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Prikaz rezultata 11-16 od 16
Examination of 8-CI-cAMP genotoxicity by two in vivo test in BALB/c strain mice / Ispitivanje genotoksičnosti 8-CI-cAMP u dva in vivo testa na miševima soja BALB/c
(Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd, 2000)
The antitumor agent 8-CI-cAMP (8-chloro-cyclic adenosine monophosphate) is the most potent site-selective analogue of cAMP. It acts primarily by selective down-regulation of regulatory sub-units of cAMP-dependent protein ...
Assessment of adrenaline-induced DNA damage in whole blood cells with the comet assay
(Inst Medical Research & Occupational Health, Zagreb, 2018)
Harmful effects of elevated levels of catecholamines are mediated by various mechanisms, including gene transcription and formation of oxidation products. The aim of this study was to see whether the molecular mechanisms ...
Evaluation of the genotoxic effects of thyroxine using in vivo cytogenetic test on Swiss albino mice / Evaluacija genotoksičnih efekata tiroksina primenom in vivo citogenetičkog testa na Swiss albino miševima
(Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd, 2007)
Thyroid hormones enhance aerobic metabolism favoring oxidative stress which may lead to covalent damage of various molecules including DNA. Previous investigations revealed that thyroid hormones induce DNA damage on human ...
The genotoxic effects of alphachlorhydrin in BALB/C laboratory mice
(Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd, 1999)
The genotoxic properties of different doses (7,5, 15 and 30 mg/kg body mass) of alphachlorchydrin were investigated in vivo in BALB/C mice and in vitro using cell cultures. Thus, mouse bone marrow cells were examined after ...
Fumagillin-induced chromosome aberrations in mouse bone-marrow cells / Hromozomske aberacije prouzrokovane fumagilinom u ćelijama kostne srži miša
(Srpsko biološko društvo, Beograd, i dr., 2010)
The genotoxicity of fumagillin was evaluated assessing the mitotic index and chromosome aberrations in mouse bone-marrow cells. Mice were given fumagillin orally in doses 5, 10 and 20 mg/kg bw. All doses significantly (p ...
Chromosome aberrations produced by mestranol in human lymphocyte cultures
(Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd, 2019)
In this investigation, the genotoxic properties of mestranol were examined in vitro. Human lymphocyte cultures were exposed for 72 h to mestranol at concentrations of 7.5, 15 and 30 mu g/g. The genotoxic effects of the ...