TY  - JOUR
AU  - Milošević-Stanković, Ivana
AU  - Hristov, Slavica
AU  - Maksimović, Nevena
AU  - Popović, Blaženka
AU  - Davidović, Vesna
AU  - Mekić, Cvijan
AU  - Dimitrijević, Blagoje
AU  - Cincović, Marko
AU  - Stanković, Branislav
PY  - 2020
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1870
AB  - The investigation was performed on two groups of primiparous and multiparous healthy dewormed Alpine dairy goats (25 each) during peripartal period. Blood samples were collected (jugular venipuncture) 10-15 days before and 10-15 and 30 days after the parturition into BD SST-II Advance (3.5 mL) and BD NaF 3.0 mg Na2EDTA 6.0 mg (2 mL) vacutainers, cooled and centrifuged (1500 r/min, 15 minutes and ≤1300 r/min, 10 minutes, respectively). Glucose, non-esterified fatty acids (NEFA) and β-hydroxybutyrate (BHBA) concentrations in blood sera were determined using A15 automatic spectrophotometric analyzer (Biosystem, Spain). Simultaneously, body condition scoring (BCS) was performed by Villaquiran et al. (2007) method. The obtained data were analyzed by IBM SPSS statistics 21. The glucose concentration inclined to increase in both groups. Differences between glucose levels were significant (P<0.05) 15 days before and 15 days after, as well as 15 and 30 days after the parturition, and very significant (P<0.01) 15 days before and 30 days after the parturition. The BHBA blood levels significantly differed 15 days before and 30 days after and 15 and 30 days after the parturition (P<0.05). BHBA concentration peaked at week 2 postpartum, following the increase of NEFA, providing the substrate for BHBA synthesis. NEFA levels significantly (P<0.05) differed 15 days before and 15 days after the parturition. Goats’ BCS ranged from 2 to 4 and significantly depended on glucose (r=0.392; P<0.05) and BHBA (r=0.317; P<0.05) level 15 days before parturition. BCS 30 days postpartum very significantly depended on the glucose level (r=0.450; P<0.01), significantly higher than the concentration of BHBA (r=0.351; P<0.05) and NEFA concentration (r=-0.304; P<0.05). BCS 15 days before parturition did not depend on the NEFA concentration. Fifteen days after the parturition BCS did not statistically depend on the observed indicators. Obtained data suggest that knowledge of BCS and energy indicators levels may be very useful in research and practice in order to appreciate energy metabolism of pregnant and lactating dairy ruminants, particularly dairy goats. These data are poorly documented for goats, but they can reveal early pathological metabolic changes in transiting female goat organism, enabling successful prophylactic, as well as, therapeutic intervention.
PB  - Sivar-Soc Italiana Veterinari Animali Reddito, Cremona
T2  - Large Animal Review
T1  - Energy metabolism indicators and body condition in peripartal period of alpine goats
VL  - 26
IS  - 1
SP  - 13
EP  - 18
UR  - https://hdl.handle.net/21.15107/rcub_agrospace_5444
ER  - 

@article{
author = "Milošević-Stanković, Ivana and Hristov, Slavica and Maksimović, Nevena and Popović, Blaženka and Davidović, Vesna and Mekić, Cvijan and Dimitrijević, Blagoje and Cincović, Marko and Stanković, Branislav",
year = "2020",
abstract = "The investigation was performed on two groups of primiparous and multiparous healthy dewormed Alpine dairy goats (25 each) during peripartal period. Blood samples were collected (jugular venipuncture) 10-15 days before and 10-15 and 30 days after the parturition into BD SST-II Advance (3.5 mL) and BD NaF 3.0 mg Na2EDTA 6.0 mg (2 mL) vacutainers, cooled and centrifuged (1500 r/min, 15 minutes and ≤1300 r/min, 10 minutes, respectively). Glucose, non-esterified fatty acids (NEFA) and β-hydroxybutyrate (BHBA) concentrations in blood sera were determined using A15 automatic spectrophotometric analyzer (Biosystem, Spain). Simultaneously, body condition scoring (BCS) was performed by Villaquiran et al. (2007) method. The obtained data were analyzed by IBM SPSS statistics 21. The glucose concentration inclined to increase in both groups. Differences between glucose levels were significant (P<0.05) 15 days before and 15 days after, as well as 15 and 30 days after the parturition, and very significant (P<0.01) 15 days before and 30 days after the parturition. The BHBA blood levels significantly differed 15 days before and 30 days after and 15 and 30 days after the parturition (P<0.05). BHBA concentration peaked at week 2 postpartum, following the increase of NEFA, providing the substrate for BHBA synthesis. NEFA levels significantly (P<0.05) differed 15 days before and 15 days after the parturition. Goats’ BCS ranged from 2 to 4 and significantly depended on glucose (r=0.392; P<0.05) and BHBA (r=0.317; P<0.05) level 15 days before parturition. BCS 30 days postpartum very significantly depended on the glucose level (r=0.450; P<0.01), significantly higher than the concentration of BHBA (r=0.351; P<0.05) and NEFA concentration (r=-0.304; P<0.05). BCS 15 days before parturition did not depend on the NEFA concentration. Fifteen days after the parturition BCS did not statistically depend on the observed indicators. Obtained data suggest that knowledge of BCS and energy indicators levels may be very useful in research and practice in order to appreciate energy metabolism of pregnant and lactating dairy ruminants, particularly dairy goats. These data are poorly documented for goats, but they can reveal early pathological metabolic changes in transiting female goat organism, enabling successful prophylactic, as well as, therapeutic intervention.",
publisher = "Sivar-Soc Italiana Veterinari Animali Reddito, Cremona",
journal = "Large Animal Review",
title = "Energy metabolism indicators and body condition in peripartal period of alpine goats",
volume = "26",
number = "1",
pages = "13-18",
url = "https://hdl.handle.net/21.15107/rcub_agrospace_5444"
}

Milošević-Stanković, I., Hristov, S., Maksimović, N., Popović, B., Davidović, V., Mekić, C., Dimitrijević, B., Cincović, M.,& Stanković, B.. (2020). Energy metabolism indicators and body condition in peripartal period of alpine goats. in Large Animal Review
Sivar-Soc Italiana Veterinari Animali Reddito, Cremona., 26(1), 13-18.
https://hdl.handle.net/21.15107/rcub_agrospace_5444

Milošević-Stanković I, Hristov S, Maksimović N, Popović B, Davidović V, Mekić C, Dimitrijević B, Cincović M, Stanković B. Energy metabolism indicators and body condition in peripartal period of alpine goats. in Large Animal Review. 2020;26(1):13-18.
https://hdl.handle.net/21.15107/rcub_agrospace_5444 .

Milošević-Stanković, Ivana, Hristov, Slavica, Maksimović, Nevena, Popović, Blaženka, Davidović, Vesna, Mekić, Cvijan, Dimitrijević, Blagoje, Cincović, Marko, Stanković, Branislav, "Energy metabolism indicators and body condition in peripartal period of alpine goats" in Large Animal Review, 26, no. 1 (2020):13-18,
https://hdl.handle.net/21.15107/rcub_agrospace_5444 .

TY  - JOUR
AU  - Becskei, Zsolt
AU  - Savić, Mila
AU  - Gaspardy, Andras
AU  - Petrujkić, Branko
AU  - Dimitrijević, Blagoje
AU  - Trailović, Ružica
AU  - Dimitrijević, Vladimir
PY  - 2018
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1614
AB  - The aim of this study was to emphasize the importance of conservation of the Lipe sheep, as a local endangered type of Zackel breed, and to perform a comprehensive phenotypic characterization in order to ensure a better use and preservation of this genetic resource. In addition, we compared the results of a detailed morphometric characterization of the modern Lipe sheep carried out in the present study with the morphometric parameters of the native form of this breed described in 1935. The comparative analysis revealed the development dynamics of the local Lipe sheep in the traditional habitat, over a period of nearly one century. Throughout this period, different factors affecting Lipe sheep management, such as biogeografic, agro-economic, sociocultural and others, led to significant population erosion, and to the current status of the Lipe sheep as an endangered genetic resource. Although a slight increase has been registered in some body measurements, the major body indexes of the Lipe sheep, such as body format, body compactness, body massiveness, body proportion, pelvic, and head index, remained without significant fluctuations over the last century (p>0.05). Body length of the modern type still exceeds the height at withers, which was also recorded in the native Lipe sheep nearly 100 years ago. A prominent sexual dimorphism is still evident. Therefore, our comparative analysis showed no significant differences between the native and modern form of Lipe sheep in their body format and growth potential. The slight increases in absolute body measurements of the modern Lipe type we recorded could be linked to better housing conditions and improved quality of feed, without application of strategic selection measures over the last 100 years. The importance of conservation of this ovine resource is less economical, but mostly cultural, historical and heritage oriented, and still essential for the survival of the breed.
PB  - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
T2  - Acta Veterinaria-Beograd
T1  - In situ programme for the conservation of the autochthonous lipe type of zackel sheep
VL  - 68
IS  - 4
SP  - 457
EP  - 473
DO  - 10.2478/acve-2018-0037
ER  - 

@article{
author = "Becskei, Zsolt and Savić, Mila and Gaspardy, Andras and Petrujkić, Branko and Dimitrijević, Blagoje and Trailović, Ružica and Dimitrijević, Vladimir",
year = "2018",
abstract = "The aim of this study was to emphasize the importance of conservation of the Lipe sheep, as a local endangered type of Zackel breed, and to perform a comprehensive phenotypic characterization in order to ensure a better use and preservation of this genetic resource. In addition, we compared the results of a detailed morphometric characterization of the modern Lipe sheep carried out in the present study with the morphometric parameters of the native form of this breed described in 1935. The comparative analysis revealed the development dynamics of the local Lipe sheep in the traditional habitat, over a period of nearly one century. Throughout this period, different factors affecting Lipe sheep management, such as biogeografic, agro-economic, sociocultural and others, led to significant population erosion, and to the current status of the Lipe sheep as an endangered genetic resource. Although a slight increase has been registered in some body measurements, the major body indexes of the Lipe sheep, such as body format, body compactness, body massiveness, body proportion, pelvic, and head index, remained without significant fluctuations over the last century (p>0.05). Body length of the modern type still exceeds the height at withers, which was also recorded in the native Lipe sheep nearly 100 years ago. A prominent sexual dimorphism is still evident. Therefore, our comparative analysis showed no significant differences between the native and modern form of Lipe sheep in their body format and growth potential. The slight increases in absolute body measurements of the modern Lipe type we recorded could be linked to better housing conditions and improved quality of feed, without application of strategic selection measures over the last 100 years. The importance of conservation of this ovine resource is less economical, but mostly cultural, historical and heritage oriented, and still essential for the survival of the breed.",
publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd",
journal = "Acta Veterinaria-Beograd",
title = "In situ programme for the conservation of the autochthonous lipe type of zackel sheep",
volume = "68",
number = "4",
pages = "457-473",
doi = "10.2478/acve-2018-0037"
}

Becskei, Z., Savić, M., Gaspardy, A., Petrujkić, B., Dimitrijević, B., Trailović, R.,& Dimitrijević, V.. (2018). In situ programme for the conservation of the autochthonous lipe type of zackel sheep. in Acta Veterinaria-Beograd
Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 68(4), 457-473.
https://doi.org/10.2478/acve-2018-0037

Becskei Z, Savić M, Gaspardy A, Petrujkić B, Dimitrijević B, Trailović R, Dimitrijević V. In situ programme for the conservation of the autochthonous lipe type of zackel sheep. in Acta Veterinaria-Beograd. 2018;68(4):457-473.
doi:10.2478/acve-2018-0037 .

Becskei, Zsolt, Savić, Mila, Gaspardy, Andras, Petrujkić, Branko, Dimitrijević, Blagoje, Trailović, Ružica, Dimitrijević, Vladimir, "In situ programme for the conservation of the autochthonous lipe type of zackel sheep" in Acta Veterinaria-Beograd, 68, no. 4 (2018):457-473,
https://doi.org/10.2478/acve-2018-0037 . .

TY  - CONF
AU  - Becskei, Zsolt
AU  - Pavlović, Ivan
AU  - Savić, Mila
AU  - Tarić, Elmin
AU  - Dimitrijević, Blagoje
AU  - Gáspárdy, András
PY  - 2018
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/2770
AB  - Sheep breeding represents one of the most perspective branches of the livestock production in
Serbia. The specific climate and the unic habitat include a high variability of flora and fauna
of grasslands, pastures and meadows throughout the country, ensuring high biodiversity of the
ecosystem. Autochthonous breeds are most adapted to the local environment. The present
study was performed on 143 autochthonous sheep breed flocks in Serbia during the grazing
season from March to October 2016 and 2017, and included a total of 1069 adult sheep. Tick
infection was detected in all tested flocks, affecting 49.02% of examined sheep. The most
dominant was Ixodes ricinus (44.71%), followed by Dermacentor marginatus (30.40%),
Rhipicephalus bursa (15.15%), Ripicephalus sanguineus (8.70%), Hyalomma savignyi
(3.18%), Haemaphysalis punctata (2.81%) and Dermacentor recticulatus (2.62%). In tested
years the recorded tick infections showed two peaks, in spring (April-May) and in autumn
(September-October). The considerable difference between detected spring and autumn tick
populations can be attributed mainly to climatic and environmental conditions of the
ecosystem where ticks and sheep cohabitat.
PB  - DAGENE - International association for the conservation of animal breeds in the Danube region
C3  - 29th Joint Annual Meeting of DAGENE and SAVE in Kozárd, Hungary from 24th to 27th of June 2018
T1  - The role of ecosystem service in conservation of autochthonous sheep breeds exposed to tick infections in Serbia
VL  - 3
SP  - 38
EP  - 43
UR  - https://hdl.handle.net/21.15107/rcub_veterinar_2770
ER  - 

@conference{
author = "Becskei, Zsolt and Pavlović, Ivan and Savić, Mila and Tarić, Elmin and Dimitrijević, Blagoje and Gáspárdy, András",
year = "2018",
abstract = "Sheep breeding represents one of the most perspective branches of the livestock production in
Serbia. The specific climate and the unic habitat include a high variability of flora and fauna
of grasslands, pastures and meadows throughout the country, ensuring high biodiversity of the
ecosystem. Autochthonous breeds are most adapted to the local environment. The present
study was performed on 143 autochthonous sheep breed flocks in Serbia during the grazing
season from March to October 2016 and 2017, and included a total of 1069 adult sheep. Tick
infection was detected in all tested flocks, affecting 49.02% of examined sheep. The most
dominant was Ixodes ricinus (44.71%), followed by Dermacentor marginatus (30.40%),
Rhipicephalus bursa (15.15%), Ripicephalus sanguineus (8.70%), Hyalomma savignyi
(3.18%), Haemaphysalis punctata (2.81%) and Dermacentor recticulatus (2.62%). In tested
years the recorded tick infections showed two peaks, in spring (April-May) and in autumn
(September-October). The considerable difference between detected spring and autumn tick
populations can be attributed mainly to climatic and environmental conditions of the
ecosystem where ticks and sheep cohabitat.",
publisher = "DAGENE - International association for the conservation of animal breeds in the Danube region",
journal = "29th Joint Annual Meeting of DAGENE and SAVE in Kozárd, Hungary from 24th to 27th of June 2018",
title = "The role of ecosystem service in conservation of autochthonous sheep breeds exposed to tick infections in Serbia",
volume = "3",
pages = "38-43",
url = "https://hdl.handle.net/21.15107/rcub_veterinar_2770"
}

Becskei, Z., Pavlović, I., Savić, M., Tarić, E., Dimitrijević, B.,& Gáspárdy, A.. (2018). The role of ecosystem service in conservation of autochthonous sheep breeds exposed to tick infections in Serbia. in 29th Joint Annual Meeting of DAGENE and SAVE in Kozárd, Hungary from 24th to 27th of June 2018
DAGENE - International association for the conservation of animal breeds in the Danube region., 3, 38-43.
https://hdl.handle.net/21.15107/rcub_veterinar_2770

Becskei Z, Pavlović I, Savić M, Tarić E, Dimitrijević B, Gáspárdy A. The role of ecosystem service in conservation of autochthonous sheep breeds exposed to tick infections in Serbia. in 29th Joint Annual Meeting of DAGENE and SAVE in Kozárd, Hungary from 24th to 27th of June 2018. 2018;3:38-43.
https://hdl.handle.net/21.15107/rcub_veterinar_2770 .

Becskei, Zsolt, Pavlović, Ivan, Savić, Mila, Tarić, Elmin, Dimitrijević, Blagoje, Gáspárdy, András, "The role of ecosystem service in conservation of autochthonous sheep breeds exposed to tick infections in Serbia" in 29th Joint Annual Meeting of DAGENE and SAVE in Kozárd, Hungary from 24th to 27th of June 2018, 3 (2018):38-43,
https://hdl.handle.net/21.15107/rcub_veterinar_2770 .

TY  - CONF
AU  - Savić, Mila
AU  - Popović Vranješ, Anka
AU  - Vučković, Savo
AU  - Becskei, Zsolt
AU  - Relić, Renata
AU  - Dimitrijević, Blagoje
AU  - Trailović, Ružica
AU  - Prodanović, Slaven
AU  - Dimitrijević, Vladimir
PY  - 2017
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/2775
AB  - The 2030 Agenda for Sustainable Development, including 17 Sustainable
Development Goals (SDGs), represents the new global objectives that succeed the
Millennium Development Goals. The Agenda emphasizes the link between food,
livelihoods and the management of natural resources. The primary objective of this
strategy is the improvement of the environment and, consequently, the improvement of
public health and quality of life. Harmful effects of ecosystem changes on human health
through pollution and loss of natural areas, combined with lifestyle changes, lead to public
health problems like obesity, diabetes, cancer, diseases of the cardiovascular system and
nervous system. Animal health management and food security control play an important
role in The 2030 Agenda for Sustainable Development. It's purpose is to support the
improvement of public health and sustainable development of regions. The value of
Sjenica Zackel sheep for rural development has been evaluated considering the new global
objectives and their importance for sustainable development. Sjenica Pester plateau,
characterized by specific floristic composition of pasture, traditionally is related to high
quality products, such are lamb meet and Sjenica cheese. The obtained results have shown
that the genetic constitution of Sjenica type of Zackel sheep, it's evolutionary adaptation to
the habitat, the method of breeding and the specific floristically composition favorably
affect the high-quality animal products.
The Sjenica lamb meat favorable fatty acid profile, important for human health and
especially for infant and children nutrition, raises the interest for sustainable production
and rural development at Sjenica Pester plateau. The obtained results are in accordance
with the new global objectives.
PB  - Novi Sad : Faculty of Agriculture
C3  - The International Symposium on Animal Science (ISAS) 2017, Herceg Novi, Montenegro, 5-10 June 2017
T1  - Importance of Sjenica Zackel sheep for sustainable development at Sjenica Pester plateu
SP  - 115
EP  - 121
UR  - https://hdl.handle.net/21.15107/rcub_veterinar_2775
ER  - 

@conference{
author = "Savić, Mila and Popović Vranješ, Anka and Vučković, Savo and Becskei, Zsolt and Relić, Renata and Dimitrijević, Blagoje and Trailović, Ružica and Prodanović, Slaven and Dimitrijević, Vladimir",
year = "2017",
abstract = "The 2030 Agenda for Sustainable Development, including 17 Sustainable
Development Goals (SDGs), represents the new global objectives that succeed the
Millennium Development Goals. The Agenda emphasizes the link between food,
livelihoods and the management of natural resources. The primary objective of this
strategy is the improvement of the environment and, consequently, the improvement of
public health and quality of life. Harmful effects of ecosystem changes on human health
through pollution and loss of natural areas, combined with lifestyle changes, lead to public
health problems like obesity, diabetes, cancer, diseases of the cardiovascular system and
nervous system. Animal health management and food security control play an important
role in The 2030 Agenda for Sustainable Development. It's purpose is to support the
improvement of public health and sustainable development of regions. The value of
Sjenica Zackel sheep for rural development has been evaluated considering the new global
objectives and their importance for sustainable development. Sjenica Pester plateau,
characterized by specific floristic composition of pasture, traditionally is related to high
quality products, such are lamb meet and Sjenica cheese. The obtained results have shown
that the genetic constitution of Sjenica type of Zackel sheep, it's evolutionary adaptation to
the habitat, the method of breeding and the specific floristically composition favorably
affect the high-quality animal products.
The Sjenica lamb meat favorable fatty acid profile, important for human health and
especially for infant and children nutrition, raises the interest for sustainable production
and rural development at Sjenica Pester plateau. The obtained results are in accordance
with the new global objectives.",
publisher = "Novi Sad : Faculty of Agriculture",
journal = "The International Symposium on Animal Science (ISAS) 2017, Herceg Novi, Montenegro, 5-10 June 2017",
title = "Importance of Sjenica Zackel sheep for sustainable development at Sjenica Pester plateu",
pages = "115-121",
url = "https://hdl.handle.net/21.15107/rcub_veterinar_2775"
}

Savić, M., Popović Vranješ, A., Vučković, S., Becskei, Z., Relić, R., Dimitrijević, B., Trailović, R., Prodanović, S.,& Dimitrijević, V.. (2017). Importance of Sjenica Zackel sheep for sustainable development at Sjenica Pester plateu. in The International Symposium on Animal Science (ISAS) 2017, Herceg Novi, Montenegro, 5-10 June 2017
Novi Sad : Faculty of Agriculture., 115-121.
https://hdl.handle.net/21.15107/rcub_veterinar_2775

Savić M, Popović Vranješ A, Vučković S, Becskei Z, Relić R, Dimitrijević B, Trailović R, Prodanović S, Dimitrijević V. Importance of Sjenica Zackel sheep for sustainable development at Sjenica Pester plateu. in The International Symposium on Animal Science (ISAS) 2017, Herceg Novi, Montenegro, 5-10 June 2017. 2017;:115-121.
https://hdl.handle.net/21.15107/rcub_veterinar_2775 .

Savić, Mila, Popović Vranješ, Anka, Vučković, Savo, Becskei, Zsolt, Relić, Renata, Dimitrijević, Blagoje, Trailović, Ružica, Prodanović, Slaven, Dimitrijević, Vladimir, "Importance of Sjenica Zackel sheep for sustainable development at Sjenica Pester plateu" in The International Symposium on Animal Science (ISAS) 2017, Herceg Novi, Montenegro, 5-10 June 2017 (2017):115-121,
https://hdl.handle.net/21.15107/rcub_veterinar_2775 .

TY  - CONF
AU  - Becskei, Zsolt
AU  - Savić, Mila
AU  - Pavlović, Ivan
AU  - Ivanović, Snežana
AU  - Dimitrijević, Blagoje
AU  - Gáspárdy, András
AU  - Könyves, Tibor
AU  - Relić, Renata
PY  - 2016
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/2791
AB  - Hilly mountain region of Serbia represents a valuable natural resource with high potential in
livestock production, especially for sustainable goat and sheep rearing. The Balkan Goat, as a
transboundary breed, is on the list of endangered breeds. For decades it has been exposed to
pressure from high performance, exotic, meliorate breeds. Nowadays, it is necessary to
improve the strategy for advanced characterization and conservation of the Balkan Goat
breed. Previous investigations of the genetic structure of this autochthonous, transboundary
breed revealed the existence of genetic variability and good adaptive ability to the local,
unfavorable environment and extensive conditions. Monitoring of some health traits is
necessary for effective planning of advanced breed characterization and conservation. As the
most severe health problem in goat production systems are parasitic infections, determination
of gastro-intestinal parasites is important for definition of health status. The aim of this study
was to assess the prevalence and extensity of gastro-intestinal parasitism of Balkan goat
populations in hilly mountain regions of Serbia, where the breed is traditionally reared. The
study was conducted in 131 Balkan Goat flocks, kept mainly under extensive production
system. The results show that all the tested flocks are infected, while the predominant gastrointestinal
parasites detected were nematodes. Such results are valuable in making strategies
for development of integrated approach to achieve the best control of parasitic infections of
Balkan Goat flocks. Keeping in mind that one of the main challenges of livestock production
are parasitic infections, obtained resultants can also be an important point to determine some
advanced characteristics of Balkan Goat, necessary for conservation process. The importance
of conservation of Balkan Goat, as an endangered, autochthonous genetic resource is less
economical, but mostly cultural, historical and heritage oriented. There is also the aesthetic
argument that Balkan goat is an element of nature and landscape protection.
PB  - DAGENE - International Association for the Conservation of Animal Breeds in the Danube Region
C3  - 27th Annual Meeting of DAGENE in Hilgertshausen, Schwaiganger and Glentleiten, Germany from 22nd to 24th of April 2016
T1  - Assessment of some health status traits of endangered Balkan goat in order to improve in situ conservation program
VL  - 1
SP  - 34
EP  - 39
UR  - https://hdl.handle.net/21.15107/rcub_veterinar_2791
ER  - 

@conference{
author = "Becskei, Zsolt and Savić, Mila and Pavlović, Ivan and Ivanović, Snežana and Dimitrijević, Blagoje and Gáspárdy, András and Könyves, Tibor and Relić, Renata",
year = "2016",
abstract = "Hilly mountain region of Serbia represents a valuable natural resource with high potential in
livestock production, especially for sustainable goat and sheep rearing. The Balkan Goat, as a
transboundary breed, is on the list of endangered breeds. For decades it has been exposed to
pressure from high performance, exotic, meliorate breeds. Nowadays, it is necessary to
improve the strategy for advanced characterization and conservation of the Balkan Goat
breed. Previous investigations of the genetic structure of this autochthonous, transboundary
breed revealed the existence of genetic variability and good adaptive ability to the local,
unfavorable environment and extensive conditions. Monitoring of some health traits is
necessary for effective planning of advanced breed characterization and conservation. As the
most severe health problem in goat production systems are parasitic infections, determination
of gastro-intestinal parasites is important for definition of health status. The aim of this study
was to assess the prevalence and extensity of gastro-intestinal parasitism of Balkan goat
populations in hilly mountain regions of Serbia, where the breed is traditionally reared. The
study was conducted in 131 Balkan Goat flocks, kept mainly under extensive production
system. The results show that all the tested flocks are infected, while the predominant gastrointestinal
parasites detected were nematodes. Such results are valuable in making strategies
for development of integrated approach to achieve the best control of parasitic infections of
Balkan Goat flocks. Keeping in mind that one of the main challenges of livestock production
are parasitic infections, obtained resultants can also be an important point to determine some
advanced characteristics of Balkan Goat, necessary for conservation process. The importance
of conservation of Balkan Goat, as an endangered, autochthonous genetic resource is less
economical, but mostly cultural, historical and heritage oriented. There is also the aesthetic
argument that Balkan goat is an element of nature and landscape protection.",
publisher = "DAGENE - International Association for the Conservation of Animal Breeds in the Danube Region",
journal = "27th Annual Meeting of DAGENE in Hilgertshausen, Schwaiganger and Glentleiten, Germany from 22nd to 24th of April 2016",
title = "Assessment of some health status traits of endangered Balkan goat in order to improve in situ conservation program",
volume = "1",
pages = "34-39",
url = "https://hdl.handle.net/21.15107/rcub_veterinar_2791"
}

Becskei, Z., Savić, M., Pavlović, I., Ivanović, S., Dimitrijević, B., Gáspárdy, A., Könyves, T.,& Relić, R.. (2016). Assessment of some health status traits of endangered Balkan goat in order to improve in situ conservation program. in 27th Annual Meeting of DAGENE in Hilgertshausen, Schwaiganger and Glentleiten, Germany from 22nd to 24th of April 2016
DAGENE - International Association for the Conservation of Animal Breeds in the Danube Region., 1, 34-39.
https://hdl.handle.net/21.15107/rcub_veterinar_2791

Becskei Z, Savić M, Pavlović I, Ivanović S, Dimitrijević B, Gáspárdy A, Könyves T, Relić R. Assessment of some health status traits of endangered Balkan goat in order to improve in situ conservation program. in 27th Annual Meeting of DAGENE in Hilgertshausen, Schwaiganger and Glentleiten, Germany from 22nd to 24th of April 2016. 2016;1:34-39.
https://hdl.handle.net/21.15107/rcub_veterinar_2791 .

Becskei, Zsolt, Savić, Mila, Pavlović, Ivan, Ivanović, Snežana, Dimitrijević, Blagoje, Gáspárdy, András, Könyves, Tibor, Relić, Renata, "Assessment of some health status traits of endangered Balkan goat in order to improve in situ conservation program" in 27th Annual Meeting of DAGENE in Hilgertshausen, Schwaiganger and Glentleiten, Germany from 22nd to 24th of April 2016, 1 (2016):34-39,
https://hdl.handle.net/21.15107/rcub_veterinar_2791 .

TY  - CONF
AU  - Savić, Mila
AU  - Dimitrijević, Blagoje
AU  - Gáspárdy, András
AU  - Zsolnia, Attila
AU  - Becskei, Zsolt
PY  - 2016
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/2792
AB  - The focus of investigations were the health status and the adaptive characteristics of
autochthonous breeds, their ability to cope well with challenging aspects of the production
environment including knowledge of the impact of types of livestock keeping on ecosystem
functions. The multidisciplinary approach is focused on pasture impact, economic and social
factors which are driving livestock-sector trends affecting the management of Zackel sheep
genetic resources. As a result of strong support for the maintenance of Zackel sheep
populations in their traditional production environments and application of conservation
strategies that involve in situ measures, we are facing many challenges. In this sense, we shall
point out the problems of the in situ conservation of endangered type Zackel sheep. The
gastrointestinal parasitic infections were the main health problem in Lipe sheep populations.
The research presented in this paper focused on the influence of intensity and type of parasitic
infections to the degree of oxidative stress in endangered Lipe type of Zackel sheep with
special attention to the activity of the enzyme superoxide dismutase 1 (SOD 1).
PB  - DAGENE - International Association for the Conservation of Animal Breeds in the Danube Region
C3  - 27th Annual Meeting of DAGENE in Hilgertshausen, Schwaiganger and Glentleiten, Germany from 22nd to 24th of April 2016
T1  - Challenges of in situ conservation of endangered Zackel sheep type
VL  - 1
SP  - 30
EP  - 33
UR  - https://hdl.handle.net/21.15107/rcub_veterinar_2792
ER  - 

@conference{
author = "Savić, Mila and Dimitrijević, Blagoje and Gáspárdy, András and Zsolnia, Attila and Becskei, Zsolt",
year = "2016",
abstract = "The focus of investigations were the health status and the adaptive characteristics of
autochthonous breeds, their ability to cope well with challenging aspects of the production
environment including knowledge of the impact of types of livestock keeping on ecosystem
functions. The multidisciplinary approach is focused on pasture impact, economic and social
factors which are driving livestock-sector trends affecting the management of Zackel sheep
genetic resources. As a result of strong support for the maintenance of Zackel sheep
populations in their traditional production environments and application of conservation
strategies that involve in situ measures, we are facing many challenges. In this sense, we shall
point out the problems of the in situ conservation of endangered type Zackel sheep. The
gastrointestinal parasitic infections were the main health problem in Lipe sheep populations.
The research presented in this paper focused on the influence of intensity and type of parasitic
infections to the degree of oxidative stress in endangered Lipe type of Zackel sheep with
special attention to the activity of the enzyme superoxide dismutase 1 (SOD 1).",
publisher = "DAGENE - International Association for the Conservation of Animal Breeds in the Danube Region",
journal = "27th Annual Meeting of DAGENE in Hilgertshausen, Schwaiganger and Glentleiten, Germany from 22nd to 24th of April 2016",
title = "Challenges of in situ conservation of endangered Zackel sheep type",
volume = "1",
pages = "30-33",
url = "https://hdl.handle.net/21.15107/rcub_veterinar_2792"
}

Savić, M., Dimitrijević, B., Gáspárdy, A., Zsolnia, A.,& Becskei, Z.. (2016). Challenges of in situ conservation of endangered Zackel sheep type. in 27th Annual Meeting of DAGENE in Hilgertshausen, Schwaiganger and Glentleiten, Germany from 22nd to 24th of April 2016
DAGENE - International Association for the Conservation of Animal Breeds in the Danube Region., 1, 30-33.
https://hdl.handle.net/21.15107/rcub_veterinar_2792

Savić M, Dimitrijević B, Gáspárdy A, Zsolnia A, Becskei Z. Challenges of in situ conservation of endangered Zackel sheep type. in 27th Annual Meeting of DAGENE in Hilgertshausen, Schwaiganger and Glentleiten, Germany from 22nd to 24th of April 2016. 2016;1:30-33.
https://hdl.handle.net/21.15107/rcub_veterinar_2792 .

Savić, Mila, Dimitrijević, Blagoje, Gáspárdy, András, Zsolnia, Attila, Becskei, Zsolt, "Challenges of in situ conservation of endangered Zackel sheep type" in 27th Annual Meeting of DAGENE in Hilgertshausen, Schwaiganger and Glentleiten, Germany from 22nd to 24th of April 2016, 1 (2016):30-33,
https://hdl.handle.net/21.15107/rcub_veterinar_2792 .

TY  - JOUR
AU  - Dimitrijević, Blagoje
AU  - Jović, Slavoljub
AU  - Ostojić-Andrić, Dušica
AU  - Savić, Mila
AU  - Becskei, Zsolt
AU  - Davidović, Vesna
AU  - Joksimović-Todorović, Mirjana
PY  - 2016
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1321
AB  - The aim of this study was to determine and evaluate the basic haematological parameters in conditions of natural infection of sheep with Strongyloides papillosus, as well as after the administration of antihelminthic albendazole (ABZ). Based on the intensity of infection with S. papillosus the sheep were divided into three groups: mild, moderate and high, and after that the sheep received a single dose of ABZ of 5mg/kg per body weight, per orally. Sampling of faeces and blood for parasitological and haematological assaying respectively, was performed on the 0 and the 21st day after the treatment with ABZ. The presence of parasitic infection with S. papillosus leads to a decrease of erythrocyte count, while the lowest values were established in the group with the highest intensity of parasitic infection (p ˂ 0.001). After treatment with ABZ the decrease of erythrocyte count was more prominent, which was, based on comparison with control groups C1 and C2, unequivocally established to be the consequence of treatment with ABZ. Detected values of haematocrit and erythrocyte indices indicated the presence of parasitic infection: the lowest values were established in the group with the highest intensity of parasitic infection. After treatment with ABZ haematocrit levels in control group C2 were statistically significantly lower compared to the control group C1 (p ˂ 0.001). In the presence of parasitic infection, the neutrophil and eosinophil counts increased almost linearly up to the value of 44.24±2.50% and 13.29±0.61% respectively, in the group of sheep with the highest intensity of parasitic infection (p ˂ 0.001; compared to control group C1). After treatment with ABZ the decrease of the number of these white blood cells is statistically significant (p ˂ 0.001). Bearing in mind our previous research and the connection of disbalanced redox equilibrium after the treatment with ABZ with changes, it is necessary to include antioxidative substances in the anti-parasitic treatment protocols.
AB  - Cilj ovog istraživanja bio je da se utvrde i procene osnovni hematološki parametri u uslovima prirodne infekcije ovaca sa Strongyloides papillosus, kao i nakon primene antihelmintika albendazola (ABZ). Na osnovu intenziteta infekcije sa S. papillosus ovce su podeljene u tri grupe: niski, srednji i visoki intenzitet infekcije, a zatim su ovce jednokratno dobile peroralno ABZ, u terapijskoj dozi od 5 mg/kg telesne mase. Uzorkovanje fecesa za parazitološka i za hematološka ispitivanja obavljeno je nultog i 21. dana od primene ABZ. Utvrđeno je da prisustvo parazitske infekcije sa S. papillosus dovodi do pada broja eritrocita, pri čemu su najniže vrednosti utvrđene u grupi sa najvećim intenzitetom parazitske infekcije (p ˂ 0,001). Nakon terapije sa ABZ pad broja eritrocita je izraženiji, što je nesumnjivo nastalo kao posledica terapije ABZ (na osnovu poređenja C1 i C2). Utvrđene vrednosti hematokrita i eritrocitnih indeksa su ukazivali na postojanje parazitske infekcije; najniže vrednosti su utvrđene kod grupe sa najvećim intenzitetom parazitske infekcije. Nakon terapije sa ABZ vrednosti hematokrita kod C2 bile su statistički značajno niže u odnosu na kontrolnu grupu C1 (p ˂ 0,001). U prisustvu parazitske infekcije broj neutrofila i eozinofila povećava se gotovo linearno, do vrednosti od 44,24±2,50% kod neutrofila, odnosno od 13,29±0,61% kod eozinofila u grupi ovaca sa najvećim intenzitetom parazitske infekcije (p ˂ 0,001). Nakon terapije sa ABZ broj ovih ćelija bele krvne loze smanjuje se statistički značajno (p ˂ 0,001). Imajući u vidu naša prethodna istraživanja i povezanost narušene redoks ravnoteže posle terapije sa ABZ sa promenama utvrđenim u ovom istraživanju, neophodno je u antiparazitske terapijske protokole uključiti antioksidativne supstance.
PB  - Institut za stočarstvo, Beograd
T2  - Biotechnology in Animal Husbandry
T1  - Infection with Strongyloides papillosus in sheep: Effect of parasitic infection and treatment with albendazole on basic haematological parameters
T1  - Infekcija ovaca sa Strongyloides papillosus - uticaj intenziteta parazitske infekcije i terapije albendazolom na vrednosti osnovnih hematoloških parametara
VL  - 32
IS  - 4
SP  - 369
EP  - 381
DO  - 10.2298/bah1604369D
ER  - 

@article{
author = "Dimitrijević, Blagoje and Jović, Slavoljub and Ostojić-Andrić, Dušica and Savić, Mila and Becskei, Zsolt and Davidović, Vesna and Joksimović-Todorović, Mirjana",
year = "2016",
abstract = "The aim of this study was to determine and evaluate the basic haematological parameters in conditions of natural infection of sheep with Strongyloides papillosus, as well as after the administration of antihelminthic albendazole (ABZ). Based on the intensity of infection with S. papillosus the sheep were divided into three groups: mild, moderate and high, and after that the sheep received a single dose of ABZ of 5mg/kg per body weight, per orally. Sampling of faeces and blood for parasitological and haematological assaying respectively, was performed on the 0 and the 21st day after the treatment with ABZ. The presence of parasitic infection with S. papillosus leads to a decrease of erythrocyte count, while the lowest values were established in the group with the highest intensity of parasitic infection (p ˂ 0.001). After treatment with ABZ the decrease of erythrocyte count was more prominent, which was, based on comparison with control groups C1 and C2, unequivocally established to be the consequence of treatment with ABZ. Detected values of haematocrit and erythrocyte indices indicated the presence of parasitic infection: the lowest values were established in the group with the highest intensity of parasitic infection. After treatment with ABZ haematocrit levels in control group C2 were statistically significantly lower compared to the control group C1 (p ˂ 0.001). In the presence of parasitic infection, the neutrophil and eosinophil counts increased almost linearly up to the value of 44.24±2.50% and 13.29±0.61% respectively, in the group of sheep with the highest intensity of parasitic infection (p ˂ 0.001; compared to control group C1). After treatment with ABZ the decrease of the number of these white blood cells is statistically significant (p ˂ 0.001). Bearing in mind our previous research and the connection of disbalanced redox equilibrium after the treatment with ABZ with changes, it is necessary to include antioxidative substances in the anti-parasitic treatment protocols., Cilj ovog istraživanja bio je da se utvrde i procene osnovni hematološki parametri u uslovima prirodne infekcije ovaca sa Strongyloides papillosus, kao i nakon primene antihelmintika albendazola (ABZ). Na osnovu intenziteta infekcije sa S. papillosus ovce su podeljene u tri grupe: niski, srednji i visoki intenzitet infekcije, a zatim su ovce jednokratno dobile peroralno ABZ, u terapijskoj dozi od 5 mg/kg telesne mase. Uzorkovanje fecesa za parazitološka i za hematološka ispitivanja obavljeno je nultog i 21. dana od primene ABZ. Utvrđeno je da prisustvo parazitske infekcije sa S. papillosus dovodi do pada broja eritrocita, pri čemu su najniže vrednosti utvrđene u grupi sa najvećim intenzitetom parazitske infekcije (p ˂ 0,001). Nakon terapije sa ABZ pad broja eritrocita je izraženiji, što je nesumnjivo nastalo kao posledica terapije ABZ (na osnovu poređenja C1 i C2). Utvrđene vrednosti hematokrita i eritrocitnih indeksa su ukazivali na postojanje parazitske infekcije; najniže vrednosti su utvrđene kod grupe sa najvećim intenzitetom parazitske infekcije. Nakon terapije sa ABZ vrednosti hematokrita kod C2 bile su statistički značajno niže u odnosu na kontrolnu grupu C1 (p ˂ 0,001). U prisustvu parazitske infekcije broj neutrofila i eozinofila povećava se gotovo linearno, do vrednosti od 44,24±2,50% kod neutrofila, odnosno od 13,29±0,61% kod eozinofila u grupi ovaca sa najvećim intenzitetom parazitske infekcije (p ˂ 0,001). Nakon terapije sa ABZ broj ovih ćelija bele krvne loze smanjuje se statistički značajno (p ˂ 0,001). Imajući u vidu naša prethodna istraživanja i povezanost narušene redoks ravnoteže posle terapije sa ABZ sa promenama utvrđenim u ovom istraživanju, neophodno je u antiparazitske terapijske protokole uključiti antioksidativne supstance.",
publisher = "Institut za stočarstvo, Beograd",
journal = "Biotechnology in Animal Husbandry",
title = "Infection with Strongyloides papillosus in sheep: Effect of parasitic infection and treatment with albendazole on basic haematological parameters, Infekcija ovaca sa Strongyloides papillosus - uticaj intenziteta parazitske infekcije i terapije albendazolom na vrednosti osnovnih hematoloških parametara",
volume = "32",
number = "4",
pages = "369-381",
doi = "10.2298/bah1604369D"
}

Dimitrijević, B., Jović, S., Ostojić-Andrić, D., Savić, M., Becskei, Z., Davidović, V.,& Joksimović-Todorović, M.. (2016). Infection with Strongyloides papillosus in sheep: Effect of parasitic infection and treatment with albendazole on basic haematological parameters. in Biotechnology in Animal Husbandry
Institut za stočarstvo, Beograd., 32(4), 369-381.
https://doi.org/10.2298/bah1604369D

Dimitrijević B, Jović S, Ostojić-Andrić D, Savić M, Becskei Z, Davidović V, Joksimović-Todorović M. Infection with Strongyloides papillosus in sheep: Effect of parasitic infection and treatment with albendazole on basic haematological parameters. in Biotechnology in Animal Husbandry. 2016;32(4):369-381.
doi:10.2298/bah1604369D .

Dimitrijević, Blagoje, Jović, Slavoljub, Ostojić-Andrić, Dušica, Savić, Mila, Becskei, Zsolt, Davidović, Vesna, Joksimović-Todorović, Mirjana, "Infection with Strongyloides papillosus in sheep: Effect of parasitic infection and treatment with albendazole on basic haematological parameters" in Biotechnology in Animal Husbandry, 32, no. 4 (2016):369-381,
https://doi.org/10.2298/bah1604369D . .

TY  - JOUR
AU  - Jović, Slavoljub
AU  - Ćupić, Vitomir
AU  - Ristić, Gordana
AU  - Vakanjac, Slobodanka
AU  - Dimitrijević, Blagoje
AU  - Ćupić Miladinović, Dejana
AU  - Živković, Lada
PY  - 2016
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1337
AB  - The objective of this work was to investigate the influence of the day of farrowing induction on the number of newborn piglets (live born and dead born), body mass and mortality of neonatal pigs in litter by the tenth day of age. For the investigation purpose, there were chosen 167 pregnant animals, 34 gilts and 133 sows, divided into 3 groups each, according to the day of pregnancy when prostaglandin analogue, dinoprost-tromethamine, was applied (from 112th to 114th day). Fastest-induced parturition was in gilts which were administered dinoprost on the 113th day of pregnancy, (34,30 ± 6,23) h after application, that is, in sows which were administered prostaglandin on the 114th day of pregnancy, (29,57 ± 4,14) h after application of dinoprost. Most gilts (75 %) and sows (90,91%) started farrowing 24-36 h after dinoprost application, when it was given on the 113th day of pregnancy. During daily twelve-hour working time (7-19 h), 67,07% out of all the treated animals started farrowing. When farrowing was induced on the 112th day of pregnancy, 17 sows (12,78%) needed obstetric assistance for dystocia, while 47 (35,34 %) sows had troublesome farrowing. Along with the delayed induction, body mass of newborn pigs increased, and the largest recorded weight was 1,27 kg in sows, that is 1,38 kg in gilts, which were given dinoprost on the 114th day of pregnancy, with the lowest number of live born pigs of body mass less than 1 kg (23,76%). In this experiment there was determined the connection between the body mass and vitality of newborn piglets, so the lowest mortality rate of the pigs by the 10th day of age was noticed in sows and gilts which were given dinoprost on the 114th day of pregnancy (11,05%), in regard to the pigs born of sows and gilts which were given dinoprost on the 112th day of pregnancy (15,39 %).
AB  - Cilj ovog rada bio je da se ispita uticaj izbora dana indukcije prašenja na broj novorođene prasadi (živo i mrtvorođene), telesnu masu i mortalitet neonatalne prasadi u leglu do 10. dana starosti. Za ispitivanje je izabrano 167 gravidnih životinja, 34 nazimica i 133 krmača, podeljenih u po 3 grupe, prema danu graviditeta kada je aplikovan analog prostaglandina, dinoprost-trometamin (od 112­114. dana). Najbrže je indukovan partus kod nazimica kojima je aplikovan dinoprost 113. dana graviditeta (34,30 ± 6,23) h nakon aplikacije, odnosno kod krmača kojima je aplikovan prostaglandin 114. dana graviditeta (29,57 ± 4,14) h nakon aplikacije dinoprosta. Najviše nazimica (75 %) i krmača (90,91%) započelo je prašenje 24-36 h nakon aplikacije dinoprosta, kada je on aplikovan 113. dana graviditeta. U toku dnevnog dvanaestočasovnog radnog vremena (7-19 h) započelo je prašenje 67,07% od ukupno tretiranih životinja. Kada je indukovano prašenje na 112 dan graviditeta 17 krmača (12,78%) zahtevalo je akušersku pomoć zbog distocije, dok je od ukupnog broja krmača 47 (35,34 %) bilo sa problematičnim prašenjem. Sa odlaganjem indukcije rasla je telesna masa novorođene prasadi, pri čemu je najveća zabeležena iznosila 1,27 kg kod krmača, odnosno 1,38 kg kod nazimica, kojima je dinoprost aplikovan 114. dana graviditeta, sa najmanje živorođene prasadi telesne mase ispod 1 kg (23,76%). U ogledu je utvrđena povezanost telesne mase sa vitalnošću novorođene prasadi, tako da je najmanja stopa smrtnosti prasadi do 10. dana života, zabeležena kod krmača i nazimica kojima je dinoprost aplikovan 114. dana graviditeta (11,05%), u odnosu na prasad rođenu kod krmača i nazimica kojima je dinoprost aplikovan 112. dana graviditeta (15,39%).
PB  - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
T2  - Veterinarski Glasnik
T1  - The influence of the induction of farrowing on live birth, body mass, appearance of dystocia, mortality and surviving of neonatal pigs in litter during the first ten days
T1  - Vlijanie indukcii oporosa na živoroždenie, massu tela, vozniknovenie distocii, smertnost' i vyživanie novoroždennyh porosjat v pervye desjat' dnej
T1  - Uticaj indukcije prašenja na živorođenost, telesnu masu, pojavu distocije, mortalitet i preživljavanje neonatalne prasadi u leglu u prvih deset dana
VL  - 70
IS  - 1-2
SP  - 13
EP  - 29
DO  - 10.2298/VETGL1602013J
ER  - 

@article{
author = "Jović, Slavoljub and Ćupić, Vitomir and Ristić, Gordana and Vakanjac, Slobodanka and Dimitrijević, Blagoje and Ćupić Miladinović, Dejana and Živković, Lada",
year = "2016",
abstract = "The objective of this work was to investigate the influence of the day of farrowing induction on the number of newborn piglets (live born and dead born), body mass and mortality of neonatal pigs in litter by the tenth day of age. For the investigation purpose, there were chosen 167 pregnant animals, 34 gilts and 133 sows, divided into 3 groups each, according to the day of pregnancy when prostaglandin analogue, dinoprost-tromethamine, was applied (from 112th to 114th day). Fastest-induced parturition was in gilts which were administered dinoprost on the 113th day of pregnancy, (34,30 ± 6,23) h after application, that is, in sows which were administered prostaglandin on the 114th day of pregnancy, (29,57 ± 4,14) h after application of dinoprost. Most gilts (75 %) and sows (90,91%) started farrowing 24-36 h after dinoprost application, when it was given on the 113th day of pregnancy. During daily twelve-hour working time (7-19 h), 67,07% out of all the treated animals started farrowing. When farrowing was induced on the 112th day of pregnancy, 17 sows (12,78%) needed obstetric assistance for dystocia, while 47 (35,34 %) sows had troublesome farrowing. Along with the delayed induction, body mass of newborn pigs increased, and the largest recorded weight was 1,27 kg in sows, that is 1,38 kg in gilts, which were given dinoprost on the 114th day of pregnancy, with the lowest number of live born pigs of body mass less than 1 kg (23,76%). In this experiment there was determined the connection between the body mass and vitality of newborn piglets, so the lowest mortality rate of the pigs by the 10th day of age was noticed in sows and gilts which were given dinoprost on the 114th day of pregnancy (11,05%), in regard to the pigs born of sows and gilts which were given dinoprost on the 112th day of pregnancy (15,39 %)., Cilj ovog rada bio je da se ispita uticaj izbora dana indukcije prašenja na broj novorođene prasadi (živo i mrtvorođene), telesnu masu i mortalitet neonatalne prasadi u leglu do 10. dana starosti. Za ispitivanje je izabrano 167 gravidnih životinja, 34 nazimica i 133 krmača, podeljenih u po 3 grupe, prema danu graviditeta kada je aplikovan analog prostaglandina, dinoprost-trometamin (od 112­114. dana). Najbrže je indukovan partus kod nazimica kojima je aplikovan dinoprost 113. dana graviditeta (34,30 ± 6,23) h nakon aplikacije, odnosno kod krmača kojima je aplikovan prostaglandin 114. dana graviditeta (29,57 ± 4,14) h nakon aplikacije dinoprosta. Najviše nazimica (75 %) i krmača (90,91%) započelo je prašenje 24-36 h nakon aplikacije dinoprosta, kada je on aplikovan 113. dana graviditeta. U toku dnevnog dvanaestočasovnog radnog vremena (7-19 h) započelo je prašenje 67,07% od ukupno tretiranih životinja. Kada je indukovano prašenje na 112 dan graviditeta 17 krmača (12,78%) zahtevalo je akušersku pomoć zbog distocije, dok je od ukupnog broja krmača 47 (35,34 %) bilo sa problematičnim prašenjem. Sa odlaganjem indukcije rasla je telesna masa novorođene prasadi, pri čemu je najveća zabeležena iznosila 1,27 kg kod krmača, odnosno 1,38 kg kod nazimica, kojima je dinoprost aplikovan 114. dana graviditeta, sa najmanje živorođene prasadi telesne mase ispod 1 kg (23,76%). U ogledu je utvrđena povezanost telesne mase sa vitalnošću novorođene prasadi, tako da je najmanja stopa smrtnosti prasadi do 10. dana života, zabeležena kod krmača i nazimica kojima je dinoprost aplikovan 114. dana graviditeta (11,05%), u odnosu na prasad rođenu kod krmača i nazimica kojima je dinoprost aplikovan 112. dana graviditeta (15,39%).",
publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd",
journal = "Veterinarski Glasnik",
title = "The influence of the induction of farrowing on live birth, body mass, appearance of dystocia, mortality and surviving of neonatal pigs in litter during the first ten days, Vlijanie indukcii oporosa na živoroždenie, massu tela, vozniknovenie distocii, smertnost' i vyživanie novoroždennyh porosjat v pervye desjat' dnej, Uticaj indukcije prašenja na živorođenost, telesnu masu, pojavu distocije, mortalitet i preživljavanje neonatalne prasadi u leglu u prvih deset dana",
volume = "70",
number = "1-2",
pages = "13-29",
doi = "10.2298/VETGL1602013J"
}

Jović, S., Ćupić, V., Ristić, G., Vakanjac, S., Dimitrijević, B., Ćupić Miladinović, D.,& Živković, L.. (2016). The influence of the induction of farrowing on live birth, body mass, appearance of dystocia, mortality and surviving of neonatal pigs in litter during the first ten days. in Veterinarski Glasnik
Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 70(1-2), 13-29.
https://doi.org/10.2298/VETGL1602013J

Jović S, Ćupić V, Ristić G, Vakanjac S, Dimitrijević B, Ćupić Miladinović D, Živković L. The influence of the induction of farrowing on live birth, body mass, appearance of dystocia, mortality and surviving of neonatal pigs in litter during the first ten days. in Veterinarski Glasnik. 2016;70(1-2):13-29.
doi:10.2298/VETGL1602013J .

Jović, Slavoljub, Ćupić, Vitomir, Ristić, Gordana, Vakanjac, Slobodanka, Dimitrijević, Blagoje, Ćupić Miladinović, Dejana, Živković, Lada, "The influence of the induction of farrowing on live birth, body mass, appearance of dystocia, mortality and surviving of neonatal pigs in litter during the first ten days" in Veterinarski Glasnik, 70, no. 1-2 (2016):13-29,
https://doi.org/10.2298/VETGL1602013J . .

TY  - JOUR
AU  - Ivanović, Saša
AU  - Dimitrijević, Blagoje
AU  - Ćupić, Vitomir
AU  - Jezdimirović, Milanka
AU  - Borozan, Sunčica
AU  - Savić, Mila
AU  - Savić, Đorđe
PY  - 2016
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1347
AB  - Diazinon (DZN) is an organophosphate insecticide which exerts its effect through the inhibition of acetyl cholinesterase enzyme (AChE). In this work, we studied the development of tolerance to subchronic p.o. administration of DZN in rats, under both in vivo and in vitro conditions. A group of 20 rats (2 groups, n = 10) was administered p.o. the 1/10 of established LD50 DZN (namely 55.87 mg/kg bw) for 28 days. On the 14th and 28th day of study with isolated diaphragm and ileum, we examined the downregulation of nicotinic and muscarinic receptor function through Electrical Field Stimulation (EFS). Maximum contractility of the diaphragm was recorded on the 14th day of the study (25% higher compared to the non-treated rats), while on the 28th day the contractions almost did not differ from the values found in non-treated rats. EFS of isolated ileum on the 14th day of study caused significantly higher contractions compared to the non treated rats, but after 28 days, ileum contractions decreased approximately to the level of contractions in non-treated rats. On the 14th study day, we also recorded increased amplitude of spontaneous ileum contractions, compared to non-treated rats. The application of increasing ACh concentrations caused dose-dependent ileum contractions, without statistically significant differences of median effective concentration (EC50) values in non-treated and treated rats. Tolerance to subchronic DZN administration develops due to various adaptation mechanisms, including the most important one downregulation of nicotinic and muscarinic receptor function.
PB  - Elsevier Science Bv, Amsterdam
T2  - Toxicology Reports
T1  - Downregulation of nicotinic and muscarinic receptor function in rats after subchronic exposure to diazinon
VL  - 3
SP  - 523
EP  - 530
DO  - 10.1016/j.toxrep.2016.06.002
ER  - 

@article{
author = "Ivanović, Saša and Dimitrijević, Blagoje and Ćupić, Vitomir and Jezdimirović, Milanka and Borozan, Sunčica and Savić, Mila and Savić, Đorđe",
year = "2016",
abstract = "Diazinon (DZN) is an organophosphate insecticide which exerts its effect through the inhibition of acetyl cholinesterase enzyme (AChE). In this work, we studied the development of tolerance to subchronic p.o. administration of DZN in rats, under both in vivo and in vitro conditions. A group of 20 rats (2 groups, n = 10) was administered p.o. the 1/10 of established LD50 DZN (namely 55.87 mg/kg bw) for 28 days. On the 14th and 28th day of study with isolated diaphragm and ileum, we examined the downregulation of nicotinic and muscarinic receptor function through Electrical Field Stimulation (EFS). Maximum contractility of the diaphragm was recorded on the 14th day of the study (25% higher compared to the non-treated rats), while on the 28th day the contractions almost did not differ from the values found in non-treated rats. EFS of isolated ileum on the 14th day of study caused significantly higher contractions compared to the non treated rats, but after 28 days, ileum contractions decreased approximately to the level of contractions in non-treated rats. On the 14th study day, we also recorded increased amplitude of spontaneous ileum contractions, compared to non-treated rats. The application of increasing ACh concentrations caused dose-dependent ileum contractions, without statistically significant differences of median effective concentration (EC50) values in non-treated and treated rats. Tolerance to subchronic DZN administration develops due to various adaptation mechanisms, including the most important one downregulation of nicotinic and muscarinic receptor function.",
publisher = "Elsevier Science Bv, Amsterdam",
journal = "Toxicology Reports",
title = "Downregulation of nicotinic and muscarinic receptor function in rats after subchronic exposure to diazinon",
volume = "3",
pages = "523-530",
doi = "10.1016/j.toxrep.2016.06.002"
}

Ivanović, S., Dimitrijević, B., Ćupić, V., Jezdimirović, M., Borozan, S., Savić, M.,& Savić, Đ.. (2016). Downregulation of nicotinic and muscarinic receptor function in rats after subchronic exposure to diazinon. in Toxicology Reports
Elsevier Science Bv, Amsterdam., 3, 523-530.
https://doi.org/10.1016/j.toxrep.2016.06.002

Ivanović S, Dimitrijević B, Ćupić V, Jezdimirović M, Borozan S, Savić M, Savić Đ. Downregulation of nicotinic and muscarinic receptor function in rats after subchronic exposure to diazinon. in Toxicology Reports. 2016;3:523-530.
doi:10.1016/j.toxrep.2016.06.002 .

Ivanović, Saša, Dimitrijević, Blagoje, Ćupić, Vitomir, Jezdimirović, Milanka, Borozan, Sunčica, Savić, Mila, Savić, Đorđe, "Downregulation of nicotinic and muscarinic receptor function in rats after subchronic exposure to diazinon" in Toxicology Reports, 3 (2016):523-530,
https://doi.org/10.1016/j.toxrep.2016.06.002 . .

TY  - CONF
AU  - Becskei, Zsolt
AU  - Savić, Mila
AU  - Cojkić, Aleksandar
AU  - Dimitrijević, Blagoje
AU  - Rašeta, Mladen
AU  - Kilibarda, Nataša
AU  - Vegara, Mensur
PY  - 2015
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/2760
AB  - Sjenica sheep is the largest type of autochthonous Zackel sheep reared in Serbia. It is well
adapted to harsh climatic and environmental conditions, which exist on the High Nature Value
Sjenica-Pester plateau of the mountain regions of south-west Serbia. The Sjenica sheep is
considered as vulnerable due to increasing dilution of the populations under the influence of
meliorators, such as Wurttemberg sheep. Therefore, it is necessary to undertake protective
measures, such as in vivo conservation, with special attention to advanced phenotypic
characterization of adaptive and productive breed traits, as a strategy for a rational utilization
of sheep resources. The objective of the study was to perform and evaluate the advanced
phenotypic characterization of Sjenica sheep, especially its productive potential and meat
quality traits. In this paper the evaluation of sensory characteristics (odour intensity, flavour
intensity, flavour quality and overall acceptability) and the fatty acid composition of meat (M.
longissimus dorsi) samples of Sjenica sheep were done. The results indicated desirable sensory
characteristics of tested lamb meat, with high overall acceptability score (6.12 ).
Furthermore, favourable fatty acid composition has been found in the meat samples of Sjenica
sheep. The CLA content was at a high level (4.12 , also the n-6:n-3 ratio was desirable
(1.88 ), which can partly be explained by the influence of the traditional habitat, such as
specific floristic composition in which animals are reared.
C3  - 26th international Dagene symposium, Doborna, Slovenia, 17-19 June, 2015
T1  - Meat quality of autochthonous Sjenica Zackel sheep - Basis for sustainable production of genetic resource on the Sjenica-Pester plateau
SP  - 65
EP  - 72
UR  - https://hdl.handle.net/21.15107/rcub_veterinar_2760
ER  - 

@conference{
author = "Becskei, Zsolt and Savić, Mila and Cojkić, Aleksandar and Dimitrijević, Blagoje and Rašeta, Mladen and Kilibarda, Nataša and Vegara, Mensur",
year = "2015",
abstract = "Sjenica sheep is the largest type of autochthonous Zackel sheep reared in Serbia. It is well
adapted to harsh climatic and environmental conditions, which exist on the High Nature Value
Sjenica-Pester plateau of the mountain regions of south-west Serbia. The Sjenica sheep is
considered as vulnerable due to increasing dilution of the populations under the influence of
meliorators, such as Wurttemberg sheep. Therefore, it is necessary to undertake protective
measures, such as in vivo conservation, with special attention to advanced phenotypic
characterization of adaptive and productive breed traits, as a strategy for a rational utilization
of sheep resources. The objective of the study was to perform and evaluate the advanced
phenotypic characterization of Sjenica sheep, especially its productive potential and meat
quality traits. In this paper the evaluation of sensory characteristics (odour intensity, flavour
intensity, flavour quality and overall acceptability) and the fatty acid composition of meat (M.
longissimus dorsi) samples of Sjenica sheep were done. The results indicated desirable sensory
characteristics of tested lamb meat, with high overall acceptability score (6.12 ).
Furthermore, favourable fatty acid composition has been found in the meat samples of Sjenica
sheep. The CLA content was at a high level (4.12 , also the n-6:n-3 ratio was desirable
(1.88 ), which can partly be explained by the influence of the traditional habitat, such as
specific floristic composition in which animals are reared.",
journal = "26th international Dagene symposium, Doborna, Slovenia, 17-19 June, 2015",
title = "Meat quality of autochthonous Sjenica Zackel sheep - Basis for sustainable production of genetic resource on the Sjenica-Pester plateau",
pages = "65-72",
url = "https://hdl.handle.net/21.15107/rcub_veterinar_2760"
}

Becskei, Z., Savić, M., Cojkić, A., Dimitrijević, B., Rašeta, M., Kilibarda, N.,& Vegara, M.. (2015). Meat quality of autochthonous Sjenica Zackel sheep - Basis for sustainable production of genetic resource on the Sjenica-Pester plateau. in 26th international Dagene symposium, Doborna, Slovenia, 17-19 June, 2015, 65-72.
https://hdl.handle.net/21.15107/rcub_veterinar_2760

Becskei Z, Savić M, Cojkić A, Dimitrijević B, Rašeta M, Kilibarda N, Vegara M. Meat quality of autochthonous Sjenica Zackel sheep - Basis for sustainable production of genetic resource on the Sjenica-Pester plateau. in 26th international Dagene symposium, Doborna, Slovenia, 17-19 June, 2015. 2015;:65-72.
https://hdl.handle.net/21.15107/rcub_veterinar_2760 .

Becskei, Zsolt, Savić, Mila, Cojkić, Aleksandar, Dimitrijević, Blagoje, Rašeta, Mladen, Kilibarda, Nataša, Vegara, Mensur, "Meat quality of autochthonous Sjenica Zackel sheep - Basis for sustainable production of genetic resource on the Sjenica-Pester plateau" in 26th international Dagene symposium, Doborna, Slovenia, 17-19 June, 2015 (2015):65-72,
https://hdl.handle.net/21.15107/rcub_veterinar_2760 .

TY  - JOUR
AU  - Ćupić, Vitomir
AU  - Jović, Slavoljub
AU  - Ristić, Gordana
AU  - Vakanjac, Slobodanka
AU  - Dimitrijević, Blagoje
AU  - Ćupić Miladinović, Dejana
PY  - 2015
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1209
AB  - sows, induction of partus, prostaglandin, oxyitocin, duration of partus, number of born piglets, period between two expulsions of piglets.
AB  - Cilj ovog rada bio je da se ispita uticaj kombinovane primene prostaglandina i oksitocina na dužinu trajanja prašenja, broj živorođene prasadi i vremenski interval između ekspulzije dva praseta kod krmača. Ogled je izveden na 133 gravidne krmače, rase danski landras-veliki jorkšir, koje su (u zavisnosti od dana indukovanja partusa - 112, 113. i 114. dan graviditeta) podeljene u 3 grupe. U okviru svake grupe jedinke su podeljene u tri podgrupe i njima je primenjivan sintetički analog prostaglandina PGF2-alfa (dinoprost-DINOLYTIC) u dozi od 10 mg (ekv. 2 ml preparata)/životinja (I-podgrupa) sam ili u kombinaciji sa jednokratnom (nakon rađanja petog praseta) (II-pod­grupa), odnosno dvokratnom (nakon rađanja petog i desetog prase­ta) (III-podgrupa) aplikacijom oksitocina (OXYTOKEL) u dozi od 20 i.j. (ekv. 2 ml preparata/životinja (jednokratna aplikacija), odnosno 20 i.j.+ 15 i.j. (ekv. 2 ml + 1,5 ml preparata/životinja), (dvokratna aplikacija). Dobijeni rezultati pokazali su da je kod jedinki tretiranih samo prostaglandinom najduže prašenje (6,41 ± 2,20 h) trajalo kod krmača kojima je ovaj lek aplikovan 112. dana graviditeta, a najkraće (4,56 ± 1,30 h) kod jedinki tretiranih 114. dana graviditeta. Kod krmača kojima je (pored prostaglandina) aplikovan jednokratno oksitocin, najduže prašenje (6,38 ± 1,30) je zabeleženo kod jedinki tretiranih 113. dana graviditeta, a najkraće (5,26 ± 1,20) kod onih koje su tretirane 114. dana graviditeta. Kada su krmače (pored prostaglandina) tretirane dvokratno oksitocinom, najduže prašenje (7,17 ± 2,30) je utvrđeno u grupi tretiranoj 112. dana graviditeta, a najkraće (5,10 ± 1,20) kod jedinki tretiranih 113. dana graviditeta. Ukupno posmatrano, najduže prašenje (7,17 ± 2,30) je trajalo kod jedinki koje su (pored prostaglandina) dobile dvokratno oksitocin, a najkraće (4,56 ± 1,30), kod jedinki koje su tretirane samo prostaglandinom. Najveći broj živorođene prasadi (358) zabeležen je kod krmača kojima je aplikovan prostaglandin 114. dana graviditeta u kombinaciji sa jednokratnom aplikacijom oksitocina, a najmanji (250) kod krmača kojima je aplikovan prostaglandin 112. dana graviditeta u kombinaciji sa dvokratnom aplikacijom oksitocina. Najduži interval (0,22 ± 0,06) između ekspulzije dva praseta zabeležen je kod krmača kojima je indukovan partus 112. dana graviditeta u kombinaciji sa dvokratnom aplikacijom oksitocina, a najkraći (0,11 ± 0,03) kod krmača kojima je indukcija prašenja vršena 114. dana graviditeta, bez naknadne primene oksitocina.
PB  - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
T2  - Veterinarski Glasnik
T1  - The effect of combined use of prostaglandin and oxytocin in sows, on the duration of partus, number of pigs and period between two expulsions of piglets
T1  - Efekat kombinovane primene prostaglandina i oksitocina na dužinu trajanja partusa, broj prasadi i vreme između ekspulzije dva praseta kod krmača
VL  - 69
IS  - 3-4
SP  - 177
EP  - 193
DO  - 10.2298/VETGL1504177C
ER  - 

@article{
author = "Ćupić, Vitomir and Jović, Slavoljub and Ristić, Gordana and Vakanjac, Slobodanka and Dimitrijević, Blagoje and Ćupić Miladinović, Dejana",
year = "2015",
abstract = "sows, induction of partus, prostaglandin, oxyitocin, duration of partus, number of born piglets, period between two expulsions of piglets., Cilj ovog rada bio je da se ispita uticaj kombinovane primene prostaglandina i oksitocina na dužinu trajanja prašenja, broj živorođene prasadi i vremenski interval između ekspulzije dva praseta kod krmača. Ogled je izveden na 133 gravidne krmače, rase danski landras-veliki jorkšir, koje su (u zavisnosti od dana indukovanja partusa - 112, 113. i 114. dan graviditeta) podeljene u 3 grupe. U okviru svake grupe jedinke su podeljene u tri podgrupe i njima je primenjivan sintetički analog prostaglandina PGF2-alfa (dinoprost-DINOLYTIC) u dozi od 10 mg (ekv. 2 ml preparata)/životinja (I-podgrupa) sam ili u kombinaciji sa jednokratnom (nakon rađanja petog praseta) (II-pod­grupa), odnosno dvokratnom (nakon rađanja petog i desetog prase­ta) (III-podgrupa) aplikacijom oksitocina (OXYTOKEL) u dozi od 20 i.j. (ekv. 2 ml preparata/životinja (jednokratna aplikacija), odnosno 20 i.j.+ 15 i.j. (ekv. 2 ml + 1,5 ml preparata/životinja), (dvokratna aplikacija). Dobijeni rezultati pokazali su da je kod jedinki tretiranih samo prostaglandinom najduže prašenje (6,41 ± 2,20 h) trajalo kod krmača kojima je ovaj lek aplikovan 112. dana graviditeta, a najkraće (4,56 ± 1,30 h) kod jedinki tretiranih 114. dana graviditeta. Kod krmača kojima je (pored prostaglandina) aplikovan jednokratno oksitocin, najduže prašenje (6,38 ± 1,30) je zabeleženo kod jedinki tretiranih 113. dana graviditeta, a najkraće (5,26 ± 1,20) kod onih koje su tretirane 114. dana graviditeta. Kada su krmače (pored prostaglandina) tretirane dvokratno oksitocinom, najduže prašenje (7,17 ± 2,30) je utvrđeno u grupi tretiranoj 112. dana graviditeta, a najkraće (5,10 ± 1,20) kod jedinki tretiranih 113. dana graviditeta. Ukupno posmatrano, najduže prašenje (7,17 ± 2,30) je trajalo kod jedinki koje su (pored prostaglandina) dobile dvokratno oksitocin, a najkraće (4,56 ± 1,30), kod jedinki koje su tretirane samo prostaglandinom. Najveći broj živorođene prasadi (358) zabeležen je kod krmača kojima je aplikovan prostaglandin 114. dana graviditeta u kombinaciji sa jednokratnom aplikacijom oksitocina, a najmanji (250) kod krmača kojima je aplikovan prostaglandin 112. dana graviditeta u kombinaciji sa dvokratnom aplikacijom oksitocina. Najduži interval (0,22 ± 0,06) između ekspulzije dva praseta zabeležen je kod krmača kojima je indukovan partus 112. dana graviditeta u kombinaciji sa dvokratnom aplikacijom oksitocina, a najkraći (0,11 ± 0,03) kod krmača kojima je indukcija prašenja vršena 114. dana graviditeta, bez naknadne primene oksitocina.",
publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd",
journal = "Veterinarski Glasnik",
title = "The effect of combined use of prostaglandin and oxytocin in sows, on the duration of partus, number of pigs and period between two expulsions of piglets, Efekat kombinovane primene prostaglandina i oksitocina na dužinu trajanja partusa, broj prasadi i vreme između ekspulzije dva praseta kod krmača",
volume = "69",
number = "3-4",
pages = "177-193",
doi = "10.2298/VETGL1504177C"
}

Ćupić, V., Jović, S., Ristić, G., Vakanjac, S., Dimitrijević, B.,& Ćupić Miladinović, D.. (2015). The effect of combined use of prostaglandin and oxytocin in sows, on the duration of partus, number of pigs and period between two expulsions of piglets. in Veterinarski Glasnik
Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 69(3-4), 177-193.
https://doi.org/10.2298/VETGL1504177C

Ćupić V, Jović S, Ristić G, Vakanjac S, Dimitrijević B, Ćupić Miladinović D. The effect of combined use of prostaglandin and oxytocin in sows, on the duration of partus, number of pigs and period between two expulsions of piglets. in Veterinarski Glasnik. 2015;69(3-4):177-193.
doi:10.2298/VETGL1504177C .

Ćupić, Vitomir, Jović, Slavoljub, Ristić, Gordana, Vakanjac, Slobodanka, Dimitrijević, Blagoje, Ćupić Miladinović, Dejana, "The effect of combined use of prostaglandin and oxytocin in sows, on the duration of partus, number of pigs and period between two expulsions of piglets" in Veterinarski Glasnik, 69, no. 3-4 (2015):177-193,
https://doi.org/10.2298/VETGL1504177C . .

TY  - JOUR
AU  - Jezdimirović, Milanka
AU  - Ćupić, Vitomir
AU  - Ivanović, Saša
AU  - Dimitrijević, Blagoje
AU  - Jezdimirović, Nemanja
PY  - 2015
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1172
AB  - According to the Law on medicines and medicinal devices, veterinary drugs must be of high quality, efficacy and safety to be suitable for use on animals. However, there are numerous factors which can alter the intensity of drugs and their established therapeutic efficacy and safety. These factors may depend on the patients themselves i.e. animals (species, age, sex, physiological state, impaired functions of organs involved in the elimination of drugs, diseases of other organ systems, nutrition, genetic disorders, individual varia­tions, tolerance etc.), veterinary surgeons (use of the drug which is not in accordance with the instructions - 'off-label use', improper selection of a drug or drug combination intended for a certain animal species or pathological condition, inadequate drug administration route, inadequate drug dosage and duration of therapy) and the drug itself (inappropriate formulation, bioavailability, instability of formulation, diminishing drug action due to external factors). Not following the instructions on using a drug and incorrect application may affect the rate and extent of the drug absorption. The route of the administration of a pharmaceutical product is defined in clinical trials, and depends on the physical and chemical properties of the active ingredient, characteristics of the pharmaceutical formulation and the anatomical and physiological characteristics of application sites which enable absorption. An adequate drug administration ensures a predictable level and rate of absorption from the application site, drug concentration at the sites of its action and pharmacological response or therapeutic efficacy. Concomitant use of multiple drugs in the same patient should be avoided because of possible interactions (antagonism or sinergism) which may decrease the activity of a drug and its effectiveness or increase them including appearance of drug toxicity. In addition, mixing drugs in an infusion system or a syringe should be avoided because the absence of visible interaction does not mean that the drugs applied are compatible.
AB  - Prema Zakonu o lekovima i medicinskim sredstvima veterinarski lekovi moraju da budu kvalitetni, dovoljno efikasni i bezbedni za primenu na životinjama. Međutim, brojni su faktori koji mogu da menjaju jačinu dejstva leka, ustanovljenu terapijsku efikasnost i bezbednost. Ovi faktori mogu da potiču od samog pacijenta - životinje (vrsta, uzrast, pol, fiziološko stanje, poremećena funkcija organa za eliminaciju lekova, oboljenja drugih organskih sistema, ishrana, genetski poremećaji, individualne varijacije, tolerancija itd.), veterinara (upotreba leka koja nije u skladu sa uputstvom - 'off label use', nepravilan izbor leka ili kombinacije lekova za vrstu životinje ili patološko stanje, neadekvatan način aplikacije leka, neodgovarajuća doza leka i dužina primene, inkompatibilnost i interakcija) i samog leka (neodgovarajuća formulacija, niska biološka raspoloživost, nestabilnost formulacija, slabljenje dejstva leka pod uticajem spoljašnjih faktora). Nepridržavanje preporučenog uputstva o načinu aplikacije leka, kao i nepravilna aplikacija može da utiče na brzinu i stepen apsorpcije leka. Sam način aplikacije gotovog leka definisan je tokom njegovog kliničkog ispitivanja, i zavisi od fizičko-hemijskih osobina lekovite supstance, karakteristika farmaceutske formulacije i anatomskih i fizioloških osobina mesta aplikacije koja obezbeđuju apsorpciju. Primena leka na preporučen način omogućava predvidljiv stepen i brzinu apsorpcije sa mesta primene, koncentraciju leka na mestu delovanja i farmakološki odgovor, odnosno terapijsku efikasnost. Treba da se izbegava istovremena primena više lekova kod istog pacijenta zbog moguće interakcije (antagonizam ili sinergizam) koja smanjuje aktivnost leka i njegovu efikasnost ili mu, pak, pojačava efekat uključujući i pojavu toksičnosti. Takođe, treba da se izbegava mešanje lekova u infuzionom sistemu ili brizgalici, jer odsustvo vidljivih reakcija ne znači da je mešavina lekova kompatibilna.
PB  - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
T2  - Veterinarski Glasnik
T1  - Factors that affect therapeutic efficacy and safety of drugs
T1  - Faktori koji utiču na terapijsku efikasnost i bezbednost lekova
VL  - 69
IS  - 5-6
SP  - 401
EP  - 415
DO  - 10.2298/VETGL1506401J
ER  - 

@article{
author = "Jezdimirović, Milanka and Ćupić, Vitomir and Ivanović, Saša and Dimitrijević, Blagoje and Jezdimirović, Nemanja",
year = "2015",
abstract = "According to the Law on medicines and medicinal devices, veterinary drugs must be of high quality, efficacy and safety to be suitable for use on animals. However, there are numerous factors which can alter the intensity of drugs and their established therapeutic efficacy and safety. These factors may depend on the patients themselves i.e. animals (species, age, sex, physiological state, impaired functions of organs involved in the elimination of drugs, diseases of other organ systems, nutrition, genetic disorders, individual varia­tions, tolerance etc.), veterinary surgeons (use of the drug which is not in accordance with the instructions - 'off-label use', improper selection of a drug or drug combination intended for a certain animal species or pathological condition, inadequate drug administration route, inadequate drug dosage and duration of therapy) and the drug itself (inappropriate formulation, bioavailability, instability of formulation, diminishing drug action due to external factors). Not following the instructions on using a drug and incorrect application may affect the rate and extent of the drug absorption. The route of the administration of a pharmaceutical product is defined in clinical trials, and depends on the physical and chemical properties of the active ingredient, characteristics of the pharmaceutical formulation and the anatomical and physiological characteristics of application sites which enable absorption. An adequate drug administration ensures a predictable level and rate of absorption from the application site, drug concentration at the sites of its action and pharmacological response or therapeutic efficacy. Concomitant use of multiple drugs in the same patient should be avoided because of possible interactions (antagonism or sinergism) which may decrease the activity of a drug and its effectiveness or increase them including appearance of drug toxicity. In addition, mixing drugs in an infusion system or a syringe should be avoided because the absence of visible interaction does not mean that the drugs applied are compatible., Prema Zakonu o lekovima i medicinskim sredstvima veterinarski lekovi moraju da budu kvalitetni, dovoljno efikasni i bezbedni za primenu na životinjama. Međutim, brojni su faktori koji mogu da menjaju jačinu dejstva leka, ustanovljenu terapijsku efikasnost i bezbednost. Ovi faktori mogu da potiču od samog pacijenta - životinje (vrsta, uzrast, pol, fiziološko stanje, poremećena funkcija organa za eliminaciju lekova, oboljenja drugih organskih sistema, ishrana, genetski poremećaji, individualne varijacije, tolerancija itd.), veterinara (upotreba leka koja nije u skladu sa uputstvom - 'off label use', nepravilan izbor leka ili kombinacije lekova za vrstu životinje ili patološko stanje, neadekvatan način aplikacije leka, neodgovarajuća doza leka i dužina primene, inkompatibilnost i interakcija) i samog leka (neodgovarajuća formulacija, niska biološka raspoloživost, nestabilnost formulacija, slabljenje dejstva leka pod uticajem spoljašnjih faktora). Nepridržavanje preporučenog uputstva o načinu aplikacije leka, kao i nepravilna aplikacija može da utiče na brzinu i stepen apsorpcije leka. Sam način aplikacije gotovog leka definisan je tokom njegovog kliničkog ispitivanja, i zavisi od fizičko-hemijskih osobina lekovite supstance, karakteristika farmaceutske formulacije i anatomskih i fizioloških osobina mesta aplikacije koja obezbeđuju apsorpciju. Primena leka na preporučen način omogućava predvidljiv stepen i brzinu apsorpcije sa mesta primene, koncentraciju leka na mestu delovanja i farmakološki odgovor, odnosno terapijsku efikasnost. Treba da se izbegava istovremena primena više lekova kod istog pacijenta zbog moguće interakcije (antagonizam ili sinergizam) koja smanjuje aktivnost leka i njegovu efikasnost ili mu, pak, pojačava efekat uključujući i pojavu toksičnosti. Takođe, treba da se izbegava mešanje lekova u infuzionom sistemu ili brizgalici, jer odsustvo vidljivih reakcija ne znači da je mešavina lekova kompatibilna.",
publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd",
journal = "Veterinarski Glasnik",
title = "Factors that affect therapeutic efficacy and safety of drugs, Faktori koji utiču na terapijsku efikasnost i bezbednost lekova",
volume = "69",
number = "5-6",
pages = "401-415",
doi = "10.2298/VETGL1506401J"
}

Jezdimirović, M., Ćupić, V., Ivanović, S., Dimitrijević, B.,& Jezdimirović, N.. (2015). Factors that affect therapeutic efficacy and safety of drugs. in Veterinarski Glasnik
Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 69(5-6), 401-415.
https://doi.org/10.2298/VETGL1506401J

Jezdimirović M, Ćupić V, Ivanović S, Dimitrijević B, Jezdimirović N. Factors that affect therapeutic efficacy and safety of drugs. in Veterinarski Glasnik. 2015;69(5-6):401-415.
doi:10.2298/VETGL1506401J .

Jezdimirović, Milanka, Ćupić, Vitomir, Ivanović, Saša, Dimitrijević, Blagoje, Jezdimirović, Nemanja, "Factors that affect therapeutic efficacy and safety of drugs" in Veterinarski Glasnik, 69, no. 5-6 (2015):401-415,
https://doi.org/10.2298/VETGL1506401J . .

TY  - JOUR
AU  - Savić, Mila
AU  - Dimitrijević, Vladimir
AU  - Trailović, Ružica
AU  - Vegara, Mensur
AU  - Dimitrijević, Blagoje
AU  - Becskei, Zsolt
AU  - Petrujkić, Branko
AU  - Cojkić, Aleksandar
PY  - 2014
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1128
AB  - The central issue in process of organizing organic cattle breeding is the knowledge about specificities of this kind of production, good knowledge of breed characteristics (body composition, immune tolerance, expressed predisposition towards some diseases, production properties). Research centres, in collaboration with producers, have defined the essential features on which the selection programmes in organic cattle breeding are based on. Of the greatest importance for veterinary service is the fact that selection programmes in organic cattle breeding are in the first place based on giving priority to healthy animals, with strong immune system, good reproductive characteristics, which can be in production system for a long period. Additional important selective criteria is specific body resistance and adaptability of autochtonous breeds to environmental conditions.
AB  - Centralno pitanje u procesu organizovanja organskog stočarstva je poznavanje specifičnosti ovog vida proizvodnje, dobro poznavanje karakteristika rasa (konstitucije, otpornosti, izražene predispozicije prema pojedinim oboljenjima, proizvodnih svojstava). Istraživački centri su u saradnji sa proizvođačima definisali bitne osobine na kojima se zasnivaju selekcijski programi u organskom stočarstvu. Važna činjenica za veterinarsku službu je da se selekcijski programi u organskom stočarstvu prvenstveno zasnivaju na favorizovanju zdravih životinja, otpornih, dobrih reproduktivnih karakteristika, koje dugo mogu da se gaje u proizvodnom sistemu. Specifična otpornost i adaptiranost autohtonih rasa na uslove sredine predstavijaju važan selekcijski kriterijum.
PB  - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
T2  - Veterinarski Glasnik
T1  - Selection criteria in organic cattle breeding
T1  - Selekcionnye kriterii v organičeskom životnovodstve
T1  - Selekcijski kriterijumi u organskom stočarstvu
VL  - 68
IS  - 5-6
SP  - 363
EP  - 369
DO  - 10.2298/VETGL1406363S
ER  - 

@article{
author = "Savić, Mila and Dimitrijević, Vladimir and Trailović, Ružica and Vegara, Mensur and Dimitrijević, Blagoje and Becskei, Zsolt and Petrujkić, Branko and Cojkić, Aleksandar",
year = "2014",
abstract = "The central issue in process of organizing organic cattle breeding is the knowledge about specificities of this kind of production, good knowledge of breed characteristics (body composition, immune tolerance, expressed predisposition towards some diseases, production properties). Research centres, in collaboration with producers, have defined the essential features on which the selection programmes in organic cattle breeding are based on. Of the greatest importance for veterinary service is the fact that selection programmes in organic cattle breeding are in the first place based on giving priority to healthy animals, with strong immune system, good reproductive characteristics, which can be in production system for a long period. Additional important selective criteria is specific body resistance and adaptability of autochtonous breeds to environmental conditions., Centralno pitanje u procesu organizovanja organskog stočarstva je poznavanje specifičnosti ovog vida proizvodnje, dobro poznavanje karakteristika rasa (konstitucije, otpornosti, izražene predispozicije prema pojedinim oboljenjima, proizvodnih svojstava). Istraživački centri su u saradnji sa proizvođačima definisali bitne osobine na kojima se zasnivaju selekcijski programi u organskom stočarstvu. Važna činjenica za veterinarsku službu je da se selekcijski programi u organskom stočarstvu prvenstveno zasnivaju na favorizovanju zdravih životinja, otpornih, dobrih reproduktivnih karakteristika, koje dugo mogu da se gaje u proizvodnom sistemu. Specifična otpornost i adaptiranost autohtonih rasa na uslove sredine predstavijaju važan selekcijski kriterijum.",
publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd",
journal = "Veterinarski Glasnik",
title = "Selection criteria in organic cattle breeding, Selekcionnye kriterii v organičeskom životnovodstve, Selekcijski kriterijumi u organskom stočarstvu",
volume = "68",
number = "5-6",
pages = "363-369",
doi = "10.2298/VETGL1406363S"
}

Savić, M., Dimitrijević, V., Trailović, R., Vegara, M., Dimitrijević, B., Becskei, Z., Petrujkić, B.,& Cojkić, A.. (2014). Selection criteria in organic cattle breeding. in Veterinarski Glasnik
Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 68(5-6), 363-369.
https://doi.org/10.2298/VETGL1406363S

Savić M, Dimitrijević V, Trailović R, Vegara M, Dimitrijević B, Becskei Z, Petrujkić B, Cojkić A. Selection criteria in organic cattle breeding. in Veterinarski Glasnik. 2014;68(5-6):363-369.
doi:10.2298/VETGL1406363S .

Savić, Mila, Dimitrijević, Vladimir, Trailović, Ružica, Vegara, Mensur, Dimitrijević, Blagoje, Becskei, Zsolt, Petrujkić, Branko, Cojkić, Aleksandar, "Selection criteria in organic cattle breeding" in Veterinarski Glasnik, 68, no. 5-6 (2014):363-369,
https://doi.org/10.2298/VETGL1406363S . .

TY  - JOUR
AU  - Savić, Mila
AU  - Baltić, Milan Ž.
AU  - Becskei, Zsolt
AU  - Dimitrijević, Blagoje
AU  - Dimitrijević, Vladimir
AU  - Savić, Đorđe
AU  - Vegara, Mensur
PY  - 2014
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1151
AB  - The objective of the study was to perform and evaluate the advanced phenotypic characterization of endangered Zackel sheep types, especially their productive potential and meat quality traits. Meat quality characteristics (m. longissimus dorsi) were evaluated in lambs of three types of autochthonous Zackel sheep: Sjenica sheep, Lipe sheep and Vlashko Vitoroga sheep, reared in traditional habitats in a sustainable management system. For the evaluation of sensory characteristics of lamb meat, quantitative descriptive analysis was performed according to ISO 6564:1985, i.e. structural intensity scale of seven points. All Zackel meat samples had an overall acceptability, the most favorable being in Sjenica sheep, with detected differences between Sjenica and Vlashko Vitoroga sheep (p lt 0.01), as well as between Lipe and Vlashko Vitoroga sheep (p lt 0.05). For the determination of fatty acids profile the prepared samples were analyzed using gas chromatography. The results showed that all tested lamb meat samples contain favorable amounts of conjugated linoleic acid (CLA). The average content of conjugated linoleic acid was higher in Sjenica lamb meat compared with Lipe lamb meat, and the difference was significant (p lt 0.01). It is also shown that examined samples of Sjenica, Lipe and Vlashko Vitoroga lambs, compared to many other exotic and local breeds, were characterized by preferable values of n-6:n-3 fatty acid ratio. Polyunsaturated fatty acid n-6:n-3 ratio difference between tested Zackel types was not significant. The favorable fatty acid profile, important for human health and especially for infant and children nutrition, raises the interest for sustainable production and conservation of Zackel sheep.
AB  - Predmet istraživanja je bio da se bliže ispitaju fenotipske osobine različitih ugroženih sojeva pramenke, a naročito potencijal za proizvodnju i kvalitet mesa. Karakteristike kvaliteta mesa (m. longissimus dorsi) su ispitivane kod tri soja autohtone rase pramenke, i to kod sjeničkog, lipskog i vlaško vitorogog soja, koji se gaje u tradicionalnim uslovima. Za kvantitativnu deskriptivnu analizu senzornih osobina mesa jagnjadi korišćene su strukturne skale intenziteta sa sedam tačaka (ISO 6564:1985). Svi uzorci mesa pramenke su imali visoku ocenu ukupne prihvatljivosti, najpovoljnije je ocenjen sjenički soj, uz utvrđenu razliku između sjeničkog i vlaško vitorogog soja (p lt 0,01), kao i između lipskog i vlaško vitorogog soja (p lt 0,05). Za određivanje sadržaja masnih kiselina uzorci su analizirani korišćenjem gasne hromatografi je. Rezultati su pokazali da svi ispitivani sojevi pramenke sadrže povoljan masnokiselinski sastav uz visok sadržaj konjugovane linoleinske kiseline (CLA). Utvrđen je veći prosečan sadržaj konjugovane linoleinske kiseline kod sjeničkog soja u odnosu na lipski soj (p lt 0,01). Takođe je utvrđeno da ispitivani uzorci sjeničkog, lipskog i vlaško vitorogog soja, poređeni sa drugim egzotičnim i lokalnim rasama, imaju bolji odnos n-6:n-3 polinezasićenih masnih kiselina, a statistička značajnost razlike između pojedinih sojeva pramenke nije utvrđena. Poželjan profi l masnih kiselina, značajan za zdravlje ljudi, a posebno za ishranu odojčadi i dece, podstiče interes za održivu proizvodnju i proces očuvanja ugroženih sojeva pramenke.
PB  - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
T2  - Acta Veterinaria-Beograd
T1  - Evaluation of Zackel lamb meat quality with the aim of increasing the conservation value of the breed
T1  - Ispitivanje kvaliteta mesa jagnjadi pramenke u cilju povećanja vrednosti rase u procesu konzervacije
VL  - 64
IS  - 4
SP  - 438
EP  - 446
DO  - 10.2478/acve-2014-0041
ER  - 

@article{
author = "Savić, Mila and Baltić, Milan Ž. and Becskei, Zsolt and Dimitrijević, Blagoje and Dimitrijević, Vladimir and Savić, Đorđe and Vegara, Mensur",
year = "2014",
abstract = "The objective of the study was to perform and evaluate the advanced phenotypic characterization of endangered Zackel sheep types, especially their productive potential and meat quality traits. Meat quality characteristics (m. longissimus dorsi) were evaluated in lambs of three types of autochthonous Zackel sheep: Sjenica sheep, Lipe sheep and Vlashko Vitoroga sheep, reared in traditional habitats in a sustainable management system. For the evaluation of sensory characteristics of lamb meat, quantitative descriptive analysis was performed according to ISO 6564:1985, i.e. structural intensity scale of seven points. All Zackel meat samples had an overall acceptability, the most favorable being in Sjenica sheep, with detected differences between Sjenica and Vlashko Vitoroga sheep (p lt 0.01), as well as between Lipe and Vlashko Vitoroga sheep (p lt 0.05). For the determination of fatty acids profile the prepared samples were analyzed using gas chromatography. The results showed that all tested lamb meat samples contain favorable amounts of conjugated linoleic acid (CLA). The average content of conjugated linoleic acid was higher in Sjenica lamb meat compared with Lipe lamb meat, and the difference was significant (p lt 0.01). It is also shown that examined samples of Sjenica, Lipe and Vlashko Vitoroga lambs, compared to many other exotic and local breeds, were characterized by preferable values of n-6:n-3 fatty acid ratio. Polyunsaturated fatty acid n-6:n-3 ratio difference between tested Zackel types was not significant. The favorable fatty acid profile, important for human health and especially for infant and children nutrition, raises the interest for sustainable production and conservation of Zackel sheep., Predmet istraživanja je bio da se bliže ispitaju fenotipske osobine različitih ugroženih sojeva pramenke, a naročito potencijal za proizvodnju i kvalitet mesa. Karakteristike kvaliteta mesa (m. longissimus dorsi) su ispitivane kod tri soja autohtone rase pramenke, i to kod sjeničkog, lipskog i vlaško vitorogog soja, koji se gaje u tradicionalnim uslovima. Za kvantitativnu deskriptivnu analizu senzornih osobina mesa jagnjadi korišćene su strukturne skale intenziteta sa sedam tačaka (ISO 6564:1985). Svi uzorci mesa pramenke su imali visoku ocenu ukupne prihvatljivosti, najpovoljnije je ocenjen sjenički soj, uz utvrđenu razliku između sjeničkog i vlaško vitorogog soja (p lt 0,01), kao i između lipskog i vlaško vitorogog soja (p lt 0,05). Za određivanje sadržaja masnih kiselina uzorci su analizirani korišćenjem gasne hromatografi je. Rezultati su pokazali da svi ispitivani sojevi pramenke sadrže povoljan masnokiselinski sastav uz visok sadržaj konjugovane linoleinske kiseline (CLA). Utvrđen je veći prosečan sadržaj konjugovane linoleinske kiseline kod sjeničkog soja u odnosu na lipski soj (p lt 0,01). Takođe je utvrđeno da ispitivani uzorci sjeničkog, lipskog i vlaško vitorogog soja, poređeni sa drugim egzotičnim i lokalnim rasama, imaju bolji odnos n-6:n-3 polinezasićenih masnih kiselina, a statistička značajnost razlike između pojedinih sojeva pramenke nije utvrđena. Poželjan profi l masnih kiselina, značajan za zdravlje ljudi, a posebno za ishranu odojčadi i dece, podstiče interes za održivu proizvodnju i proces očuvanja ugroženih sojeva pramenke.",
publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd",
journal = "Acta Veterinaria-Beograd",
title = "Evaluation of Zackel lamb meat quality with the aim of increasing the conservation value of the breed, Ispitivanje kvaliteta mesa jagnjadi pramenke u cilju povećanja vrednosti rase u procesu konzervacije",
volume = "64",
number = "4",
pages = "438-446",
doi = "10.2478/acve-2014-0041"
}

Savić, M., Baltić, M. Ž., Becskei, Z., Dimitrijević, B., Dimitrijević, V., Savić, Đ.,& Vegara, M.. (2014). Evaluation of Zackel lamb meat quality with the aim of increasing the conservation value of the breed. in Acta Veterinaria-Beograd
Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 64(4), 438-446.
https://doi.org/10.2478/acve-2014-0041

Savić M, Baltić MŽ, Becskei Z, Dimitrijević B, Dimitrijević V, Savić Đ, Vegara M. Evaluation of Zackel lamb meat quality with the aim of increasing the conservation value of the breed. in Acta Veterinaria-Beograd. 2014;64(4):438-446.
doi:10.2478/acve-2014-0041 .

Savić, Mila, Baltić, Milan Ž., Becskei, Zsolt, Dimitrijević, Blagoje, Dimitrijević, Vladimir, Savić, Đorđe, Vegara, Mensur, "Evaluation of Zackel lamb meat quality with the aim of increasing the conservation value of the breed" in Acta Veterinaria-Beograd, 64, no. 4 (2014):438-446,
https://doi.org/10.2478/acve-2014-0041 . .

TY  - JOUR
AU  - Savić, Mila
AU  - Prodanović, Slaven
AU  - Vučković, Savo
AU  - Dimitrijević, Blagoje
AU  - Becskei, Zsolt
AU  - Vegara, Mensur
PY  - 2014
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/2809
PB  - Wageningen Academic Publishers
T2  - 65th Annual Meeting of the European Federation of Animal Science, Copenhage, Denmark, 25 - 29 August 2014
T1  - Evaluation the autochtonous genetic resources and their use in organic sheep production in Serbia
SP  - 252
EP  - 252
UR  - https://hdl.handle.net/21.15107/rcub_veterinar_2809
ER  - 

@article{
author = "Savić, Mila and Prodanović, Slaven and Vučković, Savo and Dimitrijević, Blagoje and Becskei, Zsolt and Vegara, Mensur",
year = "2014",
publisher = "Wageningen Academic Publishers",
journal = "65th Annual Meeting of the European Federation of Animal Science, Copenhage, Denmark, 25 - 29 August 2014",
title = "Evaluation the autochtonous genetic resources and their use in organic sheep production in Serbia",
pages = "252-252",
url = "https://hdl.handle.net/21.15107/rcub_veterinar_2809"
}

Savić, M., Prodanović, S., Vučković, S., Dimitrijević, B., Becskei, Z.,& Vegara, M.. (2014). Evaluation the autochtonous genetic resources and their use in organic sheep production in Serbia. in 65th Annual Meeting of the European Federation of Animal Science, Copenhage, Denmark, 25 - 29 August 2014
Wageningen Academic Publishers., 252-252.
https://hdl.handle.net/21.15107/rcub_veterinar_2809

Savić M, Prodanović S, Vučković S, Dimitrijević B, Becskei Z, Vegara M. Evaluation the autochtonous genetic resources and their use in organic sheep production in Serbia. in 65th Annual Meeting of the European Federation of Animal Science, Copenhage, Denmark, 25 - 29 August 2014. 2014;:252-252.
https://hdl.handle.net/21.15107/rcub_veterinar_2809 .

Savić, Mila, Prodanović, Slaven, Vučković, Savo, Dimitrijević, Blagoje, Becskei, Zsolt, Vegara, Mensur, "Evaluation the autochtonous genetic resources and their use in organic sheep production in Serbia" in 65th Annual Meeting of the European Federation of Animal Science, Copenhage, Denmark, 25 - 29 August 2014 (2014):252-252,
https://hdl.handle.net/21.15107/rcub_veterinar_2809 .

TY  - JOUR
AU  - Jović, Slavoljub
AU  - Stevanović, Jelka
AU  - Borozan, Sunčica
AU  - Dimitrijević, Blagoje
AU  - Fišter, Svetlana
AU  - Aleksić, Jelena
PY  - 2013
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/972
AB  - In living systems synthesis of nitric oxide occurs during metabolism from Larginin, nitrite and ascorbate. Being very significant carrier of information within numerous both physiological and pathological processes in mammals' organisms, nitric oxid could possibly be useful as well as harmful. Nitric oxide synthesis is adjuvant in a healthy organism because it represents the basic molecule for understanding numerous processes in neurology, psychology, immunology and varios related fields. In other words, nitric oxide participate in number of physiological processes, such as: transmission of nerve signals (neurotransmitter role), regulation of smooth muscle tissue relaxation (eg. vasodilatation), peristaltic movements, immunomodulation, mastocyte activation, development of inflammatory response, apoptosis regulation, angiogenesis and glucose metabolism, normal heart functioning and antioxidation role. Besides being useful, nitric oxide can be harmful as well, because it has one unpaired electron, so consequently it is susceptible to oxidation becoming a stable free radical. Being such, it reacts quickly with superoxide-anion radical, givind at first an extremely reactive peroxinitrite anion, and subsequently peroxidnitrite acid. This acid is very dangerous causing thiol groups oxidation, tyrosine and phenylalanine nitrosylation, lipid oxidation, DNK chain splitting, nitrification and nucleic bases deamination. These damages of macromolecules can cause a series of undesirable changes which subsequently disturb functions of molecules, and thus of cells, tissues and even organs.
AB  - U živim sistemima sinteza azot-monoksida nastaje tokom metabolizma, od L-arginina, nitrita i askorbata. S obzirom da je važan prenosilac informacija u okviru mnogih fizioloških ali i patoloških procesa u organizmu sisara, azot-monoksid može biti i koristan i štetan. Sinteza azot-monoksida u zdravom organizmu je poželjna jer predstavlja osnovni molekul za razumevanje brojnih procesa u neurologiji, psihologiji, imunologiji i najrazličitijim drugim oblastima. Naime, azotmonoksid učestvuje u nizu fizioloških procesa, među kojima su: prenos nervnih signala (neurotransmiterska uloga), regulacija relaksacije glatkomišićnih tkiva (npr. vazodilatacija), odvijanje peristaltičkih pokreta, imunomodulacija, aktivacija mastocita, razvoj zapaljenske reakcije, regulacija apoptoze, angiogeneze i metabolizma glukoze, normalno funkcionisanje srca i antioksidantna uloga. Osim što je koristan, azot-monoksid može da bude i štetan jer poseduje jedan nespareni elektron, tako da podleže oksidaciji i postaje stabilan slobodni radikal. Kao takav, brzo reaguje sa superoksidanjon radikalom, dajući prvo izuzetno reaktivan peroksinitrit anjon, a potom i peroksinitritnu kiselinu. Ona je vrlo opasna jer dovodi do: oksidacije tiolnih grupa, nitrozilovanja tirozina i fenil-alanina, oksidacije lipida, cepanja lanaca DNK, nitrovanja i dezaminacije nukleinskih baza. Ova oštećenja makromolekula mogu izazvati niz nepoželjnih promena kojima se remeti funkcija molekula a time i ćelije, tkiva pa i organa.
PB  - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
T2  - Veterinarski Glasnik
T1  - Useful and harmful effects of nitric oxide
T1  - Korisni i štetni efekti azot-monoksida
VL  - 67
IS  - 3-4
SP  - 245
EP  - 257
DO  - 10.2298/VETGL1304245J
ER  - 

@article{
author = "Jović, Slavoljub and Stevanović, Jelka and Borozan, Sunčica and Dimitrijević, Blagoje and Fišter, Svetlana and Aleksić, Jelena",
year = "2013",
abstract = "In living systems synthesis of nitric oxide occurs during metabolism from Larginin, nitrite and ascorbate. Being very significant carrier of information within numerous both physiological and pathological processes in mammals' organisms, nitric oxid could possibly be useful as well as harmful. Nitric oxide synthesis is adjuvant in a healthy organism because it represents the basic molecule for understanding numerous processes in neurology, psychology, immunology and varios related fields. In other words, nitric oxide participate in number of physiological processes, such as: transmission of nerve signals (neurotransmitter role), regulation of smooth muscle tissue relaxation (eg. vasodilatation), peristaltic movements, immunomodulation, mastocyte activation, development of inflammatory response, apoptosis regulation, angiogenesis and glucose metabolism, normal heart functioning and antioxidation role. Besides being useful, nitric oxide can be harmful as well, because it has one unpaired electron, so consequently it is susceptible to oxidation becoming a stable free radical. Being such, it reacts quickly with superoxide-anion radical, givind at first an extremely reactive peroxinitrite anion, and subsequently peroxidnitrite acid. This acid is very dangerous causing thiol groups oxidation, tyrosine and phenylalanine nitrosylation, lipid oxidation, DNK chain splitting, nitrification and nucleic bases deamination. These damages of macromolecules can cause a series of undesirable changes which subsequently disturb functions of molecules, and thus of cells, tissues and even organs., U živim sistemima sinteza azot-monoksida nastaje tokom metabolizma, od L-arginina, nitrita i askorbata. S obzirom da je važan prenosilac informacija u okviru mnogih fizioloških ali i patoloških procesa u organizmu sisara, azot-monoksid može biti i koristan i štetan. Sinteza azot-monoksida u zdravom organizmu je poželjna jer predstavlja osnovni molekul za razumevanje brojnih procesa u neurologiji, psihologiji, imunologiji i najrazličitijim drugim oblastima. Naime, azotmonoksid učestvuje u nizu fizioloških procesa, među kojima su: prenos nervnih signala (neurotransmiterska uloga), regulacija relaksacije glatkomišićnih tkiva (npr. vazodilatacija), odvijanje peristaltičkih pokreta, imunomodulacija, aktivacija mastocita, razvoj zapaljenske reakcije, regulacija apoptoze, angiogeneze i metabolizma glukoze, normalno funkcionisanje srca i antioksidantna uloga. Osim što je koristan, azot-monoksid može da bude i štetan jer poseduje jedan nespareni elektron, tako da podleže oksidaciji i postaje stabilan slobodni radikal. Kao takav, brzo reaguje sa superoksidanjon radikalom, dajući prvo izuzetno reaktivan peroksinitrit anjon, a potom i peroksinitritnu kiselinu. Ona je vrlo opasna jer dovodi do: oksidacije tiolnih grupa, nitrozilovanja tirozina i fenil-alanina, oksidacije lipida, cepanja lanaca DNK, nitrovanja i dezaminacije nukleinskih baza. Ova oštećenja makromolekula mogu izazvati niz nepoželjnih promena kojima se remeti funkcija molekula a time i ćelije, tkiva pa i organa.",
publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd",
journal = "Veterinarski Glasnik",
title = "Useful and harmful effects of nitric oxide, Korisni i štetni efekti azot-monoksida",
volume = "67",
number = "3-4",
pages = "245-257",
doi = "10.2298/VETGL1304245J"
}

Jović, S., Stevanović, J., Borozan, S., Dimitrijević, B., Fišter, S.,& Aleksić, J.. (2013). Useful and harmful effects of nitric oxide. in Veterinarski Glasnik
Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 67(3-4), 245-257.
https://doi.org/10.2298/VETGL1304245J

Jović S, Stevanović J, Borozan S, Dimitrijević B, Fišter S, Aleksić J. Useful and harmful effects of nitric oxide. in Veterinarski Glasnik. 2013;67(3-4):245-257.
doi:10.2298/VETGL1304245J .

Jović, Slavoljub, Stevanović, Jelka, Borozan, Sunčica, Dimitrijević, Blagoje, Fišter, Svetlana, Aleksić, Jelena, "Useful and harmful effects of nitric oxide" in Veterinarski Glasnik, 67, no. 3-4 (2013):245-257,
https://doi.org/10.2298/VETGL1304245J . .

TY  - JOUR
AU  - Dimitrijević, Blagoje
AU  - Borozan, Sunčica
AU  - Jović, Slavoljub
AU  - Bacić, Dragan
AU  - Katić-Radivojević, Sofija
AU  - Stojanović, S.
AU  - Savić, Mila
PY  - 2013
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/953
AB  - The aim of this report was to study the biochemical parameters in sheep blood under conditions of various intensities of parasitic infection with Strongyloides papillosus, as well as after therapy with albendazole (ABZ). Investigations were performed on sheep of the Würtemberg race (n = 30) in which were detected mild, moderate and high intensities of parasitic infection with S. papillosus. The control group (n = 10) was composed of sheep negative to parasitic infections. The degree and type of changes were monitored by determining the concentrations of glucose, total proteins, albumin, A/G ratio, AST, urea, total bilirubin, calcium, phosphorus, total LDH activity and isoenzymatic LDH1-5 distributions. On the basis of the obtained results, we determined, through isoenzymatic LDH distribution, that during parasitic infection with S. papillosus, there is ongoing damage to the liver, heart muscle and lung, while after therapy with ABZ, the liver suffers the most damage. The concentration of glucose, total proteins and albumin fell linearly with the rise in the intensity of parasitic infection (p lt 0.05), while after therapy with ABZ, the fall of these parameters was at a statistically significantly higher level (p lt 0.01). The activity of AST, concentration of urea and total bilirubin also rose linearly with the intensity of parasitic infection (p lt 0.05). After therapy with ABZ, the activity of AST and the concentration of total bilirubin were at a statistically significantly higher level (p lt 0.001), while the concentration of urea retained the same levels as in the case of parasitic infection. Values of calcium concentrations (p>0.05) and phosphorus (p lt 0.05) also fall linearly with the rise of the intesity of the parasitic infection. The trend in the concentration fall of these macroelements, continues also after treatment with albendazole (p lt 0.001). Having in mind our previous studies in the field of oxidative stress and phenomena lying behind these changes, we strongly recommend that in antiparasitic treatment protocols, beside antihelminthics, compounds with antioxidative properties should also be used.
AB  - Cilj ovog rada je bio da se ispitaju biohemijski parametri u krvi ovaca u uslovima različitog intenziteta parazitske infekcije sa Strongyloides papillosus, kao i nakon terapije sa albendazolom (ABZ). Istraživanje je izvedeno na ovcama Wurtemberg rase (n = 30) kod kojih je utvrđen blagi, srednji i visoki intenzitet parazitske infekcije sa S. papillosus. Kontrolnu grupu (n = 10) činile su ovce negativne na prisustvo parazitske infekcije. Stepen i vrsta promene praćeni su određivanjem koncentracije glukoze, ukupnih proteina, albumina, A/G ratio, AST, urea, ukupnog bilirubina, kalcijuma, fosfora, ukupne aktivnosti LDH i izoenzimske distribucije LDH1-5. Na osnovu dobijenih rezultata utvrdili smo, preko izoenzimske distribucije LDH, da u toku parazitske infekcije sa S. papillosus dolazi do oštećenja jetre, srčanog mišića i pluća, dok nakon terapije sa ABZ jetra je organ koji je najviše oštećen. Koncentracija glukoze, ukupnih proteina i albumina linearno je opadala sa rastom intenziteta parazitske infekcije (p lt 0.05), a nakon terapije sa ABZ pad koncentracije ovih parametara bio je na statistički značajnom većem nivou (p lt 0.01). Aktivnost AST, koncentracija uree i ukupnog bilirubina takođe su linearno rasle sa intenzitetom parazitske infekcije (p lt 0.05). Nakon terapije sa ABZ aktivnost AST i koncentracija ukupnog bilirubina bile su na statistički značajno većem nivou (p lt 0.001), dok je koncentracija uree zadržala iste nivoe kao u slučaju parazitske infekcije. Vrednosti koncentracija kalcijuma (p > 0.05) i fosfora (p lt 0.05) takođe linearno opadaju sa rastom intenziteta parazitske infekcije. Trend pada koncentracije ovih makroelemenata, nastavlja se i nakon terapije sa albendazolom (p lt 0.001). Imajući u vidu naša prethodna istraživanja na polju oksidativnog stresa, fenomena koji se nalazi u osnovi ovih promena, strogo preporučujemo da se u antiparazitske protokole, pored antihelmintika koriste i preparati sa antioksidativnim osobinama.
PB  - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
T2  - Acta Veterinaria-Beograd
T1  - The effect of the intensity of parasitic infection with Strongyloides papillosus and albendazole therapy on biochemical parameters in sheep blood
T1  - Uticaj intenziteta parazitske infekcije sa Strongyloides papillosus i terapije albendazolom na biohemijske parametre u krvi ovaca
VL  - 63
IS  - 5-6
SP  - 581
EP  - 600
DO  - 10.2298/AVB1306581D
ER  - 

@article{
author = "Dimitrijević, Blagoje and Borozan, Sunčica and Jović, Slavoljub and Bacić, Dragan and Katić-Radivojević, Sofija and Stojanović, S. and Savić, Mila",
year = "2013",
abstract = "The aim of this report was to study the biochemical parameters in sheep blood under conditions of various intensities of parasitic infection with Strongyloides papillosus, as well as after therapy with albendazole (ABZ). Investigations were performed on sheep of the Würtemberg race (n = 30) in which were detected mild, moderate and high intensities of parasitic infection with S. papillosus. The control group (n = 10) was composed of sheep negative to parasitic infections. The degree and type of changes were monitored by determining the concentrations of glucose, total proteins, albumin, A/G ratio, AST, urea, total bilirubin, calcium, phosphorus, total LDH activity and isoenzymatic LDH1-5 distributions. On the basis of the obtained results, we determined, through isoenzymatic LDH distribution, that during parasitic infection with S. papillosus, there is ongoing damage to the liver, heart muscle and lung, while after therapy with ABZ, the liver suffers the most damage. The concentration of glucose, total proteins and albumin fell linearly with the rise in the intensity of parasitic infection (p lt 0.05), while after therapy with ABZ, the fall of these parameters was at a statistically significantly higher level (p lt 0.01). The activity of AST, concentration of urea and total bilirubin also rose linearly with the intensity of parasitic infection (p lt 0.05). After therapy with ABZ, the activity of AST and the concentration of total bilirubin were at a statistically significantly higher level (p lt 0.001), while the concentration of urea retained the same levels as in the case of parasitic infection. Values of calcium concentrations (p>0.05) and phosphorus (p lt 0.05) also fall linearly with the rise of the intesity of the parasitic infection. The trend in the concentration fall of these macroelements, continues also after treatment with albendazole (p lt 0.001). Having in mind our previous studies in the field of oxidative stress and phenomena lying behind these changes, we strongly recommend that in antiparasitic treatment protocols, beside antihelminthics, compounds with antioxidative properties should also be used., Cilj ovog rada je bio da se ispitaju biohemijski parametri u krvi ovaca u uslovima različitog intenziteta parazitske infekcije sa Strongyloides papillosus, kao i nakon terapije sa albendazolom (ABZ). Istraživanje je izvedeno na ovcama Wurtemberg rase (n = 30) kod kojih je utvrđen blagi, srednji i visoki intenzitet parazitske infekcije sa S. papillosus. Kontrolnu grupu (n = 10) činile su ovce negativne na prisustvo parazitske infekcije. Stepen i vrsta promene praćeni su određivanjem koncentracije glukoze, ukupnih proteina, albumina, A/G ratio, AST, urea, ukupnog bilirubina, kalcijuma, fosfora, ukupne aktivnosti LDH i izoenzimske distribucije LDH1-5. Na osnovu dobijenih rezultata utvrdili smo, preko izoenzimske distribucije LDH, da u toku parazitske infekcije sa S. papillosus dolazi do oštećenja jetre, srčanog mišića i pluća, dok nakon terapije sa ABZ jetra je organ koji je najviše oštećen. Koncentracija glukoze, ukupnih proteina i albumina linearno je opadala sa rastom intenziteta parazitske infekcije (p lt 0.05), a nakon terapije sa ABZ pad koncentracije ovih parametara bio je na statistički značajnom većem nivou (p lt 0.01). Aktivnost AST, koncentracija uree i ukupnog bilirubina takođe su linearno rasle sa intenzitetom parazitske infekcije (p lt 0.05). Nakon terapije sa ABZ aktivnost AST i koncentracija ukupnog bilirubina bile su na statistički značajno većem nivou (p lt 0.001), dok je koncentracija uree zadržala iste nivoe kao u slučaju parazitske infekcije. Vrednosti koncentracija kalcijuma (p > 0.05) i fosfora (p lt 0.05) takođe linearno opadaju sa rastom intenziteta parazitske infekcije. Trend pada koncentracije ovih makroelemenata, nastavlja se i nakon terapije sa albendazolom (p lt 0.001). Imajući u vidu naša prethodna istraživanja na polju oksidativnog stresa, fenomena koji se nalazi u osnovi ovih promena, strogo preporučujemo da se u antiparazitske protokole, pored antihelmintika koriste i preparati sa antioksidativnim osobinama.",
publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd",
journal = "Acta Veterinaria-Beograd",
title = "The effect of the intensity of parasitic infection with Strongyloides papillosus and albendazole therapy on biochemical parameters in sheep blood, Uticaj intenziteta parazitske infekcije sa Strongyloides papillosus i terapije albendazolom na biohemijske parametre u krvi ovaca",
volume = "63",
number = "5-6",
pages = "581-600",
doi = "10.2298/AVB1306581D"
}

Dimitrijević, B., Borozan, S., Jović, S., Bacić, D., Katić-Radivojević, S., Stojanović, S.,& Savić, M.. (2013). The effect of the intensity of parasitic infection with Strongyloides papillosus and albendazole therapy on biochemical parameters in sheep blood. in Acta Veterinaria-Beograd
Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 63(5-6), 581-600.
https://doi.org/10.2298/AVB1306581D

Dimitrijević B, Borozan S, Jović S, Bacić D, Katić-Radivojević S, Stojanović S, Savić M. The effect of the intensity of parasitic infection with Strongyloides papillosus and albendazole therapy on biochemical parameters in sheep blood. in Acta Veterinaria-Beograd. 2013;63(5-6):581-600.
doi:10.2298/AVB1306581D .

Dimitrijević, Blagoje, Borozan, Sunčica, Jović, Slavoljub, Bacić, Dragan, Katić-Radivojević, Sofija, Stojanović, S., Savić, Mila, "The effect of the intensity of parasitic infection with Strongyloides papillosus and albendazole therapy on biochemical parameters in sheep blood" in Acta Veterinaria-Beograd, 63, no. 5-6 (2013):581-600,
https://doi.org/10.2298/AVB1306581D . .

TY  - JOUR
AU  - Božić, Tatjana
AU  - Stevanović, Jelka
AU  - Borozan, Sunčica
AU  - Jović, Slavoljub
AU  - Dimitrijević, Blagoje
AU  - Ignjatović, Igor
PY  - 2013
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/962
AB  - There is ever increasing data indicating the vmast contribution of oxidative stress to the pathogenesis of numerous diseases (atherosclerosis, hypertension, heart failure, diabetes mellitus, stroke, rheumatoid arthritis, and others). Thus, in the pathogenesis of atherosclerosis the primary role is held by reactive oxygen species that are synthetized by endothelial cells of arterial blood vessels, leukocytes and macrophages. Furthermore, native particles of lipoproteins of small density become atherogenic through oxidation caused by reactive oxygen species. The oxidation of small-density lipoproteins stimulates the inflammatory process, and it in turn steps up adhesion and the inflow of monocytes and affects the synthesis and release of numerous proinflammatory cytokines involved in the further course of the process. One of the reasons for the development of arterial hypertension is the simultaneous activation of NAD(P)H oxidase and 12/15-lipoxygenase, since it results in the stepped up production of reactive oxygen species. These stimulate the production of matrix metalloproteinase 2, which lead to vascular remodelling and to increased apoptosis of heart muscle cells. Stepped up apoptosis is linked with myocardial infarction, cardiomyopathies and the development of heart failure. The sensitivity of β-cells of the endocrine part of the pancreas to reactive oxygen species favor the naturally low concentrations of the collectors of free radicals in them, as well as an increase in the concentration of proinflammatory cytokines, glucosis and lipids that induce a reduction in the mass and function of β-cells. Hyperglycemia in diabetes mellitus causes tissue damage through non-enzyme glycosylation of intracellular and extracellular proteins, which results in: reduced enzyme activity, damaged nucleic acid, disrupted natural decomposition of proteins, and activation of cytotoxic pathways. These processes are the basis of the pathogenesis of numerous complications of diabetes mellitus. Since inducible nitrogen-oxide synthesis launches processes that stimulate apoptosis of cerebral endothelial cells, and superoxide-anion radicals, hypochloric acid and hydrogen peroxide damage the parenchyma of an ischemic brain and biomacromolecules (causing lipid peroxidation, oxidation of proteins and deoxyribonucleic acid), brain damage occurs during cerebral ischemia and reperfusion.
AB  - Sve više podataka ukazuje na veliki doprinos oksidativnog stresa patogenezi brojnih bolesti (aterosklerozi, hipertenziji, srčanoj insuficijenciji, šećernoj bolesti, moždanom udaru, reumatoidnom artritisu i dr.). Tako, u patogenezi ateroskleroze primarno mesto zauzimaju reaktivne kiseonične vrste koje sintetišu endotelne ćelije arterijskih krvnih sudova, leukociti i makrofagi. Uz to, nativne čestice lipoproteina male gustine postaju aterogene, oksidacijom izazvanom reaktivnim kiseoničnim vrstama. Oksidacija lipoproteina male gustine stimuliše zapaljenjski proces, a on pojačava adheziju i dotok monocita i utiče na sintezu i oslobađanje brojnih proinflamatornih citokina uključenih u dalji tok procesa. Jedan od razloga za razvoj arterijske hipertenzije je istovremena aktivacija NAD(P)H oksidaza i 12/15-lipoksigenaze, jer rezultira pojačanom proizvodnjom reaktivnih kiseoničnih vrsta. One podstiču proizvodnju metaloproteinaza-2 matriksa, koje dovode do vaskularnog remodeliranja i do pojačane apoptoze srčanih mišićnih ćelija. Pojačana apoptoza je povezana sa infarktom miokarda, kardiomiopatijama i razvojem srčane insuficijencije. Osetljivosti β-ćelija endokrinog dela pankreasa na reaktivne kiseonične vrste pogoduju prirodno niske koncentracije skupljača slobodnih radikala u njima, kao i porast koncentracije proinflamatornih citokina, glukoze i lipida koji indukuju smanjenje mase i funkcije β-ćelija. Hiperglikemija kod šećerne bolesti izaziva oštećenja tkiva neenzimskim glikozilovanjem intracelularnih i ekstracelularnih proteina, usled čega se smanjuje enzimska aktivnost, oštećuju nukleinske kiseline, re meti prirodna razgradnja proteina i aktiviraju citotoksični putevi. Ovi procesi su i osnova patogeneze mnogih komplikacija šećerne bolesti. S obzirom na to da inducibilna azot-oksid sintaza pokreće procese koji podstiču apoptozu cerebralnih endotelnih ćelija, a superoksid-anjon radikal, hipohlorna kiselina i vodonik-peroksid oštećuju parenhim ishemičnog mozga i biomakromolekule (izazivaju peroksidaciju lipida, oksidaciju proteina i dezoksiribonukleinske kiseline), tokom cerebralne ishemije i reperfuzije nastaju oštećenja mozga.
PB  - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
T2  - Veterinarski Glasnik
T1  - Influence of oxidative stress on disease development
T1  - Uticaj oksidativnog stresa na razvoj bolesti
VL  - 67
IS  - 1-2
SP  - 75
EP  - 85
DO  - 10.2298/VETGL1302075B
ER  - 

@article{
author = "Božić, Tatjana and Stevanović, Jelka and Borozan, Sunčica and Jović, Slavoljub and Dimitrijević, Blagoje and Ignjatović, Igor",
year = "2013",
abstract = "There is ever increasing data indicating the vmast contribution of oxidative stress to the pathogenesis of numerous diseases (atherosclerosis, hypertension, heart failure, diabetes mellitus, stroke, rheumatoid arthritis, and others). Thus, in the pathogenesis of atherosclerosis the primary role is held by reactive oxygen species that are synthetized by endothelial cells of arterial blood vessels, leukocytes and macrophages. Furthermore, native particles of lipoproteins of small density become atherogenic through oxidation caused by reactive oxygen species. The oxidation of small-density lipoproteins stimulates the inflammatory process, and it in turn steps up adhesion and the inflow of monocytes and affects the synthesis and release of numerous proinflammatory cytokines involved in the further course of the process. One of the reasons for the development of arterial hypertension is the simultaneous activation of NAD(P)H oxidase and 12/15-lipoxygenase, since it results in the stepped up production of reactive oxygen species. These stimulate the production of matrix metalloproteinase 2, which lead to vascular remodelling and to increased apoptosis of heart muscle cells. Stepped up apoptosis is linked with myocardial infarction, cardiomyopathies and the development of heart failure. The sensitivity of β-cells of the endocrine part of the pancreas to reactive oxygen species favor the naturally low concentrations of the collectors of free radicals in them, as well as an increase in the concentration of proinflammatory cytokines, glucosis and lipids that induce a reduction in the mass and function of β-cells. Hyperglycemia in diabetes mellitus causes tissue damage through non-enzyme glycosylation of intracellular and extracellular proteins, which results in: reduced enzyme activity, damaged nucleic acid, disrupted natural decomposition of proteins, and activation of cytotoxic pathways. These processes are the basis of the pathogenesis of numerous complications of diabetes mellitus. Since inducible nitrogen-oxide synthesis launches processes that stimulate apoptosis of cerebral endothelial cells, and superoxide-anion radicals, hypochloric acid and hydrogen peroxide damage the parenchyma of an ischemic brain and biomacromolecules (causing lipid peroxidation, oxidation of proteins and deoxyribonucleic acid), brain damage occurs during cerebral ischemia and reperfusion., Sve više podataka ukazuje na veliki doprinos oksidativnog stresa patogenezi brojnih bolesti (aterosklerozi, hipertenziji, srčanoj insuficijenciji, šećernoj bolesti, moždanom udaru, reumatoidnom artritisu i dr.). Tako, u patogenezi ateroskleroze primarno mesto zauzimaju reaktivne kiseonične vrste koje sintetišu endotelne ćelije arterijskih krvnih sudova, leukociti i makrofagi. Uz to, nativne čestice lipoproteina male gustine postaju aterogene, oksidacijom izazvanom reaktivnim kiseoničnim vrstama. Oksidacija lipoproteina male gustine stimuliše zapaljenjski proces, a on pojačava adheziju i dotok monocita i utiče na sintezu i oslobađanje brojnih proinflamatornih citokina uključenih u dalji tok procesa. Jedan od razloga za razvoj arterijske hipertenzije je istovremena aktivacija NAD(P)H oksidaza i 12/15-lipoksigenaze, jer rezultira pojačanom proizvodnjom reaktivnih kiseoničnih vrsta. One podstiču proizvodnju metaloproteinaza-2 matriksa, koje dovode do vaskularnog remodeliranja i do pojačane apoptoze srčanih mišićnih ćelija. Pojačana apoptoza je povezana sa infarktom miokarda, kardiomiopatijama i razvojem srčane insuficijencije. Osetljivosti β-ćelija endokrinog dela pankreasa na reaktivne kiseonične vrste pogoduju prirodno niske koncentracije skupljača slobodnih radikala u njima, kao i porast koncentracije proinflamatornih citokina, glukoze i lipida koji indukuju smanjenje mase i funkcije β-ćelija. Hiperglikemija kod šećerne bolesti izaziva oštećenja tkiva neenzimskim glikozilovanjem intracelularnih i ekstracelularnih proteina, usled čega se smanjuje enzimska aktivnost, oštećuju nukleinske kiseline, re meti prirodna razgradnja proteina i aktiviraju citotoksični putevi. Ovi procesi su i osnova patogeneze mnogih komplikacija šećerne bolesti. S obzirom na to da inducibilna azot-oksid sintaza pokreće procese koji podstiču apoptozu cerebralnih endotelnih ćelija, a superoksid-anjon radikal, hipohlorna kiselina i vodonik-peroksid oštećuju parenhim ishemičnog mozga i biomakromolekule (izazivaju peroksidaciju lipida, oksidaciju proteina i dezoksiribonukleinske kiseline), tokom cerebralne ishemije i reperfuzije nastaju oštećenja mozga.",
publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd",
journal = "Veterinarski Glasnik",
title = "Influence of oxidative stress on disease development, Uticaj oksidativnog stresa na razvoj bolesti",
volume = "67",
number = "1-2",
pages = "75-85",
doi = "10.2298/VETGL1302075B"
}

Božić, T., Stevanović, J., Borozan, S., Jović, S., Dimitrijević, B.,& Ignjatović, I.. (2013). Influence of oxidative stress on disease development. in Veterinarski Glasnik
Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 67(1-2), 75-85.
https://doi.org/10.2298/VETGL1302075B

Božić T, Stevanović J, Borozan S, Jović S, Dimitrijević B, Ignjatović I. Influence of oxidative stress on disease development. in Veterinarski Glasnik. 2013;67(1-2):75-85.
doi:10.2298/VETGL1302075B .

Božić, Tatjana, Stevanović, Jelka, Borozan, Sunčica, Jović, Slavoljub, Dimitrijević, Blagoje, Ignjatović, Igor, "Influence of oxidative stress on disease development" in Veterinarski Glasnik, 67, no. 1-2 (2013):75-85,
https://doi.org/10.2298/VETGL1302075B . .

TY  - JOUR
AU  - Borozan, Sunčica
AU  - Dimitrijević, Blagoje
AU  - Stojanović, Srđan
PY  - 2013
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/988
AB  - In this work, we have analyzed the influence of cation-pi interactions to the stability of 59 high resolution protein-RNA complex crystal structures. The total number of Lys and Arg are similar in the dataset as well as the number of their interactions. On the other hand, the aromatic chains of purines are exhibiting more cation-pi interactions than pyrimidines. 35% of the total interactions in the dataset are involved in the formation of multiple cation-pi interactions. The multiple cation-pi interactions have been conserved more than the single interactions. The analysis of the geometry of the cation-pi interactions has revealed that the average distance (d) value falls into distinct ranges corresponding to the multiple (4.28 angstrom) and single (5.50 angstrom) cation-pi interactions. The G-Arg pair has the strongest interaction energy of -3.68 kcal mol(-1) among all the possible pairs of amino acids and bases. Further, we found that the cation-pi interactions due to five-membered rings of A and G are stronger than that with the atoms in six-membered rings. 8.7% stabilizing residues are involved in building cation-pi interactions with the nucleic bases. There are three types of structural motifs significantly over-represented in protein-RNA interfaces: beta-turn-ir, niche-4r and st-staple. Tetraloops and kink-turns are the most abundant RNA motifs in protein-RNA interfaces. Amino acids deployed in the protein-RNA interfaces are deposited in helices, sheets and coils. Arg and Lys, involved in cation-pi interactions, prefer to be in the solvent exposed surface. The results from this study might be used for structure-based prediction and as scaffolds for future protein-RNA complex design.
PB  - Elsevier Sci Ltd, Oxford
T2  - Computational Biology and Chemistry
T1  - Cation-pi interactions in high resolution protein-RNA complex crystal structures
VL  - 47
SP  - 105
EP  - 112
DO  - 10.1016/j.compbiolchem.2013.08.005
ER  - 

@article{
author = "Borozan, Sunčica and Dimitrijević, Blagoje and Stojanović, Srđan",
year = "2013",
abstract = "In this work, we have analyzed the influence of cation-pi interactions to the stability of 59 high resolution protein-RNA complex crystal structures. The total number of Lys and Arg are similar in the dataset as well as the number of their interactions. On the other hand, the aromatic chains of purines are exhibiting more cation-pi interactions than pyrimidines. 35% of the total interactions in the dataset are involved in the formation of multiple cation-pi interactions. The multiple cation-pi interactions have been conserved more than the single interactions. The analysis of the geometry of the cation-pi interactions has revealed that the average distance (d) value falls into distinct ranges corresponding to the multiple (4.28 angstrom) and single (5.50 angstrom) cation-pi interactions. The G-Arg pair has the strongest interaction energy of -3.68 kcal mol(-1) among all the possible pairs of amino acids and bases. Further, we found that the cation-pi interactions due to five-membered rings of A and G are stronger than that with the atoms in six-membered rings. 8.7% stabilizing residues are involved in building cation-pi interactions with the nucleic bases. There are three types of structural motifs significantly over-represented in protein-RNA interfaces: beta-turn-ir, niche-4r and st-staple. Tetraloops and kink-turns are the most abundant RNA motifs in protein-RNA interfaces. Amino acids deployed in the protein-RNA interfaces are deposited in helices, sheets and coils. Arg and Lys, involved in cation-pi interactions, prefer to be in the solvent exposed surface. The results from this study might be used for structure-based prediction and as scaffolds for future protein-RNA complex design.",
publisher = "Elsevier Sci Ltd, Oxford",
journal = "Computational Biology and Chemistry",
title = "Cation-pi interactions in high resolution protein-RNA complex crystal structures",
volume = "47",
pages = "105-112",
doi = "10.1016/j.compbiolchem.2013.08.005"
}

Borozan, S., Dimitrijević, B.,& Stojanović, S.. (2013). Cation-pi interactions in high resolution protein-RNA complex crystal structures. in Computational Biology and Chemistry
Elsevier Sci Ltd, Oxford., 47, 105-112.
https://doi.org/10.1016/j.compbiolchem.2013.08.005

Borozan S, Dimitrijević B, Stojanović S. Cation-pi interactions in high resolution protein-RNA complex crystal structures. in Computational Biology and Chemistry. 2013;47:105-112.
doi:10.1016/j.compbiolchem.2013.08.005 .

Borozan, Sunčica, Dimitrijević, Blagoje, Stojanović, Srđan, "Cation-pi interactions in high resolution protein-RNA complex crystal structures" in Computational Biology and Chemistry, 47 (2013):105-112,
https://doi.org/10.1016/j.compbiolchem.2013.08.005 . .

TY  - JOUR
AU  - Bacić, Dragan
AU  - Obrenović, Sonja
AU  - Kirovski, Marko
AU  - Dimitrijević, Blagoje
AU  - Radojičić, Sonja
AU  - Valčić, Miroslav
AU  - Mirilović, Milorad
PY  - 2012
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/848
AB  - The objective of these investigations was to check on laboratory white mice the protective effect of an inactivated bivalent vaccine prepared from serotypes 1/2a and 4b L. monocytogenes. Following verification of the sterility and toxicity of the prepared vaccine, the mice were divided into 6 groups with 10 animals in each group. The first and second group of mice were administered the vaccine without saponin (vaccine A) and the third and fourth group the vaccine with saponin (vaccine B). Mice of the fifth and the sixth group were not vaccinated and served as a negative control. Two weeks following vaccination, the experimental groups were revaccinated, with the exception of the two control groups. Two weeks following revaccination, all groups were artificially infected with serotypes 1/2a and 4b L. monocytogenes. During the course of the investigations (60 days) a total of 4 mice died in the vaccinated groups. Mice of the control groups started dying after day 7, and the last mouse in these groups died 14 days after the infection. Examinations of preparations of parenchymatous organs of the dead mice stained according to Gram proved the presence of L. monocytogenes. Homogenates of parenchymatous organs were sown on tryptose agar for reisolation and a pure culture of L. monocytogenes was obtained. Through the use of specific antiserums, serotypes 1/2a and 4b were confirmed. Considering the total number of vaccinated mice in the experiment and the percent deaths (10%), it can be said that the investigated vaccine with saponin had a satisfactory protective effect.
AB  - Cilj ovog istraživanja bio je da se na laboratorijskim belim miševima proveri zaštitno dejstvo inaktivisane dvovalentne vakcine pripremljene od serotipova L. monocytogenes 1/2a i 4b. Nakon provere sterilnosti i toksičnosti pripremljene vakcine miševi su podeljeni u 6 grupa sa po 10 životinja. Prva i druga grupa miševa su dobile vakcinu bez saponina (vakcina A), a treća i četvrta grupa vakcinu sa saponinom (vakcina B). Miševi pete i šeste grupe nisu vakcinisani i služili su kao negativna kontrola. Dve nedelje nakon vakcinacije izvršena je revakcinacija oglednih grupa, osim kontrolnih. Dve nedelje nakon revakcinacije izvršena je veštačka infekcija svih grupa sa serotipovima L. monocytogenes 1/2a i 4b. Za vreme ispitivanja (60 dana) uginula su 4 miša iz vakcinisanih grupa. Miševi kontrolnih grupa su počeli da uginjavaju nakon 7. dana, a poslednji miš je uginuo 14 dana posle infekcije. Pregledom preparata iz parenhimatoznih organa uginulih miševa obojenih po Gramu dokazano je prisustvo L. monocytogenes. Zasejavanjem homogenizata parenhimatoznih organa na triptozni agar urađena je reizolacija i dobijena je čista kultura L. monocytogenes. Upotrebom specifičnih antiseruma potvrđeni su serotipovi 1/2a i 4b. S obzirom na ukupan broj vakcinisanih miševa u ogledu i procenat uginuća (10%), može se reći da je ispitivana vakcina sa saponinom imala zadovoljavajuć i zaštitni efekat.
PB  - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
T2  - Veterinarski Glasnik
T1  - Investigations of protective effects of bivalent inactivated vaccine prepared from serotypes 1/2a and 4b Listeria monocytogenes on mice
T1  - Ispitivanje zaštitnog dejstva dvovalentne inaktivisane vakcine pripremljene od serotipova 1/2a i 4b Listeria monocytogenes na miševima
VL  - 66
IS  - 1-2
SP  - 49
EP  - 57
DO  - 10.2298/VETGL1202049B
ER  - 

@article{
author = "Bacić, Dragan and Obrenović, Sonja and Kirovski, Marko and Dimitrijević, Blagoje and Radojičić, Sonja and Valčić, Miroslav and Mirilović, Milorad",
year = "2012",
abstract = "The objective of these investigations was to check on laboratory white mice the protective effect of an inactivated bivalent vaccine prepared from serotypes 1/2a and 4b L. monocytogenes. Following verification of the sterility and toxicity of the prepared vaccine, the mice were divided into 6 groups with 10 animals in each group. The first and second group of mice were administered the vaccine without saponin (vaccine A) and the third and fourth group the vaccine with saponin (vaccine B). Mice of the fifth and the sixth group were not vaccinated and served as a negative control. Two weeks following vaccination, the experimental groups were revaccinated, with the exception of the two control groups. Two weeks following revaccination, all groups were artificially infected with serotypes 1/2a and 4b L. monocytogenes. During the course of the investigations (60 days) a total of 4 mice died in the vaccinated groups. Mice of the control groups started dying after day 7, and the last mouse in these groups died 14 days after the infection. Examinations of preparations of parenchymatous organs of the dead mice stained according to Gram proved the presence of L. monocytogenes. Homogenates of parenchymatous organs were sown on tryptose agar for reisolation and a pure culture of L. monocytogenes was obtained. Through the use of specific antiserums, serotypes 1/2a and 4b were confirmed. Considering the total number of vaccinated mice in the experiment and the percent deaths (10%), it can be said that the investigated vaccine with saponin had a satisfactory protective effect., Cilj ovog istraživanja bio je da se na laboratorijskim belim miševima proveri zaštitno dejstvo inaktivisane dvovalentne vakcine pripremljene od serotipova L. monocytogenes 1/2a i 4b. Nakon provere sterilnosti i toksičnosti pripremljene vakcine miševi su podeljeni u 6 grupa sa po 10 životinja. Prva i druga grupa miševa su dobile vakcinu bez saponina (vakcina A), a treća i četvrta grupa vakcinu sa saponinom (vakcina B). Miševi pete i šeste grupe nisu vakcinisani i služili su kao negativna kontrola. Dve nedelje nakon vakcinacije izvršena je revakcinacija oglednih grupa, osim kontrolnih. Dve nedelje nakon revakcinacije izvršena je veštačka infekcija svih grupa sa serotipovima L. monocytogenes 1/2a i 4b. Za vreme ispitivanja (60 dana) uginula su 4 miša iz vakcinisanih grupa. Miševi kontrolnih grupa su počeli da uginjavaju nakon 7. dana, a poslednji miš je uginuo 14 dana posle infekcije. Pregledom preparata iz parenhimatoznih organa uginulih miševa obojenih po Gramu dokazano je prisustvo L. monocytogenes. Zasejavanjem homogenizata parenhimatoznih organa na triptozni agar urađena je reizolacija i dobijena je čista kultura L. monocytogenes. Upotrebom specifičnih antiseruma potvrđeni su serotipovi 1/2a i 4b. S obzirom na ukupan broj vakcinisanih miševa u ogledu i procenat uginuća (10%), može se reći da je ispitivana vakcina sa saponinom imala zadovoljavajuć i zaštitni efekat.",
publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd",
journal = "Veterinarski Glasnik",
title = "Investigations of protective effects of bivalent inactivated vaccine prepared from serotypes 1/2a and 4b Listeria monocytogenes on mice, Ispitivanje zaštitnog dejstva dvovalentne inaktivisane vakcine pripremljene od serotipova 1/2a i 4b Listeria monocytogenes na miševima",
volume = "66",
number = "1-2",
pages = "49-57",
doi = "10.2298/VETGL1202049B"
}

Bacić, D., Obrenović, S., Kirovski, M., Dimitrijević, B., Radojičić, S., Valčić, M.,& Mirilović, M.. (2012). Investigations of protective effects of bivalent inactivated vaccine prepared from serotypes 1/2a and 4b Listeria monocytogenes on mice. in Veterinarski Glasnik
Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 66(1-2), 49-57.
https://doi.org/10.2298/VETGL1202049B

Bacić D, Obrenović S, Kirovski M, Dimitrijević B, Radojičić S, Valčić M, Mirilović M. Investigations of protective effects of bivalent inactivated vaccine prepared from serotypes 1/2a and 4b Listeria monocytogenes on mice. in Veterinarski Glasnik. 2012;66(1-2):49-57.
doi:10.2298/VETGL1202049B .

Bacić, Dragan, Obrenović, Sonja, Kirovski, Marko, Dimitrijević, Blagoje, Radojičić, Sonja, Valčić, Miroslav, Mirilović, Milorad, "Investigations of protective effects of bivalent inactivated vaccine prepared from serotypes 1/2a and 4b Listeria monocytogenes on mice" in Veterinarski Glasnik, 66, no. 1-2 (2012):49-57,
https://doi.org/10.2298/VETGL1202049B . .

TY  - JOUR
AU  - Jonić, Branko
AU  - Dimitrijević, Blagoje
AU  - Mirilović, Milorad
AU  - Obrenović, Sonja
AU  - Bacić, Dragan
PY  - 2012
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/858
AB  - The aim of these investigations was to examine the concentration of total proteins and total immunoglobulins in blood serum of calves and on the bases of the obtained results to evaluate the risk of their contracting a disease in the first month of life. Examinations were carried out on 23 calves maintained in farm conditions, whose medical condition was monitored in the first month of life. Blood samples were taken by puncture from the v. jugularis immediately at birth, and at 24 and 48 hours after that, and blood serum was obtained by spontaneous coaggulation. The concentration of total proteins in blood serum was determined using biuretic probe, and the immunoglobulin level using the refractometric method with the zinc-sulphate test (ZST). The average value of total proteins in calves immediately at birth was low and stood at 42±0.3 g/l. The increased concentration of total proteins in calves after the intake of colostrum is a result of the absorption of colostrum immunoglobulins. A high positive correlation was established between the concentration of total proteins and total immunoglobulins at 24 and 48 hours after birth (rxy = 0.92 and rxy = 0.75). Based on the results of monitoring the health condition and the values for total protein concentrations during the examined period (24 and 48 hours after birth) it is possible to make the following risk evaluation regarding diseases in newborn calves: 1) proteinaemia lower than 50 g/l presents a high risk; 2) proteinaemia between 50-54 g/l presents a medium risk: and, 3) proteinaemia between 55-69 g/l presents a low risk for diseases occurring in newborn calves.
AB  - Cilj ovog istraživanja bio je da se ispita koncentracija ukupnih proteina i ukupnih imunoglobulina u krvnom serumu teladi i na osnovu toga izvrši procena rizika oboljenja u prvom mesecu života. Ispitivanje je izvedeno na 23 teleta u farmskim uslovima držanja, čije je zdravstveno stanje praćeno u prvom mesecu života. Uzorci krvi uzimani su punkcijom v. jugularis neposredno po rođenju, 24. i 48. sata, a krvni serum je dobijen spontanom koagulacijom. Koncentracija ukupnih proteina u krvnom serumu određivana je biuretskom probom, a nivo imunoglobulina refraktometrijskom metodom korišćenjem cink-sulfat testa (ZST). Prosečna vrednost ukupnih proteina kod teladi neposredno po rođenju bila je niska i iznosila je 42 ± 0,3 g/l. Povećanje koncentracije ukupnih proteina kod teladi nakon unošenja kolostruma rezultat je apsorpcije kolostralnih imunoglobulina. Visoka pozitivna korelacija utvrđ ena je između koncentracije ukupnih proteina i ukupnih imunoglobulina u periodu 24. i 48. sata po rođenju (rxy=0,92 i rxy = 0,75). Na osnovu rezultata praćenja zdravstvenog stanja i vrednosti koncentracije ukupnih proteina u ispitivanom periodu (24-og i 48-og sata) moguć e je dati sledeću procenu rizika oboljenja novorođene teladi: 1) proteinemija manja od 50 g/l odgovara visokom riziku; 2) proteinemija između 50 i 54 g/l odgovara srednjem riziku i 3) proteinemija između 55 i 69 g/l odgovara malom riziku za pojavu oboljenja novorođene teladi.
PB  - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
T2  - Veterinarski Glasnik
T1  - Evaluation of colostrum protection of calves
T1  - Procena kolostralne zaštite teladi
VL  - 66
IS  - 1-2
SP  - 13
EP  - 25
DO  - 10.2298/VETGL1202013J
ER  - 

@article{
author = "Jonić, Branko and Dimitrijević, Blagoje and Mirilović, Milorad and Obrenović, Sonja and Bacić, Dragan",
year = "2012",
abstract = "The aim of these investigations was to examine the concentration of total proteins and total immunoglobulins in blood serum of calves and on the bases of the obtained results to evaluate the risk of their contracting a disease in the first month of life. Examinations were carried out on 23 calves maintained in farm conditions, whose medical condition was monitored in the first month of life. Blood samples were taken by puncture from the v. jugularis immediately at birth, and at 24 and 48 hours after that, and blood serum was obtained by spontaneous coaggulation. The concentration of total proteins in blood serum was determined using biuretic probe, and the immunoglobulin level using the refractometric method with the zinc-sulphate test (ZST). The average value of total proteins in calves immediately at birth was low and stood at 42±0.3 g/l. The increased concentration of total proteins in calves after the intake of colostrum is a result of the absorption of colostrum immunoglobulins. A high positive correlation was established between the concentration of total proteins and total immunoglobulins at 24 and 48 hours after birth (rxy = 0.92 and rxy = 0.75). Based on the results of monitoring the health condition and the values for total protein concentrations during the examined period (24 and 48 hours after birth) it is possible to make the following risk evaluation regarding diseases in newborn calves: 1) proteinaemia lower than 50 g/l presents a high risk; 2) proteinaemia between 50-54 g/l presents a medium risk: and, 3) proteinaemia between 55-69 g/l presents a low risk for diseases occurring in newborn calves., Cilj ovog istraživanja bio je da se ispita koncentracija ukupnih proteina i ukupnih imunoglobulina u krvnom serumu teladi i na osnovu toga izvrši procena rizika oboljenja u prvom mesecu života. Ispitivanje je izvedeno na 23 teleta u farmskim uslovima držanja, čije je zdravstveno stanje praćeno u prvom mesecu života. Uzorci krvi uzimani su punkcijom v. jugularis neposredno po rođenju, 24. i 48. sata, a krvni serum je dobijen spontanom koagulacijom. Koncentracija ukupnih proteina u krvnom serumu određivana je biuretskom probom, a nivo imunoglobulina refraktometrijskom metodom korišćenjem cink-sulfat testa (ZST). Prosečna vrednost ukupnih proteina kod teladi neposredno po rođenju bila je niska i iznosila je 42 ± 0,3 g/l. Povećanje koncentracije ukupnih proteina kod teladi nakon unošenja kolostruma rezultat je apsorpcije kolostralnih imunoglobulina. Visoka pozitivna korelacija utvrđ ena je između koncentracije ukupnih proteina i ukupnih imunoglobulina u periodu 24. i 48. sata po rođenju (rxy=0,92 i rxy = 0,75). Na osnovu rezultata praćenja zdravstvenog stanja i vrednosti koncentracije ukupnih proteina u ispitivanom periodu (24-og i 48-og sata) moguć e je dati sledeću procenu rizika oboljenja novorođene teladi: 1) proteinemija manja od 50 g/l odgovara visokom riziku; 2) proteinemija između 50 i 54 g/l odgovara srednjem riziku i 3) proteinemija između 55 i 69 g/l odgovara malom riziku za pojavu oboljenja novorođene teladi.",
publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd",
journal = "Veterinarski Glasnik",
title = "Evaluation of colostrum protection of calves, Procena kolostralne zaštite teladi",
volume = "66",
number = "1-2",
pages = "13-25",
doi = "10.2298/VETGL1202013J"
}

Jonić, B., Dimitrijević, B., Mirilović, M., Obrenović, S.,& Bacić, D.. (2012). Evaluation of colostrum protection of calves. in Veterinarski Glasnik
Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 66(1-2), 13-25.
https://doi.org/10.2298/VETGL1202013J

Jonić B, Dimitrijević B, Mirilović M, Obrenović S, Bacić D. Evaluation of colostrum protection of calves. in Veterinarski Glasnik. 2012;66(1-2):13-25.
doi:10.2298/VETGL1202013J .

Jonić, Branko, Dimitrijević, Blagoje, Mirilović, Milorad, Obrenović, Sonja, Bacić, Dragan, "Evaluation of colostrum protection of calves" in Veterinarski Glasnik, 66, no. 1-2 (2012):13-25,
https://doi.org/10.2298/VETGL1202013J . .

TY  - JOUR
AU  - Stevanović, Jelka
AU  - Borozan, Sunčica
AU  - Božić, Tatjana
AU  - Jović, Slavoljub
AU  - Đekić, Tatjana
AU  - Dimitrijević, Blagoje
PY  - 2012
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/912
AB  - The unceasing need for oxygen is in contradiction to the fact that it is in fact toxic to mammals. Namely, its monovalent reduction can have as a consequence the production of short-living, chemically very active free radicals and certain non-radical agents (nitrogen-oxide, superoxide-anion-radicals, hydroxyl radicals, peroxyl radicals, singlet oxygen, peroxynitrite, hydrogen peroxide, hypochlorous acid, and others). There is no doubt that they have numerous positive roles, but when their production is stepped up to such an extent that the organism cannot eliminate them with its antioxidants (superoxide-dismutase, glutathione-peroxidase, catalase, transferrin, ceruloplasmin, reduced glutathion, and others), a series of disorders is developed that are jointly called 'oxidative stress.' The reactive oxygen species which characterize oxidative stress are capable of attacking all main classes of biological macromolecules, actually proteins, DNA and RNA molecules, and in particular lipids. The free radicals influence lipid peroxidation in cellular membranes, oxidative damage to DNA and RNA molecules, the development of genetic mutations, fragmentation, and the altered function of various protein molecules. All of this results in the following consequences: disrupted permeability of cellular membranes, disrupted cellular signalization and ion homeostasis, reduced or loss of function of damaged proteins, and similar. That is why the free radicals that are released during oxidative stress are considered pathogenic agents of numerous diseases and ageing. The type of damage that will occur, and when it will take place, depends on the nature of the free radicals, their site of action and their source.
AB  - Neprekidna potreba za kiseonikom je kontradiktorna sa činjenicom da je on toksičan po sisare. Naime, njegova jednovalentna redukcija može imati za posledicu proizvodnju kratkoživećih, hemijski vrlo aktivnih, slobodnih radikala i nekih neradikalskih agenasa (azot-oksida, superoksid anjon-radikala, hidroksilnog radikala, peroksilnog radikala, singletnog kiseonika, peroksinitrita, vodonik-peroksida, hipohloraste kiseline i dr.). Neosporno je da oni imaju brojne poželjne uloge, ali kada im se proizvodnja pojača toliko da organizam ne može svojim antioksidansima (superoksid dismutaza, glutation peroksidaza, katalaza, transferin, ceruloplazmin, redukovani glutation i sl.) da ih ukloni, razvija se serija poremećaja koji se jednim imenom nazivaju 'oksidativni stres'. Reaktivne kiseonične vrste koje karakterišu oksidativni stres su sposobne da napadnu sve glavne klase bioloških makromolekula, odnosno proteine, DNK i RNK molekule, a naročito lipide. Pod uticajem slobodnih radikala dolazi do peroksidacije lipida ćelijskih membrana, oksidativnih oštećenja DNK i RNK molekula, razvoja genetskih mutacija, fragmentacije i promene funkcije najrazličitijih proteinskih molekula. Sve to ima za posledicu: narušavanje propustljivosti ćelijskih membrana, poremećaja ćelijske signalizacije i homeostaze jona, smanjenja ili gubitka funkcija oštećenih proteina i sl. Zato se slobodni radikali, koji se oslobađaju tokom oksidativnog stresa, smatraju patogenim agensima mnogih bolesti i starenja. Koja vrsta oštećenja će se desiti i kada, zavisi od prirode slobodnih radikala, mesta delovanja i njihovog izvora.
PB  - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
T2  - Veterinarski Glasnik
T1  - Oxidative stress
T1  - Oksidativni stres
VL  - 66
IS  - 3-4
SP  - 273
EP  - 283
DO  - 10.2298/VETGL1204273S
ER  - 

@article{
author = "Stevanović, Jelka and Borozan, Sunčica and Božić, Tatjana and Jović, Slavoljub and Đekić, Tatjana and Dimitrijević, Blagoje",
year = "2012",
abstract = "The unceasing need for oxygen is in contradiction to the fact that it is in fact toxic to mammals. Namely, its monovalent reduction can have as a consequence the production of short-living, chemically very active free radicals and certain non-radical agents (nitrogen-oxide, superoxide-anion-radicals, hydroxyl radicals, peroxyl radicals, singlet oxygen, peroxynitrite, hydrogen peroxide, hypochlorous acid, and others). There is no doubt that they have numerous positive roles, but when their production is stepped up to such an extent that the organism cannot eliminate them with its antioxidants (superoxide-dismutase, glutathione-peroxidase, catalase, transferrin, ceruloplasmin, reduced glutathion, and others), a series of disorders is developed that are jointly called 'oxidative stress.' The reactive oxygen species which characterize oxidative stress are capable of attacking all main classes of biological macromolecules, actually proteins, DNA and RNA molecules, and in particular lipids. The free radicals influence lipid peroxidation in cellular membranes, oxidative damage to DNA and RNA molecules, the development of genetic mutations, fragmentation, and the altered function of various protein molecules. All of this results in the following consequences: disrupted permeability of cellular membranes, disrupted cellular signalization and ion homeostasis, reduced or loss of function of damaged proteins, and similar. That is why the free radicals that are released during oxidative stress are considered pathogenic agents of numerous diseases and ageing. The type of damage that will occur, and when it will take place, depends on the nature of the free radicals, their site of action and their source., Neprekidna potreba za kiseonikom je kontradiktorna sa činjenicom da je on toksičan po sisare. Naime, njegova jednovalentna redukcija može imati za posledicu proizvodnju kratkoživećih, hemijski vrlo aktivnih, slobodnih radikala i nekih neradikalskih agenasa (azot-oksida, superoksid anjon-radikala, hidroksilnog radikala, peroksilnog radikala, singletnog kiseonika, peroksinitrita, vodonik-peroksida, hipohloraste kiseline i dr.). Neosporno je da oni imaju brojne poželjne uloge, ali kada im se proizvodnja pojača toliko da organizam ne može svojim antioksidansima (superoksid dismutaza, glutation peroksidaza, katalaza, transferin, ceruloplazmin, redukovani glutation i sl.) da ih ukloni, razvija se serija poremećaja koji se jednim imenom nazivaju 'oksidativni stres'. Reaktivne kiseonične vrste koje karakterišu oksidativni stres su sposobne da napadnu sve glavne klase bioloških makromolekula, odnosno proteine, DNK i RNK molekule, a naročito lipide. Pod uticajem slobodnih radikala dolazi do peroksidacije lipida ćelijskih membrana, oksidativnih oštećenja DNK i RNK molekula, razvoja genetskih mutacija, fragmentacije i promene funkcije najrazličitijih proteinskih molekula. Sve to ima za posledicu: narušavanje propustljivosti ćelijskih membrana, poremećaja ćelijske signalizacije i homeostaze jona, smanjenja ili gubitka funkcija oštećenih proteina i sl. Zato se slobodni radikali, koji se oslobađaju tokom oksidativnog stresa, smatraju patogenim agensima mnogih bolesti i starenja. Koja vrsta oštećenja će se desiti i kada, zavisi od prirode slobodnih radikala, mesta delovanja i njihovog izvora.",
publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd",
journal = "Veterinarski Glasnik",
title = "Oxidative stress, Oksidativni stres",
volume = "66",
number = "3-4",
pages = "273-283",
doi = "10.2298/VETGL1204273S"
}

Stevanović, J., Borozan, S., Božić, T., Jović, S., Đekić, T.,& Dimitrijević, B.. (2012). Oxidative stress. in Veterinarski Glasnik
Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 66(3-4), 273-283.
https://doi.org/10.2298/VETGL1204273S

Stevanović J, Borozan S, Božić T, Jović S, Đekić T, Dimitrijević B. Oxidative stress. in Veterinarski Glasnik. 2012;66(3-4):273-283.
doi:10.2298/VETGL1204273S .

Stevanović, Jelka, Borozan, Sunčica, Božić, Tatjana, Jović, Slavoljub, Đekić, Tatjana, Dimitrijević, Blagoje, "Oxidative stress" in Veterinarski Glasnik, 66, no. 3-4 (2012):273-283,
https://doi.org/10.2298/VETGL1204273S . .

TY  - JOUR
AU  - Dimitrijević, Blagoje
AU  - Borozan, Sunčica
AU  - Stojanović, Srđan
PY  - 2012
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/935
AB  - In this study we have described the pi-pi and cation-pi interactions between the porphyrin ring and the protein part of porphyrin-containing proteins to better understand their stabilizing role. The number of pi-pi interactions was higher than that of cation-pi interactions in the same set of proteins studied. The pyrrole groups of one porphyrin can be involved in pi-pi interactions with pi systems of another porphyrin in the protein. We have found 5.1% cation-pi interactions between porphyrin Fe2+ metal cations and pi systems of surrounding amino acids as well as the pyrrole rings of other porphyrins. We observed that most of the pi-pi interactions have an energy in the range -0.5 to -2.0 kcal mol(-1), while the cation-pi interactions showed an energy in the range 22 to -4 kcal mol(-1). Further, an appreciable number of metal/cation-pi interaction pairs have an energy in the range -6 to -13 kcal mol(-1). The preferred parallel-stacked orientation is found to be more stable than a T-shaped structure for the full set of pi-pi interaction pairs. In the case of cation-pi interactions, it was found that 44% of the cation-pi interactions involved planar stacking, 37% of the interactions belonged to the oblique category, and the remaining 19% of the interactions were of the orthogonal type. The separation distance between the cation group and the aromatic ring decreases as the interplanar angle decreases. Furthermore, in the present study we have found that 10.4% of pi residues and 3.9% of cationic residues were found to have one or more stabilization centers. Amino acids deployed in the environment of porphyrin rings are deposited in helices and coils. The results from this study might be used for structure-based porphyrin protein prediction and as scaffolds for future porphyrin-containing protein design.
PB  - Royal Soc Chemistry, Cambridge
T2  - RSC Advances
T1  - pi-pi and cation-pi interactions in protein-porphyrin complex crystal structures
VL  - 2
IS  - 33
SP  - 12963
EP  - 12972
DO  - 10.1039/c2ra21937a
ER  - 

@article{
author = "Dimitrijević, Blagoje and Borozan, Sunčica and Stojanović, Srđan",
year = "2012",
abstract = "In this study we have described the pi-pi and cation-pi interactions between the porphyrin ring and the protein part of porphyrin-containing proteins to better understand their stabilizing role. The number of pi-pi interactions was higher than that of cation-pi interactions in the same set of proteins studied. The pyrrole groups of one porphyrin can be involved in pi-pi interactions with pi systems of another porphyrin in the protein. We have found 5.1% cation-pi interactions between porphyrin Fe2+ metal cations and pi systems of surrounding amino acids as well as the pyrrole rings of other porphyrins. We observed that most of the pi-pi interactions have an energy in the range -0.5 to -2.0 kcal mol(-1), while the cation-pi interactions showed an energy in the range 22 to -4 kcal mol(-1). Further, an appreciable number of metal/cation-pi interaction pairs have an energy in the range -6 to -13 kcal mol(-1). The preferred parallel-stacked orientation is found to be more stable than a T-shaped structure for the full set of pi-pi interaction pairs. In the case of cation-pi interactions, it was found that 44% of the cation-pi interactions involved planar stacking, 37% of the interactions belonged to the oblique category, and the remaining 19% of the interactions were of the orthogonal type. The separation distance between the cation group and the aromatic ring decreases as the interplanar angle decreases. Furthermore, in the present study we have found that 10.4% of pi residues and 3.9% of cationic residues were found to have one or more stabilization centers. Amino acids deployed in the environment of porphyrin rings are deposited in helices and coils. The results from this study might be used for structure-based porphyrin protein prediction and as scaffolds for future porphyrin-containing protein design.",
publisher = "Royal Soc Chemistry, Cambridge",
journal = "RSC Advances",
title = "pi-pi and cation-pi interactions in protein-porphyrin complex crystal structures",
volume = "2",
number = "33",
pages = "12963-12972",
doi = "10.1039/c2ra21937a"
}

Dimitrijević, B., Borozan, S.,& Stojanović, S.. (2012). pi-pi and cation-pi interactions in protein-porphyrin complex crystal structures. in RSC Advances
Royal Soc Chemistry, Cambridge., 2(33), 12963-12972.
https://doi.org/10.1039/c2ra21937a

Dimitrijević B, Borozan S, Stojanović S. pi-pi and cation-pi interactions in protein-porphyrin complex crystal structures. in RSC Advances. 2012;2(33):12963-12972.
doi:10.1039/c2ra21937a .

Dimitrijević, Blagoje, Borozan, Sunčica, Stojanović, Srđan, "pi-pi and cation-pi interactions in protein-porphyrin complex crystal structures" in RSC Advances, 2, no. 33 (2012):12963-12972,
https://doi.org/10.1039/c2ra21937a . .

TY  - JOUR
AU  - Dimitrijević, Blagoje
AU  - Borozan, Sunčica
AU  - Katić-Radivojević, Sofija
AU  - Stojanović, Srđan
PY  - 2012
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/855
AB  - The objective of this study was to estimate and evaluate oxidative/nitrosative stress parameters in sheep infected with Strongyloides papillosus and after antihelminthic treatment with albendazole (ABZ). This parasite, especially during development stages can seriously damage parenchaematous organs during migration within the host. The presence of parasites leads to increased productions of reactive oxygen species (ROS) and reactive nitrogen species (RNS). It is also well known that certain drugs can be very harmful for the delicate oxidant-antioxidant equilibrium, provoking oxidative stress during their biotransformation. ABZ is a broad spectrum antihelminthic drug, frequently used in veterinary medicine for therapy of parasitic infections. The current research was performed on female Wurttemberg sheep (n = 48). The distribution of parasites in sheep was evaluated using the native smear coprological technique, by sedimentation and flotation methods, revealing the presence of S. papillosus. The degree of infection intensity per sheep was quantitatively established by the method of McMaster, the animals having been divided into three groups according to the intensity of infection; mild, moderate and high. The control group consisted of sheep negative to the parasites. After determining the type of parasite infection, the sheep were treated with ABZ, per orally, in single doses of 5 mg/kg per body weight. Sampling of feces for parasitological and blood for biochemical assaying was performed on the 0 and 21st day after treatment with ABZ. The oxidative stress parameters were measured for catalase activity (CAT), the red cell membrane damage by level of malondialdehyde (MDA), while carbonyl and thiol plasma protein group concentrations were used as indicators of the degree of protein oxidative modification. The activity of Cu,Zn-superoxide dismutase (SOD) and relative distribution of lactate dehydrogenase (LDH1-LDH5) activity were determined electrophoretically. The distribution of LDH isoenzymes in sheep moderately and highly infected with S. papillosus revealed that the parasite induced damage to the myocardial (LDH2), lung (LDH3) and liver cells (LDH5) in infected animals, while ABZ treatment only damaged liver cells (LDH5). The MDA concentration revealed that lipid peroxidation increased both in the presence of parasites and the antihelminthic formulation tested (p < 0.001) when compared to the control sheep, while the increase of carbonyl concentration (p < 0.001), as well as the observed decrease of thiol concentration (p < 0.001) indicated significant oxidative damage of plasma proteins in experimental sheep, when compared to the control animals. Our results indicate that S. papillosus induces oxidative/nitrosative stress in sheep. The antihelminthic treatment with ABZ further promotes the disbalance of oxidative-antioxidative equilibrium in all tested sheep.
PB  - Elsevier, Amsterdam
T2  - Veterinary Parasitology
T1  - Effects of infection intensity with Strongyloides papillosus and albendazole treatment on development of oxidative/nitrosative stress in sheep
VL  - 186
IS  - 3-4
SP  - 364
EP  - 375
DO  - 10.1016/j.vetpar.2011.11.017
ER  - 

@article{
author = "Dimitrijević, Blagoje and Borozan, Sunčica and Katić-Radivojević, Sofija and Stojanović, Srđan",
year = "2012",
abstract = "The objective of this study was to estimate and evaluate oxidative/nitrosative stress parameters in sheep infected with Strongyloides papillosus and after antihelminthic treatment with albendazole (ABZ). This parasite, especially during development stages can seriously damage parenchaematous organs during migration within the host. The presence of parasites leads to increased productions of reactive oxygen species (ROS) and reactive nitrogen species (RNS). It is also well known that certain drugs can be very harmful for the delicate oxidant-antioxidant equilibrium, provoking oxidative stress during their biotransformation. ABZ is a broad spectrum antihelminthic drug, frequently used in veterinary medicine for therapy of parasitic infections. The current research was performed on female Wurttemberg sheep (n = 48). The distribution of parasites in sheep was evaluated using the native smear coprological technique, by sedimentation and flotation methods, revealing the presence of S. papillosus. The degree of infection intensity per sheep was quantitatively established by the method of McMaster, the animals having been divided into three groups according to the intensity of infection; mild, moderate and high. The control group consisted of sheep negative to the parasites. After determining the type of parasite infection, the sheep were treated with ABZ, per orally, in single doses of 5 mg/kg per body weight. Sampling of feces for parasitological and blood for biochemical assaying was performed on the 0 and 21st day after treatment with ABZ. The oxidative stress parameters were measured for catalase activity (CAT), the red cell membrane damage by level of malondialdehyde (MDA), while carbonyl and thiol plasma protein group concentrations were used as indicators of the degree of protein oxidative modification. The activity of Cu,Zn-superoxide dismutase (SOD) and relative distribution of lactate dehydrogenase (LDH1-LDH5) activity were determined electrophoretically. The distribution of LDH isoenzymes in sheep moderately and highly infected with S. papillosus revealed that the parasite induced damage to the myocardial (LDH2), lung (LDH3) and liver cells (LDH5) in infected animals, while ABZ treatment only damaged liver cells (LDH5). The MDA concentration revealed that lipid peroxidation increased both in the presence of parasites and the antihelminthic formulation tested (p < 0.001) when compared to the control sheep, while the increase of carbonyl concentration (p < 0.001), as well as the observed decrease of thiol concentration (p < 0.001) indicated significant oxidative damage of plasma proteins in experimental sheep, when compared to the control animals. Our results indicate that S. papillosus induces oxidative/nitrosative stress in sheep. The antihelminthic treatment with ABZ further promotes the disbalance of oxidative-antioxidative equilibrium in all tested sheep.",
publisher = "Elsevier, Amsterdam",
journal = "Veterinary Parasitology",
title = "Effects of infection intensity with Strongyloides papillosus and albendazole treatment on development of oxidative/nitrosative stress in sheep",
volume = "186",
number = "3-4",
pages = "364-375",
doi = "10.1016/j.vetpar.2011.11.017"
}

Dimitrijević, B., Borozan, S., Katić-Radivojević, S.,& Stojanović, S.. (2012). Effects of infection intensity with Strongyloides papillosus and albendazole treatment on development of oxidative/nitrosative stress in sheep. in Veterinary Parasitology
Elsevier, Amsterdam., 186(3-4), 364-375.
https://doi.org/10.1016/j.vetpar.2011.11.017

Dimitrijević B, Borozan S, Katić-Radivojević S, Stojanović S. Effects of infection intensity with Strongyloides papillosus and albendazole treatment on development of oxidative/nitrosative stress in sheep. in Veterinary Parasitology. 2012;186(3-4):364-375.
doi:10.1016/j.vetpar.2011.11.017 .

Dimitrijević, Blagoje, Borozan, Sunčica, Katić-Radivojević, Sofija, Stojanović, Srđan, "Effects of infection intensity with Strongyloides papillosus and albendazole treatment on development of oxidative/nitrosative stress in sheep" in Veterinary Parasitology, 186, no. 3-4 (2012):364-375,
https://doi.org/10.1016/j.vetpar.2011.11.017 . .

TY  - JOUR
AU  - Šamanc, Horea
AU  - Milić, Nenad
AU  - Stojić, Velibor
AU  - Knežević, Dejan
AU  - Vujanac, Ivan
AU  - Dimitrijević, Blagoje
AU  - Nišavić, Jakov
AU  - Radojičić, Marina
PY  - 2009
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/648
AB  - A total of 92 samples of bovine blood serum were examined for the presence of antibodies against the bovine respiratory syncytial virus using indirect immunoenzyme probe - iELISA. Specific antibodies against the bovine respiratory syncytial virus (BRSV) were established in 46, or 50% blood serum samples. Investigations of the 92 blood serum samples of cattle for the presence of antibodies against the parainfluenza virus 3 (PI 3), revealed their presence in 77, or 83.69% of the samples, and the presence of antibodies against the bovine herpesvirus 1 (BHV 1) was established in 19, or 20.65% of the samples.
AB  - Ukupno je ispitano 92 uzorka krvnog seruma junadi na prisustvo antitela protiv goveđeg respiratornog sincicijalnog virusa primenom indirektne imunoenzimske probe - iELISA. Kod 46, odnosno 50% uzoraka krvnog seruma ustanovljena su specifična antitela protiv goveđeg respiratornog sincicijalnog virusa (BRSV). Ispitivanjem 92 uzorka krvnog seruma goveda na prisustvo antitela protiv virusa parainfluence 3 (PI 3) ustanovljeno je njihovo prisustvo kod 77, odnosno 83,69% uzoraka, a prisustvo antitela protiv goveđeg herpesvirusa 1 (BHV 1) ustanovljeno je kod 19, odnosno 20,65% uzoraka.
PB  - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
T2  - Veterinarski Glasnik
T1  - Establishing presence of antibodies against bovine respiratory syncytial virus (BRSV), parainfluenza virus 3 (PI3) and bovine herpesvirus 1 (BHV 1) in blood serum of cattle using indirect immunoenzyme probe
T1  - Utvrđivanje prisustva antitela protiv goveđeg respiratornog sincicijalnog virusa (BRSV), virusa parainfluence 3 (PI3) i goveđeg herpesvirusa 1 (BHV 1) u krvnom serumu junadi primenom indirektne imunoenzimske probe
VL  - 63
IS  - 3-4
SP  - 145
EP  - 152
DO  - 10.2298/VETGL0904145S
ER  - 

@article{
author = "Šamanc, Horea and Milić, Nenad and Stojić, Velibor and Knežević, Dejan and Vujanac, Ivan and Dimitrijević, Blagoje and Nišavić, Jakov and Radojičić, Marina",
year = "2009",
abstract = "A total of 92 samples of bovine blood serum were examined for the presence of antibodies against the bovine respiratory syncytial virus using indirect immunoenzyme probe - iELISA. Specific antibodies against the bovine respiratory syncytial virus (BRSV) were established in 46, or 50% blood serum samples. Investigations of the 92 blood serum samples of cattle for the presence of antibodies against the parainfluenza virus 3 (PI 3), revealed their presence in 77, or 83.69% of the samples, and the presence of antibodies against the bovine herpesvirus 1 (BHV 1) was established in 19, or 20.65% of the samples., Ukupno je ispitano 92 uzorka krvnog seruma junadi na prisustvo antitela protiv goveđeg respiratornog sincicijalnog virusa primenom indirektne imunoenzimske probe - iELISA. Kod 46, odnosno 50% uzoraka krvnog seruma ustanovljena su specifična antitela protiv goveđeg respiratornog sincicijalnog virusa (BRSV). Ispitivanjem 92 uzorka krvnog seruma goveda na prisustvo antitela protiv virusa parainfluence 3 (PI 3) ustanovljeno je njihovo prisustvo kod 77, odnosno 83,69% uzoraka, a prisustvo antitela protiv goveđeg herpesvirusa 1 (BHV 1) ustanovljeno je kod 19, odnosno 20,65% uzoraka.",
publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd",
journal = "Veterinarski Glasnik",
title = "Establishing presence of antibodies against bovine respiratory syncytial virus (BRSV), parainfluenza virus 3 (PI3) and bovine herpesvirus 1 (BHV 1) in blood serum of cattle using indirect immunoenzyme probe, Utvrđivanje prisustva antitela protiv goveđeg respiratornog sincicijalnog virusa (BRSV), virusa parainfluence 3 (PI3) i goveđeg herpesvirusa 1 (BHV 1) u krvnom serumu junadi primenom indirektne imunoenzimske probe",
volume = "63",
number = "3-4",
pages = "145-152",
doi = "10.2298/VETGL0904145S"
}

Šamanc, H., Milić, N., Stojić, V., Knežević, D., Vujanac, I., Dimitrijević, B., Nišavić, J.,& Radojičić, M.. (2009). Establishing presence of antibodies against bovine respiratory syncytial virus (BRSV), parainfluenza virus 3 (PI3) and bovine herpesvirus 1 (BHV 1) in blood serum of cattle using indirect immunoenzyme probe. in Veterinarski Glasnik
Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 63(3-4), 145-152.
https://doi.org/10.2298/VETGL0904145S

Šamanc H, Milić N, Stojić V, Knežević D, Vujanac I, Dimitrijević B, Nišavić J, Radojičić M. Establishing presence of antibodies against bovine respiratory syncytial virus (BRSV), parainfluenza virus 3 (PI3) and bovine herpesvirus 1 (BHV 1) in blood serum of cattle using indirect immunoenzyme probe. in Veterinarski Glasnik. 2009;63(3-4):145-152.
doi:10.2298/VETGL0904145S .

Šamanc, Horea, Milić, Nenad, Stojić, Velibor, Knežević, Dejan, Vujanac, Ivan, Dimitrijević, Blagoje, Nišavić, Jakov, Radojičić, Marina, "Establishing presence of antibodies against bovine respiratory syncytial virus (BRSV), parainfluenza virus 3 (PI3) and bovine herpesvirus 1 (BHV 1) in blood serum of cattle using indirect immunoenzyme probe" in Veterinarski Glasnik, 63, no. 3-4 (2009):145-152,
https://doi.org/10.2298/VETGL0904145S . .