ivana | |
dc.creator | Borozan, Sunčica | |
dc.creator | Santibanez, Juan Francisco | |
dc.date.accessioned | 2020-06-03T13:24:49Z | |
dc.date.available | 2020-06-03T13:24:49Z | |
dc.date.issued | 2011 | |
dc.identifier.issn | 0223-5234 | |
dc.identifier.uri | https://vet-erinar.vet.bg.ac.rs/handle/123456789/756 | |
dc.description.abstract | Three new ruthenium(II) complexes 1-3 containing N-alkylphenothiazine molecules were synthesized by reaction of [RuCl2(eta(6)-P-cymene)](2) with chlorpromazine hydrochloride (1), trifluoperazine dihydrochloride (2) or thioridazine hydrochloride (3). The compounds of the general formula L[RuCl3(eta(6)-p-cymene)] were characterized by elemental analysis and spectroscopic methods (FT-IR, UV-Vis, H-1 and C-13 NMR). Complex 2 was structurally characterized by single crystal X-ray diffraction. In vitro cytotoxic activity of complexes 1-3 were assayed in four human carcinoma cell lines MCF-7, MDA-MB-453 (breast carcinoma), SW-480 (colon carcinoma) and IM9 (myeloma multiple cells). The highest cytotoxicity (12.1 <= IC50 <= 17.3 mu M) and induced a total (SW-480) or almost total cell death (MCF-7. MDA-MB-453) at 25 mu M in 48 h of treatment were observed for complex 2. The influence of three different doses (0.4, 4.5 and 90.4 mu M/kg bw) of complex 2 on activities of antioxidants enzymes (superoxide dismutase (SOD) and catalase (CAT)) and lactate dehydrogenase (LDH) were investigated under physiological conditions. The effects on nitrite production (NO2-) and level of erythrocytes malondialdehyde (MDA) in rats blood were evaluated, too. | en |
dc.publisher | Elsevier France-Editions Scientifiques Medicales Elsevier, Issy-Les-Moulineaux | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172014/RS// | |
dc.rights | restrictedAccess | |
dc.source | European Journal of Medicinal Chemistry | |
dc.subject | Ruthenium complexes | en |
dc.subject | p-Cymene | en |
dc.subject | N-Alkylphenothiazines | en |
dc.subject | Single crystal X-ray diffraction | en |
dc.subject | Cytotoxicity | en |
dc.subject | Antioxidant enzymes | en |
dc.title | Synthesis, structural and spectroscopic characterization, in vitro cytotoxicity and in vivo activity as free radical scavengers of chlorido(p-cymene) complexes of ruthenium(II) containing N-alkylphenothiazines | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Гргурић-Шипка, Сања; Борозан, Сунчица; Крстић, Милена; Совиљ, Софија П.; Радосављевиц-Еванс, Ивана; Сантибанез, Јуан Францисцо; | |
dc.citation.volume | 46 | |
dc.citation.issue | 9 | |
dc.citation.spage | 4168 | |
dc.citation.epage | 4177 | |
dc.citation.other | 46(9): 4168-4177 | |
dc.citation.rank | M21 | |
dc.identifier.wos | 000295237400066 | |
dc.identifier.doi | 10.1016/j.ejmech.2011.06.019 | |
dc.identifier.pmid | 21741132 | |
dc.identifier.scopus | 2-s2.0-80052929773 | |
dc.type.version | publishedVersion |