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Genotoxicity potential of 8-Cl-cyclic adenosine monophosphate assessed with cytogenetic tests in vivo
(Elsevier Science Inc, New York, 2004)
Background. Growth-modulating noncytotoxic activity of 8-chloro-adenosine 3,5-cyclic monophosphate (8-Cl-cAMP) showed inhibitory effect on growth of a wide variety of cancer cell lines in vitro and in vivo. To assess ...
The effect of different acute concentrations of cadmium chloride on the frequency of micronuclei in AO rats / Efekat različitih akutnih koncentracija kadmijum-hlorida na učestalost mikronukleusa kod pacova AO soja
(Društvo genetičara Srbije, Beograd, 2013)
Cadmium (Cd) is highly toxic heavy metal which may cause severe biological effects in vivo and in vitro. In this study, an evaluation of the acute Cd ability to trigger micronuclei (MNi) formation was carried out on ...
Genotoxicity of the anticoccidial agent salinomycin
(Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd, 1998)
This report presents an analysis of genotoxic effects of the ionophoric antibiotic salinomycin commonly used in the control of coccidiosis. Mutagenic properties were determined, after application of increasing doses to ...
Chromosome aberrations produced by mestranol in human lymphocyte cultures
(Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd, 2019)
In this investigation, the genotoxic properties of mestranol were examined in vitro. Human lymphocyte cultures were exposed for 72 h to mestranol at concentrations of 7.5, 15 and 30 mu g/g. The genotoxic effects of the ...
Evaluation of the genotoxic effects of thyroxine using in vivo cytogenetic test on Swiss albino mice / Evaluacija genotoksičnih efekata tiroksina primenom in vivo citogenetičkog testa na Swiss albino miševima
(Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd, 2007)
Thyroid hormones enhance aerobic metabolism favoring oxidative stress which may lead to covalent damage of various molecules including DNA. Previous investigations revealed that thyroid hormones induce DNA damage on human ...
The genotoxic effects of alphachlorhydrin in BALB/C laboratory mice
(Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd, 1999)
The genotoxic properties of different doses (7,5, 15 and 30 mg/kg body mass) of alphachlorchydrin were investigated in vivo in BALB/C mice and in vitro using cell cultures. Thus, mouse bone marrow cells were examined after ...
Analysis of sister-chromatid exchanges in cultured human lymphocytes treated with cymiazole hydrochloride / Analiza razmene sestrinskih hromatida u kulturama limfocita čoveka tretiranih cimiazol hidrohloridom
(Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd, 2003)
Cymiazole hydrochloride is the active component of the acaricides Apitol® and Apichem®, which are used as varroacides in beekeeping. Considering that residues of cymiazole hydrochloride were detected in all bee products ...
Examination of Carbadox genotoxicity in vitro and in vivo / Ispitivanje genotoksičnog efekta Carbadoxa in vitro i in vivo
(Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd, 2000)
Due to its bactericidal activity Carbadox is used for treatment of swine dysentery and salmonellosis. Also, it can be used as a factor for growth stimulation. Carbadox is the only drug for certain health problems in swine ...
Effects of photopolymerisation on genotoxicity of composite adhesives in the comet assay
(Društvo genetičara Srbije, Beograd, 2016)
Certain in vivo studies have shown that the application of adhesives directly onto the open pulp or on a thin layer of dentin causes inflammation and pulpal abscesses. This reaction is related to toxic effects of monomers ...
Assessment of adrenaline-induced DNA damage in whole blood cells with the comet assay
(Inst Medical Research & Occupational Health, Zagreb, 2018)
Harmful effects of elevated levels of catecholamines are mediated by various mechanisms, including gene transcription and formation of oxidation products. The aim of this study was to see whether the molecular mechanisms ...