TY  - JOUR
AU  - Milanović, Zorana
AU  - Ilić Božović, Anja
AU  - Bojić-Trbojević, Žanka
AU  - Hajduković, Ljiljana
AU  - Francuski Andrić, Jelena
AU  - Kovačević Filipović, Milica
PY  - 2024
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/3631
AB  - Acute B. canis infection can lead to an acute phase reaction (APR) in dogs. The parasite invades red blood cells causing
anemia through immune-mediated hemolysis and possible erythropoietic suppression. A regenerative response of the
erythroid lineage during the babesiosis has not been described in extension. This research examines hematologic parameters
focusing on the absolute reticulocyte count and apolipoprotein A I (ApoA I) level on the day of admission and 14 days after
treatment with imidocarb-dipropionate in young (n=11) and adult (n=11) dogs naturally infected with B. canis. Metabolic
and inflammatory processes were characterized by analyzing protein and lipid profiles, as well as ApoA I at specified time
points. Automated analyzers were used to determine complete blood count and biochemical parameters, while ApoA I was
assessed using radioimmunoassay. The reticulocyte count was determined using a manual method by means of supravital
staining. Both young and adult dogs with acute B. canis infection showed non-regenerative anemia without difference.
Fourteen days after successful treatment with imidocarb-dipropionate, the anemia was corrected and a high reticulocyte
count was observed (p<0.05). This indicates that the erythroid regenerative response was efficient in young and adult dogs,
although vital signs, leukocyte count and triglyceride concentration suggest a more intense APR in young dogs. A decrease
in ApoA I in both groups 14 days after treatment (p<0.01) confirmed that this lipoprotein acts as a positive acute-phase
protein in acute B. canis infection in dogs, but further studies are needed to connect its role in erythroid lineage regeneration.
PB  - Saints Cyril and Methodius University of Skopje, Faculty of Veterinary Medicine
T2  - Macedonian Veterinary Review
T1  - Reticulocyte response in paired blood samples of Babesia canis infected young and adult dogs
VL  - 47
IS  - 1
DO  - 10.2478/macvetrev-2024-0011
ER  - 

@article{
author = "Milanović, Zorana and Ilić Božović, Anja and Bojić-Trbojević, Žanka and Hajduković, Ljiljana and Francuski Andrić, Jelena and Kovačević Filipović, Milica",
year = "2024",
abstract = "Acute B. canis infection can lead to an acute phase reaction (APR) in dogs. The parasite invades red blood cells causing
anemia through immune-mediated hemolysis and possible erythropoietic suppression. A regenerative response of the
erythroid lineage during the babesiosis has not been described in extension. This research examines hematologic parameters
focusing on the absolute reticulocyte count and apolipoprotein A I (ApoA I) level on the day of admission and 14 days after
treatment with imidocarb-dipropionate in young (n=11) and adult (n=11) dogs naturally infected with B. canis. Metabolic
and inflammatory processes were characterized by analyzing protein and lipid profiles, as well as ApoA I at specified time
points. Automated analyzers were used to determine complete blood count and biochemical parameters, while ApoA I was
assessed using radioimmunoassay. The reticulocyte count was determined using a manual method by means of supravital
staining. Both young and adult dogs with acute B. canis infection showed non-regenerative anemia without difference.
Fourteen days after successful treatment with imidocarb-dipropionate, the anemia was corrected and a high reticulocyte
count was observed (p<0.05). This indicates that the erythroid regenerative response was efficient in young and adult dogs,
although vital signs, leukocyte count and triglyceride concentration suggest a more intense APR in young dogs. A decrease
in ApoA I in both groups 14 days after treatment (p<0.01) confirmed that this lipoprotein acts as a positive acute-phase
protein in acute B. canis infection in dogs, but further studies are needed to connect its role in erythroid lineage regeneration.",
publisher = "Saints Cyril and Methodius University of Skopje, Faculty of Veterinary Medicine",
journal = "Macedonian Veterinary Review",
title = "Reticulocyte response in paired blood samples of Babesia canis infected young and adult dogs",
volume = "47",
number = "1",
doi = "10.2478/macvetrev-2024-0011"
}

Milanović, Z., Ilić Božović, A., Bojić-Trbojević, Ž., Hajduković, L., Francuski Andrić, J.,& Kovačević Filipović, M.. (2024). Reticulocyte response in paired blood samples of Babesia canis infected young and adult dogs. in Macedonian Veterinary Review
Saints Cyril and Methodius University of Skopje, Faculty of Veterinary Medicine., 47(1).
https://doi.org/10.2478/macvetrev-2024-0011

Milanović Z, Ilić Božović A, Bojić-Trbojević Ž, Hajduković L, Francuski Andrić J, Kovačević Filipović M. Reticulocyte response in paired blood samples of Babesia canis infected young and adult dogs. in Macedonian Veterinary Review. 2024;47(1).
doi:10.2478/macvetrev-2024-0011 .

Milanović, Zorana, Ilić Božović, Anja, Bojić-Trbojević, Žanka, Hajduković, Ljiljana, Francuski Andrić, Jelena, Kovačević Filipović, Milica, "Reticulocyte response in paired blood samples of Babesia canis infected young and adult dogs" in Macedonian Veterinary Review, 47, no. 1 (2024),
https://doi.org/10.2478/macvetrev-2024-0011 . .

TY  - JOUR
AU  - Ilić, Milica
AU  - Ivković, Maša
AU  - Radaković, Milena
AU  - Spariosu, Kristina
AU  - Andrić, Nenad
AU  - Kovačević Filipović, Milica
AU  - Beletić, Anđelo
AU  - Francuski Andrić, Jelena
PY  - 2023
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/3254
AB  - Red blood cell osmotic fragility (RBCOF) refers to susceptibility to hemolysis in
vivo and in vitro. An increase in mean cellular hemoglobin concentration (MCHC)
also reflects in vivo and in vitro hemolysis. Common inflammatory infectious
diseases in dogs are often characterized by an increase in MCHC; however, it is
not known if there is a concomitant increase in RBCOF. The objective of this
study was to determine RBCOF in dogs with babesiosis, dirofilariosis,
parvovirosis, pyometra, and canine distemper and to investigate whether RBCOF
correlates with routine hematologic and biochemical parameters and lipoprotein
fractions. The diagnosis of canine infectious disease was made and complete
blood count, serum biochemical profiles, and lipoprotein electrophoresis were
determined according to current institutional protocols. RBCOF of healthy
control (n=8) and infected dogs (n=73) was measured with a phosphate-buffered
saline dilution test, and mean corpuscular fragility (MCF) was calculated. MCF
was increased in dirofilariosis, pyometra, and distemper; MCHC was increased
in all infected groups; HDL was decreased in babesiosis, pyometra, and
distemper compared with healthy controls. However, no correlation was found
between these parameters. On the other hand, hematological and biochemical
parameters, that are highly predictive of specific infections, correlated with MCF:
ALP for babesiosis (r=0.415, P=0.035), urea (r=-0.488, P=0.034) for
dirofilariosis, and leukocyte count (r=-0.820, P=0.046) for pyometra. Although
elevated MCHC levels in all samples from infected dogs indicate hemolysis,
RBCOF was elevated only in dirofilariosis, pyometra, and canine distemper,
leading to the conclusion that these apparently related phenomena are controlled
by different mechanisms.
PB  - Faculty of Veterinary Science, University of Agriculture, Faisalabad, Pakistan
T2  - Pakistan Veterinary Journal
T1  - Association of increased osmotic fragility of red blood cells with common systemic inflammatory diseases in dogs
VL  - 43
IS  - 3
SP  - 463
EP  - 469
DO  - 10.29261/pakvetj/2023.048
ER  - 

@article{
author = "Ilić, Milica and Ivković, Maša and Radaković, Milena and Spariosu, Kristina and Andrić, Nenad and Kovačević Filipović, Milica and Beletić, Anđelo and Francuski Andrić, Jelena",
year = "2023",
abstract = "Red blood cell osmotic fragility (RBCOF) refers to susceptibility to hemolysis in
vivo and in vitro. An increase in mean cellular hemoglobin concentration (MCHC)
also reflects in vivo and in vitro hemolysis. Common inflammatory infectious
diseases in dogs are often characterized by an increase in MCHC; however, it is
not known if there is a concomitant increase in RBCOF. The objective of this
study was to determine RBCOF in dogs with babesiosis, dirofilariosis,
parvovirosis, pyometra, and canine distemper and to investigate whether RBCOF
correlates with routine hematologic and biochemical parameters and lipoprotein
fractions. The diagnosis of canine infectious disease was made and complete
blood count, serum biochemical profiles, and lipoprotein electrophoresis were
determined according to current institutional protocols. RBCOF of healthy
control (n=8) and infected dogs (n=73) was measured with a phosphate-buffered
saline dilution test, and mean corpuscular fragility (MCF) was calculated. MCF
was increased in dirofilariosis, pyometra, and distemper; MCHC was increased
in all infected groups; HDL was decreased in babesiosis, pyometra, and
distemper compared with healthy controls. However, no correlation was found
between these parameters. On the other hand, hematological and biochemical
parameters, that are highly predictive of specific infections, correlated with MCF:
ALP for babesiosis (r=0.415, P=0.035), urea (r=-0.488, P=0.034) for
dirofilariosis, and leukocyte count (r=-0.820, P=0.046) for pyometra. Although
elevated MCHC levels in all samples from infected dogs indicate hemolysis,
RBCOF was elevated only in dirofilariosis, pyometra, and canine distemper,
leading to the conclusion that these apparently related phenomena are controlled
by different mechanisms.",
publisher = "Faculty of Veterinary Science, University of Agriculture, Faisalabad, Pakistan",
journal = "Pakistan Veterinary Journal",
title = "Association of increased osmotic fragility of red blood cells with common systemic inflammatory diseases in dogs",
volume = "43",
number = "3",
pages = "463-469",
doi = "10.29261/pakvetj/2023.048"
}

Ilić, M., Ivković, M., Radaković, M., Spariosu, K., Andrić, N., Kovačević Filipović, M., Beletić, A.,& Francuski Andrić, J.. (2023). Association of increased osmotic fragility of red blood cells with common systemic inflammatory diseases in dogs. in Pakistan Veterinary Journal
Faculty of Veterinary Science, University of Agriculture, Faisalabad, Pakistan., 43(3), 463-469.
https://doi.org/10.29261/pakvetj/2023.048

Ilić M, Ivković M, Radaković M, Spariosu K, Andrić N, Kovačević Filipović M, Beletić A, Francuski Andrić J. Association of increased osmotic fragility of red blood cells with common systemic inflammatory diseases in dogs. in Pakistan Veterinary Journal. 2023;43(3):463-469.
doi:10.29261/pakvetj/2023.048 .

Ilić, Milica, Ivković, Maša, Radaković, Milena, Spariosu, Kristina, Andrić, Nenad, Kovačević Filipović, Milica, Beletić, Anđelo, Francuski Andrić, Jelena, "Association of increased osmotic fragility of red blood cells with common systemic inflammatory diseases in dogs" in Pakistan Veterinary Journal, 43, no. 3 (2023):463-469,
https://doi.org/10.29261/pakvetj/2023.048 . .

TY  - CONF
AU  - Kovačević Filipović, Milica
AU  - Francuski Andrić, Jelena
AU  - Ilić Božović, Anja
AU  - Milčić Matić, Natalija
PY  - 2023
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/3310
AB  - Tankoigledna biopsija je sigurna i brza metoda koja je laka za izođenje.
Preporučuje se kao dijagnostička metoda za sve uvećane limfne čvorove, bilo da
se radi o uni- ili multicentričnim promenama kao i za sve kutane i subkutane
mase. Osim tankoiglene biopsije, po ekstirpaciji limfnog čvora, sa njegovog
preseka se može uraditi preparat – otisak.
Citološkim pregledom limfnog čvora se može utvrditi da li postoji
reaktivna hiperplazija, inflamatorne promena u tipu limfadenitisa, primarna
neoplazija limfnog čvora, infiltracija metastatskim tumorskim ćelijama ili
ekstramedularna hematopoeza.
Svaka od navedenih patoloških promena ima određene citološke
karakteristike. Preparat se pregleda na malom uveličanju da bi se uočila
celularnost, raspored ćelija, eventualne metastatske ćelije i optimalno mesto za
pregled. Potrebno je prepoznati tip pozadinskog (engl. background) materijala
primenjujući prvo malo, a potom i veliko uveličanje. To je materijal koji ne
predstavlja patološke ćelije ispitivanog tkiva/mase, već eritrocite koji dospevaju
na preparat oštećenjem krvnih sudova prilikom pravljenja preparata i/ili
ekstracelularni matriks, i/ili specifičan ekstraćelijski materijal koji može biti
tipičan za određeno tkivo i patološku promenu. Na primer, limfoglandularna
telašca predstavljaju delimično razložene delove apoptotičnih limfocita,
karakterističnog su izgleda i javljaju se u većem broju kod limfoma. Potom,
citološki nalaz uključuje prepoznavanje i opis tipova ćelija koje se vide, njihovu
morfologiju i međusobni odnos.
Osnovna pravila prilikom primene tankoiglene biopsije u pravljenju i
tumačenju citoloških preparata limfnih čvorova su sledeća: treba izbegavati da se
analiziraju submandibularni limfni čvorovi koji vrlo često imaju reaktivne promene. Ukoliko postoji generalizovana limfadenopatija treba uzeti uzorke iz
najmanje dva ili svih limfnih čvorova. Igla promera 22G treba da bude plasirana u
nekoliko pravaca i tangencionalno u odnosu na centar limfnog čvora. Kao
problem se može javiti aspiracija tkiva mimo limfnog čvora, a u
submandibularnom regionu su to često pljuvačne žlezde. Takođe, limitacija
citološke dijagnostike postoji kod sitnoćelijskih limfoma mačaka kada su limfociti
dobro diferencirani ili u slučaju fokalne distribucije metastaza. Stepen slaganja u
dijagnostici i prognozi citoloških interpretacija u odnosu na patohistološke zavisi
od tipa limfoma ili metastatske promene.
Kožni ili potkožni noduli su relativno česti problemi kod pasa i mačaka i
mogu imati različitu etiologiju. Dijagnostički pristup se sastoji od uzimanja
detaljne istorije bolesti, pre svega da li je promena nastala naglo ili je prisutna
duži vremenski period. Brzina rasta je takodje od velike važnosti, kao i sam
klinički izgled promene, kao i da li su dobro ograničene. Dubina lezije takođe
može biti od pomoći za izradu diferencijalne liste i dijagnostičkog plana. Ponovno
pojavljanje lezije u oblastima gde je izvršena operacija najčešće ukazuje na
neoplastičnu tvorevinu. Kod starijih pasa česte su potpuno benigne izrasline sa
karakterističnim izgledom. Pozitivan odgovor na antibiotike često ukazuje na
infektivnu etiologiju, ali ne isključuje mogućnost istovremenih bolesti kao što su
dermatomikoze ili tumori.
Prva diferencijacija u proceni nodula je da se utvrdi ili isključi postojanje
neoplastičnih promena za razliku od inflamatornih uzroka ili hiperplazije tkiva. U
te svrhe se koristi tankoiglena biopsija, kako bi se identifikovale prisutne ćelije. U
velikom broju slučajeva kliničar na osnovu mikroskopskog pregleda pripremljenih
pločica, može da proceni da li je u pitanju neoplazija, hiperplazija ili inflamatorni
proces. Na osnovu toga ili preuzima adekvatnu terapiju ili sprovodi dodatne
dijagnostičke postupke.
Sveobuhvatno gledano, sa pojedinim izuzecima, citologija predstavlja
brzu, jednostavnu i pouzdanu metodu za dijagnostiku inflamatornih i
neoplastičnih promena limfnih čvorova, kao i nodula na koži.
PB  - Beograd : Fakultet veterinarske medicine
C3  - 24. Regionalno savetovanje iz kliničke patologije i terapije malih životinja, Clinica veterinaria, Fruška gora, 8 - 10. jun 2023
T1  - Citologija u svakodnevnoj kliničkoj praksi (limfni čvorovi, kutane i subkutane mase)
VL  - 34
IS  - 33
UR  - https://hdl.handle.net/21.15107/rcub_veterinar_3310
ER  - 

@conference{
author = "Kovačević Filipović, Milica and Francuski Andrić, Jelena and Ilić Božović, Anja and Milčić Matić, Natalija",
year = "2023",
abstract = "Tankoigledna biopsija je sigurna i brza metoda koja je laka za izođenje.
Preporučuje se kao dijagnostička metoda za sve uvećane limfne čvorove, bilo da
se radi o uni- ili multicentričnim promenama kao i za sve kutane i subkutane
mase. Osim tankoiglene biopsije, po ekstirpaciji limfnog čvora, sa njegovog
preseka se može uraditi preparat – otisak.
Citološkim pregledom limfnog čvora se može utvrditi da li postoji
reaktivna hiperplazija, inflamatorne promena u tipu limfadenitisa, primarna
neoplazija limfnog čvora, infiltracija metastatskim tumorskim ćelijama ili
ekstramedularna hematopoeza.
Svaka od navedenih patoloških promena ima određene citološke
karakteristike. Preparat se pregleda na malom uveličanju da bi se uočila
celularnost, raspored ćelija, eventualne metastatske ćelije i optimalno mesto za
pregled. Potrebno je prepoznati tip pozadinskog (engl. background) materijala
primenjujući prvo malo, a potom i veliko uveličanje. To je materijal koji ne
predstavlja patološke ćelije ispitivanog tkiva/mase, već eritrocite koji dospevaju
na preparat oštećenjem krvnih sudova prilikom pravljenja preparata i/ili
ekstracelularni matriks, i/ili specifičan ekstraćelijski materijal koji može biti
tipičan za određeno tkivo i patološku promenu. Na primer, limfoglandularna
telašca predstavljaju delimično razložene delove apoptotičnih limfocita,
karakterističnog su izgleda i javljaju se u većem broju kod limfoma. Potom,
citološki nalaz uključuje prepoznavanje i opis tipova ćelija koje se vide, njihovu
morfologiju i međusobni odnos.
Osnovna pravila prilikom primene tankoiglene biopsije u pravljenju i
tumačenju citoloških preparata limfnih čvorova su sledeća: treba izbegavati da se
analiziraju submandibularni limfni čvorovi koji vrlo često imaju reaktivne promene. Ukoliko postoji generalizovana limfadenopatija treba uzeti uzorke iz
najmanje dva ili svih limfnih čvorova. Igla promera 22G treba da bude plasirana u
nekoliko pravaca i tangencionalno u odnosu na centar limfnog čvora. Kao
problem se može javiti aspiracija tkiva mimo limfnog čvora, a u
submandibularnom regionu su to često pljuvačne žlezde. Takođe, limitacija
citološke dijagnostike postoji kod sitnoćelijskih limfoma mačaka kada su limfociti
dobro diferencirani ili u slučaju fokalne distribucije metastaza. Stepen slaganja u
dijagnostici i prognozi citoloških interpretacija u odnosu na patohistološke zavisi
od tipa limfoma ili metastatske promene.
Kožni ili potkožni noduli su relativno česti problemi kod pasa i mačaka i
mogu imati različitu etiologiju. Dijagnostički pristup se sastoji od uzimanja
detaljne istorije bolesti, pre svega da li je promena nastala naglo ili je prisutna
duži vremenski period. Brzina rasta je takodje od velike važnosti, kao i sam
klinički izgled promene, kao i da li su dobro ograničene. Dubina lezije takođe
može biti od pomoći za izradu diferencijalne liste i dijagnostičkog plana. Ponovno
pojavljanje lezije u oblastima gde je izvršena operacija najčešće ukazuje na
neoplastičnu tvorevinu. Kod starijih pasa česte su potpuno benigne izrasline sa
karakterističnim izgledom. Pozitivan odgovor na antibiotike često ukazuje na
infektivnu etiologiju, ali ne isključuje mogućnost istovremenih bolesti kao što su
dermatomikoze ili tumori.
Prva diferencijacija u proceni nodula je da se utvrdi ili isključi postojanje
neoplastičnih promena za razliku od inflamatornih uzroka ili hiperplazije tkiva. U
te svrhe se koristi tankoiglena biopsija, kako bi se identifikovale prisutne ćelije. U
velikom broju slučajeva kliničar na osnovu mikroskopskog pregleda pripremljenih
pločica, može da proceni da li je u pitanju neoplazija, hiperplazija ili inflamatorni
proces. Na osnovu toga ili preuzima adekvatnu terapiju ili sprovodi dodatne
dijagnostičke postupke.
Sveobuhvatno gledano, sa pojedinim izuzecima, citologija predstavlja
brzu, jednostavnu i pouzdanu metodu za dijagnostiku inflamatornih i
neoplastičnih promena limfnih čvorova, kao i nodula na koži.",
publisher = "Beograd : Fakultet veterinarske medicine",
journal = "24. Regionalno savetovanje iz kliničke patologije i terapije malih životinja, Clinica veterinaria, Fruška gora, 8 - 10. jun 2023",
title = "Citologija u svakodnevnoj kliničkoj praksi (limfni čvorovi, kutane i subkutane mase)",
volume = "34",
number = "33",
url = "https://hdl.handle.net/21.15107/rcub_veterinar_3310"
}

Kovačević Filipović, M., Francuski Andrić, J., Ilić Božović, A.,& Milčić Matić, N.. (2023). Citologija u svakodnevnoj kliničkoj praksi (limfni čvorovi, kutane i subkutane mase). in 24. Regionalno savetovanje iz kliničke patologije i terapije malih životinja, Clinica veterinaria, Fruška gora, 8 - 10. jun 2023
Beograd : Fakultet veterinarske medicine., 34(33).
https://hdl.handle.net/21.15107/rcub_veterinar_3310

Kovačević Filipović M, Francuski Andrić J, Ilić Božović A, Milčić Matić N. Citologija u svakodnevnoj kliničkoj praksi (limfni čvorovi, kutane i subkutane mase). in 24. Regionalno savetovanje iz kliničke patologije i terapije malih životinja, Clinica veterinaria, Fruška gora, 8 - 10. jun 2023. 2023;34(33).
https://hdl.handle.net/21.15107/rcub_veterinar_3310 .

Kovačević Filipović, Milica, Francuski Andrić, Jelena, Ilić Božović, Anja, Milčić Matić, Natalija, "Citologija u svakodnevnoj kliničkoj praksi (limfni čvorovi, kutane i subkutane mase)" in 24. Regionalno savetovanje iz kliničke patologije i terapije malih životinja, Clinica veterinaria, Fruška gora, 8 - 10. jun 2023, 34, no. 33 (2023),
https://hdl.handle.net/21.15107/rcub_veterinar_3310 .

TY  - JOUR
AU  - Radaković, Milena
AU  - Francuski Andrić, Jelena
AU  - Spariosu, Kristina
AU  - Vejnović, Branislav
AU  - Kovačević Filipović, Milica
AU  - Andrić, Nenad
PY  - 2023
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/3391
AB  - Oxidative stress plays an important role in pathogenesis of idiopathic epilepsy (IE). Although IE is the most
common neurological condition, oxidant–antioxidant status in epileptic dogs is still unknown. The aim of this
study is to evaluate the serum oxidant-antioxidant status in dogs with newly diagnosed IE. The status in 15 dogs
with IE and 15 healthy dogs is estimated through spectrophotometric determination of two oxidant markers:
advanced oxidation protein products-albumin index (AOPP) and thiobarbituric acid reactive substances
(TBARS); and three antioxidant markers: total thiols (R-SH) level, glutathione (GSH) level, and paraoxonase-1
(PON-1) activity. Also, butyrylcholinesterase (BChE) activity is assessed in both groups of dogs. Higher AOPP
is observed in the dogs with newly diagnosed IE, while TBARS level shows no difference when compared to the
healthy dogs. In contrast, lower levels of antioxidants (R-SH, GSH, and PON-1) and BChE activity are found in the
dogs with IE. No significant differences are observed in the oxidant and antioxidant markers and BChE activity
across the investigated IE cases with focal and generalized seizures. Our findings provide evidence that dogs with
IE are characterized by an impaired serum oxidant–antioxidant balance and lower BChE activity, which may
contribute to a better understanding of IE pathogenesis.
PB  - Elsevier
T2  - Research in Veterinary Science
T1  - Serum oxidant–antioxidant status and butyrylcholinesterase activity in dogs with idiopathic epilepsy – A pilot study
VL  - 165
SP  - 105076
DO  - 10.1016/j.rvsc.2023.105076
ER  - 

@article{
author = "Radaković, Milena and Francuski Andrić, Jelena and Spariosu, Kristina and Vejnović, Branislav and Kovačević Filipović, Milica and Andrić, Nenad",
year = "2023",
abstract = "Oxidative stress plays an important role in pathogenesis of idiopathic epilepsy (IE). Although IE is the most
common neurological condition, oxidant–antioxidant status in epileptic dogs is still unknown. The aim of this
study is to evaluate the serum oxidant-antioxidant status in dogs with newly diagnosed IE. The status in 15 dogs
with IE and 15 healthy dogs is estimated through spectrophotometric determination of two oxidant markers:
advanced oxidation protein products-albumin index (AOPP) and thiobarbituric acid reactive substances
(TBARS); and three antioxidant markers: total thiols (R-SH) level, glutathione (GSH) level, and paraoxonase-1
(PON-1) activity. Also, butyrylcholinesterase (BChE) activity is assessed in both groups of dogs. Higher AOPP
is observed in the dogs with newly diagnosed IE, while TBARS level shows no difference when compared to the
healthy dogs. In contrast, lower levels of antioxidants (R-SH, GSH, and PON-1) and BChE activity are found in the
dogs with IE. No significant differences are observed in the oxidant and antioxidant markers and BChE activity
across the investigated IE cases with focal and generalized seizures. Our findings provide evidence that dogs with
IE are characterized by an impaired serum oxidant–antioxidant balance and lower BChE activity, which may
contribute to a better understanding of IE pathogenesis.",
publisher = "Elsevier",
journal = "Research in Veterinary Science",
title = "Serum oxidant–antioxidant status and butyrylcholinesterase activity in dogs with idiopathic epilepsy – A pilot study",
volume = "165",
pages = "105076",
doi = "10.1016/j.rvsc.2023.105076"
}

Radaković, M., Francuski Andrić, J., Spariosu, K., Vejnović, B., Kovačević Filipović, M.,& Andrić, N.. (2023). Serum oxidant–antioxidant status and butyrylcholinesterase activity in dogs with idiopathic epilepsy – A pilot study. in Research in Veterinary Science
Elsevier., 165, 105076.
https://doi.org/10.1016/j.rvsc.2023.105076

Radaković M, Francuski Andrić J, Spariosu K, Vejnović B, Kovačević Filipović M, Andrić N. Serum oxidant–antioxidant status and butyrylcholinesterase activity in dogs with idiopathic epilepsy – A pilot study. in Research in Veterinary Science. 2023;165:105076.
doi:10.1016/j.rvsc.2023.105076 .

Radaković, Milena, Francuski Andrić, Jelena, Spariosu, Kristina, Vejnović, Branislav, Kovačević Filipović, Milica, Andrić, Nenad, "Serum oxidant–antioxidant status and butyrylcholinesterase activity in dogs with idiopathic epilepsy – A pilot study" in Research in Veterinary Science, 165 (2023):105076,
https://doi.org/10.1016/j.rvsc.2023.105076 . .

TY  - JOUR
AU  - Kopilović, Aleksandar
AU  - Gvozdić, Dragan
AU  - Radaković, Milena
AU  - Spariosu, Kristina
AU  - Andrić, Nenad
AU  - Francuski Andrić, Jelena
PY  - 2023
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/3442
AB  - In veterinary medicine, knowledge about hematologic ratios (neutrophil-to-lymphocyte
ratio (NLR), platelet-to-lymphocyte ratio (PLR) and mean platelet volume-to-platelet
ratio (MPV/PLT)) is limited, particularly in cats. While the roles of these ratios have
been proven in oncology, systemic inflammation with or without systemic inflammatory
response syndrome (SIRS), and sepsis, information is lacking about their alterations in
non-septic effusions, like feline infectious peritonitis (FIP).
This study aimed to describe whether NLR, PLR, and MPV/PLT were changed and
whether they correlated with routine hematologic and biochemical parameters in 16
cats with non-septic effusions, highly suspected to be the effusive form of FIP without
SIRS, compared to nine clinically healthy cats.
The NLR was calculated as the absolute count of neutrophils divided by the absolute
count of lymphocytes, PLR by calculating the absolute platelet divided by the absolute
lymphocyte count, and MPV/PLT by dividing mean platelet volume by absolute platelet
count.
The NLR, MPV, and MPV/PLT ratios were higher in cats with non-septic effusions
suspected to be FIP, but PLR did not differ, when compared to healthy cats. Correlation analysis did not show any association between the selected ratios and hematological and
biochemical parameters.
In the absence of leukocytosis, increased NLR could help us to confirm the presence
of systemic inflammation in cats with non-septic effusions indicative of FIP. However,
a high MPV/PLT ratio should be interpreted with caution, especially in cats.
PB  - Beograd : Fakultet veterinarske medicine
T2  - Veterinarski Glasnik
T1  - Selected hematology ratios in cats with non-septic effusions highly suspected of feline infectious peritonitis
VL  - 77
IS  - 2
SP  - 164
EP  - 175
DO  - 10.2298/VETGL230710008K
ER  - 

@article{
author = "Kopilović, Aleksandar and Gvozdić, Dragan and Radaković, Milena and Spariosu, Kristina and Andrić, Nenad and Francuski Andrić, Jelena",
year = "2023",
abstract = "In veterinary medicine, knowledge about hematologic ratios (neutrophil-to-lymphocyte
ratio (NLR), platelet-to-lymphocyte ratio (PLR) and mean platelet volume-to-platelet
ratio (MPV/PLT)) is limited, particularly in cats. While the roles of these ratios have
been proven in oncology, systemic inflammation with or without systemic inflammatory
response syndrome (SIRS), and sepsis, information is lacking about their alterations in
non-septic effusions, like feline infectious peritonitis (FIP).
This study aimed to describe whether NLR, PLR, and MPV/PLT were changed and
whether they correlated with routine hematologic and biochemical parameters in 16
cats with non-septic effusions, highly suspected to be the effusive form of FIP without
SIRS, compared to nine clinically healthy cats.
The NLR was calculated as the absolute count of neutrophils divided by the absolute
count of lymphocytes, PLR by calculating the absolute platelet divided by the absolute
lymphocyte count, and MPV/PLT by dividing mean platelet volume by absolute platelet
count.
The NLR, MPV, and MPV/PLT ratios were higher in cats with non-septic effusions
suspected to be FIP, but PLR did not differ, when compared to healthy cats. Correlation analysis did not show any association between the selected ratios and hematological and
biochemical parameters.
In the absence of leukocytosis, increased NLR could help us to confirm the presence
of systemic inflammation in cats with non-septic effusions indicative of FIP. However,
a high MPV/PLT ratio should be interpreted with caution, especially in cats.",
publisher = "Beograd : Fakultet veterinarske medicine",
journal = "Veterinarski Glasnik",
title = "Selected hematology ratios in cats with non-septic effusions highly suspected of feline infectious peritonitis",
volume = "77",
number = "2",
pages = "164-175",
doi = "10.2298/VETGL230710008K"
}

Kopilović, A., Gvozdić, D., Radaković, M., Spariosu, K., Andrić, N.,& Francuski Andrić, J.. (2023). Selected hematology ratios in cats with non-septic effusions highly suspected of feline infectious peritonitis. in Veterinarski Glasnik
Beograd : Fakultet veterinarske medicine., 77(2), 164-175.
https://doi.org/10.2298/VETGL230710008K

Kopilović A, Gvozdić D, Radaković M, Spariosu K, Andrić N, Francuski Andrić J. Selected hematology ratios in cats with non-septic effusions highly suspected of feline infectious peritonitis. in Veterinarski Glasnik. 2023;77(2):164-175.
doi:10.2298/VETGL230710008K .

Kopilović, Aleksandar, Gvozdić, Dragan, Radaković, Milena, Spariosu, Kristina, Andrić, Nenad, Francuski Andrić, Jelena, "Selected hematology ratios in cats with non-septic effusions highly suspected of feline infectious peritonitis" in Veterinarski Glasnik, 77, no. 2 (2023):164-175,
https://doi.org/10.2298/VETGL230710008K . .

TY  - CONF
AU  - Kovačević-Filipović, Milica
AU  - Spariosu, Kristina
AU  - Janjić, Filip
AU  - Radaković, Milena
AU  - Ilić Božović, Anja
AU  - Davitkov, Darko
AU  - Francuski Andrić, Jelena
PY  - 2022
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/2501
AB  - Prema mehanizmu nastanka, anemije se klasifikuju na
hemoličke i hemoragijske i anemije koje nastaju usled
poremećaja na nivou kostne srži. Hemoličke i hemoragijske
anemije su najčešće praćene ubrzanom eritropoezom i jakim
regenerativnim odgovorom, koji se ogleda u značajnom
porastu broja retikulocita. Suprotno, poremećaji na nivou
kostne srži, koji najčešće uključuju različite oblike
imunosupresije, inhibiciju proliferacije eritroidnih progenitora
i/ili nedostatak nutritivnih faktora, dijagnostikuju se kao
neregenerativne anemije, koje se analizom krvne slike
prepoznaju na osnovu relativno malog broja retikulocita.
PB  - Fakultet veterinarske medicine Univerziteta u Beogradu
C3  - Clinica veterinaria zbornik predavanja Dvadeset trećeg regionalnog savetovanja iz kliničke patologije i terapije malih životinja, Fruška gora, 09-11. jun
T1  - Kliničko-patološki pristup dijagnostici anemija različite etiologije
SP  - 27
SP  - 29
EP  - 31
UR  - https://hdl.handle.net/21.15107/rcub_veterinar_2501
ER  - 

@conference{
author = "Kovačević-Filipović, Milica and Spariosu, Kristina and Janjić, Filip and Radaković, Milena and Ilić Božović, Anja and Davitkov, Darko and Francuski Andrić, Jelena",
year = "2022",
abstract = "Prema mehanizmu nastanka, anemije se klasifikuju na
hemoličke i hemoragijske i anemije koje nastaju usled
poremećaja na nivou kostne srži. Hemoličke i hemoragijske
anemije su najčešće praćene ubrzanom eritropoezom i jakim
regenerativnim odgovorom, koji se ogleda u značajnom
porastu broja retikulocita. Suprotno, poremećaji na nivou
kostne srži, koji najčešće uključuju različite oblike
imunosupresije, inhibiciju proliferacije eritroidnih progenitora
i/ili nedostatak nutritivnih faktora, dijagnostikuju se kao
neregenerativne anemije, koje se analizom krvne slike
prepoznaju na osnovu relativno malog broja retikulocita.",
publisher = "Fakultet veterinarske medicine Univerziteta u Beogradu",
journal = "Clinica veterinaria zbornik predavanja Dvadeset trećeg regionalnog savetovanja iz kliničke patologije i terapije malih životinja, Fruška gora, 09-11. jun",
title = "Kliničko-patološki pristup dijagnostici anemija različite etiologije",
pages = "27-29-31",
url = "https://hdl.handle.net/21.15107/rcub_veterinar_2501"
}

Kovačević-Filipović, M., Spariosu, K., Janjić, F., Radaković, M., Ilić Božović, A., Davitkov, D.,& Francuski Andrić, J.. (2022). Kliničko-patološki pristup dijagnostici anemija različite etiologije. in Clinica veterinaria zbornik predavanja Dvadeset trećeg regionalnog savetovanja iz kliničke patologije i terapije malih životinja, Fruška gora, 09-11. jun
Fakultet veterinarske medicine Univerziteta u Beogradu., 27-31.
https://hdl.handle.net/21.15107/rcub_veterinar_2501

Kovačević-Filipović M, Spariosu K, Janjić F, Radaković M, Ilić Božović A, Davitkov D, Francuski Andrić J. Kliničko-patološki pristup dijagnostici anemija različite etiologije. in Clinica veterinaria zbornik predavanja Dvadeset trećeg regionalnog savetovanja iz kliničke patologije i terapije malih životinja, Fruška gora, 09-11. jun. 2022;:27-31.
https://hdl.handle.net/21.15107/rcub_veterinar_2501 .

Kovačević-Filipović, Milica, Spariosu, Kristina, Janjić, Filip, Radaković, Milena, Ilić Božović, Anja, Davitkov, Darko, Francuski Andrić, Jelena, "Kliničko-patološki pristup dijagnostici anemija različite etiologije" in Clinica veterinaria zbornik predavanja Dvadeset trećeg regionalnog savetovanja iz kliničke patologije i terapije malih životinja, Fruška gora, 09-11. jun (2022):27-31,
https://hdl.handle.net/21.15107/rcub_veterinar_2501 .

TY  - CONF
AU  - Radaković, Milena
AU  - Spariosu, Kristina
AU  - Janjić, Filip
AU  - Francuski Andrić, Jelena
AU  - Beletić, Anđelo
AU  - Milanović, Svetlana
AU  - Kovačević Filipović, Milica
PY  - 2022
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/2612
C3  - 24th Annual Congress of the European Society of Veterinary Clinical Pathology, Belgrade, Serbia, October 5-8, 2022
T1  - Oxidative stress in canine babesiosis
SP  - 80
EP  - 81
UR  - https://hdl.handle.net/21.15107/rcub_veterinar_2612
ER  - 

@conference{
author = "Radaković, Milena and Spariosu, Kristina and Janjić, Filip and Francuski Andrić, Jelena and Beletić, Anđelo and Milanović, Svetlana and Kovačević Filipović, Milica",
year = "2022",
journal = "24th Annual Congress of the European Society of Veterinary Clinical Pathology, Belgrade, Serbia, October 5-8, 2022",
title = "Oxidative stress in canine babesiosis",
pages = "80-81",
url = "https://hdl.handle.net/21.15107/rcub_veterinar_2612"
}

Radaković, M., Spariosu, K., Janjić, F., Francuski Andrić, J., Beletić, A., Milanović, S.,& Kovačević Filipović, M.. (2022). Oxidative stress in canine babesiosis. in 24th Annual Congress of the European Society of Veterinary Clinical Pathology, Belgrade, Serbia, October 5-8, 2022, 80-81.
https://hdl.handle.net/21.15107/rcub_veterinar_2612

Radaković M, Spariosu K, Janjić F, Francuski Andrić J, Beletić A, Milanović S, Kovačević Filipović M. Oxidative stress in canine babesiosis. in 24th Annual Congress of the European Society of Veterinary Clinical Pathology, Belgrade, Serbia, October 5-8, 2022. 2022;:80-81.
https://hdl.handle.net/21.15107/rcub_veterinar_2612 .

Radaković, Milena, Spariosu, Kristina, Janjić, Filip, Francuski Andrić, Jelena, Beletić, Anđelo, Milanović, Svetlana, Kovačević Filipović, Milica, "Oxidative stress in canine babesiosis" in 24th Annual Congress of the European Society of Veterinary Clinical Pathology, Belgrade, Serbia, October 5-8, 2022 (2022):80-81,
https://hdl.handle.net/21.15107/rcub_veterinar_2612 .

TY  - JOUR
AU  - Janjić, Filip
AU  - Beletić, Anđelo
AU  - Radaković, Milena
AU  - Spariosu, Kristina
AU  - Diklić, Miloš
AU  - Francuski Andrić, Jelena
AU  - Radonjić, Vladimir
AU  - Ajtić, Jelena
AU  - Kovačević-Filipović, Milica
PY  - 2022
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/2338
AB  - The highest number of acute Babesia canis cases in dogs is recorded over the February-May (Feb-May) period, which also represents the optimal climate conditions for tick activity in Belgrade, Serbia. A possibility that the acute phase response is more intense in dogs developing the disease in the Feb-May period compared with the response in other time periods of the year was tested. A total of 63 client-owned dogs with acute B. canis infection were enrolled and the routine hematology and biochemistry parameters-serum amyloid A (SAA), IgG against B. canis, level of parasitemia, ceruloplasmin (CER), paraoxonase-1 (PON-1), and fibrinogen-were measured. Acute phase indexes (API) were calculated as (SAA×CER)/(Iron×PON-1) and (SAA×CER)/(Albumin×Iron). Statistics included Kruskal-Wallis test and logistic regression analysis. The results showed that in the Feb-May period, the following parameters were lower: creatinine, albumin, iron, and level of parasitemia. Furthermore, increased API values were more probable in the Feb-May than in the other periods. Together, higher acute phase response intensity and presumptive hemodilution in the Feb-May period indicate a more acute course of B. canis infection than in other time periods of the year.
PB  - Springer
T2  - International Journal of Biometeorology
T1  - Seasonal differences in the intensity of acute phase response in dogs infected with Babesia canis
DO  - 10.1007/s00484-021-02228-4
ER  - 

@article{
author = "Janjić, Filip and Beletić, Anđelo and Radaković, Milena and Spariosu, Kristina and Diklić, Miloš and Francuski Andrić, Jelena and Radonjić, Vladimir and Ajtić, Jelena and Kovačević-Filipović, Milica",
year = "2022",
abstract = "The highest number of acute Babesia canis cases in dogs is recorded over the February-May (Feb-May) period, which also represents the optimal climate conditions for tick activity in Belgrade, Serbia. A possibility that the acute phase response is more intense in dogs developing the disease in the Feb-May period compared with the response in other time periods of the year was tested. A total of 63 client-owned dogs with acute B. canis infection were enrolled and the routine hematology and biochemistry parameters-serum amyloid A (SAA), IgG against B. canis, level of parasitemia, ceruloplasmin (CER), paraoxonase-1 (PON-1), and fibrinogen-were measured. Acute phase indexes (API) were calculated as (SAA×CER)/(Iron×PON-1) and (SAA×CER)/(Albumin×Iron). Statistics included Kruskal-Wallis test and logistic regression analysis. The results showed that in the Feb-May period, the following parameters were lower: creatinine, albumin, iron, and level of parasitemia. Furthermore, increased API values were more probable in the Feb-May than in the other periods. Together, higher acute phase response intensity and presumptive hemodilution in the Feb-May period indicate a more acute course of B. canis infection than in other time periods of the year.",
publisher = "Springer",
journal = "International Journal of Biometeorology",
title = "Seasonal differences in the intensity of acute phase response in dogs infected with Babesia canis",
doi = "10.1007/s00484-021-02228-4"
}

Janjić, F., Beletić, A., Radaković, M., Spariosu, K., Diklić, M., Francuski Andrić, J., Radonjić, V., Ajtić, J.,& Kovačević-Filipović, M.. (2022). Seasonal differences in the intensity of acute phase response in dogs infected with Babesia canis. in International Journal of Biometeorology
Springer..
https://doi.org/10.1007/s00484-021-02228-4

Janjić F, Beletić A, Radaković M, Spariosu K, Diklić M, Francuski Andrić J, Radonjić V, Ajtić J, Kovačević-Filipović M. Seasonal differences in the intensity of acute phase response in dogs infected with Babesia canis. in International Journal of Biometeorology. 2022;.
doi:10.1007/s00484-021-02228-4 .

Janjić, Filip, Beletić, Anđelo, Radaković, Milena, Spariosu, Kristina, Diklić, Miloš, Francuski Andrić, Jelena, Radonjić, Vladimir, Ajtić, Jelena, Kovačević-Filipović, Milica, "Seasonal differences in the intensity of acute phase response in dogs infected with Babesia canis" in International Journal of Biometeorology (2022),
https://doi.org/10.1007/s00484-021-02228-4 . .

TY  - CONF
AU  - Kovačević-Filipović, Milica
AU  - Francuski Andrić, Jelena
AU  - Radaković, Milena
AU  - Spariosu, Kristina
PY  - 2022
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/2429
AB  - Procenjuje se da prevalenca bubrežnih bolesti u ukupnoj populaciji pasa i mačka iznosi oko 0,5% do 3%, ali da u gerijatrijskoj populaciji prevalenca hronične bubrežne bolesti dostiže čak 80%. Osim
rasne predispozije i starosti, kao faktori rizika navode se hiperkalcemija, bolesti srca, cistitis, urolitijaza, hipertireoidizam, periodontalni i
metabolički poremećaji i hronične ili perzistentne infekcije. Stalni monitoring funkcije bubrega je neophodan da bi se uvela odgovarajuća
terapija, koja može značajno da uspori progresivan tok gubitka funkcije bubrega koji prati bubrežne bolesti. Klasični markeri gubitka funkcije bubrega su koncentracija uree i kreatinina u serumu. Njihova koncentracija raste tek kada je rezervni kapacitet bubrega potrošen, odnosno kada propadne 75% svih nefrona. Na radionici će biti objašnjen
i demonstriran značaj 1) simetričnog dimetilarginina (SDMA) kao novog, osetljivijeg markera premećaja funkcije bubrega, potom 2) značaj
određivanja odnosa proteina i kreatinina u mokraći, kao i 3) potencijal
primene elektroforeze na gelu poliakrilamida za detekciju proteina u
urinu sa ciljem diferencijalne dijagnostike poremećaja funkcije glomerula, odnosno tubula.
AB  - It is estimated that the prevalence of kidney disease in the total population of dogs
and cats is about 0.5% to 3%, but in the geriatric population the prevalence of chronic
kidney disease reaches as much as 80%. In addition to breed predisposition and age,
hypercalcemia, heart disease, periodontal problems, cystitis, urolithiasis, hyperthyroidism,
metabolic disorders, and chronic or persistent infections are listed as risk factors.
Continuous monitoring of the renal function is important for timely and appropriate therapy
managment. Appropriate therapy can significantly slow down the progressive course of
renal disease. The classic markers to test the loss of kidney function are concentration
of urea and creatinine in the serum. Their concentration increases only when the reserve
capacity of the kidneys is lost, ie. when 75% of all nephrons fail. The workshop will explain
and demonstrate the importance of 1) symmetric dimethylarginine (SDMA) as a new, more
sensitive marker of renal dysfunction, 2) determining the urine protein-creatinine ratio, as
well as 3) differential diagnosis of glomerular or tubular proteinuria using polyacrilamid gel
electrophoresis.
PB  - Fakultet veterinarske medicine, Centar za izdavačku delatnost i promet učila
C3  - Zbornik radova - XLIII seminar inovacija znanja veterinara
T1  - Novi laboratorijski parametri dijagnostike poremećaja funkcije bubrega kod pasa i mačaka
T1  - New laboratory parameters for the diagnostic algorithm of kidney function disorders in dogs and cats
SP  - 191
EP  - 202
UR  - https://hdl.handle.net/21.15107/rcub_veterinar_2429
ER  - 

@conference{
author = "Kovačević-Filipović, Milica and Francuski Andrić, Jelena and Radaković, Milena and Spariosu, Kristina",
year = "2022",
abstract = "Procenjuje se da prevalenca bubrežnih bolesti u ukupnoj populaciji pasa i mačka iznosi oko 0,5% do 3%, ali da u gerijatrijskoj populaciji prevalenca hronične bubrežne bolesti dostiže čak 80%. Osim
rasne predispozije i starosti, kao faktori rizika navode se hiperkalcemija, bolesti srca, cistitis, urolitijaza, hipertireoidizam, periodontalni i
metabolički poremećaji i hronične ili perzistentne infekcije. Stalni monitoring funkcije bubrega je neophodan da bi se uvela odgovarajuća
terapija, koja može značajno da uspori progresivan tok gubitka funkcije bubrega koji prati bubrežne bolesti. Klasični markeri gubitka funkcije bubrega su koncentracija uree i kreatinina u serumu. Njihova koncentracija raste tek kada je rezervni kapacitet bubrega potrošen, odnosno kada propadne 75% svih nefrona. Na radionici će biti objašnjen
i demonstriran značaj 1) simetričnog dimetilarginina (SDMA) kao novog, osetljivijeg markera premećaja funkcije bubrega, potom 2) značaj
određivanja odnosa proteina i kreatinina u mokraći, kao i 3) potencijal
primene elektroforeze na gelu poliakrilamida za detekciju proteina u
urinu sa ciljem diferencijalne dijagnostike poremećaja funkcije glomerula, odnosno tubula., It is estimated that the prevalence of kidney disease in the total population of dogs
and cats is about 0.5% to 3%, but in the geriatric population the prevalence of chronic
kidney disease reaches as much as 80%. In addition to breed predisposition and age,
hypercalcemia, heart disease, periodontal problems, cystitis, urolithiasis, hyperthyroidism,
metabolic disorders, and chronic or persistent infections are listed as risk factors.
Continuous monitoring of the renal function is important for timely and appropriate therapy
managment. Appropriate therapy can significantly slow down the progressive course of
renal disease. The classic markers to test the loss of kidney function are concentration
of urea and creatinine in the serum. Their concentration increases only when the reserve
capacity of the kidneys is lost, ie. when 75% of all nephrons fail. The workshop will explain
and demonstrate the importance of 1) symmetric dimethylarginine (SDMA) as a new, more
sensitive marker of renal dysfunction, 2) determining the urine protein-creatinine ratio, as
well as 3) differential diagnosis of glomerular or tubular proteinuria using polyacrilamid gel
electrophoresis.",
publisher = "Fakultet veterinarske medicine, Centar za izdavačku delatnost i promet učila",
journal = "Zbornik radova - XLIII seminar inovacija znanja veterinara",
title = "Novi laboratorijski parametri dijagnostike poremećaja funkcije bubrega kod pasa i mačaka, New laboratory parameters for the diagnostic algorithm of kidney function disorders in dogs and cats",
pages = "191-202",
url = "https://hdl.handle.net/21.15107/rcub_veterinar_2429"
}

Kovačević-Filipović, M., Francuski Andrić, J., Radaković, M.,& Spariosu, K.. (2022). Novi laboratorijski parametri dijagnostike poremećaja funkcije bubrega kod pasa i mačaka. in Zbornik radova - XLIII seminar inovacija znanja veterinara
Fakultet veterinarske medicine, Centar za izdavačku delatnost i promet učila., 191-202.
https://hdl.handle.net/21.15107/rcub_veterinar_2429

Kovačević-Filipović M, Francuski Andrić J, Radaković M, Spariosu K. Novi laboratorijski parametri dijagnostike poremećaja funkcije bubrega kod pasa i mačaka. in Zbornik radova - XLIII seminar inovacija znanja veterinara. 2022;:191-202.
https://hdl.handle.net/21.15107/rcub_veterinar_2429 .

Kovačević-Filipović, Milica, Francuski Andrić, Jelena, Radaković, Milena, Spariosu, Kristina, "Novi laboratorijski parametri dijagnostike poremećaja funkcije bubrega kod pasa i mačaka" in Zbornik radova - XLIII seminar inovacija znanja veterinara (2022):191-202,
https://hdl.handle.net/21.15107/rcub_veterinar_2429 .

TY  - CONF
AU  - Janjić, Filip
AU  - Beletić, Anđelo
AU  - Radaković, Milena
AU  - Spariosu, Kristina
AU  - Francuski Andrić, Jelena
AU  - Ajtić, Jelena
AU  - Kovačević-Filipović, Milica
PY  - 2022
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/2488
AB  - Background: Canine babesiosis is a disease with a seasonal character. We have
previously observed that in Belgrade, the capital of the Republic of Serbia, 60% of
cases with the acute-phase response (APR) give a notable maximum between mid-
February and May, the so-called “high season”. The other two peak seasons with
less pronounced maxima are in winter, from January to mid-February, and in
autumn, from October to December. Objectives: Based on clinical observations, we
postulate that dogs infected with B. canis in the “high season” develop a more
intense APR than dogs in the other two seasons. Material and Methods: To test this
hypothesis, we compare the relative parasite load and the level of acute-phase
proteins and reactants, their indexes (calculated as a combination of
concentrations of fast and slow positive, and fast and slow negative acute phase
reactants), as well as the concentration of coagulation factors, complete blood
count, and biochemistry among dogs that developed the disease in the autumn,
winter, and “high season”. Results: The relative parasite load is the lowest, and APR
Indexes are the highest in dogs infected in “high season”. These findings are
accompanied by relatively low creatinine and urea, implying that dogs in “high
season” had hemodilution, thus further suggesting short incubation. Unlike other
acute-phase proteins, fibrinogen showed the lowest concentration in “high
season”. Conclusion: Future research will help unveil the connection between
more intense APR and relatively low parasite load and fibrinogen concentration.
C3  - 24th Annual Congress of the European Society of Veterinary Clinical Pathology, Belgrade, Serbia, October 5-8
T1  - Canine babesiosis in different seasons - a fertile ground for multiple questions
SP  - 78
EP  - 79
UR  - https://hdl.handle.net/21.15107/rcub_veterinar_2488
ER  - 

@conference{
author = "Janjić, Filip and Beletić, Anđelo and Radaković, Milena and Spariosu, Kristina and Francuski Andrić, Jelena and Ajtić, Jelena and Kovačević-Filipović, Milica",
year = "2022",
abstract = "Background: Canine babesiosis is a disease with a seasonal character. We have
previously observed that in Belgrade, the capital of the Republic of Serbia, 60% of
cases with the acute-phase response (APR) give a notable maximum between mid-
February and May, the so-called “high season”. The other two peak seasons with
less pronounced maxima are in winter, from January to mid-February, and in
autumn, from October to December. Objectives: Based on clinical observations, we
postulate that dogs infected with B. canis in the “high season” develop a more
intense APR than dogs in the other two seasons. Material and Methods: To test this
hypothesis, we compare the relative parasite load and the level of acute-phase
proteins and reactants, their indexes (calculated as a combination of
concentrations of fast and slow positive, and fast and slow negative acute phase
reactants), as well as the concentration of coagulation factors, complete blood
count, and biochemistry among dogs that developed the disease in the autumn,
winter, and “high season”. Results: The relative parasite load is the lowest, and APR
Indexes are the highest in dogs infected in “high season”. These findings are
accompanied by relatively low creatinine and urea, implying that dogs in “high
season” had hemodilution, thus further suggesting short incubation. Unlike other
acute-phase proteins, fibrinogen showed the lowest concentration in “high
season”. Conclusion: Future research will help unveil the connection between
more intense APR and relatively low parasite load and fibrinogen concentration.",
journal = "24th Annual Congress of the European Society of Veterinary Clinical Pathology, Belgrade, Serbia, October 5-8",
title = "Canine babesiosis in different seasons - a fertile ground for multiple questions",
pages = "78-79",
url = "https://hdl.handle.net/21.15107/rcub_veterinar_2488"
}

Janjić, F., Beletić, A., Radaković, M., Spariosu, K., Francuski Andrić, J., Ajtić, J.,& Kovačević-Filipović, M.. (2022). Canine babesiosis in different seasons - a fertile ground for multiple questions. in 24th Annual Congress of the European Society of Veterinary Clinical Pathology, Belgrade, Serbia, October 5-8, 78-79.
https://hdl.handle.net/21.15107/rcub_veterinar_2488

Janjić F, Beletić A, Radaković M, Spariosu K, Francuski Andrić J, Ajtić J, Kovačević-Filipović M. Canine babesiosis in different seasons - a fertile ground for multiple questions. in 24th Annual Congress of the European Society of Veterinary Clinical Pathology, Belgrade, Serbia, October 5-8. 2022;:78-79.
https://hdl.handle.net/21.15107/rcub_veterinar_2488 .

Janjić, Filip, Beletić, Anđelo, Radaković, Milena, Spariosu, Kristina, Francuski Andrić, Jelena, Ajtić, Jelena, Kovačević-Filipović, Milica, "Canine babesiosis in different seasons - a fertile ground for multiple questions" in 24th Annual Congress of the European Society of Veterinary Clinical Pathology, Belgrade, Serbia, October 5-8 (2022):78-79,
https://hdl.handle.net/21.15107/rcub_veterinar_2488 .

TY  - JOUR
AU  - Sukara, Ratko
AU  - Andrić, Nenad
AU  - Francuski Andrić, Jelena
AU  - Mihaljica, Darko
AU  - Veinović, Gorana
AU  - Ranković, Vladan
AU  - Tomanović, Snežana
PY  - 2022
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/2511
AB  - Background
The epidemiological status concerning many canine tick-borne diseases (TBDs) in Serbia is still insufficiently known.

Objectives
Our study aimed to investigate the presence of tick-borne pathogens of the family Anaplasmataceae and Hepatozoon spp., as a cause of illnesses accompanied by clinical signs that can occur in dogs with anaplasmosis, ehrlichiosis and hepatozoonosis.

Methods
Dogs are included in the study based on the presence of a minimum of three clinical and/or pathological findings that could be associated with anaplasmosis, ehrlichiosis and hepatozoonosis. During the study (April–October 2018), 11 dogs met the conditions to be included in the survey. Identification of the causative agent in the blood of diseased dogs was performed by conventional PCR followed by sequencing.

Results
The presence of the pathogens was confirmed in three animals (3/11, 27.3%). The presence of Ehrlichia canis was confirmed in 3-month-old female Rottweiler puppy, an 8-year old Miniature Schnauzer female was positive for Hepatozoon canis infection, while 4-year-old mixed breed male dog was co-infected with both mentioned pathogens. These are the first cases of autochthonous infection with E. canis and H. canis in dogs from Serbia confirmed by molecular methods.

Conclusions
The results of our study indicate the importance of molecular methods to establish a reliable diagnosis of TBDs. Also, the confirmed presence of causative agents of canine monocytic ehrlichiosis and hepatozoonosis in Serbia appeals to veterinary practitioners that it is necessary to exclude the presence of those diseases in suspicious dogs.
PB  - John Wiley & Sons Ltd.
T2  - Veterinary Medicine and Science
T1  - Autochthonous infection with Ehrlichia Canis and Hepatozoon Canis in dogs from Serbia
VL  - 9
IS  - 1
IS  - 111
SP  - 111
EP  - 118
DO  - 10.1002/vms3.1061
ER  - 

@article{
author = "Sukara, Ratko and Andrić, Nenad and Francuski Andrić, Jelena and Mihaljica, Darko and Veinović, Gorana and Ranković, Vladan and Tomanović, Snežana",
year = "2022",
abstract = "Background
The epidemiological status concerning many canine tick-borne diseases (TBDs) in Serbia is still insufficiently known.

Objectives
Our study aimed to investigate the presence of tick-borne pathogens of the family Anaplasmataceae and Hepatozoon spp., as a cause of illnesses accompanied by clinical signs that can occur in dogs with anaplasmosis, ehrlichiosis and hepatozoonosis.

Methods
Dogs are included in the study based on the presence of a minimum of three clinical and/or pathological findings that could be associated with anaplasmosis, ehrlichiosis and hepatozoonosis. During the study (April–October 2018), 11 dogs met the conditions to be included in the survey. Identification of the causative agent in the blood of diseased dogs was performed by conventional PCR followed by sequencing.

Results
The presence of the pathogens was confirmed in three animals (3/11, 27.3%). The presence of Ehrlichia canis was confirmed in 3-month-old female Rottweiler puppy, an 8-year old Miniature Schnauzer female was positive for Hepatozoon canis infection, while 4-year-old mixed breed male dog was co-infected with both mentioned pathogens. These are the first cases of autochthonous infection with E. canis and H. canis in dogs from Serbia confirmed by molecular methods.

Conclusions
The results of our study indicate the importance of molecular methods to establish a reliable diagnosis of TBDs. Also, the confirmed presence of causative agents of canine monocytic ehrlichiosis and hepatozoonosis in Serbia appeals to veterinary practitioners that it is necessary to exclude the presence of those diseases in suspicious dogs.",
publisher = "John Wiley & Sons Ltd.",
journal = "Veterinary Medicine and Science",
title = "Autochthonous infection with Ehrlichia Canis and Hepatozoon Canis in dogs from Serbia",
volume = "9",
number = "1, 111",
pages = "111-118",
doi = "10.1002/vms3.1061"
}

Sukara, R., Andrić, N., Francuski Andrić, J., Mihaljica, D., Veinović, G., Ranković, V.,& Tomanović, S.. (2022). Autochthonous infection with Ehrlichia Canis and Hepatozoon Canis in dogs from Serbia. in Veterinary Medicine and Science
John Wiley & Sons Ltd.., 9(1), 111-118.
https://doi.org/10.1002/vms3.1061

Sukara R, Andrić N, Francuski Andrić J, Mihaljica D, Veinović G, Ranković V, Tomanović S. Autochthonous infection with Ehrlichia Canis and Hepatozoon Canis in dogs from Serbia. in Veterinary Medicine and Science. 2022;9(1):111-118.
doi:10.1002/vms3.1061 .

Sukara, Ratko, Andrić, Nenad, Francuski Andrić, Jelena, Mihaljica, Darko, Veinović, Gorana, Ranković, Vladan, Tomanović, Snežana, "Autochthonous infection with Ehrlichia Canis and Hepatozoon Canis in dogs from Serbia" in Veterinary Medicine and Science, 9, no. 1 (2022):111-118,
https://doi.org/10.1002/vms3.1061 . .

TY  - CONF
AU  - Marković, Lazar
AU  - Đoković, Stefan
AU  - Radaković, Milena
AU  - Francuski Andrić, Jelena
AU  - Milošević, Ivan
AU  - Beletić, Anđelo
AU  - Kovačević Filipović, Milica
PY  - 2022
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/2590
AB  - Inflamatorni i degenerativni procesi na zglobovima konja se mogu postepeno razvijati,
pri čemu klinički znaci patoloških promena često nisu vidljivi. Cilj ove studije je
bio da se na osnovu rutinskog pregleda sinovijalne tečnosti (ST) poreklom iz metakarpo/
metatarzofalangealnih (MCP/MTP) zglobova radnih konja, koji su bili upućeni na
klanje i njenih biohemijskih karakteristika utvrdi da li je postojala lokalna inflamacija.
Studija je sprovedena na 6 konja starosti 3 do 12 godina (medijana 8), odnosno 24
MCP/MTP zgloba. Post mortem, iz svakog zgloba je uzorkovana ST. Kliničkim pregledom
pre klanja, nisu uočene promene u izgledu i funkciji mišićno-skeletnog sistema.
Urađen je rutinski pregled ST kojim je opisana boja, prozirnost, viskoznost i broj ćelija.
Određena je koncentracija sledećih biohemijskih parametara: ukupnih proteina,
albumina, aktivnost alkalne fosfataze (ALP), aspartat aminotransferaze (AST), kreatin
kinaze (CK), kao i koncentracije haptoglobina (Hp) i ceruloplazmina (Cp). Kod svih
uzoraka, ST je bila bistra, providna, viskozna i blede do bledo žute boje. Najmlađi konj,
star tri godine, je u sva četiri pregledana zgloba imao ukupan broj ćelija 200-890/μL,
što odgovara fiziološkim vrednostima. Dva konja su imala povećan broj ćelija na jednom,
odnosno dva zgloba (1 400-2 560/μL), dok su tri konja imala promene na sva četiri
zgloba (1 100-2 200/μL). Ispitivani biohemijski parametri se nisu razlikovali u uzorcima
ST iz zglobova sa ukupnim brojem ćelija u okviru fizioloških vrednosti i onih kod
kojih je broj ćelija bio povećan. Pozitivne, umerene korelacije su postojale između koncentracije
proteina i aktivnosti ALP, koncentracije proteina i albumina, aktivnosti AST
i CK. Ispitivanjem ST radnih konja, dokazano je da inflamatorne promene u MCP/MTP
zglobovima nisu prisutne. Nalaz povećanog broja ćelija u ST bez inflamatornih promena
zahteva dodatna ispitivanja.
PB  - Beograd : Srpsko veterinarsko društvo
C3  - 33. Savetovanje Veterinara Srbije, Zlatibor, 08 - 11. septembra, 2022
T1  - Laboratorijski profil sinovijalne tečnosti kod šest radnih konja različite starosti
SP  - 294
EP  - 300
UR  - https://hdl.handle.net/21.15107/rcub_veterinar_2590
ER  - 

@conference{
author = "Marković, Lazar and Đoković, Stefan and Radaković, Milena and Francuski Andrić, Jelena and Milošević, Ivan and Beletić, Anđelo and Kovačević Filipović, Milica",
year = "2022",
abstract = "Inflamatorni i degenerativni procesi na zglobovima konja se mogu postepeno razvijati,
pri čemu klinički znaci patoloških promena često nisu vidljivi. Cilj ove studije je
bio da se na osnovu rutinskog pregleda sinovijalne tečnosti (ST) poreklom iz metakarpo/
metatarzofalangealnih (MCP/MTP) zglobova radnih konja, koji su bili upućeni na
klanje i njenih biohemijskih karakteristika utvrdi da li je postojala lokalna inflamacija.
Studija je sprovedena na 6 konja starosti 3 do 12 godina (medijana 8), odnosno 24
MCP/MTP zgloba. Post mortem, iz svakog zgloba je uzorkovana ST. Kliničkim pregledom
pre klanja, nisu uočene promene u izgledu i funkciji mišićno-skeletnog sistema.
Urađen je rutinski pregled ST kojim je opisana boja, prozirnost, viskoznost i broj ćelija.
Određena je koncentracija sledećih biohemijskih parametara: ukupnih proteina,
albumina, aktivnost alkalne fosfataze (ALP), aspartat aminotransferaze (AST), kreatin
kinaze (CK), kao i koncentracije haptoglobina (Hp) i ceruloplazmina (Cp). Kod svih
uzoraka, ST je bila bistra, providna, viskozna i blede do bledo žute boje. Najmlađi konj,
star tri godine, je u sva četiri pregledana zgloba imao ukupan broj ćelija 200-890/μL,
što odgovara fiziološkim vrednostima. Dva konja su imala povećan broj ćelija na jednom,
odnosno dva zgloba (1 400-2 560/μL), dok su tri konja imala promene na sva četiri
zgloba (1 100-2 200/μL). Ispitivani biohemijski parametri se nisu razlikovali u uzorcima
ST iz zglobova sa ukupnim brojem ćelija u okviru fizioloških vrednosti i onih kod
kojih je broj ćelija bio povećan. Pozitivne, umerene korelacije su postojale između koncentracije
proteina i aktivnosti ALP, koncentracije proteina i albumina, aktivnosti AST
i CK. Ispitivanjem ST radnih konja, dokazano je da inflamatorne promene u MCP/MTP
zglobovima nisu prisutne. Nalaz povećanog broja ćelija u ST bez inflamatornih promena
zahteva dodatna ispitivanja.",
publisher = "Beograd : Srpsko veterinarsko društvo",
journal = "33. Savetovanje Veterinara Srbije, Zlatibor, 08 - 11. septembra, 2022",
title = "Laboratorijski profil sinovijalne tečnosti kod šest radnih konja različite starosti",
pages = "294-300",
url = "https://hdl.handle.net/21.15107/rcub_veterinar_2590"
}

Marković, L., Đoković, S., Radaković, M., Francuski Andrić, J., Milošević, I., Beletić, A.,& Kovačević Filipović, M.. (2022). Laboratorijski profil sinovijalne tečnosti kod šest radnih konja različite starosti. in 33. Savetovanje Veterinara Srbije, Zlatibor, 08 - 11. septembra, 2022
Beograd : Srpsko veterinarsko društvo., 294-300.
https://hdl.handle.net/21.15107/rcub_veterinar_2590

Marković L, Đoković S, Radaković M, Francuski Andrić J, Milošević I, Beletić A, Kovačević Filipović M. Laboratorijski profil sinovijalne tečnosti kod šest radnih konja različite starosti. in 33. Savetovanje Veterinara Srbije, Zlatibor, 08 - 11. septembra, 2022. 2022;:294-300.
https://hdl.handle.net/21.15107/rcub_veterinar_2590 .

Marković, Lazar, Đoković, Stefan, Radaković, Milena, Francuski Andrić, Jelena, Milošević, Ivan, Beletić, Anđelo, Kovačević Filipović, Milica, "Laboratorijski profil sinovijalne tečnosti kod šest radnih konja različite starosti" in 33. Savetovanje Veterinara Srbije, Zlatibor, 08 - 11. septembra, 2022 (2022):294-300,
https://hdl.handle.net/21.15107/rcub_veterinar_2590 .

TY  - CONF
AU  - Kovandžić, Marija
AU  - Janjić, Filip
AU  - Spariosu, Kristina
AU  - Radaković, Milena
AU  - Francuski Andrić, Jelena
AU  - Beletić, Anđelo
AU  - Kovačević Filipović, Milica
PY  - 2022
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/2588
PB  - Beograd : Srpsko veterinarsko društvo
C3  - 33. Savetovanje Veterinara Srbije, Zlatibor, 08 - 11. Septembar 2022
T1  - Analiza krvne slike magaraca na velikim i malim farmama – implikacije u vezi sa eozinofilijom
IS  - 310
EP  - 311
UR  - https://hdl.handle.net/21.15107/rcub_veterinar_2588
ER  - 

@conference{
author = "Kovandžić, Marija and Janjić, Filip and Spariosu, Kristina and Radaković, Milena and Francuski Andrić, Jelena and Beletić, Anđelo and Kovačević Filipović, Milica",
year = "2022",
publisher = "Beograd : Srpsko veterinarsko društvo",
journal = "33. Savetovanje Veterinara Srbije, Zlatibor, 08 - 11. Septembar 2022",
title = "Analiza krvne slike magaraca na velikim i malim farmama – implikacije u vezi sa eozinofilijom",
number = "310",
pages = "311",
url = "https://hdl.handle.net/21.15107/rcub_veterinar_2588"
}

Kovandžić, M., Janjić, F., Spariosu, K., Radaković, M., Francuski Andrić, J., Beletić, A.,& Kovačević Filipović, M.. (2022). Analiza krvne slike magaraca na velikim i malim farmama – implikacije u vezi sa eozinofilijom. in 33. Savetovanje Veterinara Srbije, Zlatibor, 08 - 11. Septembar 2022
Beograd : Srpsko veterinarsko društvo.(310).
https://hdl.handle.net/21.15107/rcub_veterinar_2588

Kovandžić M, Janjić F, Spariosu K, Radaković M, Francuski Andrić J, Beletić A, Kovačević Filipović M. Analiza krvne slike magaraca na velikim i malim farmama – implikacije u vezi sa eozinofilijom. in 33. Savetovanje Veterinara Srbije, Zlatibor, 08 - 11. Septembar 2022. 2022;(310):null-311.
https://hdl.handle.net/21.15107/rcub_veterinar_2588 .

Kovandžić, Marija, Janjić, Filip, Spariosu, Kristina, Radaković, Milena, Francuski Andrić, Jelena, Beletić, Anđelo, Kovačević Filipović, Milica, "Analiza krvne slike magaraca na velikim i malim farmama – implikacije u vezi sa eozinofilijom" in 33. Savetovanje Veterinara Srbije, Zlatibor, 08 - 11. Septembar 2022, no. 310 (2022),
https://hdl.handle.net/21.15107/rcub_veterinar_2588 .

TY  - CONF
AU  - Janjić, Filip
AU  - Spariosu, Kristina
AU  - Kitanović, Sara
AU  - Radaković, Milena
AU  - Francuski Andrić, Jelena
AU  - Beletić, Anđelo
AU  - Kovačević Filipović, Milica
PY  - 2022
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/2586
PB  - Beograd : Srpsko veterinarsko društvo
C3  - 33. Savetovanje Veterinara Srbije, Zlatibor, 08 - 11. Septembar 2022
T1  - Retrospektivna analiza prevalence anemija i faktori rizika kod pasa i mačaka u toku 2021–2022. godine na klinici za male životinje Fakulteta Veterinarske Medicine Univerziteta u Beogradu
SP  - 312
EP  - 313
UR  - https://hdl.handle.net/21.15107/rcub_veterinar_2586
ER  - 

@conference{
author = "Janjić, Filip and Spariosu, Kristina and Kitanović, Sara and Radaković, Milena and Francuski Andrić, Jelena and Beletić, Anđelo and Kovačević Filipović, Milica",
year = "2022",
publisher = "Beograd : Srpsko veterinarsko društvo",
journal = "33. Savetovanje Veterinara Srbije, Zlatibor, 08 - 11. Septembar 2022",
title = "Retrospektivna analiza prevalence anemija i faktori rizika kod pasa i mačaka u toku 2021–2022. godine na klinici za male životinje Fakulteta Veterinarske Medicine Univerziteta u Beogradu",
pages = "312-313",
url = "https://hdl.handle.net/21.15107/rcub_veterinar_2586"
}

Janjić, F., Spariosu, K., Kitanović, S., Radaković, M., Francuski Andrić, J., Beletić, A.,& Kovačević Filipović, M.. (2022). Retrospektivna analiza prevalence anemija i faktori rizika kod pasa i mačaka u toku 2021–2022. godine na klinici za male životinje Fakulteta Veterinarske Medicine Univerziteta u Beogradu. in 33. Savetovanje Veterinara Srbije, Zlatibor, 08 - 11. Septembar 2022
Beograd : Srpsko veterinarsko društvo., 312-313.
https://hdl.handle.net/21.15107/rcub_veterinar_2586

Janjić F, Spariosu K, Kitanović S, Radaković M, Francuski Andrić J, Beletić A, Kovačević Filipović M. Retrospektivna analiza prevalence anemija i faktori rizika kod pasa i mačaka u toku 2021–2022. godine na klinici za male životinje Fakulteta Veterinarske Medicine Univerziteta u Beogradu. in 33. Savetovanje Veterinara Srbije, Zlatibor, 08 - 11. Septembar 2022. 2022;:312-313.
https://hdl.handle.net/21.15107/rcub_veterinar_2586 .

Janjić, Filip, Spariosu, Kristina, Kitanović, Sara, Radaković, Milena, Francuski Andrić, Jelena, Beletić, Anđelo, Kovačević Filipović, Milica, "Retrospektivna analiza prevalence anemija i faktori rizika kod pasa i mačaka u toku 2021–2022. godine na klinici za male životinje Fakulteta Veterinarske Medicine Univerziteta u Beogradu" in 33. Savetovanje Veterinara Srbije, Zlatibor, 08 - 11. Septembar 2022 (2022):312-313,
https://hdl.handle.net/21.15107/rcub_veterinar_2586 .

TY  - CONF
AU  - Nikolić, Milica
AU  - Radaković, Milena
AU  - Spariosu, Kristina
AU  - Kovačević Filipović, Milica
AU  - Francuski Andrić, Jelena
PY  - 2022
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/2587
PB  - Beograd : Srpsko veterinarsko društvo
C3  - 33. Savetovanje Veterinara Srbije, Zlatibor, 08 - 11. Septembar 2022
T1  - Značaj indeksa anizocitoze u dijagnostici najčešćih infektivnih anemija mačaka
SP  - 322
EP  - 323
UR  - https://hdl.handle.net/21.15107/rcub_veterinar_2587
ER  - 

@conference{
author = "Nikolić, Milica and Radaković, Milena and Spariosu, Kristina and Kovačević Filipović, Milica and Francuski Andrić, Jelena",
year = "2022",
publisher = "Beograd : Srpsko veterinarsko društvo",
journal = "33. Savetovanje Veterinara Srbije, Zlatibor, 08 - 11. Septembar 2022",
title = "Značaj indeksa anizocitoze u dijagnostici najčešćih infektivnih anemija mačaka",
pages = "322-323",
url = "https://hdl.handle.net/21.15107/rcub_veterinar_2587"
}

Nikolić, M., Radaković, M., Spariosu, K., Kovačević Filipović, M.,& Francuski Andrić, J.. (2022). Značaj indeksa anizocitoze u dijagnostici najčešćih infektivnih anemija mačaka. in 33. Savetovanje Veterinara Srbije, Zlatibor, 08 - 11. Septembar 2022
Beograd : Srpsko veterinarsko društvo., 322-323.
https://hdl.handle.net/21.15107/rcub_veterinar_2587

Nikolić M, Radaković M, Spariosu K, Kovačević Filipović M, Francuski Andrić J. Značaj indeksa anizocitoze u dijagnostici najčešćih infektivnih anemija mačaka. in 33. Savetovanje Veterinara Srbije, Zlatibor, 08 - 11. Septembar 2022. 2022;:322-323.
https://hdl.handle.net/21.15107/rcub_veterinar_2587 .

Nikolić, Milica, Radaković, Milena, Spariosu, Kristina, Kovačević Filipović, Milica, Francuski Andrić, Jelena, "Značaj indeksa anizocitoze u dijagnostici najčešćih infektivnih anemija mačaka" in 33. Savetovanje Veterinara Srbije, Zlatibor, 08 - 11. Septembar 2022 (2022):322-323,
https://hdl.handle.net/21.15107/rcub_veterinar_2587 .

TY  - CONF
AU  - Beletić, Anđelo
AU  - Kuleš, Josipa
AU  - Farkaš, Vladimir
AU  - Radaković, Milena
AU  - Rešetar Maslov, Dina
AU  - Francuski Andrić, Jelena
AU  - Spariosu, Kristina
AU  - Janjić, Filip
AU  - Rubić, Ivana
AU  - Kovačević Filipović, Milica
AU  - Mrljak, Vladimir
PY  - 2022
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/2615
C3  - 24th Annual Congress of the European Society of Veterinary Clinical Pathology, Belgrade, Serbia, October 5-8, 2022
T1  - Canine babesiosis through the eyes of proteomics and metabolomics
SP  - 72
EP  - 73
UR  - https://hdl.handle.net/21.15107/rcub_veterinar_2615
ER  - 

@conference{
author = "Beletić, Anđelo and Kuleš, Josipa and Farkaš, Vladimir and Radaković, Milena and Rešetar Maslov, Dina and Francuski Andrić, Jelena and Spariosu, Kristina and Janjić, Filip and Rubić, Ivana and Kovačević Filipović, Milica and Mrljak, Vladimir",
year = "2022",
journal = "24th Annual Congress of the European Society of Veterinary Clinical Pathology, Belgrade, Serbia, October 5-8, 2022",
title = "Canine babesiosis through the eyes of proteomics and metabolomics",
pages = "72-73",
url = "https://hdl.handle.net/21.15107/rcub_veterinar_2615"
}

Beletić, A., Kuleš, J., Farkaš, V., Radaković, M., Rešetar Maslov, D., Francuski Andrić, J., Spariosu, K., Janjić, F., Rubić, I., Kovačević Filipović, M.,& Mrljak, V.. (2022). Canine babesiosis through the eyes of proteomics and metabolomics. in 24th Annual Congress of the European Society of Veterinary Clinical Pathology, Belgrade, Serbia, October 5-8, 2022, 72-73.
https://hdl.handle.net/21.15107/rcub_veterinar_2615

Beletić A, Kuleš J, Farkaš V, Radaković M, Rešetar Maslov D, Francuski Andrić J, Spariosu K, Janjić F, Rubić I, Kovačević Filipović M, Mrljak V. Canine babesiosis through the eyes of proteomics and metabolomics. in 24th Annual Congress of the European Society of Veterinary Clinical Pathology, Belgrade, Serbia, October 5-8, 2022. 2022;:72-73.
https://hdl.handle.net/21.15107/rcub_veterinar_2615 .

Beletić, Anđelo, Kuleš, Josipa, Farkaš, Vladimir, Radaković, Milena, Rešetar Maslov, Dina, Francuski Andrić, Jelena, Spariosu, Kristina, Janjić, Filip, Rubić, Ivana, Kovačević Filipović, Milica, Mrljak, Vladimir, "Canine babesiosis through the eyes of proteomics and metabolomics" in 24th Annual Congress of the European Society of Veterinary Clinical Pathology, Belgrade, Serbia, October 5-8, 2022 (2022):72-73,
https://hdl.handle.net/21.15107/rcub_veterinar_2615 .

TY  - CONF
AU  - Francuski Andrić, Jelena
AU  - Magaš, Vladimir
AU  - Ilić Božović, Anja
AU  - Spariosu, Kristina
AU  - Radaković, Milena
AU  - Sukara, Ratko
AU  - Tomanović, Snežana
AU  - Kovačević Filipović, Milica
PY  - 2022
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/2614
C3  - 24th Annual Congress of the European Society of Veterinary Clinical Pathology, Belgrade, Serbia, October 5-8, 2022
T1  - Three clinical cases of Babesia gibsoni infection in Serbia should we worry?
SP  - 74
EP  - 75
UR  - https://hdl.handle.net/21.15107/rcub_veterinar_2614
ER  - 

@conference{
author = "Francuski Andrić, Jelena and Magaš, Vladimir and Ilić Božović, Anja and Spariosu, Kristina and Radaković, Milena and Sukara, Ratko and Tomanović, Snežana and Kovačević Filipović, Milica",
year = "2022",
journal = "24th Annual Congress of the European Society of Veterinary Clinical Pathology, Belgrade, Serbia, October 5-8, 2022",
title = "Three clinical cases of Babesia gibsoni infection in Serbia should we worry?",
pages = "74-75",
url = "https://hdl.handle.net/21.15107/rcub_veterinar_2614"
}

Francuski Andrić, J., Magaš, V., Ilić Božović, A., Spariosu, K., Radaković, M., Sukara, R., Tomanović, S.,& Kovačević Filipović, M.. (2022). Three clinical cases of Babesia gibsoni infection in Serbia should we worry?. in 24th Annual Congress of the European Society of Veterinary Clinical Pathology, Belgrade, Serbia, October 5-8, 2022, 74-75.
https://hdl.handle.net/21.15107/rcub_veterinar_2614

Francuski Andrić J, Magaš V, Ilić Božović A, Spariosu K, Radaković M, Sukara R, Tomanović S, Kovačević Filipović M. Three clinical cases of Babesia gibsoni infection in Serbia should we worry?. in 24th Annual Congress of the European Society of Veterinary Clinical Pathology, Belgrade, Serbia, October 5-8, 2022. 2022;:74-75.
https://hdl.handle.net/21.15107/rcub_veterinar_2614 .

Francuski Andrić, Jelena, Magaš, Vladimir, Ilić Božović, Anja, Spariosu, Kristina, Radaković, Milena, Sukara, Ratko, Tomanović, Snežana, Kovačević Filipović, Milica, "Three clinical cases of Babesia gibsoni infection in Serbia should we worry?" in 24th Annual Congress of the European Society of Veterinary Clinical Pathology, Belgrade, Serbia, October 5-8, 2022 (2022):74-75,
https://hdl.handle.net/21.15107/rcub_veterinar_2614 .

TY  - CONF
AU  - Spariosu, Kristina
AU  - Marković, Lazar
AU  - Radaković, Milena
AU  - Francuski Andrić, Jelena
AU  - Beletić, Anđelo
AU  - Kovačević Filipović, Milica
PY  - 2022
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/2613
C3  - 24th Annual Congress of the European Society of Veterinary Clinical Pathology, Belgrade, Serbia, October 5-8, 2022
T1  - Septic versus non-septic canine babesiosis: is there a difference in leukocyte function?
SP  - 70
EP  - 71
UR  - https://hdl.handle.net/21.15107/rcub_veterinar_2613
ER  - 

@conference{
author = "Spariosu, Kristina and Marković, Lazar and Radaković, Milena and Francuski Andrić, Jelena and Beletić, Anđelo and Kovačević Filipović, Milica",
year = "2022",
journal = "24th Annual Congress of the European Society of Veterinary Clinical Pathology, Belgrade, Serbia, October 5-8, 2022",
title = "Septic versus non-septic canine babesiosis: is there a difference in leukocyte function?",
pages = "70-71",
url = "https://hdl.handle.net/21.15107/rcub_veterinar_2613"
}

Spariosu, K., Marković, L., Radaković, M., Francuski Andrić, J., Beletić, A.,& Kovačević Filipović, M.. (2022). Septic versus non-septic canine babesiosis: is there a difference in leukocyte function?. in 24th Annual Congress of the European Society of Veterinary Clinical Pathology, Belgrade, Serbia, October 5-8, 2022, 70-71.
https://hdl.handle.net/21.15107/rcub_veterinar_2613

Spariosu K, Marković L, Radaković M, Francuski Andrić J, Beletić A, Kovačević Filipović M. Septic versus non-septic canine babesiosis: is there a difference in leukocyte function?. in 24th Annual Congress of the European Society of Veterinary Clinical Pathology, Belgrade, Serbia, October 5-8, 2022. 2022;:70-71.
https://hdl.handle.net/21.15107/rcub_veterinar_2613 .

Spariosu, Kristina, Marković, Lazar, Radaković, Milena, Francuski Andrić, Jelena, Beletić, Anđelo, Kovačević Filipović, Milica, "Septic versus non-septic canine babesiosis: is there a difference in leukocyte function?" in 24th Annual Congress of the European Society of Veterinary Clinical Pathology, Belgrade, Serbia, October 5-8, 2022 (2022):70-71,
https://hdl.handle.net/21.15107/rcub_veterinar_2613 .

TY  - JOUR
AU  - Spariosu, Kristina
AU  - Janjić, Filip
AU  - Francuski Andrić, Jelena
AU  - Radaković, Milena
AU  - Beletić, Anđelo
AU  - Kovačević-Filipović, Milica
AU  - Milanović, Svetlana
PY  - 2021
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/2132
AB  - Hemolysis and systemic acute inflammation characterize canine babesiosis caused by the intraerythrocytic protozoan parasite Babesia canis. Our hypothesis was that blood redox homeostasis of patients that suffered acute B. canis infection might be disturbed even after treatment with imidocarb-dipropionate and successful clinical recovery. Eight owner dogs with acute B. canis infection were used for this study. We analyzed the complete blood count, acute phase proteins (ceruloplasmin, haptoglobin, paraoxonase-1) in the serum, antioxidant enzymes (catalase and glutathione peroxidase) in the erythrocytes, and oxidative stress markers (malondialdehyde in erythrocytes and thiol groups in serum) at presentation and 15 days after treatment. Results were evaluated by corresponding statistical tests. At presentation, anemia, low/normal leukocyte count and severe thrombocytopenia occurred together with increased ceruloplasmin, haptoglobin levels within the reference interval, decreased paraoxonase-1 and compromised antioxidant defense in the red blood cells. After treatment and successful clinical recovery, hematological values generally fitted within the reference intervals, acute phase proteins were within the physiological levels in the majority of cases and the activities of the antioxidant enzymes were increased. However, elevated malondialdehyde levels indicated increased oxidative damage of erythrocytes that remained as a deleterious sequel despite a successful clinical recovery of the dogs.
AB  - Babezioza pasa, koju izaziva protozoa Babesia canis, praćena je hemolizom i sistemskom akutnom infl amacijom. Naša hipoteza je da kod pasa sa akutnom B. canis infekcijom, čak i nakon terapije imidokarb-dipropionatom i uspešnog kliničkog oporavka, postoji poremećaj redoks homeostaze. Studija uključuje osam vlasničkih pasa akutno infi ciranih babezijom. Analizirani su kompletna krvna slika, proteini akutne faze (ceruloplazmin, haptoglobin i paraoksonaza-1) u serumu, antioksidativni enzimi (katalaza i glutation peroksidaza) u eritrocitima i markeri oksidativnog stresa (malondialdehid u eritrocitima, tiolne grupe u serumu) na prezentaciji i 15 dana nakon terapije. Za procenu značajnosti rezultata primenjeni su odgovarajući statistički testovi. Anemija, nizak/normalan broj leukocita i teška trombocitopenija praćeni povišenom koncentracijom ceruloplazmina, haptoglobinom u fi ziološkim intervalima i sniženim nivoom paraoksonaze-1, kao i kompromitovana antioksidativna zaštita, uočeni su na prezentaciji. Nakon terapije i uspešnog kliničkog oporavka, hematološke vrednosti su bile u fi ziološkom opsegu, kao i proteini akutne faze kod većine pacijenata, a aktivnost antioksidativnih enzima je pojačana. Međutim, povišena koncentracija malondialdehida ukazuje na povećano oštećenje eritrocita koje je zaostalo uprkos uspešnom kliničkom oporavku pasa.
PB  - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
T2  - Acta Veterinaria-Beograd
T1  - Relationship between changes in hematological parameters, levels of acute phase proteins and redox homeostasis during acute Babesia canis infection in dogs
T1  - Povezanost promena hematoloških parametara, nivoa proteina akutne faze i redoks homeostaze tokom akutne infekcije pasa sa babesia canis
VL  - 71
IS  - 2
SP  - 158
EP  - 169
DO  - 10.2478/acve-2021-0014
ER  - 

@article{
author = "Spariosu, Kristina and Janjić, Filip and Francuski Andrić, Jelena and Radaković, Milena and Beletić, Anđelo and Kovačević-Filipović, Milica and Milanović, Svetlana",
year = "2021",
abstract = "Hemolysis and systemic acute inflammation characterize canine babesiosis caused by the intraerythrocytic protozoan parasite Babesia canis. Our hypothesis was that blood redox homeostasis of patients that suffered acute B. canis infection might be disturbed even after treatment with imidocarb-dipropionate and successful clinical recovery. Eight owner dogs with acute B. canis infection were used for this study. We analyzed the complete blood count, acute phase proteins (ceruloplasmin, haptoglobin, paraoxonase-1) in the serum, antioxidant enzymes (catalase and glutathione peroxidase) in the erythrocytes, and oxidative stress markers (malondialdehyde in erythrocytes and thiol groups in serum) at presentation and 15 days after treatment. Results were evaluated by corresponding statistical tests. At presentation, anemia, low/normal leukocyte count and severe thrombocytopenia occurred together with increased ceruloplasmin, haptoglobin levels within the reference interval, decreased paraoxonase-1 and compromised antioxidant defense in the red blood cells. After treatment and successful clinical recovery, hematological values generally fitted within the reference intervals, acute phase proteins were within the physiological levels in the majority of cases and the activities of the antioxidant enzymes were increased. However, elevated malondialdehyde levels indicated increased oxidative damage of erythrocytes that remained as a deleterious sequel despite a successful clinical recovery of the dogs., Babezioza pasa, koju izaziva protozoa Babesia canis, praćena je hemolizom i sistemskom akutnom infl amacijom. Naša hipoteza je da kod pasa sa akutnom B. canis infekcijom, čak i nakon terapije imidokarb-dipropionatom i uspešnog kliničkog oporavka, postoji poremećaj redoks homeostaze. Studija uključuje osam vlasničkih pasa akutno infi ciranih babezijom. Analizirani su kompletna krvna slika, proteini akutne faze (ceruloplazmin, haptoglobin i paraoksonaza-1) u serumu, antioksidativni enzimi (katalaza i glutation peroksidaza) u eritrocitima i markeri oksidativnog stresa (malondialdehid u eritrocitima, tiolne grupe u serumu) na prezentaciji i 15 dana nakon terapije. Za procenu značajnosti rezultata primenjeni su odgovarajući statistički testovi. Anemija, nizak/normalan broj leukocita i teška trombocitopenija praćeni povišenom koncentracijom ceruloplazmina, haptoglobinom u fi ziološkim intervalima i sniženim nivoom paraoksonaze-1, kao i kompromitovana antioksidativna zaštita, uočeni su na prezentaciji. Nakon terapije i uspešnog kliničkog oporavka, hematološke vrednosti su bile u fi ziološkom opsegu, kao i proteini akutne faze kod većine pacijenata, a aktivnost antioksidativnih enzima je pojačana. Međutim, povišena koncentracija malondialdehida ukazuje na povećano oštećenje eritrocita koje je zaostalo uprkos uspešnom kliničkom oporavku pasa.",
publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd",
journal = "Acta Veterinaria-Beograd",
title = "Relationship between changes in hematological parameters, levels of acute phase proteins and redox homeostasis during acute Babesia canis infection in dogs, Povezanost promena hematoloških parametara, nivoa proteina akutne faze i redoks homeostaze tokom akutne infekcije pasa sa babesia canis",
volume = "71",
number = "2",
pages = "158-169",
doi = "10.2478/acve-2021-0014"
}

Spariosu, K., Janjić, F., Francuski Andrić, J., Radaković, M., Beletić, A., Kovačević-Filipović, M.,& Milanović, S.. (2021). Relationship between changes in hematological parameters, levels of acute phase proteins and redox homeostasis during acute Babesia canis infection in dogs. in Acta Veterinaria-Beograd
Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 71(2), 158-169.
https://doi.org/10.2478/acve-2021-0014

Spariosu K, Janjić F, Francuski Andrić J, Radaković M, Beletić A, Kovačević-Filipović M, Milanović S. Relationship between changes in hematological parameters, levels of acute phase proteins and redox homeostasis during acute Babesia canis infection in dogs. in Acta Veterinaria-Beograd. 2021;71(2):158-169.
doi:10.2478/acve-2021-0014 .

Spariosu, Kristina, Janjić, Filip, Francuski Andrić, Jelena, Radaković, Milena, Beletić, Anđelo, Kovačević-Filipović, Milica, Milanović, Svetlana, "Relationship between changes in hematological parameters, levels of acute phase proteins and redox homeostasis during acute Babesia canis infection in dogs" in Acta Veterinaria-Beograd, 71, no. 2 (2021):158-169,
https://doi.org/10.2478/acve-2021-0014 . .

TY  - JOUR
AU  - Beletić, Anđelo
AU  - Janjić, Filip
AU  - Radaković, Milena
AU  - Spariosu, Kristina
AU  - Francuski Andrić, Jelena
AU  - Chandrashekar, Ramaswamy
AU  - Tyrrell, Phyllis
AU  - Radonjić, Vladimir
AU  - Balint, Bela
AU  - Ajtić, Jelena
AU  - Kovačević-Filipović, Milica
PY  - 2021
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/2015
AB  - The common signs of canine babesiosis caused by an infection with Babesia canis are fever, anorexia, lethargy, pulse alterations, anemia, and occasionally mild icterus. Dogs with these clinical signs can be divided into two groups: those with acute-phase reaction and those with systemic inflammatory response syndrome (SIRS). Factors associated with the occurrence of SIRS in canine babesiosis have not been thoroughly researched. This article outlines a cross-sectional study of 54 client-owned dogs with an acute B. canis infection, and evaluates the differences in age, gender, laboratory findings, parasite load, and seroreactivity against B. canis between the SIRS and the SIRS-free dogs. We have analyzed a complete blood count, serum biochemistry, serum amyloid A, ceruloplasmin, paraoxonase-1, serology, and PCR testing using standard methodologies. The frequency of SIRS among the investigated dogs reached 0.59. Male dogs and those seronegative against B. canis, were more frequent in the SIRS group, whilst age and parasite load could not be associated with the presence of SIRS. Dogs with SIRS had a lower count of total leukocytes, neutrophils, lymphocytes, and monocytes, and a lower concentration of iron and bilirubin compared with SIRS-free dogs. No significant differences in the concentration of acute-phase proteins have been noticed to exist between the groups of dogs. Further, the seronegative dogs had a lower count of lymphocytes and monocytes and a higher parasite load than the seroreactive dogs. Multivariate logistic regression analysis has identified leukopenia (<6 × 109/L) and monocytopenia (<0.2 × 109/L) as independent associates of SIRS in the investigated dogs, thus implying that these routine tests could be used as reliable markers for SIRS.
PB  - Elsevier
T2  - Veterinary Parasitology
T1  - Systemic inflammatory response syndrome in dogs naturally infected with Babesia canis: Association with the parasite load and host factors
VL  - 291
DO  - 10.1016/j.vetpar.2021.109366
ER  - 

@article{
author = "Beletić, Anđelo and Janjić, Filip and Radaković, Milena and Spariosu, Kristina and Francuski Andrić, Jelena and Chandrashekar, Ramaswamy and Tyrrell, Phyllis and Radonjić, Vladimir and Balint, Bela and Ajtić, Jelena and Kovačević-Filipović, Milica",
year = "2021",
abstract = "The common signs of canine babesiosis caused by an infection with Babesia canis are fever, anorexia, lethargy, pulse alterations, anemia, and occasionally mild icterus. Dogs with these clinical signs can be divided into two groups: those with acute-phase reaction and those with systemic inflammatory response syndrome (SIRS). Factors associated with the occurrence of SIRS in canine babesiosis have not been thoroughly researched. This article outlines a cross-sectional study of 54 client-owned dogs with an acute B. canis infection, and evaluates the differences in age, gender, laboratory findings, parasite load, and seroreactivity against B. canis between the SIRS and the SIRS-free dogs. We have analyzed a complete blood count, serum biochemistry, serum amyloid A, ceruloplasmin, paraoxonase-1, serology, and PCR testing using standard methodologies. The frequency of SIRS among the investigated dogs reached 0.59. Male dogs and those seronegative against B. canis, were more frequent in the SIRS group, whilst age and parasite load could not be associated with the presence of SIRS. Dogs with SIRS had a lower count of total leukocytes, neutrophils, lymphocytes, and monocytes, and a lower concentration of iron and bilirubin compared with SIRS-free dogs. No significant differences in the concentration of acute-phase proteins have been noticed to exist between the groups of dogs. Further, the seronegative dogs had a lower count of lymphocytes and monocytes and a higher parasite load than the seroreactive dogs. Multivariate logistic regression analysis has identified leukopenia (<6 × 109/L) and monocytopenia (<0.2 × 109/L) as independent associates of SIRS in the investigated dogs, thus implying that these routine tests could be used as reliable markers for SIRS.",
publisher = "Elsevier",
journal = "Veterinary Parasitology",
title = "Systemic inflammatory response syndrome in dogs naturally infected with Babesia canis: Association with the parasite load and host factors",
volume = "291",
doi = "10.1016/j.vetpar.2021.109366"
}

Beletić, A., Janjić, F., Radaković, M., Spariosu, K., Francuski Andrić, J., Chandrashekar, R., Tyrrell, P., Radonjić, V., Balint, B., Ajtić, J.,& Kovačević-Filipović, M.. (2021). Systemic inflammatory response syndrome in dogs naturally infected with Babesia canis: Association with the parasite load and host factors. in Veterinary Parasitology
Elsevier., 291.
https://doi.org/10.1016/j.vetpar.2021.109366

Beletić A, Janjić F, Radaković M, Spariosu K, Francuski Andrić J, Chandrashekar R, Tyrrell P, Radonjić V, Balint B, Ajtić J, Kovačević-Filipović M. Systemic inflammatory response syndrome in dogs naturally infected with Babesia canis: Association with the parasite load and host factors. in Veterinary Parasitology. 2021;291.
doi:10.1016/j.vetpar.2021.109366 .

Beletić, Anđelo, Janjić, Filip, Radaković, Milena, Spariosu, Kristina, Francuski Andrić, Jelena, Chandrashekar, Ramaswamy, Tyrrell, Phyllis, Radonjić, Vladimir, Balint, Bela, Ajtić, Jelena, Kovačević-Filipović, Milica, "Systemic inflammatory response syndrome in dogs naturally infected with Babesia canis: Association with the parasite load and host factors" in Veterinary Parasitology, 291 (2021),
https://doi.org/10.1016/j.vetpar.2021.109366 . .

TY  - JOUR
AU  - Spariosu, Kristina
AU  - Janjić, Filip
AU  - Radaković, Milena
AU  - Francuski Andrić, Jelena
AU  - Beletić, Anđelo
AU  - Kovačević-Filipović, Milica
PY  - 2021
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/2240
AB  - Inflammation is a hallmark of the acute Babesia canis infection. Promatrix metalloproteinase (proMMP)-2 and -9 are involved in inflammation, but their levels have not been analyzed in canine babesiosis. We hypothesized that in dogs infected with B. canis, serum proMMP-2 and -9 levels change between presentation and recovery. Degree of the change differs if dogs develop systemic inflammatory response syndrome (SIRS). This study included 24 dogs with an acute B. canis infection, at presentation and after two weeks. We used routine hematology and biochemistry methods, spectrophotometry for the acute-phase proteins, microscopy for parasitemia and zymography for (pro)MMPs. In vitro endothelial cells and leukocyte short-term cultures, and platelet lysates were used to detect specific MMP activity. Statistical analyses included Wilcoxon test for paired samples, Mann-Whitney U test and Spearman’s rank correlation. Our results showed that endothelial cells, leukocytes and platelets are the source of proMMP-2 and proMMP-9. Furthermore, both proMMPs were lower at presentation than after recovery (p < 0.001). At presentation, proMMP-9 levels correlated with parasitemia (rho = -0.616, p = 0.009), total leukocyte (rho = 0.704, p < 0.001) and neutrophil counts (rho = 0.741, p < 0.001). Extent of alterations in proMMP-2 levels between presentation and recovery was lower (p = 0.038) in dogs with SIRS than in non-SIRS dogs, while levels of proMMP-9 were comparable between these groups. Our conclusion is that during the acute B. canis infection, low serum levels of proMMP-2 and proMMP-9 at presentation reflect thrombocytopenia and leukopenia. Decreased proMMP-2 level could be associated with SIRS.
PB  - Elsevier
T2  - Veterinary Parasitology
T1  - Low serum levels of promatrix metalloproteinase-2 and -9 occur during acute Babesia canis infection in dogs
VL  - 300
SP  - 109612
DO  - 10.1016/j.vetpar.2021.109612
ER  - 

@article{
author = "Spariosu, Kristina and Janjić, Filip and Radaković, Milena and Francuski Andrić, Jelena and Beletić, Anđelo and Kovačević-Filipović, Milica",
year = "2021",
abstract = "Inflammation is a hallmark of the acute Babesia canis infection. Promatrix metalloproteinase (proMMP)-2 and -9 are involved in inflammation, but their levels have not been analyzed in canine babesiosis. We hypothesized that in dogs infected with B. canis, serum proMMP-2 and -9 levels change between presentation and recovery. Degree of the change differs if dogs develop systemic inflammatory response syndrome (SIRS). This study included 24 dogs with an acute B. canis infection, at presentation and after two weeks. We used routine hematology and biochemistry methods, spectrophotometry for the acute-phase proteins, microscopy for parasitemia and zymography for (pro)MMPs. In vitro endothelial cells and leukocyte short-term cultures, and platelet lysates were used to detect specific MMP activity. Statistical analyses included Wilcoxon test for paired samples, Mann-Whitney U test and Spearman’s rank correlation. Our results showed that endothelial cells, leukocytes and platelets are the source of proMMP-2 and proMMP-9. Furthermore, both proMMPs were lower at presentation than after recovery (p < 0.001). At presentation, proMMP-9 levels correlated with parasitemia (rho = -0.616, p = 0.009), total leukocyte (rho = 0.704, p < 0.001) and neutrophil counts (rho = 0.741, p < 0.001). Extent of alterations in proMMP-2 levels between presentation and recovery was lower (p = 0.038) in dogs with SIRS than in non-SIRS dogs, while levels of proMMP-9 were comparable between these groups. Our conclusion is that during the acute B. canis infection, low serum levels of proMMP-2 and proMMP-9 at presentation reflect thrombocytopenia and leukopenia. Decreased proMMP-2 level could be associated with SIRS.",
publisher = "Elsevier",
journal = "Veterinary Parasitology",
title = "Low serum levels of promatrix metalloproteinase-2 and -9 occur during acute Babesia canis infection in dogs",
volume = "300",
pages = "109612",
doi = "10.1016/j.vetpar.2021.109612"
}

Spariosu, K., Janjić, F., Radaković, M., Francuski Andrić, J., Beletić, A.,& Kovačević-Filipović, M.. (2021). Low serum levels of promatrix metalloproteinase-2 and -9 occur during acute Babesia canis infection in dogs. in Veterinary Parasitology
Elsevier., 300, 109612.
https://doi.org/10.1016/j.vetpar.2021.109612

Spariosu K, Janjić F, Radaković M, Francuski Andrić J, Beletić A, Kovačević-Filipović M. Low serum levels of promatrix metalloproteinase-2 and -9 occur during acute Babesia canis infection in dogs. in Veterinary Parasitology. 2021;300:109612.
doi:10.1016/j.vetpar.2021.109612 .

Spariosu, Kristina, Janjić, Filip, Radaković, Milena, Francuski Andrić, Jelena, Beletić, Anđelo, Kovačević-Filipović, Milica, "Low serum levels of promatrix metalloproteinase-2 and -9 occur during acute Babesia canis infection in dogs" in Veterinary Parasitology, 300 (2021):109612,
https://doi.org/10.1016/j.vetpar.2021.109612 . .

TY  - CONF
AU  - Spariosu, Kristina
AU  - Marković, Lazar
AU  - Radaković, Milena
AU  - Francuski Andrić, Jelena
AU  - Beletić, Anđelo
AU  - Kovačević Filipović, Milica
PY  - 2021
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/2620
C3  - 7th European Veterinary Immunology Workshop Online, Belgrade, August 29 – 31, 2021
T1  - In vitro functional activity of neutrophils and lymphocytes of dogs with acute Babesia canis infection
SP  - 61
EP  - 61
UR  - https://hdl.handle.net/21.15107/rcub_veterinar_2620
ER  - 

@conference{
author = "Spariosu, Kristina and Marković, Lazar and Radaković, Milena and Francuski Andrić, Jelena and Beletić, Anđelo and Kovačević Filipović, Milica",
year = "2021",
journal = "7th European Veterinary Immunology Workshop Online, Belgrade, August 29 – 31, 2021",
title = "In vitro functional activity of neutrophils and lymphocytes of dogs with acute Babesia canis infection",
pages = "61-61",
url = "https://hdl.handle.net/21.15107/rcub_veterinar_2620"
}

Spariosu, K., Marković, L., Radaković, M., Francuski Andrić, J., Beletić, A.,& Kovačević Filipović, M.. (2021). In vitro functional activity of neutrophils and lymphocytes of dogs with acute Babesia canis infection. in 7th European Veterinary Immunology Workshop Online, Belgrade, August 29 – 31, 2021, 61-61.
https://hdl.handle.net/21.15107/rcub_veterinar_2620

Spariosu K, Marković L, Radaković M, Francuski Andrić J, Beletić A, Kovačević Filipović M. In vitro functional activity of neutrophils and lymphocytes of dogs with acute Babesia canis infection. in 7th European Veterinary Immunology Workshop Online, Belgrade, August 29 – 31, 2021. 2021;:61-61.
https://hdl.handle.net/21.15107/rcub_veterinar_2620 .

Spariosu, Kristina, Marković, Lazar, Radaković, Milena, Francuski Andrić, Jelena, Beletić, Anđelo, Kovačević Filipović, Milica, "In vitro functional activity of neutrophils and lymphocytes of dogs with acute Babesia canis infection" in 7th European Veterinary Immunology Workshop Online, Belgrade, August 29 – 31, 2021 (2021):61-61,
https://hdl.handle.net/21.15107/rcub_veterinar_2620 .

TY  - CONF
AU  - Sukara, Ratko
AU  - Andrić, Nenad
AU  - Francuski Andrić, Jelena
AU  - Tomanović, Snežana
PY  - 2021
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/3603
AB  - Mоноцитна ерлихиоза паса (МЕП) једна је од важнијих крпељима преносивих
болести у јужној Европи. Главни узрочник је грам негативнa бактерије Ehrlichia
canis, која у цитоплазми инфицираних леукоцита формира структуре зване моруле.
У Европи се смеђи псећи крпељ - Rhipicephalus sanguineus сматра главним
вектором. Различите фазе и вишеструке клиничке манифестације МЕП, као и
потенцијалне коинфекције другим патогенима који се преносе крпељима (Babesia
spp., Hepatozoon canis, Anaplasma phagocytophilum, A. platys) компликују
постављање поуздане дијагнозе. Иако су хематолошке, серолошке и цитолошке
дијагностичке технике од велике важности за МЕП, молекуларне методе (PCR,
qPCR) су често неопходне за коначну дијагнозу.
Тромесечно власничко женско штене ротвајлера из околине Београда без историје
путовања у ендемскa подручјa, доведено је на клинику Ветеринарског факултета у
Београду због летаргије, анорексије и генерализоване лифаденопатије. Девет дана
пре довођења на преглед извађен је крпељ. Хематолошке анализе потврдиле су
присуство нормоцитно нормохромне анемије, лимфоцитозе и тромбоцитопеније.
На крвном размазу и размазу издвојених леукоцита (buffy coat) уочено је присуство
гранулираних лимфоцита. Брзи антитело тест (Bionote, Korea) указао на
изложеност Е. canis. Да би се потврдила дијагноза, изолована је укупна ДНК из
ЕДТА крви и изведен је конвенционални PCR праћен секвенцирањем.
Упоређивањем добијене секвенце са секвенцама депонованим у GenBank®,
потврђено је присуство E. canis. Иако серолошке методе могу указивати на
изложеност E. canis (индиректна имунофлуоресценција- ИФА, ЕЛИСА тест), PCR
са великом специфичности и осетљивости је од суштинског значаја за детекцију
ДНК E. canis и овај налаз указује на активну инфекцију. Поред тога, детекција ДНК
је могућа и пре сероконверзије. Недостатак серолошких испитивања такође је и
појава унакрсне реактивности E. canis са другим врстама из породице
Anaplasmacataceae (E. chaffeensis, E. ewingii, A. phagocytophilum). Описани случај
је прва молекуларна потврда МЕП и присуства E.canis у Србији и указује на
важност примене молекуларних метода у циљу успостављања поуздане дијагнозе
код крпељима преносивих болести паса.
AB  - Canine monocytic ehrlichiosis (CME) is one of the major tick-borne diseases in
southern Europe. The main causative agent is gram-negative bacteria Ehrlichia canis,
which in the cytoplasm of infected leukocytes forming structures called morulae. In
Europe, brown dog tick Rhipicephalus sanguineus, is considered as the main vector.
Different phases and multiple clinical manifestations of CME, as well as potential coinfections with other tick-borne pathogens (Babesia spp., Hepatozoon canis,
Anaplasma phagocytophilum, A. platys) complicate reliable diagnosis. Even
haematological, serological and cytological diagnostic techniques are of great
importance for CME, molecular methods (PCR, qPCR) are often necessary for a
definitive diagnosis.
Proprietary, three months old female Rottweiler puppy from the vicinity of Belgrade
city without a history of travel to the endemic area was brought to the clinic of the
Faculty of Veterinary Medicine in Belgrade due to the presence of lethargy, anorexia
and generalized lymphadenopathy. Nine days before presentation tick was removed
from the dog. Haematological analyses showed the presence of normocytic
normochromic anemia, lymphocytosis and thrombocytopenia. On blood and buffy
coat smears granular lymphocytes were noted. Antibody SNAP test (Bionote, Korea)
indicated exposure to E. canis. To confirm the diagnosis, total DNA was extracted
from EDTA blood and conventional PCR followed by sequencing was performed. By
comparing the obtained sequence with the sequences deposited in GenBank®, the
presence of E. canis was confirmed.
Although serological methods may indicate exposure to E. canis (indirect fluorescent
antibody- IFA, enzyme-linked immunosorbent assays- ELISA), PCR with high
specificity and sensitivity is essential to detect DNK of E. canis indicating active
infection. Also, DNA detection is possible before seroconversion. The ambiguity of
serological assays may be also the appearance of cross-reactivity among E. canis and
other species of the Anaplasmacataceae family (E. chaffeensis, E. ewingii, A.
phagocytophilum). The described case was the first molecular confirmation of CME
and E. canis in Serbia, pointing to the importance of molecular methods in reliable
diagnosis.
PB  - Beograd : Srpsko veterinarsko društvo, Sekcija za zoonoze
C3  - XXII/XXIII Simpozijum epizootiologa i epidemiologa, Beograd, 26 - 28. april, 2021
T1  - Značaj molekularnih metoda u dijagnostici krpeljima prenosivih bolesti pasa - molekularna potvrda monocitne erlihoze pasa uzrokovane sa Ehrlichia canis
T1  - Importance of molecular methods in diagnostic of canine tick-borne diseases - molecular confirmation of canine monocytic ehrlichiosis caused by Ehrlichia canis
SP  - 178
EP  - 179
UR  - https://hdl.handle.net/21.15107/rcub_veterinar_3603
ER  - 

@conference{
author = "Sukara, Ratko and Andrić, Nenad and Francuski Andrić, Jelena and Tomanović, Snežana",
year = "2021",
abstract = "Mоноцитна ерлихиоза паса (МЕП) једна је од важнијих крпељима преносивих
болести у јужној Европи. Главни узрочник је грам негативнa бактерије Ehrlichia
canis, која у цитоплазми инфицираних леукоцита формира структуре зване моруле.
У Европи се смеђи псећи крпељ - Rhipicephalus sanguineus сматра главним
вектором. Различите фазе и вишеструке клиничке манифестације МЕП, као и
потенцијалне коинфекције другим патогенима који се преносе крпељима (Babesia
spp., Hepatozoon canis, Anaplasma phagocytophilum, A. platys) компликују
постављање поуздане дијагнозе. Иако су хематолошке, серолошке и цитолошке
дијагностичке технике од велике важности за МЕП, молекуларне методе (PCR,
qPCR) су често неопходне за коначну дијагнозу.
Тромесечно власничко женско штене ротвајлера из околине Београда без историје
путовања у ендемскa подручјa, доведено је на клинику Ветеринарског факултета у
Београду због летаргије, анорексије и генерализоване лифаденопатије. Девет дана
пре довођења на преглед извађен је крпељ. Хематолошке анализе потврдиле су
присуство нормоцитно нормохромне анемије, лимфоцитозе и тромбоцитопеније.
На крвном размазу и размазу издвојених леукоцита (buffy coat) уочено је присуство
гранулираних лимфоцита. Брзи антитело тест (Bionote, Korea) указао на
изложеност Е. canis. Да би се потврдила дијагноза, изолована је укупна ДНК из
ЕДТА крви и изведен је конвенционални PCR праћен секвенцирањем.
Упоређивањем добијене секвенце са секвенцама депонованим у GenBank®,
потврђено је присуство E. canis. Иако серолошке методе могу указивати на
изложеност E. canis (индиректна имунофлуоресценција- ИФА, ЕЛИСА тест), PCR
са великом специфичности и осетљивости је од суштинског значаја за детекцију
ДНК E. canis и овај налаз указује на активну инфекцију. Поред тога, детекција ДНК
је могућа и пре сероконверзије. Недостатак серолошких испитивања такође је и
појава унакрсне реактивности E. canis са другим врстама из породице
Anaplasmacataceae (E. chaffeensis, E. ewingii, A. phagocytophilum). Описани случај
је прва молекуларна потврда МЕП и присуства E.canis у Србији и указује на
важност примене молекуларних метода у циљу успостављања поуздане дијагнозе
код крпељима преносивих болести паса., Canine monocytic ehrlichiosis (CME) is one of the major tick-borne diseases in
southern Europe. The main causative agent is gram-negative bacteria Ehrlichia canis,
which in the cytoplasm of infected leukocytes forming structures called morulae. In
Europe, brown dog tick Rhipicephalus sanguineus, is considered as the main vector.
Different phases and multiple clinical manifestations of CME, as well as potential coinfections with other tick-borne pathogens (Babesia spp., Hepatozoon canis,
Anaplasma phagocytophilum, A. platys) complicate reliable diagnosis. Even
haematological, serological and cytological diagnostic techniques are of great
importance for CME, molecular methods (PCR, qPCR) are often necessary for a
definitive diagnosis.
Proprietary, three months old female Rottweiler puppy from the vicinity of Belgrade
city without a history of travel to the endemic area was brought to the clinic of the
Faculty of Veterinary Medicine in Belgrade due to the presence of lethargy, anorexia
and generalized lymphadenopathy. Nine days before presentation tick was removed
from the dog. Haematological analyses showed the presence of normocytic
normochromic anemia, lymphocytosis and thrombocytopenia. On blood and buffy
coat smears granular lymphocytes were noted. Antibody SNAP test (Bionote, Korea)
indicated exposure to E. canis. To confirm the diagnosis, total DNA was extracted
from EDTA blood and conventional PCR followed by sequencing was performed. By
comparing the obtained sequence with the sequences deposited in GenBank®, the
presence of E. canis was confirmed.
Although serological methods may indicate exposure to E. canis (indirect fluorescent
antibody- IFA, enzyme-linked immunosorbent assays- ELISA), PCR with high
specificity and sensitivity is essential to detect DNK of E. canis indicating active
infection. Also, DNA detection is possible before seroconversion. The ambiguity of
serological assays may be also the appearance of cross-reactivity among E. canis and
other species of the Anaplasmacataceae family (E. chaffeensis, E. ewingii, A.
phagocytophilum). The described case was the first molecular confirmation of CME
and E. canis in Serbia, pointing to the importance of molecular methods in reliable
diagnosis.",
publisher = "Beograd : Srpsko veterinarsko društvo, Sekcija za zoonoze",
journal = "XXII/XXIII Simpozijum epizootiologa i epidemiologa, Beograd, 26 - 28. april, 2021",
title = "Značaj molekularnih metoda u dijagnostici krpeljima prenosivih bolesti pasa - molekularna potvrda monocitne erlihoze pasa uzrokovane sa Ehrlichia canis, Importance of molecular methods in diagnostic of canine tick-borne diseases - molecular confirmation of canine monocytic ehrlichiosis caused by Ehrlichia canis",
pages = "178-179",
url = "https://hdl.handle.net/21.15107/rcub_veterinar_3603"
}

Sukara, R., Andrić, N., Francuski Andrić, J.,& Tomanović, S.. (2021). Značaj molekularnih metoda u dijagnostici krpeljima prenosivih bolesti pasa - molekularna potvrda monocitne erlihoze pasa uzrokovane sa Ehrlichia canis. in XXII/XXIII Simpozijum epizootiologa i epidemiologa, Beograd, 26 - 28. april, 2021
Beograd : Srpsko veterinarsko društvo, Sekcija za zoonoze., 178-179.
https://hdl.handle.net/21.15107/rcub_veterinar_3603

Sukara R, Andrić N, Francuski Andrić J, Tomanović S. Značaj molekularnih metoda u dijagnostici krpeljima prenosivih bolesti pasa - molekularna potvrda monocitne erlihoze pasa uzrokovane sa Ehrlichia canis. in XXII/XXIII Simpozijum epizootiologa i epidemiologa, Beograd, 26 - 28. april, 2021. 2021;:178-179.
https://hdl.handle.net/21.15107/rcub_veterinar_3603 .

Sukara, Ratko, Andrić, Nenad, Francuski Andrić, Jelena, Tomanović, Snežana, "Značaj molekularnih metoda u dijagnostici krpeljima prenosivih bolesti pasa - molekularna potvrda monocitne erlihoze pasa uzrokovane sa Ehrlichia canis" in XXII/XXIII Simpozijum epizootiologa i epidemiologa, Beograd, 26 - 28. april, 2021 (2021):178-179,
https://hdl.handle.net/21.15107/rcub_veterinar_3603 .

TY  - JOUR
AU  - Andrić, Nenad
AU  - Nešić, Slađan
AU  - Krstić, Nikola
AU  - Francuski Andrić, Jelena
PY  - 2020
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1873
AB  - A 15-year-old indoor/outdoor female, neutered, domestic European short haired cat was presented to our clinic with a history of neck-elongation and wheezing during inspiration/expiration. The first signs of respiratory disease occurred two weeks before the clinical presentation. After taking of clinical history, clinical examination and basic laboratory tests (complete blood count, blood smear, snap Feline Immunodeficiency Virus/Feline Leukemia Virus Combo test), a lung x-ray was performed showing the presence of left lung atelectasis and pneumothorax. The primary causes of lung atelectasis were not determined. Given that the general condition of the cat was very bad, she was put in an oxygen cage, thoracocentesis was performed, but the animal’s condition did not improve, and 24 hours after clinical presentation, the cat died. Autopsy revealed the presence of a tumor mass on the caudal lobe of the right lung, tumor formation in the area of trachea bifurcation and changes in the liver in the form of four round structures of different sizes. Histopathologically, the existence of primary undifferentiated lung adenocarcinoma with metastases on the liver and trachea was determined.
AB  - U ovom radu predstavljen je slučaj primarnog adenokarcinoma pluća kod domaće
kratkodlake mačke stare 15 godina. Prvi znaci oboljenja respiratornog sistema pojavili
su se dve nedelje pre dovođenja mačke na pregled, pri čemu su dominirali znaci disanja
sa ispruženim vratom i šištanje tokom inspirijuma i ekspirijuma. Nakon uzimanja istorije
bolesti, kliničkog i laboratorijskog ispitivanja (krvna slika, krvni razmaz, FIV/FeLV
brzi dijagnostički test) urađen je rendgen pluća koji je pokazao postojanje atelektaze
levog plućnog krila i pneumotoraks. Nije utvrđeno koji patofiziološki mehanizam je
odgovoran za atelektazu pluća. S obzirom da je opšte stanje mačke bilo jako loše,
stavljena je u kiseonički kavez, urađena je torakocenteza ali stanje se nije popravilo i
24h od dolaska na kliniku mačka je uginula. Na obdukciji je utvrđeno odstupanje od
normalnog nalaza na levom plućnom krilu, postojanje promena na desnom plućnom
krilu, tumorozna tvorevina u predelu bifurkacije traheje i promene na jetri u vidu četiri
okrugle tvorevine različite veličine. Histopatološki je utvrđeno postojanje primarnog
nediferentovanog adenokarcinoma pluća sa metastazama na već pomenutim organima.
PB  - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
T2  - Veterinarski Glasnik
T1  - Lung adenocarcinoma as a cause of spontaneous pneumothorax in a cat
T1  - Adenokarcinom pluća kao uzrok pneumotoraksa kod mačke
IS  - 00
SP  - 6
EP  - 6
DO  - doi.org/10.2298/VETGL191227006A
ER  - 

@article{
author = "Andrić, Nenad and Nešić, Slađan and Krstić, Nikola and Francuski Andrić, Jelena",
year = "2020",
abstract = "A 15-year-old indoor/outdoor female, neutered, domestic European short haired cat was presented to our clinic with a history of neck-elongation and wheezing during inspiration/expiration. The first signs of respiratory disease occurred two weeks before the clinical presentation. After taking of clinical history, clinical examination and basic laboratory tests (complete blood count, blood smear, snap Feline Immunodeficiency Virus/Feline Leukemia Virus Combo test), a lung x-ray was performed showing the presence of left lung atelectasis and pneumothorax. The primary causes of lung atelectasis were not determined. Given that the general condition of the cat was very bad, she was put in an oxygen cage, thoracocentesis was performed, but the animal’s condition did not improve, and 24 hours after clinical presentation, the cat died. Autopsy revealed the presence of a tumor mass on the caudal lobe of the right lung, tumor formation in the area of trachea bifurcation and changes in the liver in the form of four round structures of different sizes. Histopathologically, the existence of primary undifferentiated lung adenocarcinoma with metastases on the liver and trachea was determined., U ovom radu predstavljen je slučaj primarnog adenokarcinoma pluća kod domaće
kratkodlake mačke stare 15 godina. Prvi znaci oboljenja respiratornog sistema pojavili
su se dve nedelje pre dovođenja mačke na pregled, pri čemu su dominirali znaci disanja
sa ispruženim vratom i šištanje tokom inspirijuma i ekspirijuma. Nakon uzimanja istorije
bolesti, kliničkog i laboratorijskog ispitivanja (krvna slika, krvni razmaz, FIV/FeLV
brzi dijagnostički test) urađen je rendgen pluća koji je pokazao postojanje atelektaze
levog plućnog krila i pneumotoraks. Nije utvrđeno koji patofiziološki mehanizam je
odgovoran za atelektazu pluća. S obzirom da je opšte stanje mačke bilo jako loše,
stavljena je u kiseonički kavez, urađena je torakocenteza ali stanje se nije popravilo i
24h od dolaska na kliniku mačka je uginula. Na obdukciji je utvrđeno odstupanje od
normalnog nalaza na levom plućnom krilu, postojanje promena na desnom plućnom
krilu, tumorozna tvorevina u predelu bifurkacije traheje i promene na jetri u vidu četiri
okrugle tvorevine različite veličine. Histopatološki je utvrđeno postojanje primarnog
nediferentovanog adenokarcinoma pluća sa metastazama na već pomenutim organima.",
publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd",
journal = "Veterinarski Glasnik",
title = "Lung adenocarcinoma as a cause of spontaneous pneumothorax in a cat, Adenokarcinom pluća kao uzrok pneumotoraksa kod mačke",
number = "00",
pages = "6-6",
doi = "doi.org/10.2298/VETGL191227006A"
}

Andrić, N., Nešić, S., Krstić, N.,& Francuski Andrić, J.. (2020). Lung adenocarcinoma as a cause of spontaneous pneumothorax in a cat. in Veterinarski Glasnik
Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd.(00), 6-6.
https://doi.org/doi.org/10.2298/VETGL191227006A

Andrić N, Nešić S, Krstić N, Francuski Andrić J. Lung adenocarcinoma as a cause of spontaneous pneumothorax in a cat. in Veterinarski Glasnik. 2020;(00):6-6.
doi:doi.org/10.2298/VETGL191227006A .

Andrić, Nenad, Nešić, Slađan, Krstić, Nikola, Francuski Andrić, Jelena, "Lung adenocarcinoma as a cause of spontaneous pneumothorax in a cat" in Veterinarski Glasnik, no. 00 (2020):6-6,
https://doi.org/doi.org/10.2298/VETGL191227006A . .

TY  - CONF
AU  - Giger, Urs
AU  - Francuski, Jelena
AU  - Stojić, Milica
PY  - 2020
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/3800
PB  - Beograd : Fakultet veterinarske medicine, Centar za izdavačku delatnost i promet učila
C3  - XLI Seminar za inovacije znanja veterinara, Beograd, 2020
T1  - Klinička hematologija
SP  - 143
EP  - 144
UR  - https://hdl.handle.net/21.15107/rcub_veterinar_3800
ER  - 

@conference{
author = "Giger, Urs and Francuski, Jelena and Stojić, Milica",
year = "2020",
publisher = "Beograd : Fakultet veterinarske medicine, Centar za izdavačku delatnost i promet učila",
journal = "XLI Seminar za inovacije znanja veterinara, Beograd, 2020",
title = "Klinička hematologija",
pages = "143-144",
url = "https://hdl.handle.net/21.15107/rcub_veterinar_3800"
}

Giger, U., Francuski, J.,& Stojić, M.. (2020). Klinička hematologija. in XLI Seminar za inovacije znanja veterinara, Beograd, 2020
Beograd : Fakultet veterinarske medicine, Centar za izdavačku delatnost i promet učila., 143-144.
https://hdl.handle.net/21.15107/rcub_veterinar_3800

Giger U, Francuski J, Stojić M. Klinička hematologija. in XLI Seminar za inovacije znanja veterinara, Beograd, 2020. 2020;:143-144.
https://hdl.handle.net/21.15107/rcub_veterinar_3800 .

Giger, Urs, Francuski, Jelena, Stojić, Milica, "Klinička hematologija" in XLI Seminar za inovacije znanja veterinara, Beograd, 2020 (2020):143-144,
https://hdl.handle.net/21.15107/rcub_veterinar_3800 .