TY  - CONF
AU  - Marković, Radmila
AU  - Milanković, Branko
AU  - Perić, Dejan
AU  - Starčević, Marija
AU  - Jovanović, Dragoljub
AU  - Krstić, Milena
AU  - Šefer, Dragan
PY  - 2024
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/3636
C3  - 20th Biennial International Conference of Animal Nutrition Society of India on Sustainable animal nutrition for global health and production: innovations and directions, Tamil Nadu, 23rd to 25th January, 2024
T1  - The use of different fat sources in broiler feed and the effect on production performance and meat quality
SP  - 132
EP  - 140
UR  - https://hdl.handle.net/21.15107/rcub_veterinar_3636
ER  - 

@conference{
author = "Marković, Radmila and Milanković, Branko and Perić, Dejan and Starčević, Marija and Jovanović, Dragoljub and Krstić, Milena and Šefer, Dragan",
year = "2024",
journal = "20th Biennial International Conference of Animal Nutrition Society of India on Sustainable animal nutrition for global health and production: innovations and directions, Tamil Nadu, 23rd to 25th January, 2024",
title = "The use of different fat sources in broiler feed and the effect on production performance and meat quality",
pages = "132-140",
url = "https://hdl.handle.net/21.15107/rcub_veterinar_3636"
}

Marković, R., Milanković, B., Perić, D., Starčević, M., Jovanović, D., Krstić, M.,& Šefer, D.. (2024). The use of different fat sources in broiler feed and the effect on production performance and meat quality. in 20th Biennial International Conference of Animal Nutrition Society of India on Sustainable animal nutrition for global health and production: innovations and directions, Tamil Nadu, 23rd to 25th January, 2024, 132-140.
https://hdl.handle.net/21.15107/rcub_veterinar_3636

Marković R, Milanković B, Perić D, Starčević M, Jovanović D, Krstić M, Šefer D. The use of different fat sources in broiler feed and the effect on production performance and meat quality. in 20th Biennial International Conference of Animal Nutrition Society of India on Sustainable animal nutrition for global health and production: innovations and directions, Tamil Nadu, 23rd to 25th January, 2024. 2024;:132-140.
https://hdl.handle.net/21.15107/rcub_veterinar_3636 .

Marković, Radmila, Milanković, Branko, Perić, Dejan, Starčević, Marija, Jovanović, Dragoljub, Krstić, Milena, Šefer, Dragan, "The use of different fat sources in broiler feed and the effect on production performance and meat quality" in 20th Biennial International Conference of Animal Nutrition Society of India on Sustainable animal nutrition for global health and production: innovations and directions, Tamil Nadu, 23rd to 25th January, 2024 (2024):132-140,
https://hdl.handle.net/21.15107/rcub_veterinar_3636 .

TY  - CONF
AU  - Krstić, Milena
AU  - Santibanez, Juan Francisco
AU  - Poljarević, Jelena
AU  - Grgurić-Šipka, Sanja
AU  - Borozan, Sunčica
PY  - 2023
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/3795
AB  - C-Jun N-terminalne kinaze (JNK) spadaju u mitogen-aktivirane protein kinaze (MAPK) i
imaju važnu ulogu u kontroli niza ćelijskih procesa uključujući proliferaciju,
kancerogenezu i apoptozu. Kompleksi rutenijuma pokazali su izuzetan potencijal kao
mogući citostatici. Upravo iz ovih razloga ispitivan je mehanizam delovanja kompleksa
Ru(II) sa N-alkilfenotiazinima (hlorpromazinom, trifluoperazinom i tioridazinom) na
signalne parametre (t-JNK, p-JNK i β-aktin) u THP-1 ćelijama humane leukemije. U
ćelijama tretiranim kompleksom sa fluoperazinom u koncentraciji od 10 μM (IC50 je 10,5
μM) ekspresija t-JNK povećana je za 47,45%, dok je ekspresija p-JNK dvostruko veća u
poređenju sa netretiranim ćelijama, što sugeriše da su t-JNK i p-JNK uključeni u apoptozu
ovih ćelija.
AB  - The c-Jun N-terminal kinase (JNK) belongs to the family of mitogen-activated protein
kinases (MAPKs) that play an important role in the control of a number of celular
processes, including proliferation, cancerogenesis and apoptosis. Ruthenium complexes
have shown remarkable potential as possible cytostatics. Precisely for these reasons, the
mechanism of action of Ru(II) complexes with N-alkylphenothiazines (chlorpromazine,
trifluoperazine, and thioridazine) on signalling parameters (t-JNK, p-JNK and β-actin) in
THP-1 human leucemic cells was investigated. In cells treated with fluoperazine complex
at a concentration of 10 μM (IC50 is 10.5 μM), an increased expression of t-JNK by 47.45%
was found while the expression of p-JNK was twice higher compared to untreated cells,
suggesting that t-JNK and p-JNK are involved in the apoptosis of these cells.
PB  - Beograd : Srpsko hemijsko društvo
C3  - 59. Savetovanje Srpskog hemijskog društva, Novi Sad, 1 - 2. jun 2023
T1  - Ekspresija JNK kinaza u THP-1 celijama tretiranim Ru(II) kompleksima
T1  - Expression of JNK kinases in THP-1 cells treated with Ru(II) complexes
SP  - 51
EP  - 51
UR  - https://hdl.handle.net/21.15107/rcub_veterinar_3795
ER  - 

@conference{
author = "Krstić, Milena and Santibanez, Juan Francisco and Poljarević, Jelena and Grgurić-Šipka, Sanja and Borozan, Sunčica",
year = "2023",
abstract = "C-Jun N-terminalne kinaze (JNK) spadaju u mitogen-aktivirane protein kinaze (MAPK) i
imaju važnu ulogu u kontroli niza ćelijskih procesa uključujući proliferaciju,
kancerogenezu i apoptozu. Kompleksi rutenijuma pokazali su izuzetan potencijal kao
mogući citostatici. Upravo iz ovih razloga ispitivan je mehanizam delovanja kompleksa
Ru(II) sa N-alkilfenotiazinima (hlorpromazinom, trifluoperazinom i tioridazinom) na
signalne parametre (t-JNK, p-JNK i β-aktin) u THP-1 ćelijama humane leukemije. U
ćelijama tretiranim kompleksom sa fluoperazinom u koncentraciji od 10 μM (IC50 je 10,5
μM) ekspresija t-JNK povećana je za 47,45%, dok je ekspresija p-JNK dvostruko veća u
poređenju sa netretiranim ćelijama, što sugeriše da su t-JNK i p-JNK uključeni u apoptozu
ovih ćelija., The c-Jun N-terminal kinase (JNK) belongs to the family of mitogen-activated protein
kinases (MAPKs) that play an important role in the control of a number of celular
processes, including proliferation, cancerogenesis and apoptosis. Ruthenium complexes
have shown remarkable potential as possible cytostatics. Precisely for these reasons, the
mechanism of action of Ru(II) complexes with N-alkylphenothiazines (chlorpromazine,
trifluoperazine, and thioridazine) on signalling parameters (t-JNK, p-JNK and β-actin) in
THP-1 human leucemic cells was investigated. In cells treated with fluoperazine complex
at a concentration of 10 μM (IC50 is 10.5 μM), an increased expression of t-JNK by 47.45%
was found while the expression of p-JNK was twice higher compared to untreated cells,
suggesting that t-JNK and p-JNK are involved in the apoptosis of these cells.",
publisher = "Beograd : Srpsko hemijsko društvo",
journal = "59. Savetovanje Srpskog hemijskog društva, Novi Sad, 1 - 2. jun 2023",
title = "Ekspresija JNK kinaza u THP-1 celijama tretiranim Ru(II) kompleksima, Expression of JNK kinases in THP-1 cells treated with Ru(II) complexes",
pages = "51-51",
url = "https://hdl.handle.net/21.15107/rcub_veterinar_3795"
}

Krstić, M., Santibanez, J. F., Poljarević, J., Grgurić-Šipka, S.,& Borozan, S.. (2023). Ekspresija JNK kinaza u THP-1 celijama tretiranim Ru(II) kompleksima. in 59. Savetovanje Srpskog hemijskog društva, Novi Sad, 1 - 2. jun 2023
Beograd : Srpsko hemijsko društvo., 51-51.
https://hdl.handle.net/21.15107/rcub_veterinar_3795

Krstić M, Santibanez JF, Poljarević J, Grgurić-Šipka S, Borozan S. Ekspresija JNK kinaza u THP-1 celijama tretiranim Ru(II) kompleksima. in 59. Savetovanje Srpskog hemijskog društva, Novi Sad, 1 - 2. jun 2023. 2023;:51-51.
https://hdl.handle.net/21.15107/rcub_veterinar_3795 .

Krstić, Milena, Santibanez, Juan Francisco, Poljarević, Jelena, Grgurić-Šipka, Sanja, Borozan, Sunčica, "Ekspresija JNK kinaza u THP-1 celijama tretiranim Ru(II) kompleksima" in 59. Savetovanje Srpskog hemijskog društva, Novi Sad, 1 - 2. jun 2023 (2023):51-51,
https://hdl.handle.net/21.15107/rcub_veterinar_3795 .

TY  - CONF
AU  - Krstić, Milena
AU  - Santibanez, Juan Francisco
AU  - Poljarević, Jelena
AU  - Nikolić, Stefan
AU  - Grguric-Šipka, Sanja R.
AU  - Borozan, Sunčica
PY  - 2022
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/2797
AB  - U cilju pronalaženja adekvatne terapije u lecenju maligniteta kompleksi rutenijuma
pokazali su zavidan potencijal. Kompleksi Ru(II) sa N-alkilfenotiazinima,
hlorpromazinom, trifluoperazinom i tioridazinom, korišceni su u ispitivanju mogucih
puteva apoptoze u K562 celijama. Ispitivana je spektrofotometrijski ekstracelularna LDH,
ekspresija COX-2, t-JNK, p-JNK i b-aktina imunohemijski nakon SDS elektroforeze.
Kompleks Ru(II) sa trifluoperazinom u koncentraciji od 10 μM smanjuje ekspresiju t-JNK,
inhibira COX-2 oko 42%, znacajno povecava kolicinu ekstracelularne LDH u odnosu na
netretirane K562 celije i time potvrdjuje apoptozu ovih celija
AB  - Ruthenium complexes are of significant interest in the treatment of malignancies. Ru(II)
complexes with N-alkylphenothiazines (chlorpromazine, trifluoperazine, and thioridazine)
were used in the study of possible apoptosis pathways in K562 cells.
Spectrophotometrically extracellular LDH was quantified and immunochemical expression
of COX-2, t-JNK, p-JNK and b-actin after SDS electrophoresis was determined. The
Ru(II) complex with trifluoperazine at a concentration of 10 μM reduced t-JNK
expression, inhibited COX-2 by about 42%, significantly increased the amount of
extracellular LDH compared to the untreated K562 cells and thus confirmed apoptosis.
PB  - Beograd : Razvojno-istraživački centar grafičkog inženjerstva TMF
C3  - 58. savetovanje Srpskog hemijskog društva, Beograd, 9 - 10. jun 2022.
T1  - Uticaj kompleksa Ru(II) na moguce puteve apoptoze u K562 celijama leukemije
T1  - Influence of Ru(II) complex on possible pathways of apoptosis in
K562 leukemia cells
SP  - 89
EP  - 89
UR  - https://hdl.handle.net/21.15107/rcub_veterinar_2797
ER  - 

@conference{
author = "Krstić, Milena and Santibanez, Juan Francisco and Poljarević, Jelena and Nikolić, Stefan and Grguric-Šipka, Sanja R. and Borozan, Sunčica",
year = "2022",
abstract = "U cilju pronalaženja adekvatne terapije u lecenju maligniteta kompleksi rutenijuma
pokazali su zavidan potencijal. Kompleksi Ru(II) sa N-alkilfenotiazinima,
hlorpromazinom, trifluoperazinom i tioridazinom, korišceni su u ispitivanju mogucih
puteva apoptoze u K562 celijama. Ispitivana je spektrofotometrijski ekstracelularna LDH,
ekspresija COX-2, t-JNK, p-JNK i b-aktina imunohemijski nakon SDS elektroforeze.
Kompleks Ru(II) sa trifluoperazinom u koncentraciji od 10 μM smanjuje ekspresiju t-JNK,
inhibira COX-2 oko 42%, znacajno povecava kolicinu ekstracelularne LDH u odnosu na
netretirane K562 celije i time potvrdjuje apoptozu ovih celija, Ruthenium complexes are of significant interest in the treatment of malignancies. Ru(II)
complexes with N-alkylphenothiazines (chlorpromazine, trifluoperazine, and thioridazine)
were used in the study of possible apoptosis pathways in K562 cells.
Spectrophotometrically extracellular LDH was quantified and immunochemical expression
of COX-2, t-JNK, p-JNK and b-actin after SDS electrophoresis was determined. The
Ru(II) complex with trifluoperazine at a concentration of 10 μM reduced t-JNK
expression, inhibited COX-2 by about 42%, significantly increased the amount of
extracellular LDH compared to the untreated K562 cells and thus confirmed apoptosis.",
publisher = "Beograd : Razvojno-istraživački centar grafičkog inženjerstva TMF",
journal = "58. savetovanje Srpskog hemijskog društva, Beograd, 9 - 10. jun 2022.",
title = "Uticaj kompleksa Ru(II) na moguce puteve apoptoze u K562 celijama leukemije, Influence of Ru(II) complex on possible pathways of apoptosis in
K562 leukemia cells",
pages = "89-89",
url = "https://hdl.handle.net/21.15107/rcub_veterinar_2797"
}

Krstić, M., Santibanez, J. F., Poljarević, J., Nikolić, S., Grguric-Šipka, S. R.,& Borozan, S.. (2022). Uticaj kompleksa Ru(II) na moguce puteve apoptoze u K562 celijama leukemije. in 58. savetovanje Srpskog hemijskog društva, Beograd, 9 - 10. jun 2022.
Beograd : Razvojno-istraživački centar grafičkog inženjerstva TMF., 89-89.
https://hdl.handle.net/21.15107/rcub_veterinar_2797

Krstić M, Santibanez JF, Poljarević J, Nikolić S, Grguric-Šipka SR, Borozan S. Uticaj kompleksa Ru(II) na moguce puteve apoptoze u K562 celijama leukemije. in 58. savetovanje Srpskog hemijskog društva, Beograd, 9 - 10. jun 2022.. 2022;:89-89.
https://hdl.handle.net/21.15107/rcub_veterinar_2797 .

Krstić, Milena, Santibanez, Juan Francisco, Poljarević, Jelena, Nikolić, Stefan, Grguric-Šipka, Sanja R., Borozan, Sunčica, "Uticaj kompleksa Ru(II) na moguce puteve apoptoze u K562 celijama leukemije" in 58. savetovanje Srpskog hemijskog društva, Beograd, 9 - 10. jun 2022. (2022):89-89,
https://hdl.handle.net/21.15107/rcub_veterinar_2797 .

TY  - CONF
AU  - Petrović, Tamara
AU  - Gligorijević, Nevenka
AU  - Belaj, Ferdinand
AU  - Grgurić-Šipka, Sanja
AU  - Nikolić, Stefan
AU  - Krstić, Milena
AU  - Poljarević, Jelena
AU  - Mihajlović-Lalić, Ljiljana E.
PY  - 2022
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/2798
AB  - Rhenium complexes merit particular attention in the area of metallodrug design due to rhenium’s broad spectrum of oxidation states and consequently, the possibility to design compounds of a great structural diversity. Thus, the synthesis, chemical characterization and antitumor activity in vitro of the three Re(V) complexes is described. Novel compounds were obtained via reaction of [ReOCl3(PPh3)2] with corresponding ligands (pyridine-2-carboxylic acid, 3-methylpyridine-2-carboxylic acid and 6-methylpyridine- 2-carboxylic acid) in acetonitrile at 78 °C for 3h. The complexes were fully characterized using NMR, IR, MS and elemental analysis. Their octahedral geometry with bidentate N^O ligand was confirmed by X-ray diffraction analysis. Antiproliferative effect was determined by MTT assay and only the complex with pyridine-2-carboxylic acid (1) showed dose-dependent cytotoxic potential, particularly toward triple-negative breast adenocarcinoma cells MDA-MB-231 with IC50 68.90 ±
1.73 μM and pancreatic adenocarcinoma cells PANC-1 with IC50 69.8 ± 2.3 μM. Drug combination studies in PANC-1 cells with 1 and Verapamil hydrochloride (VRP) showed slight arrest of cell cycle in the S phase and also it increase its antiproliferative potential to IC50 51.4 ± 2.8 μM. Part of the research included a depletion of the glutathione (GSH) level by L-buthionine-sulfoximine (L-BSO) at sub-toxic concentrations (100 μM) in PANC-1 cells which caused an increase of activity of 1 to the IC50 57.67 ± 6.51 μM.
C3  - Osterreichische Chemietage, Wienna, Austria, September 20-22, 2022
T1  - Oxorhenium(V) complexes in the drug combination study
SP  - 90
EP  - 90
UR  - https://hdl.handle.net/21.15107/rcub_veterinar_2798
ER  - 

@conference{
author = "Petrović, Tamara and Gligorijević, Nevenka and Belaj, Ferdinand and Grgurić-Šipka, Sanja and Nikolić, Stefan and Krstić, Milena and Poljarević, Jelena and Mihajlović-Lalić, Ljiljana E.",
year = "2022",
abstract = "Rhenium complexes merit particular attention in the area of metallodrug design due to rhenium’s broad spectrum of oxidation states and consequently, the possibility to design compounds of a great structural diversity. Thus, the synthesis, chemical characterization and antitumor activity in vitro of the three Re(V) complexes is described. Novel compounds were obtained via reaction of [ReOCl3(PPh3)2] with corresponding ligands (pyridine-2-carboxylic acid, 3-methylpyridine-2-carboxylic acid and 6-methylpyridine- 2-carboxylic acid) in acetonitrile at 78 °C for 3h. The complexes were fully characterized using NMR, IR, MS and elemental analysis. Their octahedral geometry with bidentate N^O ligand was confirmed by X-ray diffraction analysis. Antiproliferative effect was determined by MTT assay and only the complex with pyridine-2-carboxylic acid (1) showed dose-dependent cytotoxic potential, particularly toward triple-negative breast adenocarcinoma cells MDA-MB-231 with IC50 68.90 ±
1.73 μM and pancreatic adenocarcinoma cells PANC-1 with IC50 69.8 ± 2.3 μM. Drug combination studies in PANC-1 cells with 1 and Verapamil hydrochloride (VRP) showed slight arrest of cell cycle in the S phase and also it increase its antiproliferative potential to IC50 51.4 ± 2.8 μM. Part of the research included a depletion of the glutathione (GSH) level by L-buthionine-sulfoximine (L-BSO) at sub-toxic concentrations (100 μM) in PANC-1 cells which caused an increase of activity of 1 to the IC50 57.67 ± 6.51 μM.",
journal = "Osterreichische Chemietage, Wienna, Austria, September 20-22, 2022",
title = "Oxorhenium(V) complexes in the drug combination study",
pages = "90-90",
url = "https://hdl.handle.net/21.15107/rcub_veterinar_2798"
}

Petrović, T., Gligorijević, N., Belaj, F., Grgurić-Šipka, S., Nikolić, S., Krstić, M., Poljarević, J.,& Mihajlović-Lalić, L. E.. (2022). Oxorhenium(V) complexes in the drug combination study. in Osterreichische Chemietage, Wienna, Austria, September 20-22, 2022, 90-90.
https://hdl.handle.net/21.15107/rcub_veterinar_2798

Petrović T, Gligorijević N, Belaj F, Grgurić-Šipka S, Nikolić S, Krstić M, Poljarević J, Mihajlović-Lalić LE. Oxorhenium(V) complexes in the drug combination study. in Osterreichische Chemietage, Wienna, Austria, September 20-22, 2022. 2022;:90-90.
https://hdl.handle.net/21.15107/rcub_veterinar_2798 .

Petrović, Tamara, Gligorijević, Nevenka, Belaj, Ferdinand, Grgurić-Šipka, Sanja, Nikolić, Stefan, Krstić, Milena, Poljarević, Jelena, Mihajlović-Lalić, Ljiljana E., "Oxorhenium(V) complexes in the drug combination study" in Osterreichische Chemietage, Wienna, Austria, September 20-22, 2022 (2022):90-90,
https://hdl.handle.net/21.15107/rcub_veterinar_2798 .

TY  - CONF
AU  - Radulović, Stamen
AU  - Šefer, Dragan
AU  - Marković, Radmila
AU  - Perić, Dejan
AU  - Jovanović, Dragoljub
AU  - Krstić, Milena
AU  - Borozan, Sunčica
PY  - 2021
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/2006
AB  - U intenzivnoj stočarskoj proizvodnji, životinje su izložene brojnim stresogenim faktorima koji vode poreklo iz hrane, okruženja, tehnolo- gije proizvodnje, kao i bioloških/individualnih karakteristika svake je- dinke. Navedeni stresori su odgovorni za slabije proizvodne rezultate, lošije reproduktivne karakteristike, kao i smanjenu otpornost organiz- ma prema bolestima. Na molekularnom nivou, aktivnost stresora se vezuje za stvaranje slobodnih radikala i nastanak oksidativnog stresa sa posledičnim oštećenjem biološki važnih molekula. U telu životinje, postoji veliki broj jedinjenja koja ispoljavaju antioksidativni efekat. Ne- ka od njih se sintetišu u tkivima (askorbinska kiselina, koenzim Q, kar- nitin, taurin i antioksidativni enzimi), dok se druga unose putem hrane (vitamini, karotenoidi, fenolna jedinjenja i mineralne materije). Najvaž- niji praktičan korak u sprečavanju oksidativnog oštećenja i održava- nju ravnoteže antioksidativne odbrane u telu životinja se postiže po- boljšanjem antioksidativnog kapaciteta hrane, odnosno optimizacijom unosa antioksidanasa putem hrane za životinje. Pravilnom upotrebom antioksidanasa usporavaju se oksidacioni procesi u hrani i smanjuje se unos slobodnih radikala od strane životinja, čime se poboljšava- ju njihove proizvodno-reproduktivne karakteristike, kao i kvalitet me- sa. Najjednostavniji način predstavljanja antioksidativnog kapaciteta uzorka se vrši na osnovu određenog referentnog standarda, najčešće 6-hidroksi-2,5,7,8-tetrametilhroman-2-karboksilne kiseline, poznate kao Trolox. Na osnovu rezultata dobijenih pomoću Trolox standarda vrši se procena antioksidativnog kapaciteta hraniva i smeša za ishra- nu životinja, kao i upotrebljenih aditiva sa antioksidativnim dejstvom.
PB  - Fakultet veterinarske medicine, Centar za izdavačku delatnost i promet učila
C3  - Zbornik radova - XLII seminar inovacija znanja veterinara
T1  - Određivanje antioksidativnog kapaciteta hrane u funkciji optimalnih proizvodnih rezultata monogastričnih životinja
SP  - 133
EP  - 147
UR  - https://hdl.handle.net/21.15107/rcub_veterinar_2006
ER  - 

@conference{
author = "Radulović, Stamen and Šefer, Dragan and Marković, Radmila and Perić, Dejan and Jovanović, Dragoljub and Krstić, Milena and Borozan, Sunčica",
year = "2021",
abstract = "U intenzivnoj stočarskoj proizvodnji, životinje su izložene brojnim stresogenim faktorima koji vode poreklo iz hrane, okruženja, tehnolo- gije proizvodnje, kao i bioloških/individualnih karakteristika svake je- dinke. Navedeni stresori su odgovorni za slabije proizvodne rezultate, lošije reproduktivne karakteristike, kao i smanjenu otpornost organiz- ma prema bolestima. Na molekularnom nivou, aktivnost stresora se vezuje za stvaranje slobodnih radikala i nastanak oksidativnog stresa sa posledičnim oštećenjem biološki važnih molekula. U telu životinje, postoji veliki broj jedinjenja koja ispoljavaju antioksidativni efekat. Ne- ka od njih se sintetišu u tkivima (askorbinska kiselina, koenzim Q, kar- nitin, taurin i antioksidativni enzimi), dok se druga unose putem hrane (vitamini, karotenoidi, fenolna jedinjenja i mineralne materije). Najvaž- niji praktičan korak u sprečavanju oksidativnog oštećenja i održava- nju ravnoteže antioksidativne odbrane u telu životinja se postiže po- boljšanjem antioksidativnog kapaciteta hrane, odnosno optimizacijom unosa antioksidanasa putem hrane za životinje. Pravilnom upotrebom antioksidanasa usporavaju se oksidacioni procesi u hrani i smanjuje se unos slobodnih radikala od strane životinja, čime se poboljšava- ju njihove proizvodno-reproduktivne karakteristike, kao i kvalitet me- sa. Najjednostavniji način predstavljanja antioksidativnog kapaciteta uzorka se vrši na osnovu određenog referentnog standarda, najčešće 6-hidroksi-2,5,7,8-tetrametilhroman-2-karboksilne kiseline, poznate kao Trolox. Na osnovu rezultata dobijenih pomoću Trolox standarda vrši se procena antioksidativnog kapaciteta hraniva i smeša za ishra- nu životinja, kao i upotrebljenih aditiva sa antioksidativnim dejstvom.",
publisher = "Fakultet veterinarske medicine, Centar za izdavačku delatnost i promet učila",
journal = "Zbornik radova - XLII seminar inovacija znanja veterinara",
title = "Određivanje antioksidativnog kapaciteta hrane u funkciji optimalnih proizvodnih rezultata monogastričnih životinja",
pages = "133-147",
url = "https://hdl.handle.net/21.15107/rcub_veterinar_2006"
}

Radulović, S., Šefer, D., Marković, R., Perić, D., Jovanović, D., Krstić, M.,& Borozan, S.. (2021). Određivanje antioksidativnog kapaciteta hrane u funkciji optimalnih proizvodnih rezultata monogastričnih životinja. in Zbornik radova - XLII seminar inovacija znanja veterinara
Fakultet veterinarske medicine, Centar za izdavačku delatnost i promet učila., 133-147.
https://hdl.handle.net/21.15107/rcub_veterinar_2006

Radulović S, Šefer D, Marković R, Perić D, Jovanović D, Krstić M, Borozan S. Određivanje antioksidativnog kapaciteta hrane u funkciji optimalnih proizvodnih rezultata monogastričnih životinja. in Zbornik radova - XLII seminar inovacija znanja veterinara. 2021;:133-147.
https://hdl.handle.net/21.15107/rcub_veterinar_2006 .

Radulović, Stamen, Šefer, Dragan, Marković, Radmila, Perić, Dejan, Jovanović, Dragoljub, Krstić, Milena, Borozan, Sunčica, "Određivanje antioksidativnog kapaciteta hrane u funkciji optimalnih proizvodnih rezultata monogastričnih životinja" in Zbornik radova - XLII seminar inovacija znanja veterinara (2021):133-147,
https://hdl.handle.net/21.15107/rcub_veterinar_2006 .

TY  - CONF
AU  - Jovanović, Dragoljub
AU  - Marković, Radmila
AU  - Šefer, Dragan
AU  - Krstić, Milena
AU  - Stanić, Vojislav
AU  - Perić, Dejan
AU  - Baltić, Milan Ž.
PY  - 2021
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/2561
AB  - The aim of this study was to determine the contamination of some toxic metals (Pb, Cd, Hg and As) in muscle tissue of Common carp (Cyprinus carpio) from four different localities (Veliko Blato, Grabovac, Mokri Sebeš and Bečmen) near Belgrade. Generally, the highest average content of lead, cadmium, mercury and arsenic was found in fish muscle tissue from lake Veliko Blato. Concentrations of Pb, Hg and As were under the maximum residual levels prescribed by the European Union (EU) and the maximum allowed concentrations (MAC) for Serbia. In all investigated samples, levels of Cd exceeded MAC values. Data on the finding of toxic metals in fish at the same time speak about the safety of fish as food and can be an indicator of environmental pollution.
PB  - Belgrade : Vinča institute of nuclear sciences- National institute of the republic of serbia Vinča
C3  - 15th International Conference on Fundamental and Applied Aspects of Physical Chemistry. 7th Workshop: Specific methods for food safety and quality, Sept. 22. 2021
T1  - Toxic metals content in muscle tissue of common carp from locations near Belgrade
SP  - 69
EP  - 74
UR  - https://hdl.handle.net/21.15107/rcub_veterinar_2561
ER  - 

@conference{
author = "Jovanović, Dragoljub and Marković, Radmila and Šefer, Dragan and Krstić, Milena and Stanić, Vojislav and Perić, Dejan and Baltić, Milan Ž.",
year = "2021",
abstract = "The aim of this study was to determine the contamination of some toxic metals (Pb, Cd, Hg and As) in muscle tissue of Common carp (Cyprinus carpio) from four different localities (Veliko Blato, Grabovac, Mokri Sebeš and Bečmen) near Belgrade. Generally, the highest average content of lead, cadmium, mercury and arsenic was found in fish muscle tissue from lake Veliko Blato. Concentrations of Pb, Hg and As were under the maximum residual levels prescribed by the European Union (EU) and the maximum allowed concentrations (MAC) for Serbia. In all investigated samples, levels of Cd exceeded MAC values. Data on the finding of toxic metals in fish at the same time speak about the safety of fish as food and can be an indicator of environmental pollution.",
publisher = "Belgrade : Vinča institute of nuclear sciences- National institute of the republic of serbia Vinča",
journal = "15th International Conference on Fundamental and Applied Aspects of Physical Chemistry. 7th Workshop: Specific methods for food safety and quality, Sept. 22. 2021",
title = "Toxic metals content in muscle tissue of common carp from locations near Belgrade",
pages = "69-74",
url = "https://hdl.handle.net/21.15107/rcub_veterinar_2561"
}

Jovanović, D., Marković, R., Šefer, D., Krstić, M., Stanić, V., Perić, D.,& Baltić, M. Ž.. (2021). Toxic metals content in muscle tissue of common carp from locations near Belgrade. in 15th International Conference on Fundamental and Applied Aspects of Physical Chemistry. 7th Workshop: Specific methods for food safety and quality, Sept. 22. 2021
Belgrade : Vinča institute of nuclear sciences- National institute of the republic of serbia Vinča., 69-74.
https://hdl.handle.net/21.15107/rcub_veterinar_2561

Jovanović D, Marković R, Šefer D, Krstić M, Stanić V, Perić D, Baltić MŽ. Toxic metals content in muscle tissue of common carp from locations near Belgrade. in 15th International Conference on Fundamental and Applied Aspects of Physical Chemistry. 7th Workshop: Specific methods for food safety and quality, Sept. 22. 2021. 2021;:69-74.
https://hdl.handle.net/21.15107/rcub_veterinar_2561 .

Jovanović, Dragoljub, Marković, Radmila, Šefer, Dragan, Krstić, Milena, Stanić, Vojislav, Perić, Dejan, Baltić, Milan Ž., "Toxic metals content in muscle tissue of common carp from locations near Belgrade" in 15th International Conference on Fundamental and Applied Aspects of Physical Chemistry. 7th Workshop: Specific methods for food safety and quality, Sept. 22. 2021 (2021):69-74,
https://hdl.handle.net/21.15107/rcub_veterinar_2561 .

TY  - JOUR
AU  - Petković, B.B.
AU  - Ognjanović, M.
AU  - Krstić, Milena
AU  - Stanković, V.
AU  - Babincev, L.
AU  - Pergal, M.
AU  - Stanković, D.M.
PY  - 2020
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1813
AB  - Mefenamic acid and indomethacin, medicaments belonging to the group of non-steroidal anti-inflammatory agents, were determined separately and simultaneously at anodically prepared BDDE. Differential pulse voltammetry was used to establish simple and fast analytical procedure based on electrooxidation of mefenamic acid at 0.6 V and indomethacin at 1.0 V (and 1.1 V). At optimal conditions, it was suitable for highly sensitive and selective determination of these compounds with LODs comparable to previously reported modified electrodes. Additionally, considering the importance of these compounds, we proposed precise and accurate quantification of these species based on green and simple pre-treatable electrochemical sensor. The effect of interfering agents (tablet ingredients and vitamins) was appeared to be negligibly confirming a favourable selectivity of the method. The proposed method was analytically applied by simultaneously determining mefenamic acid and indomethacin in pharmaceutical formulations.
PB  - Elsevier Ltd
T2  - Diamond and Related Materials
T1  - Boron-doped diamond electrode as efficient sensing platform for simultaneous quantification of mefenamic acid and indomethacin
VL  - 105
SP  - 107785
DO  - 10.1016/j.diamond.2020.107785
ER  - 

@article{
author = "Petković, B.B. and Ognjanović, M. and Krstić, Milena and Stanković, V. and Babincev, L. and Pergal, M. and Stanković, D.M.",
year = "2020",
abstract = "Mefenamic acid and indomethacin, medicaments belonging to the group of non-steroidal anti-inflammatory agents, were determined separately and simultaneously at anodically prepared BDDE. Differential pulse voltammetry was used to establish simple and fast analytical procedure based on electrooxidation of mefenamic acid at 0.6 V and indomethacin at 1.0 V (and 1.1 V). At optimal conditions, it was suitable for highly sensitive and selective determination of these compounds with LODs comparable to previously reported modified electrodes. Additionally, considering the importance of these compounds, we proposed precise and accurate quantification of these species based on green and simple pre-treatable electrochemical sensor. The effect of interfering agents (tablet ingredients and vitamins) was appeared to be negligibly confirming a favourable selectivity of the method. The proposed method was analytically applied by simultaneously determining mefenamic acid and indomethacin in pharmaceutical formulations.",
publisher = "Elsevier Ltd",
journal = "Diamond and Related Materials",
title = "Boron-doped diamond electrode as efficient sensing platform for simultaneous quantification of mefenamic acid and indomethacin",
volume = "105",
pages = "107785",
doi = "10.1016/j.diamond.2020.107785"
}

Petković, B.B., Ognjanović, M., Krstić, M., Stanković, V., Babincev, L., Pergal, M.,& Stanković, D.M.. (2020). Boron-doped diamond electrode as efficient sensing platform for simultaneous quantification of mefenamic acid and indomethacin. in Diamond and Related Materials
Elsevier Ltd., 105, 107785.
https://doi.org/10.1016/j.diamond.2020.107785

Petković B, Ognjanović M, Krstić M, Stanković V, Babincev L, Pergal M, Stanković D. Boron-doped diamond electrode as efficient sensing platform for simultaneous quantification of mefenamic acid and indomethacin. in Diamond and Related Materials. 2020;105:107785.
doi:10.1016/j.diamond.2020.107785 .

Petković, B.B., Ognjanović, M., Krstić, Milena, Stanković, V., Babincev, L., Pergal, M., Stanković, D.M., "Boron-doped diamond electrode as efficient sensing platform for simultaneous quantification of mefenamic acid and indomethacin" in Diamond and Related Materials, 105 (2020):107785,
https://doi.org/10.1016/j.diamond.2020.107785 . .

TY  - JOUR
AU  - Ognjanović, Miloš
AU  - Stanković, Dalibor M.
AU  - Jović, Milica
AU  - Krstić, Milena
AU  - Lesch, Andreas
AU  - Girault, Hubert H.
AU  - Antić, Branislav
PY  - 2020
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1856
AB  - Here, we report the design of a disposable single-drop voltammetric sensor for the quantitative determination of antipsychotic drug trifluoperazine (TFP). The sensor was built using inkjet-printed carbon nanotube (CNT) electrodes, which were modified with dimercaptosuccinic acid (DMSA)-coated magnetite nanoparticles uniformly dispersed over reduced graphene oxide nanosheets (DMSA/Fe3O4/RGO). The used modifying materials were characterized by electron microscopy techniques (transmission electron microscopy (TEM) and field emission-scanning electron microscopy (FE-SEM)), X-ray powder diffraction, ζ-potential measurements, dynamic light scattering (DLS), and electrochemical methods (cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS)). The developed sensor, best operated at pH 7 in the Britton-Robinson buffer solution (BRBS), shows linear electrocatalytic activity with TFP in the concentration range of 1-50 μM, a low detection limit of 0.54 μM, and excellent selectivity, repeatability, and reproducibility with an relative standard deviation (RSD) of 2.4%. A voltammetric approach using square wave voltammetry (SWV) is a sensitive technique under optimized conditions for the analytical determination of submicromolar amounts of TFP. Bare CNT and RGO- and DMSA/Fe3O4-modified CNT electrodes showed lower electrocatalytic activity than the DMSA/Fe3O4/RGO/CNT electrode. The development of this kind of TFP sensor based on nanoparticle-decorated graphene nanosheets can offer a tool for point-of-care applications as sensors in biomedicine.
T2  - ACS Applied Nano Materials
T1  - Inkjet-Printed Carbon Nanotube Electrodes Modified with Dimercaptosuccinic Acid-Capped Fe3O4Nanoparticles on Reduced Graphene Oxide Nanosheets for Single-Drop Determination of Trifluoperazine
VL  - 3
IS  - 5
SP  - 4654
EP  - 4662
DO  - 10.1021/acsanm.0c00661
ER  - 

@article{
author = "Ognjanović, Miloš and Stanković, Dalibor M. and Jović, Milica and Krstić, Milena and Lesch, Andreas and Girault, Hubert H. and Antić, Branislav",
year = "2020",
abstract = "Here, we report the design of a disposable single-drop voltammetric sensor for the quantitative determination of antipsychotic drug trifluoperazine (TFP). The sensor was built using inkjet-printed carbon nanotube (CNT) electrodes, which were modified with dimercaptosuccinic acid (DMSA)-coated magnetite nanoparticles uniformly dispersed over reduced graphene oxide nanosheets (DMSA/Fe3O4/RGO). The used modifying materials were characterized by electron microscopy techniques (transmission electron microscopy (TEM) and field emission-scanning electron microscopy (FE-SEM)), X-ray powder diffraction, ζ-potential measurements, dynamic light scattering (DLS), and electrochemical methods (cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS)). The developed sensor, best operated at pH 7 in the Britton-Robinson buffer solution (BRBS), shows linear electrocatalytic activity with TFP in the concentration range of 1-50 μM, a low detection limit of 0.54 μM, and excellent selectivity, repeatability, and reproducibility with an relative standard deviation (RSD) of 2.4%. A voltammetric approach using square wave voltammetry (SWV) is a sensitive technique under optimized conditions for the analytical determination of submicromolar amounts of TFP. Bare CNT and RGO- and DMSA/Fe3O4-modified CNT electrodes showed lower electrocatalytic activity than the DMSA/Fe3O4/RGO/CNT electrode. The development of this kind of TFP sensor based on nanoparticle-decorated graphene nanosheets can offer a tool for point-of-care applications as sensors in biomedicine.",
journal = "ACS Applied Nano Materials",
title = "Inkjet-Printed Carbon Nanotube Electrodes Modified with Dimercaptosuccinic Acid-Capped Fe3O4Nanoparticles on Reduced Graphene Oxide Nanosheets for Single-Drop Determination of Trifluoperazine",
volume = "3",
number = "5",
pages = "4654-4662",
doi = "10.1021/acsanm.0c00661"
}

Ognjanović, M., Stanković, D. M., Jović, M., Krstić, M., Lesch, A., Girault, H. H.,& Antić, B.. (2020). Inkjet-Printed Carbon Nanotube Electrodes Modified with Dimercaptosuccinic Acid-Capped Fe3O4Nanoparticles on Reduced Graphene Oxide Nanosheets for Single-Drop Determination of Trifluoperazine. in ACS Applied Nano Materials, 3(5), 4654-4662.
https://doi.org/10.1021/acsanm.0c00661

Ognjanović M, Stanković DM, Jović M, Krstić M, Lesch A, Girault HH, Antić B. Inkjet-Printed Carbon Nanotube Electrodes Modified with Dimercaptosuccinic Acid-Capped Fe3O4Nanoparticles on Reduced Graphene Oxide Nanosheets for Single-Drop Determination of Trifluoperazine. in ACS Applied Nano Materials. 2020;3(5):4654-4662.
doi:10.1021/acsanm.0c00661 .

Ognjanović, Miloš, Stanković, Dalibor M., Jović, Milica, Krstić, Milena, Lesch, Andreas, Girault, Hubert H., Antić, Branislav, "Inkjet-Printed Carbon Nanotube Electrodes Modified with Dimercaptosuccinic Acid-Capped Fe3O4Nanoparticles on Reduced Graphene Oxide Nanosheets for Single-Drop Determination of Trifluoperazine" in ACS Applied Nano Materials, 3, no. 5 (2020):4654-4662,
https://doi.org/10.1021/acsanm.0c00661 . .

TY  - JOUR
AU  - Krstić, Milena
AU  - Petković, Branka B.
AU  - Milcić, Milos
AU  - Mišić, Dušan
AU  - Francisco Santibanez, Juan
PY  - 2019
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1752
AB  - Two new nitrato complexes of zinc and nickel with 1,4,8,11-tetrakis(2-pyridylmethyl)-1,4,8,11-tetraazacyclotetradecane (tpmc), have been synthesized and characterized. The IR spectral peaks showed that the coordinated and ionic nitrate ions are in agreement with the formula proposed by elemental analysis. Conductometric titrations predicted methanol to be a convenient solvent for synthesis and revealed the stoichiometry of the complexes, while molar electrical conductivities indicated a 1 : 3 complex electrolyte type for the zinc complex, and a 1 : 2 complex electrolyte type for the nickel complex. The optimized complex structure was obtained by molecular modeling and density functional theory calculations. The biological activity of the novel complexes was examined by screening eight different bacterial strains and two cancer cell lines. The zinc complex showed better antimicrobial activity against the bacterial strains, while the complexes did not show significance antiproliferative activity toward cancer cells MCF-7 and MDA-MB-231.
PB  - Soc Chemists Technologists Madeconia, Skopje
T2  - Macedonian Journal of Chemistry and Chemical Engineering
T1  - Synthesis, characterization and biological study of new dinuclear zinc(ii) and nickel(ii) octaaza macrocyclic complexes
VL  - 38
IS  - 1
SP  - 1
EP  - 11
DO  - 10.20450/mjcce.2019.1599
ER  - 

@article{
author = "Krstić, Milena and Petković, Branka B. and Milcić, Milos and Mišić, Dušan and Francisco Santibanez, Juan",
year = "2019",
abstract = "Two new nitrato complexes of zinc and nickel with 1,4,8,11-tetrakis(2-pyridylmethyl)-1,4,8,11-tetraazacyclotetradecane (tpmc), have been synthesized and characterized. The IR spectral peaks showed that the coordinated and ionic nitrate ions are in agreement with the formula proposed by elemental analysis. Conductometric titrations predicted methanol to be a convenient solvent for synthesis and revealed the stoichiometry of the complexes, while molar electrical conductivities indicated a 1 : 3 complex electrolyte type for the zinc complex, and a 1 : 2 complex electrolyte type for the nickel complex. The optimized complex structure was obtained by molecular modeling and density functional theory calculations. The biological activity of the novel complexes was examined by screening eight different bacterial strains and two cancer cell lines. The zinc complex showed better antimicrobial activity against the bacterial strains, while the complexes did not show significance antiproliferative activity toward cancer cells MCF-7 and MDA-MB-231.",
publisher = "Soc Chemists Technologists Madeconia, Skopje",
journal = "Macedonian Journal of Chemistry and Chemical Engineering",
title = "Synthesis, characterization and biological study of new dinuclear zinc(ii) and nickel(ii) octaaza macrocyclic complexes",
volume = "38",
number = "1",
pages = "1-11",
doi = "10.20450/mjcce.2019.1599"
}

Krstić, M., Petković, B. B., Milcić, M., Mišić, D.,& Francisco Santibanez, J.. (2019). Synthesis, characterization and biological study of new dinuclear zinc(ii) and nickel(ii) octaaza macrocyclic complexes. in Macedonian Journal of Chemistry and Chemical Engineering
Soc Chemists Technologists Madeconia, Skopje., 38(1), 1-11.
https://doi.org/10.20450/mjcce.2019.1599

Krstić M, Petković BB, Milcić M, Mišić D, Francisco Santibanez J. Synthesis, characterization and biological study of new dinuclear zinc(ii) and nickel(ii) octaaza macrocyclic complexes. in Macedonian Journal of Chemistry and Chemical Engineering. 2019;38(1):1-11.
doi:10.20450/mjcce.2019.1599 .

Krstić, Milena, Petković, Branka B., Milcić, Milos, Mišić, Dušan, Francisco Santibanez, Juan, "Synthesis, characterization and biological study of new dinuclear zinc(ii) and nickel(ii) octaaza macrocyclic complexes" in Macedonian Journal of Chemistry and Chemical Engineering, 38, no. 1 (2019):1-11,
https://doi.org/10.20450/mjcce.2019.1599 . .

TY  - JOUR
AU  - Milanković, Branko
AU  - Ćirić, Jelena
AU  - Krstić, Milena
AU  - Starcević, Marija
AU  - Baltić, Branislav
AU  - Šefer, Dragan
AU  - Đorđević, Vesna
AU  - Popović, Milka
AU  - Marković, Radmila
PY  - 2019
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1757
AB  - This study was undertaken to investigate the effect of dietary fat supplementation with linseed oil and/or pig lard on performance, carcass characteristics, fatty acid profile and serum biochemistry parameters in broiler chickens. In the study, 240 one-day-old Cobb 500 broiler chickens were randomly distributed to one control and three experimental dietary groups: diet supplemented with pig lard; diet supplemented with linseed oil, and; diet supplemented with a 1: 1 ratio of lard to linseed oil. The fat sources influenced serum biochemistry parameters and fatty acid profiles of drumsticks with thighs, but had no influence on growth performance or carcass characteristics. With dietary linseed oil, eicosapentaenoic acid and docosahexaenoic acid increased (P<0.05) in meat from drumsticks with thighs. Supplementation with pig lard significantly (P<0.05) increased the saturated and monounsaturated fatty acids in drumsticks with thighs. In conclusion, dietary incorporation of linseed oil and pig lard during starter, grower and finisher phases can enrich broiler chickens meat with n-3 PUFA. This study has clearly shown that linseed oil in broiler nutrition provided the best n-6/n-3 ratio.
PB  - Kafkas Univ, Veteriner Fakultesi Dergisi, Kars
T2  - Kafkas Üniversitesi Veteriner Fakültesi Dergisi
T1  - Effect of Dietary Fatty Acid Pattern on Growth Performance, Carcass Characteristics, Fatty Acid Profile, and Serum Biochemistry Parameters in Broiler Chickens
VL  - 25
IS  - 4
SP  - 507
EP  - 516
DO  - 10.9775/kvfd.2018.21205
ER  - 

@article{
author = "Milanković, Branko and Ćirić, Jelena and Krstić, Milena and Starcević, Marija and Baltić, Branislav and Šefer, Dragan and Đorđević, Vesna and Popović, Milka and Marković, Radmila",
year = "2019",
abstract = "This study was undertaken to investigate the effect of dietary fat supplementation with linseed oil and/or pig lard on performance, carcass characteristics, fatty acid profile and serum biochemistry parameters in broiler chickens. In the study, 240 one-day-old Cobb 500 broiler chickens were randomly distributed to one control and three experimental dietary groups: diet supplemented with pig lard; diet supplemented with linseed oil, and; diet supplemented with a 1: 1 ratio of lard to linseed oil. The fat sources influenced serum biochemistry parameters and fatty acid profiles of drumsticks with thighs, but had no influence on growth performance or carcass characteristics. With dietary linseed oil, eicosapentaenoic acid and docosahexaenoic acid increased (P<0.05) in meat from drumsticks with thighs. Supplementation with pig lard significantly (P<0.05) increased the saturated and monounsaturated fatty acids in drumsticks with thighs. In conclusion, dietary incorporation of linseed oil and pig lard during starter, grower and finisher phases can enrich broiler chickens meat with n-3 PUFA. This study has clearly shown that linseed oil in broiler nutrition provided the best n-6/n-3 ratio.",
publisher = "Kafkas Univ, Veteriner Fakultesi Dergisi, Kars",
journal = "Kafkas Üniversitesi Veteriner Fakültesi Dergisi",
title = "Effect of Dietary Fatty Acid Pattern on Growth Performance, Carcass Characteristics, Fatty Acid Profile, and Serum Biochemistry Parameters in Broiler Chickens",
volume = "25",
number = "4",
pages = "507-516",
doi = "10.9775/kvfd.2018.21205"
}

Milanković, B., Ćirić, J., Krstić, M., Starcević, M., Baltić, B., Šefer, D., Đorđević, V., Popović, M.,& Marković, R.. (2019). Effect of Dietary Fatty Acid Pattern on Growth Performance, Carcass Characteristics, Fatty Acid Profile, and Serum Biochemistry Parameters in Broiler Chickens. in Kafkas Üniversitesi Veteriner Fakültesi Dergisi
Kafkas Univ, Veteriner Fakultesi Dergisi, Kars., 25(4), 507-516.
https://doi.org/10.9775/kvfd.2018.21205

Milanković B, Ćirić J, Krstić M, Starcević M, Baltić B, Šefer D, Đorđević V, Popović M, Marković R. Effect of Dietary Fatty Acid Pattern on Growth Performance, Carcass Characteristics, Fatty Acid Profile, and Serum Biochemistry Parameters in Broiler Chickens. in Kafkas Üniversitesi Veteriner Fakültesi Dergisi. 2019;25(4):507-516.
doi:10.9775/kvfd.2018.21205 .

Milanković, Branko, Ćirić, Jelena, Krstić, Milena, Starcević, Marija, Baltić, Branislav, Šefer, Dragan, Đorđević, Vesna, Popović, Milka, Marković, Radmila, "Effect of Dietary Fatty Acid Pattern on Growth Performance, Carcass Characteristics, Fatty Acid Profile, and Serum Biochemistry Parameters in Broiler Chickens" in Kafkas Üniversitesi Veteriner Fakültesi Dergisi, 25, no. 4 (2019):507-516,
https://doi.org/10.9775/kvfd.2018.21205 . .

TY  - JOUR
AU  - Jovanović, Dragoljub
AU  - Teodorović, Vlado
AU  - Marković, Radmila
AU  - Krstić, Milena
AU  - Ćirić, Jelena
AU  - Baltić, Branislav
AU  - Baltić, Milan Ž.
AU  - Šefer, Dragan
PY  - 2019
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1877
AB  - The aim of this study was to determine the content of some elements (Pb, Cd, Hg, Fe, Cu, Zn, As) in muscle tissue of Prussian carp (Carassius auratus gibelio) from seven different lakes in the Belgrade region, Serbia. Concentrations of Pb, Hg and As in fish muscle tissues from all examined lakes were under the maximum residual levels prescribed by the European Union (EU) and the maximum allowed concentrations (MAC) for Serbia. In all investigated fish, levels of Cd exceeded maximum allowed concentrations (0.05 mg kg-1). Data on the finding of elements in fish speak concurrently about the safety of fish as food and are good indicators of environmental pollution.
PB  - Institute of meat hygiene and technology, Belgrade
T2  - Meat Technology
T1  - Element contents in muscle tissue of Prussian carp from different lakes in an urban area
VL  - 60
IS  - 2
SP  - 121
EP  - 127
DO  - 10.18485/meattech.2019.60.2.6
ER  - 

@article{
author = "Jovanović, Dragoljub and Teodorović, Vlado and Marković, Radmila and Krstić, Milena and Ćirić, Jelena and Baltić, Branislav and Baltić, Milan Ž. and Šefer, Dragan",
year = "2019",
abstract = "The aim of this study was to determine the content of some elements (Pb, Cd, Hg, Fe, Cu, Zn, As) in muscle tissue of Prussian carp (Carassius auratus gibelio) from seven different lakes in the Belgrade region, Serbia. Concentrations of Pb, Hg and As in fish muscle tissues from all examined lakes were under the maximum residual levels prescribed by the European Union (EU) and the maximum allowed concentrations (MAC) for Serbia. In all investigated fish, levels of Cd exceeded maximum allowed concentrations (0.05 mg kg-1). Data on the finding of elements in fish speak concurrently about the safety of fish as food and are good indicators of environmental pollution.",
publisher = "Institute of meat hygiene and technology, Belgrade",
journal = "Meat Technology",
title = "Element contents in muscle tissue of Prussian carp from different lakes in an urban area",
volume = "60",
number = "2",
pages = "121-127",
doi = "10.18485/meattech.2019.60.2.6"
}

Jovanović, D., Teodorović, V., Marković, R., Krstić, M., Ćirić, J., Baltić, B., Baltić, M. Ž.,& Šefer, D.. (2019). Element contents in muscle tissue of Prussian carp from different lakes in an urban area. in Meat Technology
Institute of meat hygiene and technology, Belgrade., 60(2), 121-127.
https://doi.org/10.18485/meattech.2019.60.2.6

Jovanović D, Teodorović V, Marković R, Krstić M, Ćirić J, Baltić B, Baltić MŽ, Šefer D. Element contents in muscle tissue of Prussian carp from different lakes in an urban area. in Meat Technology. 2019;60(2):121-127.
doi:10.18485/meattech.2019.60.2.6 .

Jovanović, Dragoljub, Teodorović, Vlado, Marković, Radmila, Krstić, Milena, Ćirić, Jelena, Baltić, Branislav, Baltić, Milan Ž., Šefer, Dragan, "Element contents in muscle tissue of Prussian carp from different lakes in an urban area" in Meat Technology, 60, no. 2 (2019):121-127,
https://doi.org/10.18485/meattech.2019.60.2.6 . .

TY  - JOUR
AU  - Jovanović, Dragoljub
AU  - Marković, Radmila
AU  - Radulović, Stamen
AU  - Grdović, Svetlana
AU  - Krstić, Milena
AU  - Šefer, Dragan
PY  - 2018
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1603
AB  - Background. Mycotoxins are toxic secondary metabolites, which are synthesized from a large number of intermediates from the primary metabolism of saprophytic molds. Aflatoxins, due to their genotoxic and carcinogenic effects, are the most important group of mycotoxins from the aspect of their impact on human and animal health. Of all known aflatoxins, AFB1 is the most frequent, with the most harmful impact on human and animal health. Scope and Approach. Due to their prevalence and toxicity, monitoring the presence of aflatoxins in the food chain is required. The scope of this paper is to provide information on the presence of aflatoxins in animal feed and in milk. This paper describes temperature increases in Europe that are contributing to the increased presence of aflatoxins in food, as well as aflatoxin prevention and protection measures. Key Findings and Conclusions. During the last decade, serious contamination of corn with aflatoxins was recorded in southern Europe. In the summer of 2012, Serbia recorded high concentrations of aflatoxins in corn and milk. Based on climate change data, it is expected that aflatoxin contamination in corn will become more frequent.
AB  - Uvod. Mikotoksini su toksični produkti sekundarnog metabolizma saprofitskih plesni, koji se sintetišu od velikog broja međuprodukata primarnog metabolizma. Aflatoksini zbog genotoksičnog i kancerogenog dejstva predstavljaju najznačajniju grupu mikotoksina sa aspekta uticaja na zdravlje ljudi i životinja. Od svih poznatih aflatoksina, AFB1 je najfrekventniji sa najštetnijim uticajem na zdravlje ljudi i životinja. Cilj i pristup. Zbog svoje zastupljenosti i toksičnosti aflatoksini zahtevaju praćenje njihovog prisustva u lancu hrane. Cilj ovog rada je da pruži informaciju o prisustvu aflatoksina u hrani za životinje i u mleku. U radu su opisane globalne temperaturne promene koje povećavaju prisustvo aflatoksina u hrani, kao i mere prevencije i zaštite Ključni nalazi i zaključak. Tokom poslednje decenije, zabeleženo je ozbiljno zagađenje kukuruza sa aflatoksinima u južnoj Evropi. Republika Srbija je u leto 2012. godine zabeležila visoke koncentracije aflatoksina u kukuruzu i u mleku. Na osnovu podataka o klimatskim promenama, očekuje se da kontaminacije aflatoksinima u kukuruzu postanu učestalije.
PB  - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
T2  - Veterinarski Glasnik
T1  - Aflatoxins in feed
T1  - Aflatoksini u hrani za životinje
VL  - 72
IS  - 1
SP  - 14
EP  - 21
DO  - 10.2298/VETGL1801015J
ER  - 

@article{
author = "Jovanović, Dragoljub and Marković, Radmila and Radulović, Stamen and Grdović, Svetlana and Krstić, Milena and Šefer, Dragan",
year = "2018",
abstract = "Background. Mycotoxins are toxic secondary metabolites, which are synthesized from a large number of intermediates from the primary metabolism of saprophytic molds. Aflatoxins, due to their genotoxic and carcinogenic effects, are the most important group of mycotoxins from the aspect of their impact on human and animal health. Of all known aflatoxins, AFB1 is the most frequent, with the most harmful impact on human and animal health. Scope and Approach. Due to their prevalence and toxicity, monitoring the presence of aflatoxins in the food chain is required. The scope of this paper is to provide information on the presence of aflatoxins in animal feed and in milk. This paper describes temperature increases in Europe that are contributing to the increased presence of aflatoxins in food, as well as aflatoxin prevention and protection measures. Key Findings and Conclusions. During the last decade, serious contamination of corn with aflatoxins was recorded in southern Europe. In the summer of 2012, Serbia recorded high concentrations of aflatoxins in corn and milk. Based on climate change data, it is expected that aflatoxin contamination in corn will become more frequent., Uvod. Mikotoksini su toksični produkti sekundarnog metabolizma saprofitskih plesni, koji se sintetišu od velikog broja međuprodukata primarnog metabolizma. Aflatoksini zbog genotoksičnog i kancerogenog dejstva predstavljaju najznačajniju grupu mikotoksina sa aspekta uticaja na zdravlje ljudi i životinja. Od svih poznatih aflatoksina, AFB1 je najfrekventniji sa najštetnijim uticajem na zdravlje ljudi i životinja. Cilj i pristup. Zbog svoje zastupljenosti i toksičnosti aflatoksini zahtevaju praćenje njihovog prisustva u lancu hrane. Cilj ovog rada je da pruži informaciju o prisustvu aflatoksina u hrani za životinje i u mleku. U radu su opisane globalne temperaturne promene koje povećavaju prisustvo aflatoksina u hrani, kao i mere prevencije i zaštite Ključni nalazi i zaključak. Tokom poslednje decenije, zabeleženo je ozbiljno zagađenje kukuruza sa aflatoksinima u južnoj Evropi. Republika Srbija je u leto 2012. godine zabeležila visoke koncentracije aflatoksina u kukuruzu i u mleku. Na osnovu podataka o klimatskim promenama, očekuje se da kontaminacije aflatoksinima u kukuruzu postanu učestalije.",
publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd",
journal = "Veterinarski Glasnik",
title = "Aflatoxins in feed, Aflatoksini u hrani za životinje",
volume = "72",
number = "1",
pages = "14-21",
doi = "10.2298/VETGL1801015J"
}

Jovanović, D., Marković, R., Radulović, S., Grdović, S., Krstić, M.,& Šefer, D.. (2018). Aflatoxins in feed. in Veterinarski Glasnik
Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 72(1), 14-21.
https://doi.org/10.2298/VETGL1801015J

Jovanović D, Marković R, Radulović S, Grdović S, Krstić M, Šefer D. Aflatoxins in feed. in Veterinarski Glasnik. 2018;72(1):14-21.
doi:10.2298/VETGL1801015J .

Jovanović, Dragoljub, Marković, Radmila, Radulović, Stamen, Grdović, Svetlana, Krstić, Milena, Šefer, Dragan, "Aflatoxins in feed" in Veterinarski Glasnik, 72, no. 1 (2018):14-21,
https://doi.org/10.2298/VETGL1801015J . .

TY  - JOUR
AU  - Tadić, Ana
AU  - Poljarević, Jelena
AU  - Krstić, Milena
AU  - Kajzerberger, Marijana
AU  - Aranđelović, Sandra
AU  - Radulović, Siniša
AU  - Kakoulidou, Chrisoula
AU  - Papadopoulos, Athanasios N.
AU  - Psomas, George
AU  - Grgurić-Šipka, Sanja
PY  - 2018
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1639
AB  - Two non-steroidal antiinflammatory drugs indomethacin and mefenamic acid were coordinated to Ru(II)-arenes to afford four new complexes. The cytotoxic activities of the ligands and ruthenium complexes were tested in three human cancer cell lines (K562, A549, MDA-MB-231) and non-tumour human fetal lung fibroblast cells (MRC-5) by MTT assay. Cytotoxicity studies revealed that indomethacin Ru(II)-arene complexes 1 and 3 displayed good cytotoxicity and apparent cytoselective profiles. The IC50 values obtained in leukemia K562 cells were comparable to those of cisplatin (10.3 mu M (CDDP), 11.9 mu M (1) and 13.2 mu M (3)). Flow cytometric analysis of 1 and 3 in triple-negative breast cancer MDA-MB-231 cells revealed an interesting mechanism of action. At IC50 concentrations, 1 and 3 arrested cell cycle progression in S phase and caused rapid accumulation of cells in sub-G1 phase (up to 48%), while Annexin V-FITC/PI staining showed simultaneous occurrence of apoptotic and necrotic cell populations at approximately similar levels of 20%. Measurement of reactive oxygen species (ROS) production by DCFH-DA staining confirmed the potential of 1 and 3 to increase ROS even more than cisplatin. The interaction of the complexes with serum albumins showed their potential ability to bind tightly and reversibly to albumins. The affinity of the complexes to calf-thymus DNA was investigated by UV-vis spectroscopy, viscosity measurements and fluorescence emission spectroscopy for competitive studies of the complexes with ethidium bromide, revealing that their interaction probably occurs via intercalation. Taken together, the results strongly suggest the potential of complexes 1 and 3 to alter cell cycle progression and cause DNA-damage by means of direct DNA-binding or indirectly by ROS production.
PB  - Royal Soc Chemistry, Cambridge
T2  - New Journal of Chemistry
T1  - Ruthenium-arene complexes with NSAIDs: synthesis, characterization and bioactivity
VL  - 42
IS  - 4
SP  - 3001
EP  - 3019
DO  - 10.1039/c7nj04416j
ER  - 

@article{
author = "Tadić, Ana and Poljarević, Jelena and Krstić, Milena and Kajzerberger, Marijana and Aranđelović, Sandra and Radulović, Siniša and Kakoulidou, Chrisoula and Papadopoulos, Athanasios N. and Psomas, George and Grgurić-Šipka, Sanja",
year = "2018",
abstract = "Two non-steroidal antiinflammatory drugs indomethacin and mefenamic acid were coordinated to Ru(II)-arenes to afford four new complexes. The cytotoxic activities of the ligands and ruthenium complexes were tested in three human cancer cell lines (K562, A549, MDA-MB-231) and non-tumour human fetal lung fibroblast cells (MRC-5) by MTT assay. Cytotoxicity studies revealed that indomethacin Ru(II)-arene complexes 1 and 3 displayed good cytotoxicity and apparent cytoselective profiles. The IC50 values obtained in leukemia K562 cells were comparable to those of cisplatin (10.3 mu M (CDDP), 11.9 mu M (1) and 13.2 mu M (3)). Flow cytometric analysis of 1 and 3 in triple-negative breast cancer MDA-MB-231 cells revealed an interesting mechanism of action. At IC50 concentrations, 1 and 3 arrested cell cycle progression in S phase and caused rapid accumulation of cells in sub-G1 phase (up to 48%), while Annexin V-FITC/PI staining showed simultaneous occurrence of apoptotic and necrotic cell populations at approximately similar levels of 20%. Measurement of reactive oxygen species (ROS) production by DCFH-DA staining confirmed the potential of 1 and 3 to increase ROS even more than cisplatin. The interaction of the complexes with serum albumins showed their potential ability to bind tightly and reversibly to albumins. The affinity of the complexes to calf-thymus DNA was investigated by UV-vis spectroscopy, viscosity measurements and fluorescence emission spectroscopy for competitive studies of the complexes with ethidium bromide, revealing that their interaction probably occurs via intercalation. Taken together, the results strongly suggest the potential of complexes 1 and 3 to alter cell cycle progression and cause DNA-damage by means of direct DNA-binding or indirectly by ROS production.",
publisher = "Royal Soc Chemistry, Cambridge",
journal = "New Journal of Chemistry",
title = "Ruthenium-arene complexes with NSAIDs: synthesis, characterization and bioactivity",
volume = "42",
number = "4",
pages = "3001-3019",
doi = "10.1039/c7nj04416j"
}

Tadić, A., Poljarević, J., Krstić, M., Kajzerberger, M., Aranđelović, S., Radulović, S., Kakoulidou, C., Papadopoulos, A. N., Psomas, G.,& Grgurić-Šipka, S.. (2018). Ruthenium-arene complexes with NSAIDs: synthesis, characterization and bioactivity. in New Journal of Chemistry
Royal Soc Chemistry, Cambridge., 42(4), 3001-3019.
https://doi.org/10.1039/c7nj04416j

Tadić A, Poljarević J, Krstić M, Kajzerberger M, Aranđelović S, Radulović S, Kakoulidou C, Papadopoulos AN, Psomas G, Grgurić-Šipka S. Ruthenium-arene complexes with NSAIDs: synthesis, characterization and bioactivity. in New Journal of Chemistry. 2018;42(4):3001-3019.
doi:10.1039/c7nj04416j .

Tadić, Ana, Poljarević, Jelena, Krstić, Milena, Kajzerberger, Marijana, Aranđelović, Sandra, Radulović, Siniša, Kakoulidou, Chrisoula, Papadopoulos, Athanasios N., Psomas, George, Grgurić-Šipka, Sanja, "Ruthenium-arene complexes with NSAIDs: synthesis, characterization and bioactivity" in New Journal of Chemistry, 42, no. 4 (2018):3001-3019,
https://doi.org/10.1039/c7nj04416j . .

TY  - JOUR
AU  - Leskovac, Andreja
AU  - Petrović, Sandra
AU  - Lazarevic-Pasti, Tamara
AU  - Krstić, Milena
AU  - Vasić, Vesna
PY  - 2018
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1672
AB  - In recent years, the search for effective anticancer compounds based on transition metal complexes has been the focus of medical investigations. The synergy between the ruthenium(II) and N-alkylphenothiazine counter-ions (chlorpromazine hydrochloride, thioridazine hydrochloride and trifluoperazine dihydrochloride, respectively) through the formation of three different complexes (1-3) was investigated. We explored whether the selected counter-ions and complexes might affect redox homeostasis and genome integrity of normal human blood cells, and induce an inhibition of Na+/K+-ATPase and AChE at pharmacologically relevant doses. Our results have shown that counter-ions and complexes did not affect the activity of Na+/K+-ATPase, while AChE activity was inhibited in a dose-dependent manner. All investigated compounds disturbed the viability and redox homeostasis of lymphocytes. Complexes 1 and 2 displayed potent cytotoxic and prooxidant action while complex 3 behaved as a weaker genotoxic inducer. Still, the tested complexes appeared to be less genotoxic and more cytostatic than the corresponding counter-ions. The effects of selected complexes were also tested in PC12 and U2OS cancer cells with special attention being given to the ability of phenothiazines to affect dopamine D2 receptors. Using the confocal laser scanning microscopy, we observed that all the complexes reduced cell viability. Although all investigated complexes have been bound to the dopamine receptor D-2-eGFP, only complex 3 reduced its surface density and increased its lateral mobility in investigated cell lines. Albeit the role of alternative targets for complex 3 cannot be ruled out, its effects should be further examined as potential treatment strategy against cancer cells that overexpress D2.
PB  - Springer, New York
T2  - Journal of Biological Inorganic Chemistry
T1  - Ruthenium(II)-N-alkyl phenothiazine complexes as potential anticancer agents
VL  - 23
IS  - 5
SP  - 689
EP  - 704
DO  - 10.1007/s00775-018-1560-x
ER  - 

@article{
author = "Leskovac, Andreja and Petrović, Sandra and Lazarevic-Pasti, Tamara and Krstić, Milena and Vasić, Vesna",
year = "2018",
abstract = "In recent years, the search for effective anticancer compounds based on transition metal complexes has been the focus of medical investigations. The synergy between the ruthenium(II) and N-alkylphenothiazine counter-ions (chlorpromazine hydrochloride, thioridazine hydrochloride and trifluoperazine dihydrochloride, respectively) through the formation of three different complexes (1-3) was investigated. We explored whether the selected counter-ions and complexes might affect redox homeostasis and genome integrity of normal human blood cells, and induce an inhibition of Na+/K+-ATPase and AChE at pharmacologically relevant doses. Our results have shown that counter-ions and complexes did not affect the activity of Na+/K+-ATPase, while AChE activity was inhibited in a dose-dependent manner. All investigated compounds disturbed the viability and redox homeostasis of lymphocytes. Complexes 1 and 2 displayed potent cytotoxic and prooxidant action while complex 3 behaved as a weaker genotoxic inducer. Still, the tested complexes appeared to be less genotoxic and more cytostatic than the corresponding counter-ions. The effects of selected complexes were also tested in PC12 and U2OS cancer cells with special attention being given to the ability of phenothiazines to affect dopamine D2 receptors. Using the confocal laser scanning microscopy, we observed that all the complexes reduced cell viability. Although all investigated complexes have been bound to the dopamine receptor D-2-eGFP, only complex 3 reduced its surface density and increased its lateral mobility in investigated cell lines. Albeit the role of alternative targets for complex 3 cannot be ruled out, its effects should be further examined as potential treatment strategy against cancer cells that overexpress D2.",
publisher = "Springer, New York",
journal = "Journal of Biological Inorganic Chemistry",
title = "Ruthenium(II)-N-alkyl phenothiazine complexes as potential anticancer agents",
volume = "23",
number = "5",
pages = "689-704",
doi = "10.1007/s00775-018-1560-x"
}

Leskovac, A., Petrović, S., Lazarevic-Pasti, T., Krstić, M.,& Vasić, V.. (2018). Ruthenium(II)-N-alkyl phenothiazine complexes as potential anticancer agents. in Journal of Biological Inorganic Chemistry
Springer, New York., 23(5), 689-704.
https://doi.org/10.1007/s00775-018-1560-x

Leskovac A, Petrović S, Lazarevic-Pasti T, Krstić M, Vasić V. Ruthenium(II)-N-alkyl phenothiazine complexes as potential anticancer agents. in Journal of Biological Inorganic Chemistry. 2018;23(5):689-704.
doi:10.1007/s00775-018-1560-x .

Leskovac, Andreja, Petrović, Sandra, Lazarevic-Pasti, Tamara, Krstić, Milena, Vasić, Vesna, "Ruthenium(II)-N-alkyl phenothiazine complexes as potential anticancer agents" in Journal of Biological Inorganic Chemistry, 23, no. 5 (2018):689-704,
https://doi.org/10.1007/s00775-018-1560-x . .

TY  - CONF
AU  - Krstić, Milena
AU  - Borozan, Sunčica
AU  - Santibanez, Juan Francisco
AU  - Sovilj, Sofija
AU  - Grgurić-Šipka, Sanja
PY  - 2018
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/3797
AB  - Kompleks rutenijuma(II) sa trifluoperazinom TF.2H[RuCl3(DMSO)3], gde je TF.2H protonovani trifluoperazin, u koncentracijama 10 i 15 μM, ispitan je na oksido-redukcione procese
na proteinima i lipidima (sadržaj karbonilnih (CO) grupa i malondialdehida (MDA)) i
aktivnost enzima antioksidativne odbrane (superoksidne-dismutaze (SOD) i katalaze (CAT))
u zdravim humanim ćelijama HS-5, kao i ćelijama humane leukemije THP1, K562 i Hel.
Primenom 10 μM kompleksa zabeležena je povećana aktivnost SOD i CAT, kao i veći sadržaj
MDA i slobodnih CO grupa u THP1 ćelijama. U koncentraciji od 15 μM kompleks povećava
aktivnost SOD za 37 % u odnosu na kontrolnu grupu u Hel ćelijama, u kojima izaziva i najveće
oštećenje proteina praćenjem sadržaja CO grupa. Povećan sadržaj MDA primenom obe
koncentracije kompleksa rutenijuma posledica je visokog procenta lipidne peroksidacije u
ćelijama kancera, dok u HS-5 ćelijama ima zaštitni efekat. Sadržaj MDA i povećana aktivnosti
SOD primenom kompleksa u svim tretiranim ćelijama u odnosu na kontrolnu grupu, rezultat
je veće produkcije reaktivnih kiseoničnih vrsta i oksidativnog stresa, što dovodi do nekroze
i apoptoze ćelijskih linija humane leukemije.
AB  - Ruthenium(II) complex with trifluoperazine TF.2H [RuCl3(DMSO)3], where TF.2H is protonated
trifluroperazine, applied in concentrations of 10 and 15 μM, are investigated on the oxidationreduction processes in proteins and lipids (carbonyl (CO) group and malondialdehyde content
(MDA)) and activities of enzymes antioxidative defenses (superoxide dismutase (SOD) and
catalase (CAT)) in normal human cells HS-5 and human leukemic cells, THP1, K562 and Hel.
Using 10 μM of the complex is increased activity of SOD and CAT, as well as higher content of
MDA and free CO groups in THP1 cells. Ruthenium complex increased 37 % of the SOD activity
in compared to the control group in concentration of 15 μM and shows high damage on CO
groups of proteins in Hel cells. The higher MDA level by applying both concentrations of the
ruthenium complex results from a great degree of lipid’s peroxidation in cancer cells, while in
HS-5 cells it has protective effect. Content of MDA and increased activity of SOD by the
complex in all treated cells compared to the control group is the result of higher production
of reactive oxygen species and oxidative stress, which leads to necrosis and apoptosis in cell
lines of human leukemia.
PB  - Beograd : Srpsko hemijsko društvo
C3  - 55. Savetovanje Srpskog hemijskog društva, Novi Sad, 8 - 9. jun 2018
T1  - Uticaj kompleksa rutenijuma(II) sa trifluoperazinom na oksido-redukcione procese u ćelijama humane leukemije
T1  - The effect of ruthenium(II) complex with trifluoperazine on the oxidationreduction processes in human leukemic cells
SP  - 79
EP  - 79
UR  - https://hdl.handle.net/21.15107/rcub_veterinar_3797
ER  - 

@conference{
author = "Krstić, Milena and Borozan, Sunčica and Santibanez, Juan Francisco and Sovilj, Sofija and Grgurić-Šipka, Sanja",
year = "2018",
abstract = "Kompleks rutenijuma(II) sa trifluoperazinom TF.2H[RuCl3(DMSO)3], gde je TF.2H protonovani trifluoperazin, u koncentracijama 10 i 15 μM, ispitan je na oksido-redukcione procese
na proteinima i lipidima (sadržaj karbonilnih (CO) grupa i malondialdehida (MDA)) i
aktivnost enzima antioksidativne odbrane (superoksidne-dismutaze (SOD) i katalaze (CAT))
u zdravim humanim ćelijama HS-5, kao i ćelijama humane leukemije THP1, K562 i Hel.
Primenom 10 μM kompleksa zabeležena je povećana aktivnost SOD i CAT, kao i veći sadržaj
MDA i slobodnih CO grupa u THP1 ćelijama. U koncentraciji od 15 μM kompleks povećava
aktivnost SOD za 37 % u odnosu na kontrolnu grupu u Hel ćelijama, u kojima izaziva i najveće
oštećenje proteina praćenjem sadržaja CO grupa. Povećan sadržaj MDA primenom obe
koncentracije kompleksa rutenijuma posledica je visokog procenta lipidne peroksidacije u
ćelijama kancera, dok u HS-5 ćelijama ima zaštitni efekat. Sadržaj MDA i povećana aktivnosti
SOD primenom kompleksa u svim tretiranim ćelijama u odnosu na kontrolnu grupu, rezultat
je veće produkcije reaktivnih kiseoničnih vrsta i oksidativnog stresa, što dovodi do nekroze
i apoptoze ćelijskih linija humane leukemije., Ruthenium(II) complex with trifluoperazine TF.2H [RuCl3(DMSO)3], where TF.2H is protonated
trifluroperazine, applied in concentrations of 10 and 15 μM, are investigated on the oxidationreduction processes in proteins and lipids (carbonyl (CO) group and malondialdehyde content
(MDA)) and activities of enzymes antioxidative defenses (superoxide dismutase (SOD) and
catalase (CAT)) in normal human cells HS-5 and human leukemic cells, THP1, K562 and Hel.
Using 10 μM of the complex is increased activity of SOD and CAT, as well as higher content of
MDA and free CO groups in THP1 cells. Ruthenium complex increased 37 % of the SOD activity
in compared to the control group in concentration of 15 μM and shows high damage on CO
groups of proteins in Hel cells. The higher MDA level by applying both concentrations of the
ruthenium complex results from a great degree of lipid’s peroxidation in cancer cells, while in
HS-5 cells it has protective effect. Content of MDA and increased activity of SOD by the
complex in all treated cells compared to the control group is the result of higher production
of reactive oxygen species and oxidative stress, which leads to necrosis and apoptosis in cell
lines of human leukemia.",
publisher = "Beograd : Srpsko hemijsko društvo",
journal = "55. Savetovanje Srpskog hemijskog društva, Novi Sad, 8 - 9. jun 2018",
title = "Uticaj kompleksa rutenijuma(II) sa trifluoperazinom na oksido-redukcione procese u ćelijama humane leukemije, The effect of ruthenium(II) complex with trifluoperazine on the oxidationreduction processes in human leukemic cells",
pages = "79-79",
url = "https://hdl.handle.net/21.15107/rcub_veterinar_3797"
}

Krstić, M., Borozan, S., Santibanez, J. F., Sovilj, S.,& Grgurić-Šipka, S.. (2018). Uticaj kompleksa rutenijuma(II) sa trifluoperazinom na oksido-redukcione procese u ćelijama humane leukemije. in 55. Savetovanje Srpskog hemijskog društva, Novi Sad, 8 - 9. jun 2018
Beograd : Srpsko hemijsko društvo., 79-79.
https://hdl.handle.net/21.15107/rcub_veterinar_3797

Krstić M, Borozan S, Santibanez JF, Sovilj S, Grgurić-Šipka S. Uticaj kompleksa rutenijuma(II) sa trifluoperazinom na oksido-redukcione procese u ćelijama humane leukemije. in 55. Savetovanje Srpskog hemijskog društva, Novi Sad, 8 - 9. jun 2018. 2018;:79-79.
https://hdl.handle.net/21.15107/rcub_veterinar_3797 .

Krstić, Milena, Borozan, Sunčica, Santibanez, Juan Francisco, Sovilj, Sofija, Grgurić-Šipka, Sanja, "Uticaj kompleksa rutenijuma(II) sa trifluoperazinom na oksido-redukcione procese u ćelijama humane leukemije" in 55. Savetovanje Srpskog hemijskog društva, Novi Sad, 8 - 9. jun 2018 (2018):79-79,
https://hdl.handle.net/21.15107/rcub_veterinar_3797 .

TY  - CONF
AU  - Poljarević, Jelena
AU  - Tadić, Ana
AU  - Krstić, Milena
AU  - Mihajlović-Lalić, Ljiljana
AU  - Savić, Aleksandar
AU  - Nikolić, Stefan
AU  - Kajzergerber, Marijana
AU  - Ranđelović, Sandra
AU  - Grgurić-Šipka, Sanja
PY  - 2018
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/3798
AB  - U ovom radu sintetisano je četiri nova arenska kompleksa Ru(II) sa dva nesteroidna
antiimflamatorna leka, indometacin i mefenaminskom kiselininom. Kompleksi su sintetisani
polazeći od metanolnog rastvora polaznog Ru(II) polusendvič jedinjenja i baznog metanolnog rastvora odgovarajućeg liganda. Strukture novih kompleksa određene su NMR i IC
spektroskopijom, kao i masenom spektrometrijom. Pokazano je da se ligandi koordinuju
monodentatno preko karboksilnih kiseonika. Citotoksična aktivnost liganada i kompleksa
ispitana je na tri ćelijske linije humanog kancera i zdravih humanih fibroblastnih ćelija, korišćenjem MTT metode. IC50 vrednosti dobijene na ćelijama leukemije K562 bile su uporedive sa onim za cisplatinu (10.3 µM (cisplatina), 11.9 µM (kompleks 1) i 13.2 µM (kompleks 3)). Korišćenjem protočne citometrije pokazano je da ovi kompleksi pri IC50 koncentracijama zaustavljaju ćelijski ciklus u S fazi. Merenje produkcije reaktivnih kiseoničnih
DCFH-DA metodom potvrdilo je njihov potencijal da povećavaju ROS više od cisplatine.
AB  - Two non-steroidal antiinflammatory drugs, indomethacin and mefenamic acid, were
coordinated to Ru(II)-arenes to give four new complexes. These four complexes were
synthesized by mixing methanolic solution of starting half-sandwich Ru complexes with base
solution of ligand in methanol. Structures of complexes were determinated by NMR, IR
spectroscopy and mass spectrometry. It was shown that they coordinates monodentatly via
carboxylic oxygen. The cytotoxic activity of the ligands and ruthenium complexes was tested
in three human cancer cell lines and non-tumour human fetal lung fibroblast cells by MTT
assay. The IC50 values obtained in leukemia K562 cells, were comparable to cisplatin (10.3
µM (CDDP), 11.9 µM (1) and 13.2 µM (3)). Flow cytometric analysis of these conplexes,
showed that at IC50 concentrations, they arrested cell cycle progression in the S phase.
Measurement of reactive oxygen species (ROS) production, by DCFH-DA staining, confirmed
their potential to increase ROS even more than cisplatin.
PB  - Beograd : Srpsko hemijsko društvo
C3  - 55. Savetovanje Srpskog hemijskog društva, Novi Sad, 8 - 9. jun 2018
T1  - Novi rutenijum–arenski kompleksi sa antiinflamatornim lekovima
T1  - Novel ruthenium–arene complexes with antiinflamatory drugs
SP  - 44
EP  - 44
UR  - https://hdl.handle.net/21.15107/rcub_veterinar_3798
ER  - 

@conference{
author = "Poljarević, Jelena and Tadić, Ana and Krstić, Milena and Mihajlović-Lalić, Ljiljana and Savić, Aleksandar and Nikolić, Stefan and Kajzergerber, Marijana and Ranđelović, Sandra and Grgurić-Šipka, Sanja",
year = "2018",
abstract = "U ovom radu sintetisano je četiri nova arenska kompleksa Ru(II) sa dva nesteroidna
antiimflamatorna leka, indometacin i mefenaminskom kiselininom. Kompleksi su sintetisani
polazeći od metanolnog rastvora polaznog Ru(II) polusendvič jedinjenja i baznog metanolnog rastvora odgovarajućeg liganda. Strukture novih kompleksa određene su NMR i IC
spektroskopijom, kao i masenom spektrometrijom. Pokazano je da se ligandi koordinuju
monodentatno preko karboksilnih kiseonika. Citotoksična aktivnost liganada i kompleksa
ispitana je na tri ćelijske linije humanog kancera i zdravih humanih fibroblastnih ćelija, korišćenjem MTT metode. IC50 vrednosti dobijene na ćelijama leukemije K562 bile su uporedive sa onim za cisplatinu (10.3 µM (cisplatina), 11.9 µM (kompleks 1) i 13.2 µM (kompleks 3)). Korišćenjem protočne citometrije pokazano je da ovi kompleksi pri IC50 koncentracijama zaustavljaju ćelijski ciklus u S fazi. Merenje produkcije reaktivnih kiseoničnih
DCFH-DA metodom potvrdilo je njihov potencijal da povećavaju ROS više od cisplatine., Two non-steroidal antiinflammatory drugs, indomethacin and mefenamic acid, were
coordinated to Ru(II)-arenes to give four new complexes. These four complexes were
synthesized by mixing methanolic solution of starting half-sandwich Ru complexes with base
solution of ligand in methanol. Structures of complexes were determinated by NMR, IR
spectroscopy and mass spectrometry. It was shown that they coordinates monodentatly via
carboxylic oxygen. The cytotoxic activity of the ligands and ruthenium complexes was tested
in three human cancer cell lines and non-tumour human fetal lung fibroblast cells by MTT
assay. The IC50 values obtained in leukemia K562 cells, were comparable to cisplatin (10.3
µM (CDDP), 11.9 µM (1) and 13.2 µM (3)). Flow cytometric analysis of these conplexes,
showed that at IC50 concentrations, they arrested cell cycle progression in the S phase.
Measurement of reactive oxygen species (ROS) production, by DCFH-DA staining, confirmed
their potential to increase ROS even more than cisplatin.",
publisher = "Beograd : Srpsko hemijsko društvo",
journal = "55. Savetovanje Srpskog hemijskog društva, Novi Sad, 8 - 9. jun 2018",
title = "Novi rutenijum–arenski kompleksi sa antiinflamatornim lekovima, Novel ruthenium–arene complexes with antiinflamatory drugs",
pages = "44-44",
url = "https://hdl.handle.net/21.15107/rcub_veterinar_3798"
}

Poljarević, J., Tadić, A., Krstić, M., Mihajlović-Lalić, L., Savić, A., Nikolić, S., Kajzergerber, M., Ranđelović, S.,& Grgurić-Šipka, S.. (2018). Novi rutenijum–arenski kompleksi sa antiinflamatornim lekovima. in 55. Savetovanje Srpskog hemijskog društva, Novi Sad, 8 - 9. jun 2018
Beograd : Srpsko hemijsko društvo., 44-44.
https://hdl.handle.net/21.15107/rcub_veterinar_3798

Poljarević J, Tadić A, Krstić M, Mihajlović-Lalić L, Savić A, Nikolić S, Kajzergerber M, Ranđelović S, Grgurić-Šipka S. Novi rutenijum–arenski kompleksi sa antiinflamatornim lekovima. in 55. Savetovanje Srpskog hemijskog društva, Novi Sad, 8 - 9. jun 2018. 2018;:44-44.
https://hdl.handle.net/21.15107/rcub_veterinar_3798 .

Poljarević, Jelena, Tadić, Ana, Krstić, Milena, Mihajlović-Lalić, Ljiljana, Savić, Aleksandar, Nikolić, Stefan, Kajzergerber, Marijana, Ranđelović, Sandra, Grgurić-Šipka, Sanja, "Novi rutenijum–arenski kompleksi sa antiinflamatornim lekovima" in 55. Savetovanje Srpskog hemijskog društva, Novi Sad, 8 - 9. jun 2018 (2018):44-44,
https://hdl.handle.net/21.15107/rcub_veterinar_3798 .

TY  - JOUR
AU  - Krstić, Milena
AU  - Mitrović, Radmila
AU  - Marković, Radmila
AU  - Ivanović, Jelena
AU  - Ćirković, Miroslav
AU  - Đorđević, Vesna
AU  - Baltić, Milan Ž.
PY  - 2017
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1510
AB  - The aim of this study was to determine the influence of different feed composition and cultivation on the composition of fatty acids, their relationships, and the cholesterol content in the tissue of rainbow trout (Oncorhynchus mykiss). Trout were reared in ponds at two different altitudes and raised on different feeds. The total amount of monounsaturated fatty acids in fillets of both groups showed no statistically significant difference. However, higher levels of n-6 fatty acids were found in Pond I trout fillets than in Pond II fillets, while Pond II fillets contained almost even amounts of n-3 and n-6 fatty acids. Total cholesterol content in Pond I trout fillets was significantly lower (p<0.05) than in Pond II fillets. The results indicate that the final composition of the trout fillets was mostly dependent on the feed the live fish had consumed; the altitude of the ponds had less effect. Also, both groups of trout could be used in the human diet as biologically valuable foods. Practical application: Our results show influence of altitude, feed, and fatty acid composition of feed on trout fillets. The average fatty acid level in the trout fillets increased in the order SFA <MUFA <PUFA. Trout fillets contain low levels of cholesterol but high levels of EPA, DPA, and DHA. These facts are important for fish industries and aquaculture producers to design a healthy food.
PB  - Wiley, Hoboken
T2  - European Journal of Lipid Science and Technology
T1  - Fatty acid composition in the fillets of rainbow trout grown in different conditions
VL  - 119
IS  - 4
SP  - UNSP 1600082
DO  - 10.1002/ejlt.201600082
ER  - 

@article{
author = "Krstić, Milena and Mitrović, Radmila and Marković, Radmila and Ivanović, Jelena and Ćirković, Miroslav and Đorđević, Vesna and Baltić, Milan Ž.",
year = "2017",
abstract = "The aim of this study was to determine the influence of different feed composition and cultivation on the composition of fatty acids, their relationships, and the cholesterol content in the tissue of rainbow trout (Oncorhynchus mykiss). Trout were reared in ponds at two different altitudes and raised on different feeds. The total amount of monounsaturated fatty acids in fillets of both groups showed no statistically significant difference. However, higher levels of n-6 fatty acids were found in Pond I trout fillets than in Pond II fillets, while Pond II fillets contained almost even amounts of n-3 and n-6 fatty acids. Total cholesterol content in Pond I trout fillets was significantly lower (p<0.05) than in Pond II fillets. The results indicate that the final composition of the trout fillets was mostly dependent on the feed the live fish had consumed; the altitude of the ponds had less effect. Also, both groups of trout could be used in the human diet as biologically valuable foods. Practical application: Our results show influence of altitude, feed, and fatty acid composition of feed on trout fillets. The average fatty acid level in the trout fillets increased in the order SFA <MUFA <PUFA. Trout fillets contain low levels of cholesterol but high levels of EPA, DPA, and DHA. These facts are important for fish industries and aquaculture producers to design a healthy food.",
publisher = "Wiley, Hoboken",
journal = "European Journal of Lipid Science and Technology",
title = "Fatty acid composition in the fillets of rainbow trout grown in different conditions",
volume = "119",
number = "4",
pages = "UNSP 1600082",
doi = "10.1002/ejlt.201600082"
}

Krstić, M., Mitrović, R., Marković, R., Ivanović, J., Ćirković, M., Đorđević, V.,& Baltić, M. Ž.. (2017). Fatty acid composition in the fillets of rainbow trout grown in different conditions. in European Journal of Lipid Science and Technology
Wiley, Hoboken., 119(4), UNSP 1600082.
https://doi.org/10.1002/ejlt.201600082

Krstić M, Mitrović R, Marković R, Ivanović J, Ćirković M, Đorđević V, Baltić MŽ. Fatty acid composition in the fillets of rainbow trout grown in different conditions. in European Journal of Lipid Science and Technology. 2017;119(4):UNSP 1600082.
doi:10.1002/ejlt.201600082 .

Krstić, Milena, Mitrović, Radmila, Marković, Radmila, Ivanović, Jelena, Ćirković, Miroslav, Đorđević, Vesna, Baltić, Milan Ž., "Fatty acid composition in the fillets of rainbow trout grown in different conditions" in European Journal of Lipid Science and Technology, 119, no. 4 (2017):UNSP 1600082,
https://doi.org/10.1002/ejlt.201600082 . .

TY  - JOUR
AU  - Petković, B. B.
AU  - Kuzmanović, D.
AU  - Dimitrijević, T.
AU  - Krstić, Milena
AU  - Stanković, D.M.
PY  - 2017
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1475
AB  - A simple and fast method for determination of two phenothiazine drugs, chlorpromazine (CPZ) and thioridazine (TDZ), at the boron-doped diamond electrode (BDDE) was proposed. Oxidation peaks on potentials higher than 1 V were used for quantitation of investigated phenothiazines due to better selectivity over common interfering compounds in urine. Differential pulse voltammetry was applied for trace determination of CPZ and TDZ, in Britton-Robinson buffer solution at optimal pH. Under optimized DPV conditions a linear analytical curve was obtained from 1.0x10(-7) to 4.0x10(-5) M with a detection limit of 0.3x10(-7) M (for CPZ) and in the concentration range of 2x10(-7) M to 4.0x10(-5) M, with a detection limit of 1.2x10(-7)M (for TDZ). The applicability of the method was proved by determination of CPZ and TDZ by proposed procedures in spiked urine samples. The electrochemical behavior of those two important tranquilizers in different solvents was described, exploring the possibility of simultaneous determination.
PB  - Electrochemical Science Group, Beograd
T2  - International Journal of Electrochemical Science
T1  - Novel Strategy for Electroanalytical Detection of Antipsychotic Drugs Chlorpromazine and Thioridazine; Possibilities for Simultaneous Determination
VL  - 12
IS  - 5
SP  - 3709
EP  - 3720
DO  - 10.20964/2017.05.34
ER  - 

@article{
author = "Petković, B. B. and Kuzmanović, D. and Dimitrijević, T. and Krstić, Milena and Stanković, D.M.",
year = "2017",
abstract = "A simple and fast method for determination of two phenothiazine drugs, chlorpromazine (CPZ) and thioridazine (TDZ), at the boron-doped diamond electrode (BDDE) was proposed. Oxidation peaks on potentials higher than 1 V were used for quantitation of investigated phenothiazines due to better selectivity over common interfering compounds in urine. Differential pulse voltammetry was applied for trace determination of CPZ and TDZ, in Britton-Robinson buffer solution at optimal pH. Under optimized DPV conditions a linear analytical curve was obtained from 1.0x10(-7) to 4.0x10(-5) M with a detection limit of 0.3x10(-7) M (for CPZ) and in the concentration range of 2x10(-7) M to 4.0x10(-5) M, with a detection limit of 1.2x10(-7)M (for TDZ). The applicability of the method was proved by determination of CPZ and TDZ by proposed procedures in spiked urine samples. The electrochemical behavior of those two important tranquilizers in different solvents was described, exploring the possibility of simultaneous determination.",
publisher = "Electrochemical Science Group, Beograd",
journal = "International Journal of Electrochemical Science",
title = "Novel Strategy for Electroanalytical Detection of Antipsychotic Drugs Chlorpromazine and Thioridazine; Possibilities for Simultaneous Determination",
volume = "12",
number = "5",
pages = "3709-3720",
doi = "10.20964/2017.05.34"
}

Petković, B. B., Kuzmanović, D., Dimitrijević, T., Krstić, M.,& Stanković, D.M.. (2017). Novel Strategy for Electroanalytical Detection of Antipsychotic Drugs Chlorpromazine and Thioridazine; Possibilities for Simultaneous Determination. in International Journal of Electrochemical Science
Electrochemical Science Group, Beograd., 12(5), 3709-3720.
https://doi.org/10.20964/2017.05.34

Petković BB, Kuzmanović D, Dimitrijević T, Krstić M, Stanković D. Novel Strategy for Electroanalytical Detection of Antipsychotic Drugs Chlorpromazine and Thioridazine; Possibilities for Simultaneous Determination. in International Journal of Electrochemical Science. 2017;12(5):3709-3720.
doi:10.20964/2017.05.34 .

Petković, B. B., Kuzmanović, D., Dimitrijević, T., Krstić, Milena, Stanković, D.M., "Novel Strategy for Electroanalytical Detection of Antipsychotic Drugs Chlorpromazine and Thioridazine; Possibilities for Simultaneous Determination" in International Journal of Electrochemical Science, 12, no. 5 (2017):3709-3720,
https://doi.org/10.20964/2017.05.34 . .

TY  - JOUR
AU  - Jovanović, Dragoljub
AU  - Marković, Radmila
AU  - Teodorović, Vlado
AU  - Šefer, Dragan
AU  - Krstić, Milena
AU  - Radulović, Stamen
AU  - Ivanović-Ćirić, Jelena
AU  - Janjić, Jelena
AU  - Baltić, Milan Ž.
PY  - 2017
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1507
AB  - The aim of this study was to investigate the presence of heavy metals/metalloids (Pb, Cd, Hg, Cu, Fe, Zn, As) in the muscle tissue of fish from the Danube River (two locations: Zemun and Grocka). For the purpose of heavy metal determination in fish muscle, 120 samples of six different fish species, Prussian carp, barbel, bream, carp, pike perch, and catfish were collected. For determining heavy metals, we used microwave oven digestion and atomic absorption spectrometer methods. The highest average content of Pb (0.084 +/- 0.004 mg kg(-1)), Cd (0.082 +/- 0.003 mg kg(-1)), Hg (0.466 +/- 0.006 mg kg(-1)), and As (0.333 +/- 0.007 mg kg(-1)) was found in the muscle of carp (an omnivorous fish) from Grocka, while the highest average level of Fe (13.60 +/- 0.03 mg kg(-1)) was deposited in bream (also omnivorous) from Zemun. Also, the average Cu level (1.62 +/- 0.13 mg kg(-1)) was the highest in catfish muscle (a carnivorous fish) from Grocka, while the highest Zn content (11.16 +/- 0.17 mg kg(-1)) was determined in muscle of Prussian carp (an omnivorous fish) from Zemun. The highest content of heavy metals (Cu, Fe, and Zn, respectively) in muscle of the six different types of fish from both locations was symmetrically arranged by species (catfish, barbel, and Prussian carp, respectively). Concentrations of Pb, Hg, and As in the Danube River fish muscle were under the maximum residual levels prescribed by the European Union (EU) and the maximum allowed concentrations (MAC) for Serbia. On the other hand, in all fish muscle from both locations (Zemun and Grocka), higher concentrations of Cd than prescribed (MAC) were found, with the exception of bream and pike perch.
PB  - Springer Heidelberg, Heidelberg
T2  - Environmental Science and Pollution Research
T1  - Determination of heavy metals in muscle tissue of six fish species with different feeding habits from the Danube River, Belgrade-public health and environmental risk assessment
VL  - 24
IS  - 12
SP  - 11383
EP  - 11391
DO  - 10.1007/s11356-017-8783-1
ER  - 

@article{
author = "Jovanović, Dragoljub and Marković, Radmila and Teodorović, Vlado and Šefer, Dragan and Krstić, Milena and Radulović, Stamen and Ivanović-Ćirić, Jelena and Janjić, Jelena and Baltić, Milan Ž.",
year = "2017",
abstract = "The aim of this study was to investigate the presence of heavy metals/metalloids (Pb, Cd, Hg, Cu, Fe, Zn, As) in the muscle tissue of fish from the Danube River (two locations: Zemun and Grocka). For the purpose of heavy metal determination in fish muscle, 120 samples of six different fish species, Prussian carp, barbel, bream, carp, pike perch, and catfish were collected. For determining heavy metals, we used microwave oven digestion and atomic absorption spectrometer methods. The highest average content of Pb (0.084 +/- 0.004 mg kg(-1)), Cd (0.082 +/- 0.003 mg kg(-1)), Hg (0.466 +/- 0.006 mg kg(-1)), and As (0.333 +/- 0.007 mg kg(-1)) was found in the muscle of carp (an omnivorous fish) from Grocka, while the highest average level of Fe (13.60 +/- 0.03 mg kg(-1)) was deposited in bream (also omnivorous) from Zemun. Also, the average Cu level (1.62 +/- 0.13 mg kg(-1)) was the highest in catfish muscle (a carnivorous fish) from Grocka, while the highest Zn content (11.16 +/- 0.17 mg kg(-1)) was determined in muscle of Prussian carp (an omnivorous fish) from Zemun. The highest content of heavy metals (Cu, Fe, and Zn, respectively) in muscle of the six different types of fish from both locations was symmetrically arranged by species (catfish, barbel, and Prussian carp, respectively). Concentrations of Pb, Hg, and As in the Danube River fish muscle were under the maximum residual levels prescribed by the European Union (EU) and the maximum allowed concentrations (MAC) for Serbia. On the other hand, in all fish muscle from both locations (Zemun and Grocka), higher concentrations of Cd than prescribed (MAC) were found, with the exception of bream and pike perch.",
publisher = "Springer Heidelberg, Heidelberg",
journal = "Environmental Science and Pollution Research",
title = "Determination of heavy metals in muscle tissue of six fish species with different feeding habits from the Danube River, Belgrade-public health and environmental risk assessment",
volume = "24",
number = "12",
pages = "11383-11391",
doi = "10.1007/s11356-017-8783-1"
}

Jovanović, D., Marković, R., Teodorović, V., Šefer, D., Krstić, M., Radulović, S., Ivanović-Ćirić, J., Janjić, J.,& Baltić, M. Ž.. (2017). Determination of heavy metals in muscle tissue of six fish species with different feeding habits from the Danube River, Belgrade-public health and environmental risk assessment. in Environmental Science and Pollution Research
Springer Heidelberg, Heidelberg., 24(12), 11383-11391.
https://doi.org/10.1007/s11356-017-8783-1

Jovanović D, Marković R, Teodorović V, Šefer D, Krstić M, Radulović S, Ivanović-Ćirić J, Janjić J, Baltić MŽ. Determination of heavy metals in muscle tissue of six fish species with different feeding habits from the Danube River, Belgrade-public health and environmental risk assessment. in Environmental Science and Pollution Research. 2017;24(12):11383-11391.
doi:10.1007/s11356-017-8783-1 .

Jovanović, Dragoljub, Marković, Radmila, Teodorović, Vlado, Šefer, Dragan, Krstić, Milena, Radulović, Stamen, Ivanović-Ćirić, Jelena, Janjić, Jelena, Baltić, Milan Ž., "Determination of heavy metals in muscle tissue of six fish species with different feeding habits from the Danube River, Belgrade-public health and environmental risk assessment" in Environmental Science and Pollution Research, 24, no. 12 (2017):11383-11391,
https://doi.org/10.1007/s11356-017-8783-1 . .

TY  - CONF
AU  - Krstić, Milena
AU  - Borozan, Sunčica
AU  - Santibanez, Juan Francisco
AU  - Sovilj, Sofija
AU  - Grgurić-Šipka, Sanja
PY  - 2017
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/3796
AB  - Kompleksi rutenijuma privlače veliku pažnju kao lekovi bazirani na metalima u medicini zbog svoje
antioksidativne aktivnosti i citotoksičnosti. Uticaj tri kompleksa Ru(II), opšte formule
L[RuCl3(DMSO)3] (1-3), gde je L protonovani hlorpromazin (CP.H), trifluoperazin (TF.2H) ili
tioridazin (TR.H), u koncentraciji 15 μM ispitan je na oksido-redukcione procese u K562 ćelijama
humane leukemije (sadržaj karbonilnih (CO) grupa proteina i malondialdehida (MDA)) i aktivnost
enzima antioksidativne odbrane (superoksidne-dismutaze (SOD), katalaze (CAT) i laktatdehidrogenaze (LDH)). Primenom svih kompleksa zabeležena je povećana aktivnost SOD, a
smanjena aktivnost CAT. Kompleks 1 povećava aktivnost SOD za 48% u odnosu na kontronu grupu,
a izaziva i najveće oštećenje proteina praćenjem sadržaja CO grupa. Povećan sadržaj MDA
primenom svih kompleksa posledica je visokog procenta lipidne peroksidacije. Inhibicija totalne
aktivnosti LDH primenom kompleksa 2 u K562 ćelijama u odnosu na ostala dva kompleksa, rezultat
je povećanja reaktivnih kiseoničnih vrsta i oksidativnog stresa, što dovodi do nekroze i apoptoze.
AB  - Ruthenium complexes have a great attention as metal-based therapeutic agents in medicine because
of their antioxidant activity and cytotoxicity. The effect of three Ru(II) complexes of the general
formulae L[RuCl3(DMSO)3] (1-3) where L is protonated chlorpromazine (CP.H), trifluoperazine
(TF.2H) or thioridazine (TR.H), applied in concentration of 15 μM are investigated on the oxidationreduction processes in K562 human leukemic cells (carbonyl (CO) group of proteins,
malondyaldehyde content (MDA)) and activities of enzymes antioxidative defenses (superoxide
dismutase (SOD), catalase (CAT) and lactate-dehydrogenase (LDH)). The highest value of SOD
and the lowest value of CAT activity are observed using the complexes. The complex 1 increased
48% of the SOD activity in compared to the control group as well as this complex shows high
damage on CO groups of proteins. All complexes increased MDA content and showed a great degree
of lipid’s peroxidation. Inhibition of total LDH activity by the complex 2 in K562 cells compared to
the other two complexes is the result of an increase in reactive oxygen species and oxidative stress,
which leads to necrosis and apoptosis.
PB  - Beograd : Srpsko hemijsko društvo
C3  - 54. Savetovanje Srpskog hemijskog društva i 5. Konferencija mladih hemičara Srbije, Beograd 29 - 30. septembar 2017
T1  - Uticaj kompleksa rutenijuma(II) sa N-alkilfenotiazinima na oksidoredukcione procese u K562 ćelijama humane leukemije
T1  - The effect of ruthenium(II) complexes with N-alkylphenothiazines on the oxidation-reduction processes in K562 human leukemic cells
SP  - 75
EP  - 75
UR  - https://hdl.handle.net/21.15107/rcub_veterinar_3796
ER  - 

@conference{
author = "Krstić, Milena and Borozan, Sunčica and Santibanez, Juan Francisco and Sovilj, Sofija and Grgurić-Šipka, Sanja",
year = "2017",
abstract = "Kompleksi rutenijuma privlače veliku pažnju kao lekovi bazirani na metalima u medicini zbog svoje
antioksidativne aktivnosti i citotoksičnosti. Uticaj tri kompleksa Ru(II), opšte formule
L[RuCl3(DMSO)3] (1-3), gde je L protonovani hlorpromazin (CP.H), trifluoperazin (TF.2H) ili
tioridazin (TR.H), u koncentraciji 15 μM ispitan je na oksido-redukcione procese u K562 ćelijama
humane leukemije (sadržaj karbonilnih (CO) grupa proteina i malondialdehida (MDA)) i aktivnost
enzima antioksidativne odbrane (superoksidne-dismutaze (SOD), katalaze (CAT) i laktatdehidrogenaze (LDH)). Primenom svih kompleksa zabeležena je povećana aktivnost SOD, a
smanjena aktivnost CAT. Kompleks 1 povećava aktivnost SOD za 48% u odnosu na kontronu grupu,
a izaziva i najveće oštećenje proteina praćenjem sadržaja CO grupa. Povećan sadržaj MDA
primenom svih kompleksa posledica je visokog procenta lipidne peroksidacije. Inhibicija totalne
aktivnosti LDH primenom kompleksa 2 u K562 ćelijama u odnosu na ostala dva kompleksa, rezultat
je povećanja reaktivnih kiseoničnih vrsta i oksidativnog stresa, što dovodi do nekroze i apoptoze., Ruthenium complexes have a great attention as metal-based therapeutic agents in medicine because
of their antioxidant activity and cytotoxicity. The effect of three Ru(II) complexes of the general
formulae L[RuCl3(DMSO)3] (1-3) where L is protonated chlorpromazine (CP.H), trifluoperazine
(TF.2H) or thioridazine (TR.H), applied in concentration of 15 μM are investigated on the oxidationreduction processes in K562 human leukemic cells (carbonyl (CO) group of proteins,
malondyaldehyde content (MDA)) and activities of enzymes antioxidative defenses (superoxide
dismutase (SOD), catalase (CAT) and lactate-dehydrogenase (LDH)). The highest value of SOD
and the lowest value of CAT activity are observed using the complexes. The complex 1 increased
48% of the SOD activity in compared to the control group as well as this complex shows high
damage on CO groups of proteins. All complexes increased MDA content and showed a great degree
of lipid’s peroxidation. Inhibition of total LDH activity by the complex 2 in K562 cells compared to
the other two complexes is the result of an increase in reactive oxygen species and oxidative stress,
which leads to necrosis and apoptosis.",
publisher = "Beograd : Srpsko hemijsko društvo",
journal = "54. Savetovanje Srpskog hemijskog društva i 5. Konferencija mladih hemičara Srbije, Beograd 29 - 30. septembar 2017",
title = "Uticaj kompleksa rutenijuma(II) sa N-alkilfenotiazinima na oksidoredukcione procese u K562 ćelijama humane leukemije, The effect of ruthenium(II) complexes with N-alkylphenothiazines on the oxidation-reduction processes in K562 human leukemic cells",
pages = "75-75",
url = "https://hdl.handle.net/21.15107/rcub_veterinar_3796"
}

Krstić, M., Borozan, S., Santibanez, J. F., Sovilj, S.,& Grgurić-Šipka, S.. (2017). Uticaj kompleksa rutenijuma(II) sa N-alkilfenotiazinima na oksidoredukcione procese u K562 ćelijama humane leukemije. in 54. Savetovanje Srpskog hemijskog društva i 5. Konferencija mladih hemičara Srbije, Beograd 29 - 30. septembar 2017
Beograd : Srpsko hemijsko društvo., 75-75.
https://hdl.handle.net/21.15107/rcub_veterinar_3796

Krstić M, Borozan S, Santibanez JF, Sovilj S, Grgurić-Šipka S. Uticaj kompleksa rutenijuma(II) sa N-alkilfenotiazinima na oksidoredukcione procese u K562 ćelijama humane leukemije. in 54. Savetovanje Srpskog hemijskog društva i 5. Konferencija mladih hemičara Srbije, Beograd 29 - 30. septembar 2017. 2017;:75-75.
https://hdl.handle.net/21.15107/rcub_veterinar_3796 .

Krstić, Milena, Borozan, Sunčica, Santibanez, Juan Francisco, Sovilj, Sofija, Grgurić-Šipka, Sanja, "Uticaj kompleksa rutenijuma(II) sa N-alkilfenotiazinima na oksidoredukcione procese u K562 ćelijama humane leukemije" in 54. Savetovanje Srpskog hemijskog društva i 5. Konferencija mladih hemičara Srbije, Beograd 29 - 30. septembar 2017 (2017):75-75,
https://hdl.handle.net/21.15107/rcub_veterinar_3796 .

TY  - JOUR
AU  - Milanov, Raša Đ.
AU  - Krstić, Milena
AU  - Marković, Radmila
AU  - Jovanović, Dragoljub
AU  - Baltić, Branislav
AU  - Ivanović, Jelena
AU  - Jovetić, Milica
AU  - Baltić, Milan Ž.
PY  - 2016
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1381
AB  - The aim of this study was the investigation of water, sediments and fish tissues contamination with heavy metals. All samples were taken from the Danube River in Belgrade region, a location upstream from Batajnica. Concentrations of Cd, Hg and Pb in water samples were not detected, while concentrations of Zn, Fe, Cu and As were in the range of 0.004 - 0.330 mg L-1. Iron was the most deposited metal in sediment samples in contrast to water samples where all investigated metals were detected. For the purpose of heavy metals determination in fresh fish tissue, fifteen samples of three different fish species, silver carp (Hypophthalmichthys molitrix), common carp (Cyprinus carpio) and wels catfish (Silurus glanis) were collected. Concentrations of Pb, Cd, As and Hg were determined in the digestive tract, liver and muscle by absorption spectroscopy. The highest concentration of Pb was in the digestive tract in all three fish species, ranging from 0.036 to 1.518 μg g-1, while Cd was mostly deposited in the liver. Concentrations of As were in the range of 0.36 - 0.73 μg g-1 in Hypophthalmichthys molitrix, 0.013 - 0.18 μg g-1 in Cyprinus carpio and 0.003 - 0.005 μg g-1 in Silurus glanis tissues, while the content of Hg was equal in all tested tissues of carp. Concentrations of all metals were found to be present in the fish samples at different levels, but these values are under the maximum residual levels prescribed by the European Union (EU) and the maximum allowed concentrations (MAC) for Serbia, so the fish meat is acceptable for the human consumption.
AB  - Cilj ovog rada je ispitivanje kontaminacije teškim metalima vode, sedimenta kao i tri različite vrste sveže ribe. Svi uzorci su uzeti iz Dunava u regionu Beograda, tačnije uzvodno od Batajnice. Koncentracije Cd, Hg i Pb u uzorcima vode su približne graničnim vrednostima detekcije, dok su koncentracije Zn, Fe, Cu i As u opsegu 0.004 - 0.330 mg L-1. Gvožđe je najprisutniji metal u uzorcima sedimenata za razliku od uzoraka vode gde su svi ispitivani metali podjednako zastupljeni. U cilju ispitivanja teških metala u tkivima riba sakupljeno je po petnaest uzoraka tri različite vrste riba, tolstolobika (Hypophthalmichthys molitrix), šarana (Cyprinus carpio) i soma (Silurus glanis). Koncentracije Pb, Cd, As i Hg određene su u digestivnom traktu, jetri i mišićnom tkivu sveže dunavske ribe metodom absorpcione spektroskopije. Najveća koncentracija Pb zabeležena je u digestivnom traktu kod svih ispitivanih vrsta riba i to u opsegu 0.036 - 1.518 μg g-1, dok je Cd uglavnom deponovan u jetri. Koncentracija As bila je u opsegu 0.36 - 0.73 μg g-1 u tkivu Hypophthalmichthys molitrix, 0.013 - 0.18 μg g-1 u tkivu Cyprinus carpio i 0.003 - 0.005 μg g-1 u tkivu Silurus glanis, dok je sadržaj Hg bio izjednačen u svim ispitivanim tkivima šarana. Koncentracije svih metala u tkivima riba su različite i ispod maksimalno dozvoljenih koncentracija predvidjenih pravilnikom Evropske Unije i maksimalno dozvoljenih koncentracije (MDK) u Srbiji, a riba može da se koristi za ishranu ljudi.
PB  - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
T2  - Acta Veterinaria-Beograd
T1  - Analysis of heavy metals concentration in tissues of three different fish species included in human diet from Danube river, in the Belgrade region, Serbia
T1  - Ispitivanje koncentracije teških metala u tkivima tri različite vrste riba iz Dunava sa područja Beograda koje se koriste u ishrani ljudi
VL  - 66
IS  - 1
SP  - 89
EP  - 102
DO  - 10.1515/acve-2016-0007
ER  - 

@article{
author = "Milanov, Raša Đ. and Krstić, Milena and Marković, Radmila and Jovanović, Dragoljub and Baltić, Branislav and Ivanović, Jelena and Jovetić, Milica and Baltić, Milan Ž.",
year = "2016",
abstract = "The aim of this study was the investigation of water, sediments and fish tissues contamination with heavy metals. All samples were taken from the Danube River in Belgrade region, a location upstream from Batajnica. Concentrations of Cd, Hg and Pb in water samples were not detected, while concentrations of Zn, Fe, Cu and As were in the range of 0.004 - 0.330 mg L-1. Iron was the most deposited metal in sediment samples in contrast to water samples where all investigated metals were detected. For the purpose of heavy metals determination in fresh fish tissue, fifteen samples of three different fish species, silver carp (Hypophthalmichthys molitrix), common carp (Cyprinus carpio) and wels catfish (Silurus glanis) were collected. Concentrations of Pb, Cd, As and Hg were determined in the digestive tract, liver and muscle by absorption spectroscopy. The highest concentration of Pb was in the digestive tract in all three fish species, ranging from 0.036 to 1.518 μg g-1, while Cd was mostly deposited in the liver. Concentrations of As were in the range of 0.36 - 0.73 μg g-1 in Hypophthalmichthys molitrix, 0.013 - 0.18 μg g-1 in Cyprinus carpio and 0.003 - 0.005 μg g-1 in Silurus glanis tissues, while the content of Hg was equal in all tested tissues of carp. Concentrations of all metals were found to be present in the fish samples at different levels, but these values are under the maximum residual levels prescribed by the European Union (EU) and the maximum allowed concentrations (MAC) for Serbia, so the fish meat is acceptable for the human consumption., Cilj ovog rada je ispitivanje kontaminacije teškim metalima vode, sedimenta kao i tri različite vrste sveže ribe. Svi uzorci su uzeti iz Dunava u regionu Beograda, tačnije uzvodno od Batajnice. Koncentracije Cd, Hg i Pb u uzorcima vode su približne graničnim vrednostima detekcije, dok su koncentracije Zn, Fe, Cu i As u opsegu 0.004 - 0.330 mg L-1. Gvožđe je najprisutniji metal u uzorcima sedimenata za razliku od uzoraka vode gde su svi ispitivani metali podjednako zastupljeni. U cilju ispitivanja teških metala u tkivima riba sakupljeno je po petnaest uzoraka tri različite vrste riba, tolstolobika (Hypophthalmichthys molitrix), šarana (Cyprinus carpio) i soma (Silurus glanis). Koncentracije Pb, Cd, As i Hg određene su u digestivnom traktu, jetri i mišićnom tkivu sveže dunavske ribe metodom absorpcione spektroskopije. Najveća koncentracija Pb zabeležena je u digestivnom traktu kod svih ispitivanih vrsta riba i to u opsegu 0.036 - 1.518 μg g-1, dok je Cd uglavnom deponovan u jetri. Koncentracija As bila je u opsegu 0.36 - 0.73 μg g-1 u tkivu Hypophthalmichthys molitrix, 0.013 - 0.18 μg g-1 u tkivu Cyprinus carpio i 0.003 - 0.005 μg g-1 u tkivu Silurus glanis, dok je sadržaj Hg bio izjednačen u svim ispitivanim tkivima šarana. Koncentracije svih metala u tkivima riba su različite i ispod maksimalno dozvoljenih koncentracija predvidjenih pravilnikom Evropske Unije i maksimalno dozvoljenih koncentracije (MDK) u Srbiji, a riba može da se koristi za ishranu ljudi.",
publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd",
journal = "Acta Veterinaria-Beograd",
title = "Analysis of heavy metals concentration in tissues of three different fish species included in human diet from Danube river, in the Belgrade region, Serbia, Ispitivanje koncentracije teških metala u tkivima tri različite vrste riba iz Dunava sa područja Beograda koje se koriste u ishrani ljudi",
volume = "66",
number = "1",
pages = "89-102",
doi = "10.1515/acve-2016-0007"
}

Milanov, R. Đ., Krstić, M., Marković, R., Jovanović, D., Baltić, B., Ivanović, J., Jovetić, M.,& Baltić, M. Ž.. (2016). Analysis of heavy metals concentration in tissues of three different fish species included in human diet from Danube river, in the Belgrade region, Serbia. in Acta Veterinaria-Beograd
Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 66(1), 89-102.
https://doi.org/10.1515/acve-2016-0007

Milanov RĐ, Krstić M, Marković R, Jovanović D, Baltić B, Ivanović J, Jovetić M, Baltić MŽ. Analysis of heavy metals concentration in tissues of three different fish species included in human diet from Danube river, in the Belgrade region, Serbia. in Acta Veterinaria-Beograd. 2016;66(1):89-102.
doi:10.1515/acve-2016-0007 .

Milanov, Raša Đ., Krstić, Milena, Marković, Radmila, Jovanović, Dragoljub, Baltić, Branislav, Ivanović, Jelena, Jovetić, Milica, Baltić, Milan Ž., "Analysis of heavy metals concentration in tissues of three different fish species included in human diet from Danube river, in the Belgrade region, Serbia" in Acta Veterinaria-Beograd, 66, no. 1 (2016):89-102,
https://doi.org/10.1515/acve-2016-0007 . .

TY  - JOUR
AU  - Krstić, Milena
AU  - Borozan, Sunčica
AU  - Sovilj, Sofija P.
AU  - Grgurić-Šipka, Sanja
AU  - Poljarević, Jelena
PY  - 2016
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1353
AB  - The purpose of the present study was to investigate and compare the effects of two ruthenium complexes with trifluoperazine on acethylcholinesterase enzyme activity and lactate dehydrogenase levels in vivo under physiological conditions in rats blood. Complexes 1 and 2 showed positive effects on acethylcholinesterase at all doses and did not disturb its normal activity. Total LDH activity was inhibited in the presence of both complexes, but Ru(II) complexes showed different effects on the activity of LDH isoenzymes. The activities of LDH1 and LDH2 isoenzymes were decreased in all applied doses of the complex 2, while the activity of LDH2 reduced using complex 1 in the same doses. Results of the present study suggest the neuro- and cardio protective potential of oral administration of complexes 1 and 2, as non-toxic compounds under physiological conditions. These protective effects are the result of their potent antioxidant activity.
AB  - Cilj ovog rada je da se ispitaju i uporede efekti dva kompleksa rutenijuma sa trifluoperazinom na aktivnost enzima acetilholinesteraze i laktat-dehidrogenase in vivo pod fiziološkim uslovima u krvi pacova. Kompleksi 1 i 2 pokazali su pozitivan efekat na aktivnost acetiholinesteraze u svim primenjenim dozama. Ukupna aktivnost LDH je inhibirana u prisustvu oba kompleksa, ali kompleksi Ru(II) pokazuju različite rezultate na izoenzimske oblike ovog enzima. Aktivnosti izoenzima LDH1 i LDH2 su smanjene u svim primenjenim dozama kompleksa 2, dok kompleks 1 smanjuje aktivnost samo izoenzima LDH2 u tim istim koncentracijama. Rezultati prikazanog istraživanja ukazuju na neuro - i kardio zaštitni potencijal oralne primene kompleksa 1 i 2, kao netoksičnih jedinjenja pod fiziološkim uslovima, indukovano preko njihovog snažnog antioksidativnog efekta.
PB  - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
T2  - Acta Veterinaria-Beograd
T1  - In vivo enzymes activities of some Ru(II) compounds with N-alkylphenothiazines
T1  - In vivo ispitivanje enzimske aktivnosti nekih Ru(II) jedinjenja sa N-alkilfenotiazinima
VL  - 66
IS  - 4
SP  - 497
EP  - 508
DO  - 10.1515/acve-2016-0043
ER  - 

@article{
author = "Krstić, Milena and Borozan, Sunčica and Sovilj, Sofija P. and Grgurić-Šipka, Sanja and Poljarević, Jelena",
year = "2016",
abstract = "The purpose of the present study was to investigate and compare the effects of two ruthenium complexes with trifluoperazine on acethylcholinesterase enzyme activity and lactate dehydrogenase levels in vivo under physiological conditions in rats blood. Complexes 1 and 2 showed positive effects on acethylcholinesterase at all doses and did not disturb its normal activity. Total LDH activity was inhibited in the presence of both complexes, but Ru(II) complexes showed different effects on the activity of LDH isoenzymes. The activities of LDH1 and LDH2 isoenzymes were decreased in all applied doses of the complex 2, while the activity of LDH2 reduced using complex 1 in the same doses. Results of the present study suggest the neuro- and cardio protective potential of oral administration of complexes 1 and 2, as non-toxic compounds under physiological conditions. These protective effects are the result of their potent antioxidant activity., Cilj ovog rada je da se ispitaju i uporede efekti dva kompleksa rutenijuma sa trifluoperazinom na aktivnost enzima acetilholinesteraze i laktat-dehidrogenase in vivo pod fiziološkim uslovima u krvi pacova. Kompleksi 1 i 2 pokazali su pozitivan efekat na aktivnost acetiholinesteraze u svim primenjenim dozama. Ukupna aktivnost LDH je inhibirana u prisustvu oba kompleksa, ali kompleksi Ru(II) pokazuju različite rezultate na izoenzimske oblike ovog enzima. Aktivnosti izoenzima LDH1 i LDH2 su smanjene u svim primenjenim dozama kompleksa 2, dok kompleks 1 smanjuje aktivnost samo izoenzima LDH2 u tim istim koncentracijama. Rezultati prikazanog istraživanja ukazuju na neuro - i kardio zaštitni potencijal oralne primene kompleksa 1 i 2, kao netoksičnih jedinjenja pod fiziološkim uslovima, indukovano preko njihovog snažnog antioksidativnog efekta.",
publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd",
journal = "Acta Veterinaria-Beograd",
title = "In vivo enzymes activities of some Ru(II) compounds with N-alkylphenothiazines, In vivo ispitivanje enzimske aktivnosti nekih Ru(II) jedinjenja sa N-alkilfenotiazinima",
volume = "66",
number = "4",
pages = "497-508",
doi = "10.1515/acve-2016-0043"
}

Krstić, M., Borozan, S., Sovilj, S. P., Grgurić-Šipka, S.,& Poljarević, J.. (2016). In vivo enzymes activities of some Ru(II) compounds with N-alkylphenothiazines. in Acta Veterinaria-Beograd
Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 66(4), 497-508.
https://doi.org/10.1515/acve-2016-0043

Krstić M, Borozan S, Sovilj SP, Grgurić-Šipka S, Poljarević J. In vivo enzymes activities of some Ru(II) compounds with N-alkylphenothiazines. in Acta Veterinaria-Beograd. 2016;66(4):497-508.
doi:10.1515/acve-2016-0043 .

Krstić, Milena, Borozan, Sunčica, Sovilj, Sofija P., Grgurić-Šipka, Sanja, Poljarević, Jelena, "In vivo enzymes activities of some Ru(II) compounds with N-alkylphenothiazines" in Acta Veterinaria-Beograd, 66, no. 4 (2016):497-508,
https://doi.org/10.1515/acve-2016-0043 . .

TY  - JOUR
AU  - Krstić, Milena
AU  - Sovilj, Sofija P.
AU  - Borozan, Sunčica
AU  - Rancić, Milica
AU  - Poljarević, Jelena
AU  - Grgurić-Šipka, Sanja
PY  - 2016
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1424
AB  - Phenothiazines are a large group of heterocyclic, aromatic molecules with nitrogen and sulphur between two benzene rings. Their derivatives, N-alkylphenothiazines have substituent on heterocyclic nitrogen atom which gives them different properties. Also, a series of these molecules have substitution on carbon atom at place 2 of phenothiazine benzene ring. Alkylphenothiazines contain aminoalkyl substituent and their alkyl, acyl and sulphonil derivatives, as well as monocyclic and bicyclic heterocycles attached at thiazine nitrogen atom or directly linked to benzene ring. The N-alkylphenothiazines have been known as antipsychotic drugs, but they also possess antibacterial, antifungal, anticancer activity, and ability to react with macromolecules and to coordinate to the metals. Metal complexes with N-alkylphenothiazines are biological active compounds with different antimicrobial activities and cytotoxic effect against tumor cell lines. The large field of application of N-alkylphenothiazines is very attractive in terms of synthesis of new related derivatives, metal complexes, studying their properties and applications. This article presents a review of the literature and a contemporary view at N-alkylphenothiazines - their synthesis and application, as well as their metal complexes which have promising biological effects.
PB  - Savez hemijskih inženjera, Beograd
T2  - Hemijska Industrija
T1  - N-alkylphenothiazines - synthesis, structure and application as ligands in metal complexes
VL  - 70
IS  - 4
SP  - 461
EP  - 471
DO  - 10.2298/HEMIND150331052K
ER  - 

@article{
author = "Krstić, Milena and Sovilj, Sofija P. and Borozan, Sunčica and Rancić, Milica and Poljarević, Jelena and Grgurić-Šipka, Sanja",
year = "2016",
abstract = "Phenothiazines are a large group of heterocyclic, aromatic molecules with nitrogen and sulphur between two benzene rings. Their derivatives, N-alkylphenothiazines have substituent on heterocyclic nitrogen atom which gives them different properties. Also, a series of these molecules have substitution on carbon atom at place 2 of phenothiazine benzene ring. Alkylphenothiazines contain aminoalkyl substituent and their alkyl, acyl and sulphonil derivatives, as well as monocyclic and bicyclic heterocycles attached at thiazine nitrogen atom or directly linked to benzene ring. The N-alkylphenothiazines have been known as antipsychotic drugs, but they also possess antibacterial, antifungal, anticancer activity, and ability to react with macromolecules and to coordinate to the metals. Metal complexes with N-alkylphenothiazines are biological active compounds with different antimicrobial activities and cytotoxic effect against tumor cell lines. The large field of application of N-alkylphenothiazines is very attractive in terms of synthesis of new related derivatives, metal complexes, studying their properties and applications. This article presents a review of the literature and a contemporary view at N-alkylphenothiazines - their synthesis and application, as well as their metal complexes which have promising biological effects.",
publisher = "Savez hemijskih inženjera, Beograd",
journal = "Hemijska Industrija",
title = "N-alkylphenothiazines - synthesis, structure and application as ligands in metal complexes",
volume = "70",
number = "4",
pages = "461-471",
doi = "10.2298/HEMIND150331052K"
}

Krstić, M., Sovilj, S. P., Borozan, S., Rancić, M., Poljarević, J.,& Grgurić-Šipka, S.. (2016). N-alkylphenothiazines - synthesis, structure and application as ligands in metal complexes. in Hemijska Industrija
Savez hemijskih inženjera, Beograd., 70(4), 461-471.
https://doi.org/10.2298/HEMIND150331052K

Krstić M, Sovilj SP, Borozan S, Rancić M, Poljarević J, Grgurić-Šipka S. N-alkylphenothiazines - synthesis, structure and application as ligands in metal complexes. in Hemijska Industrija. 2016;70(4):461-471.
doi:10.2298/HEMIND150331052K .

Krstić, Milena, Sovilj, Sofija P., Borozan, Sunčica, Rancić, Milica, Poljarević, Jelena, Grgurić-Šipka, Sanja, "N-alkylphenothiazines - synthesis, structure and application as ligands in metal complexes" in Hemijska Industrija, 70, no. 4 (2016):461-471,
https://doi.org/10.2298/HEMIND150331052K . .

TY  - CONF
AU  - Krstić, Milena
AU  - Jevtić, Sonja
AU  - Petković, Branka
AU  - Milčić, Miloš
PY  - 2016
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/3799
AB  - The new complex [Zn2(tpmc)NO3](NO3)3·CH3OH, where tpmc is
N,N’,N’’,N’’’-tetrakis(2-pyridylmethyl)-1,4,8,11-tetraazacyclotetradecane,
have been synthesized and characterized. The conductometric technique
played a guiding role in planning experiment with this large macrocyclyc
ligand. In IR spectrum sharps are shown coordinated and ionic nitrate ions
which are in agreement to proposed formula by elemental analysis. Molar
electrical conductivities indicated assumption that the complex is about a
1:3 electrolyte type. The optimized complex structure is obtained by
molecular modeling and DFT calculations.
PB  - Belgrade : Society of Physical Chemists of Serbia
C3  - 13th International Conference on Fundamental and Applied Aspects of Physical Chemistry, Belgrade, September 26 - 30, 2016
T1  - New dinuclear zinc(II) octaayza macrocyclic complex: conductometric study, synthesis and characterization
SP  - 763
EP  - 766
UR  - https://hdl.handle.net/21.15107/rcub_veterinar_3799
ER  - 

@conference{
author = "Krstić, Milena and Jevtić, Sonja and Petković, Branka and Milčić, Miloš",
year = "2016",
abstract = "The new complex [Zn2(tpmc)NO3](NO3)3·CH3OH, where tpmc is
N,N’,N’’,N’’’-tetrakis(2-pyridylmethyl)-1,4,8,11-tetraazacyclotetradecane,
have been synthesized and characterized. The conductometric technique
played a guiding role in planning experiment with this large macrocyclyc
ligand. In IR spectrum sharps are shown coordinated and ionic nitrate ions
which are in agreement to proposed formula by elemental analysis. Molar
electrical conductivities indicated assumption that the complex is about a
1:3 electrolyte type. The optimized complex structure is obtained by
molecular modeling and DFT calculations.",
publisher = "Belgrade : Society of Physical Chemists of Serbia",
journal = "13th International Conference on Fundamental and Applied Aspects of Physical Chemistry, Belgrade, September 26 - 30, 2016",
title = "New dinuclear zinc(II) octaayza macrocyclic complex: conductometric study, synthesis and characterization",
pages = "763-766",
url = "https://hdl.handle.net/21.15107/rcub_veterinar_3799"
}

Krstić, M., Jevtić, S., Petković, B.,& Milčić, M.. (2016). New dinuclear zinc(II) octaayza macrocyclic complex: conductometric study, synthesis and characterization. in 13th International Conference on Fundamental and Applied Aspects of Physical Chemistry, Belgrade, September 26 - 30, 2016
Belgrade : Society of Physical Chemists of Serbia., 763-766.
https://hdl.handle.net/21.15107/rcub_veterinar_3799

Krstić M, Jevtić S, Petković B, Milčić M. New dinuclear zinc(II) octaayza macrocyclic complex: conductometric study, synthesis and characterization. in 13th International Conference on Fundamental and Applied Aspects of Physical Chemistry, Belgrade, September 26 - 30, 2016. 2016;:763-766.
https://hdl.handle.net/21.15107/rcub_veterinar_3799 .

Krstić, Milena, Jevtić, Sonja, Petković, Branka, Milčić, Miloš, "New dinuclear zinc(II) octaayza macrocyclic complex: conductometric study, synthesis and characterization" in 13th International Conference on Fundamental and Applied Aspects of Physical Chemistry, Belgrade, September 26 - 30, 2016 (2016):763-766,
https://hdl.handle.net/21.15107/rcub_veterinar_3799 .

TY  - CONF
AU  - Petković, Branka
AU  - Stanković, Dalibor
AU  - Kuzmanović, Darko
AU  - Dimitrijević, Teodora
AU  - Krstić, Milena
PY  - 2016
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/3801
AB  - The electrochemical behavior and determination of chlorpromazine (CPZ)
by differential-pulse voltammetry (DPV) at unmodified boron-doped
diamond electrode (BDDE) is proposed. Effect of pH on electrochemical
oxidation of chloropromazine in Britton–Robinson (BR) buffer solution was
investigated. Cyclic voltammetry results shoved four oxidation peaks for
CPZ and peaks at 0.6 V and 1.3 V were chosen for CPZ quantification. The
electrode reaction is controlled by diffusion as a rate-determining step.
Under optimized DPV conditions at pH 4.0, a linear analytical curve was
obtained for wide the cloropomazine concentration range from 1.0×10-7
to
4.0×10-5M with a detection limit of 0.3×10-7M.
PB  - Belgrade : Society of Physical Chemists of Serbia
C3  - 13th International Conference on Fundamental and Applied Aspects of Physical Chemistry, Belgrade, September 26 - 30, 2016
T1  - Electroanalytical determination of chloropromazine on boron-doped diamond electrode
SP  - 379
EP  - 382
UR  - https://hdl.handle.net/21.15107/rcub_veterinar_3801
ER  - 

@conference{
author = "Petković, Branka and Stanković, Dalibor and Kuzmanović, Darko and Dimitrijević, Teodora and Krstić, Milena",
year = "2016",
abstract = "The electrochemical behavior and determination of chlorpromazine (CPZ)
by differential-pulse voltammetry (DPV) at unmodified boron-doped
diamond electrode (BDDE) is proposed. Effect of pH on electrochemical
oxidation of chloropromazine in Britton–Robinson (BR) buffer solution was
investigated. Cyclic voltammetry results shoved four oxidation peaks for
CPZ and peaks at 0.6 V and 1.3 V were chosen for CPZ quantification. The
electrode reaction is controlled by diffusion as a rate-determining step.
Under optimized DPV conditions at pH 4.0, a linear analytical curve was
obtained for wide the cloropomazine concentration range from 1.0×10-7
to
4.0×10-5M with a detection limit of 0.3×10-7M.",
publisher = "Belgrade : Society of Physical Chemists of Serbia",
journal = "13th International Conference on Fundamental and Applied Aspects of Physical Chemistry, Belgrade, September 26 - 30, 2016",
title = "Electroanalytical determination of chloropromazine on boron-doped diamond electrode",
pages = "379-382",
url = "https://hdl.handle.net/21.15107/rcub_veterinar_3801"
}

Petković, B., Stanković, D., Kuzmanović, D., Dimitrijević, T.,& Krstić, M.. (2016). Electroanalytical determination of chloropromazine on boron-doped diamond electrode. in 13th International Conference on Fundamental and Applied Aspects of Physical Chemistry, Belgrade, September 26 - 30, 2016
Belgrade : Society of Physical Chemists of Serbia., 379-382.
https://hdl.handle.net/21.15107/rcub_veterinar_3801

Petković B, Stanković D, Kuzmanović D, Dimitrijević T, Krstić M. Electroanalytical determination of chloropromazine on boron-doped diamond electrode. in 13th International Conference on Fundamental and Applied Aspects of Physical Chemistry, Belgrade, September 26 - 30, 2016. 2016;:379-382.
https://hdl.handle.net/21.15107/rcub_veterinar_3801 .

Petković, Branka, Stanković, Dalibor, Kuzmanović, Darko, Dimitrijević, Teodora, Krstić, Milena, "Electroanalytical determination of chloropromazine on boron-doped diamond electrode" in 13th International Conference on Fundamental and Applied Aspects of Physical Chemistry, Belgrade, September 26 - 30, 2016 (2016):379-382,
https://hdl.handle.net/21.15107/rcub_veterinar_3801 .