Stojić, M., Ilić, V., Kovačić, M., Gvozdić, D., Stajković, S., Vejnović, B., Savić, O.,& Fratrić, N.. (2020). Effects of oral supplementation with organically modified clinoptilolite during prepartum period on colostrum quality in primiparous dairy cows. in Journal of Dairy Research
Cambridge University Press., 87(4), 429-435.
https://hdl.handle.net/21.15107/rcub_veterinar_1976

Stojić M, Ilić V, Kovačić M, Gvozdić D, Stajković S, Vejnović B, Savić O, Fratrić N. Effects of oral supplementation with organically modified clinoptilolite during prepartum period on colostrum quality in primiparous dairy cows. in Journal of Dairy Research. 2020;87(4):429-435.
https://hdl.handle.net/21.15107/rcub_veterinar_1976 .

Stojić, Milica, Ilić, Vesna, Kovačić, Marijana, Gvozdić, Dragan, Stajković, Silvana, Vejnović, Branislav, Savić, Olivera, Fratrić, Natalija, "Effects of oral supplementation with organically modified clinoptilolite during prepartum period on colostrum quality in primiparous dairy cows" in Journal of Dairy Research, 87, no. 4 (2020):429-435,
https://hdl.handle.net/21.15107/rcub_veterinar_1976 .

TY  - CONF
AU  - Fratrić, Natalija
AU  - Stojić, Milica
AU  - Gvozdić, Dragan
PY  - 2019
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/3335
AB  - Imunitet mlečne žlezde zavisi od koordinisanog delovanja elemenata nespecifičnog i specifičnog imuniteta, što uključuje, kako anatomske karakteristike žlezde tako i ćelijske i humoralne odbrambene komponente. Primarne uloge imunskog sistema su da prevenira invaziju - naseljavanje mlečne žlezde bakterijama,
eliminiše postojeću infekciju i uspostavi normalnu funkciju tkiva mlečne žlezde.
Više spoljašnjih i unutrašnjih faktora može uticati na slabljenje imunskog odgovora domaćina, koji dodatno zavisi od virulentnosti i otpornosti različitih mikroorganizama, izazivača mastitisa. Stoga je poznavanje imuniteta mlečne žlezde, kako
u fiziološkim tako i u uslovima inflamacije, ključno za razumevanje prirode intramamarnih infekcija. Imunski odgovor mlečne žlezde varira u zavisnosti od perioda
laktacije mlečnih krava i suprimiran je kod stresa, oko perioda zasušenja i partusa
što povećava osetljivost mlečne žlezde na mastitise.
PB  - Beograd : Fakultet veterinarske medicine, Centar za izdavačku delatnost i promet učila
C3  - 10. Naučni simpozijum Reprodukcija domaćih životinja i bolesti mlečne žlezde, Divčibare, 10 - 13. oktobar 2019
T1  - Spečifičnosti imunskog odgovora mlečne žlezde i otpornost na mastite kod mlečnih krava
SP  - 181
SP  - 199
UR  - https://hdl.handle.net/21.15107/rcub_veterinar_3335
ER  - 

@conference{
author = "Fratrić, Natalija and Stojić, Milica and Gvozdić, Dragan",
year = "2019",
abstract = "Imunitet mlečne žlezde zavisi od koordinisanog delovanja elemenata nespecifičnog i specifičnog imuniteta, što uključuje, kako anatomske karakteristike žlezde tako i ćelijske i humoralne odbrambene komponente. Primarne uloge imunskog sistema su da prevenira invaziju - naseljavanje mlečne žlezde bakterijama,
eliminiše postojeću infekciju i uspostavi normalnu funkciju tkiva mlečne žlezde.
Više spoljašnjih i unutrašnjih faktora može uticati na slabljenje imunskog odgovora domaćina, koji dodatno zavisi od virulentnosti i otpornosti različitih mikroorganizama, izazivača mastitisa. Stoga je poznavanje imuniteta mlečne žlezde, kako
u fiziološkim tako i u uslovima inflamacije, ključno za razumevanje prirode intramamarnih infekcija. Imunski odgovor mlečne žlezde varira u zavisnosti od perioda
laktacije mlečnih krava i suprimiran je kod stresa, oko perioda zasušenja i partusa
što povećava osetljivost mlečne žlezde na mastitise.",
publisher = "Beograd : Fakultet veterinarske medicine, Centar za izdavačku delatnost i promet učila",
journal = "10. Naučni simpozijum Reprodukcija domaćih životinja i bolesti mlečne žlezde, Divčibare, 10 - 13. oktobar 2019",
title = "Spečifičnosti imunskog odgovora mlečne žlezde i otpornost na mastite kod mlečnih krava",
pages = "181-199",
url = "https://hdl.handle.net/21.15107/rcub_veterinar_3335"
}

Fratrić, N., Stojić, M.,& Gvozdić, D.. (2019). Spečifičnosti imunskog odgovora mlečne žlezde i otpornost na mastite kod mlečnih krava. in 10. Naučni simpozijum Reprodukcija domaćih životinja i bolesti mlečne žlezde, Divčibare, 10 - 13. oktobar 2019
Beograd : Fakultet veterinarske medicine, Centar za izdavačku delatnost i promet učila., 181.
https://hdl.handle.net/21.15107/rcub_veterinar_3335

Fratrić N, Stojić M, Gvozdić D. Spečifičnosti imunskog odgovora mlečne žlezde i otpornost na mastite kod mlečnih krava. in 10. Naučni simpozijum Reprodukcija domaćih životinja i bolesti mlečne žlezde, Divčibare, 10 - 13. oktobar 2019. 2019;:181.
https://hdl.handle.net/21.15107/rcub_veterinar_3335 .

Fratrić, Natalija, Stojić, Milica, Gvozdić, Dragan, "Spečifičnosti imunskog odgovora mlečne žlezde i otpornost na mastite kod mlečnih krava" in 10. Naučni simpozijum Reprodukcija domaćih životinja i bolesti mlečne žlezde, Divčibare, 10 - 13. oktobar 2019 (2019):181,
https://hdl.handle.net/21.15107/rcub_veterinar_3335 .

TY  - THES
AU  - Stojić, Milica
PY  - 2018
UR  - http://vbs.rs/scripts/cobiss?command=DISPLAY&base=70036&RID=50006287
UR  - http://nardus.mpn.gov.rs/123456789/9409
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/45
AB  - characteristics of the full colostrum, colostral and blood serum. The total number of 36 healthy pregnant Holstein heifers was included in this study, starting 30 days before the expected calving date. Animals were divided into two groups: treated heifers (N=20) and control group of heifers (N=16). The treated group of animals has received oral supplementation of organically modified clinoptilolite, in a dose of 150g per day, dissolved in 1L of water and given by a glass bottle, starting from 20±5 days before the expected calving term up to two days after calving. The control group of animals has received pure water in the same amount (1L) and time as treated animals. Samples of colostrum and colostral serum from the first four milkings were collected and analyzed in all experimental animals included in the study...
AB  - Za zdravlje i preživljavanje novorođene teladi od najvećeg značaja je unošenje adekvatne količine kolostruma dobrog kvaliteta odmah posle rođenja. Pored svoje funkcije kao osnovnog izvora nutritijenata, kolostrum ima esencijalnu funkciju u obezbeđivanju imunske zaštite teleta u ranim fazama života. Ishrana kolostrumom visokog kvaliteta u prvim satima života obezbeđuje tele sa dovoljnom količinom imunoglobulina neophodnih za uspostavljanje pasivnog imuniteta tokom prva tri meseca života. Zeolit se već koristi kao dodatak u hranu kod životinja, u cilju poboljšanja proizvodnih performansi i sprečavanja štetnog delovanja mikotoksina. Dugotrajna suplementacija klinoptilolitom ima pozitivne efekte na zdravlje mlečnih krava međutim uticaj zeolita na kvalitet i sastav kolostruma krava do sada nije izučavan. Pored prirodnih zeolita primenom savremenih tehnologija dobijena su i nova jedinjenja, i u ovoj doktorskoj disertaciji korišćen je organski modifikovan klinoptilolit Minazel Plus® (Patent Co., Srbija). Cilj ove disertacije je bio da se ispita uticaj peroralnog davanja organski modifikovanog klinoptilolita na kvalitet kolostruma prvotelki na osnovu rezultata analize fizičko-hemijskih, biohemijskih i imunohemijskih karakteristika punog klostruma, kolostralnog i krvnog seruma. Za ogled je izabrano 36 zdravih visoko gravidnih prvotelki holštajn- frizijske rase goveda, 30 dana pre očekivanog termina teljenja. Životinje su podeljene u dve grupe, tretiranu u kojoj je bilo 20 jedinki i kontrolnu sa 16 jedinki. Tretirana grupa životinja je počevši od 20±5 dana pre očekivanog termina teljenja do dva dana posle teljenja, svakodnevno dobijala organski modifikovan klinoptilolit u dozi od 150 g dnevno, rastvaran u 1 L vode i davan per os, zalivanjem iz staklene flaše. Kontrolnoj grupi životinja je svakodnevno davana čista voda u količini od 1 L...
PB  - Univerzitet u Beogradu, Fakultet veterinarske medicine
T1  - The effect of oral administration of organically modified clinoptilolite on colostrum quality in primiparous dairy cows
T1  - Uticaj peroralnog davanja organski modifikovanog klinoptilolita na kvalitet kolostruma prvotelki
UR  - https://hdl.handle.net/21.15107/rcub_nardus_9409
ER  - 

@phdthesis{
author = "Stojić, Milica",
year = "2018",
abstract = "characteristics of the full colostrum, colostral and blood serum. The total number of 36 healthy pregnant Holstein heifers was included in this study, starting 30 days before the expected calving date. Animals were divided into two groups: treated heifers (N=20) and control group of heifers (N=16). The treated group of animals has received oral supplementation of organically modified clinoptilolite, in a dose of 150g per day, dissolved in 1L of water and given by a glass bottle, starting from 20±5 days before the expected calving term up to two days after calving. The control group of animals has received pure water in the same amount (1L) and time as treated animals. Samples of colostrum and colostral serum from the first four milkings were collected and analyzed in all experimental animals included in the study..., Za zdravlje i preživljavanje novorođene teladi od najvećeg značaja je unošenje adekvatne količine kolostruma dobrog kvaliteta odmah posle rođenja. Pored svoje funkcije kao osnovnog izvora nutritijenata, kolostrum ima esencijalnu funkciju u obezbeđivanju imunske zaštite teleta u ranim fazama života. Ishrana kolostrumom visokog kvaliteta u prvim satima života obezbeđuje tele sa dovoljnom količinom imunoglobulina neophodnih za uspostavljanje pasivnog imuniteta tokom prva tri meseca života. Zeolit se već koristi kao dodatak u hranu kod životinja, u cilju poboljšanja proizvodnih performansi i sprečavanja štetnog delovanja mikotoksina. Dugotrajna suplementacija klinoptilolitom ima pozitivne efekte na zdravlje mlečnih krava međutim uticaj zeolita na kvalitet i sastav kolostruma krava do sada nije izučavan. Pored prirodnih zeolita primenom savremenih tehnologija dobijena su i nova jedinjenja, i u ovoj doktorskoj disertaciji korišćen je organski modifikovan klinoptilolit Minazel Plus® (Patent Co., Srbija). Cilj ove disertacije je bio da se ispita uticaj peroralnog davanja organski modifikovanog klinoptilolita na kvalitet kolostruma prvotelki na osnovu rezultata analize fizičko-hemijskih, biohemijskih i imunohemijskih karakteristika punog klostruma, kolostralnog i krvnog seruma. Za ogled je izabrano 36 zdravih visoko gravidnih prvotelki holštajn- frizijske rase goveda, 30 dana pre očekivanog termina teljenja. Životinje su podeljene u dve grupe, tretiranu u kojoj je bilo 20 jedinki i kontrolnu sa 16 jedinki. Tretirana grupa životinja je počevši od 20±5 dana pre očekivanog termina teljenja do dva dana posle teljenja, svakodnevno dobijala organski modifikovan klinoptilolit u dozi od 150 g dnevno, rastvaran u 1 L vode i davan per os, zalivanjem iz staklene flaše. Kontrolnoj grupi životinja je svakodnevno davana čista voda u količini od 1 L...",
publisher = "Univerzitet u Beogradu, Fakultet veterinarske medicine",
title = "The effect of oral administration of organically modified clinoptilolite on colostrum quality in primiparous dairy cows, Uticaj peroralnog davanja organski modifikovanog klinoptilolita na kvalitet kolostruma prvotelki",
url = "https://hdl.handle.net/21.15107/rcub_nardus_9409"
}

Stojić, M.. (2018). The effect of oral administration of organically modified clinoptilolite on colostrum quality in primiparous dairy cows. 
Univerzitet u Beogradu, Fakultet veterinarske medicine..
https://hdl.handle.net/21.15107/rcub_nardus_9409

Stojić M. The effect of oral administration of organically modified clinoptilolite on colostrum quality in primiparous dairy cows. 2018;.
https://hdl.handle.net/21.15107/rcub_nardus_9409 .

Stojić, Milica, "The effect of oral administration of organically modified clinoptilolite on colostrum quality in primiparous dairy cows" (2018),
https://hdl.handle.net/21.15107/rcub_nardus_9409 .

TY  - JOUR
AU  - Suluburić, Adam
AU  - Milanović, Svetlana
AU  - Vranješ-Đurić, Sanja
AU  - Jovanović, Ivan B.
AU  - Barna, Tomislav
AU  - Stojić, Milica
AU  - Fratrić, Natalija
AU  - Szenci, Otto
AU  - Gvozdić, Dragan
PY  - 2017
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1486
AB  - Early embryonic development may be negatively affected by insufficient progesterone (P4) production. Therefore, the aim of our study was to increase P4 by gonadotropin-releasing hormone (GnRH) and/or human chorionic gonadotropin (hCG) treatments after inducing oestrus by prostaglandin (PG) treatment. Lactating Simmental dairy cows (n = 110), between 1 to 5 lactations, with an average milk production of 6,500 l/305 days, at 40-80 days postpartum were used and grouped as follows: (1) PG + GnRH treatment at AI (GnRH group), (2) PG + hCG treatment at day 7 after AI (hCG group), (3) PG + GnRH at AI + hCG treatment at day 7 after AI (GnRH/hCG group), and (4) spontaneous oestrus (C: control group). All animals were double inseminated (at the time of oestrus detection and 12 +/- 2 h thereafter). Blood serum and milk samples were collected at the day of observed oestrus (day 0), and 14, 21 and 28 days after AI. Serum P4 was determined using a commercial radioimmunoassay (RIA) test (INEP, Zemun), and milk P4 was determined using enzyme-linked immunoassay (ELISA) test (NIV Novi Sad). Pregnancy status was confirmed by ultrasonography between days 28 and 35 after AI. Differences of serum or milk P4 medians, pregnancy (and calving) rate were determined using Dunns Multiple Comparison Tests and Z test, respectively. Serum P4 medians were significantly higher at days 14, 21 and 28 after AI in the hCG-treated animals, indicating increased luteal activity, with a similar tendency in whole milk P4 values. Treatment with hCG during the early luteal phase significantly contributed to the maintenance of gestation at days 28-35 after AI, and also increased the calving rate in Simmental dairy cows.
PB  - Akademiai Kiado Rt, Budapest
T2  - Acta Veterinaria Hungarica
T1  - Progesterone concentration, pregnancy and calving rate in simmental dairy cows after oestrus synchronisation and HCG treatment during the early luteal phase
VL  - 65
IS  - 3
SP  - 446
EP  - 458
DO  - 10.1556/004.2017.042
ER  - 

@article{
author = "Suluburić, Adam and Milanović, Svetlana and Vranješ-Đurić, Sanja and Jovanović, Ivan B. and Barna, Tomislav and Stojić, Milica and Fratrić, Natalija and Szenci, Otto and Gvozdić, Dragan",
year = "2017",
abstract = "Early embryonic development may be negatively affected by insufficient progesterone (P4) production. Therefore, the aim of our study was to increase P4 by gonadotropin-releasing hormone (GnRH) and/or human chorionic gonadotropin (hCG) treatments after inducing oestrus by prostaglandin (PG) treatment. Lactating Simmental dairy cows (n = 110), between 1 to 5 lactations, with an average milk production of 6,500 l/305 days, at 40-80 days postpartum were used and grouped as follows: (1) PG + GnRH treatment at AI (GnRH group), (2) PG + hCG treatment at day 7 after AI (hCG group), (3) PG + GnRH at AI + hCG treatment at day 7 after AI (GnRH/hCG group), and (4) spontaneous oestrus (C: control group). All animals were double inseminated (at the time of oestrus detection and 12 +/- 2 h thereafter). Blood serum and milk samples were collected at the day of observed oestrus (day 0), and 14, 21 and 28 days after AI. Serum P4 was determined using a commercial radioimmunoassay (RIA) test (INEP, Zemun), and milk P4 was determined using enzyme-linked immunoassay (ELISA) test (NIV Novi Sad). Pregnancy status was confirmed by ultrasonography between days 28 and 35 after AI. Differences of serum or milk P4 medians, pregnancy (and calving) rate were determined using Dunns Multiple Comparison Tests and Z test, respectively. Serum P4 medians were significantly higher at days 14, 21 and 28 after AI in the hCG-treated animals, indicating increased luteal activity, with a similar tendency in whole milk P4 values. Treatment with hCG during the early luteal phase significantly contributed to the maintenance of gestation at days 28-35 after AI, and also increased the calving rate in Simmental dairy cows.",
publisher = "Akademiai Kiado Rt, Budapest",
journal = "Acta Veterinaria Hungarica",
title = "Progesterone concentration, pregnancy and calving rate in simmental dairy cows after oestrus synchronisation and HCG treatment during the early luteal phase",
volume = "65",
number = "3",
pages = "446-458",
doi = "10.1556/004.2017.042"
}

Suluburić, A., Milanović, S., Vranješ-Đurić, S., Jovanović, I. B., Barna, T., Stojić, M., Fratrić, N., Szenci, O.,& Gvozdić, D.. (2017). Progesterone concentration, pregnancy and calving rate in simmental dairy cows after oestrus synchronisation and HCG treatment during the early luteal phase. in Acta Veterinaria Hungarica
Akademiai Kiado Rt, Budapest., 65(3), 446-458.
https://doi.org/10.1556/004.2017.042

Suluburić A, Milanović S, Vranješ-Đurić S, Jovanović IB, Barna T, Stojić M, Fratrić N, Szenci O, Gvozdić D. Progesterone concentration, pregnancy and calving rate in simmental dairy cows after oestrus synchronisation and HCG treatment during the early luteal phase. in Acta Veterinaria Hungarica. 2017;65(3):446-458.
doi:10.1556/004.2017.042 .

Suluburić, Adam, Milanović, Svetlana, Vranješ-Đurić, Sanja, Jovanović, Ivan B., Barna, Tomislav, Stojić, Milica, Fratrić, Natalija, Szenci, Otto, Gvozdić, Dragan, "Progesterone concentration, pregnancy and calving rate in simmental dairy cows after oestrus synchronisation and HCG treatment during the early luteal phase" in Acta Veterinaria Hungarica, 65, no. 3 (2017):446-458,
https://doi.org/10.1556/004.2017.042 . .

TY  - JOUR
AU  - Bjelica, Jelena
AU  - Jovanović, Ivan B.
AU  - Ilić, Vesna
AU  - Valčić, Olivera
AU  - Kirovski, Danijela
AU  - Gvozdić, Dragan
AU  - Milanović, Svetlana
PY  - 2017
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1535
AB  - Both selenium, as an effector and regulator of antioxidative enzymes activity, and thyroid hormones are potent immunomodulators. Besides, selenium incorporated into iodothyronine deiodinases is involved in the thyroid function and thus indirectly regulates the immune response. Studies of the mutual infl uence of selenium and thyroid hormones on the immune response are scarce, hence we analyzed the effects of an iodothyronine deiodinases blocker, propylthiouracil (PTU), and selenium defi ciency on the function of peritoneal macrophages, and titer of naturally occurring anti-sheep red blood cells (SRBC) IgM antibodies in juvenile rats. The experiment was carried out on 64 Wistar male rats allotted to 4 groups: controlselenium adequate PTU-group; selenium adequate, PTU+ group; selenium defi cient, PTU-group; and selenium defi cient, PTU+. The selenium adequate and selenium defi cient groups were fed a diet containing 0.334 and 0.031 mg Se/kg, respectively. PTU+ groups received PTU (150 mg/L) in drinking water. After 3 weeks, thyroxine (T-4), triiodothyronine (T-3), and thyroid stimulating hormone (TSH) were determined. The animals having intermediate concentrations of T-3 (1.56-1.69 nmol/L) and T 4 (41-50 nmol/L) were excluded from further analysis. Thus, PTU+ groups included hypothyroid animals (T-3 <= 1.55 nmol/L; T-4 <= 40 nmol/L), while PTU-groups included euthyroid rats (T-3 <= 1.70 nmol/L; T-4 <= 50 nmol/L). Both groups of selenium defi cient rats had, when compared to the control group, a signifi cantly lower activity of glutathione peroxidase GPx1 and GPx3. Neither selenium defi ciency nor PTU infl uenced the adherence of peritoneal macrophages. Selenium defi ciency signifi cantly decreased the peroxide synthesis in macrophages and signifi cantly increased the titer of anti-SRBC IgM. Hypotyroidism alone or in combination with selenium defi ciency had no infl uence on these parameters.
PB  - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
T2  - Acta Veterinaria-Beograd
T1  - Effects of selenium and thyroid hormone deficiency on peritoneal macrophages adhesion and occurrence of natural IGM antibodies in juvenile rats
VL  - 67
IS  - 3
SP  - 340
EP  - 355
DO  - 10.1515/acve-2017-0028
ER  - 

@article{
author = "Bjelica, Jelena and Jovanović, Ivan B. and Ilić, Vesna and Valčić, Olivera and Kirovski, Danijela and Gvozdić, Dragan and Milanović, Svetlana",
year = "2017",
abstract = "Both selenium, as an effector and regulator of antioxidative enzymes activity, and thyroid hormones are potent immunomodulators. Besides, selenium incorporated into iodothyronine deiodinases is involved in the thyroid function and thus indirectly regulates the immune response. Studies of the mutual infl uence of selenium and thyroid hormones on the immune response are scarce, hence we analyzed the effects of an iodothyronine deiodinases blocker, propylthiouracil (PTU), and selenium defi ciency on the function of peritoneal macrophages, and titer of naturally occurring anti-sheep red blood cells (SRBC) IgM antibodies in juvenile rats. The experiment was carried out on 64 Wistar male rats allotted to 4 groups: controlselenium adequate PTU-group; selenium adequate, PTU+ group; selenium defi cient, PTU-group; and selenium defi cient, PTU+. The selenium adequate and selenium defi cient groups were fed a diet containing 0.334 and 0.031 mg Se/kg, respectively. PTU+ groups received PTU (150 mg/L) in drinking water. After 3 weeks, thyroxine (T-4), triiodothyronine (T-3), and thyroid stimulating hormone (TSH) were determined. The animals having intermediate concentrations of T-3 (1.56-1.69 nmol/L) and T 4 (41-50 nmol/L) were excluded from further analysis. Thus, PTU+ groups included hypothyroid animals (T-3 <= 1.55 nmol/L; T-4 <= 40 nmol/L), while PTU-groups included euthyroid rats (T-3 <= 1.70 nmol/L; T-4 <= 50 nmol/L). Both groups of selenium defi cient rats had, when compared to the control group, a signifi cantly lower activity of glutathione peroxidase GPx1 and GPx3. Neither selenium defi ciency nor PTU infl uenced the adherence of peritoneal macrophages. Selenium defi ciency signifi cantly decreased the peroxide synthesis in macrophages and signifi cantly increased the titer of anti-SRBC IgM. Hypotyroidism alone or in combination with selenium defi ciency had no infl uence on these parameters.",
publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd",
journal = "Acta Veterinaria-Beograd",
title = "Effects of selenium and thyroid hormone deficiency on peritoneal macrophages adhesion and occurrence of natural IGM antibodies in juvenile rats",
volume = "67",
number = "3",
pages = "340-355",
doi = "10.1515/acve-2017-0028"
}

Bjelica, J., Jovanović, I. B., Ilić, V., Valčić, O., Kirovski, D., Gvozdić, D.,& Milanović, S.. (2017). Effects of selenium and thyroid hormone deficiency on peritoneal macrophages adhesion and occurrence of natural IGM antibodies in juvenile rats. in Acta Veterinaria-Beograd
Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 67(3), 340-355.
https://doi.org/10.1515/acve-2017-0028

Bjelica J, Jovanović IB, Ilić V, Valčić O, Kirovski D, Gvozdić D, Milanović S. Effects of selenium and thyroid hormone deficiency on peritoneal macrophages adhesion and occurrence of natural IGM antibodies in juvenile rats. in Acta Veterinaria-Beograd. 2017;67(3):340-355.
doi:10.1515/acve-2017-0028 .

Bjelica, Jelena, Jovanović, Ivan B., Ilić, Vesna, Valčić, Olivera, Kirovski, Danijela, Gvozdić, Dragan, Milanović, Svetlana, "Effects of selenium and thyroid hormone deficiency on peritoneal macrophages adhesion and occurrence of natural IGM antibodies in juvenile rats" in Acta Veterinaria-Beograd, 67, no. 3 (2017):340-355,
https://doi.org/10.1515/acve-2017-0028 . .

TY  - JOUR
AU  - Stojić, Milica
AU  - Fratrić, Natalija
AU  - Kovacić, Marijana
AU  - Ilić, Vesna
AU  - Gvozdić, Dragan
AU  - Savić, Olivera
AU  - Doković, Radojica
AU  - Valčić, Olivera
PY  - 2017
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1519
AB  - Failure of passive transfer (FPT) of immunoglobulins (IgG) is associated with increased morbidity and mortality of calves. In this study we evaluated the digital Brix refractometer usefulness for the assessment of FPT. A number of 16 colostrum samples from the first milking (2-3h post-partum) of Holstein-Friesian dairy heifers and 29 blood sera of 3-6 days old calves were analyzed with a digital Brix refractometer. Total proteins were determined by the biuret reaction. Colostral IgG were determined by radial immunodiffusion (RID), and colostral whey and blood serum. globulin (composed almost entirely of IgG) were determined by agarose protein gel electrophoresis (APE) and densitometry. Colostral % Brix score was 25.5 +/- 3.4%. Concentrations of colostrum IgG and colostral whey. globulin were 130 +/- 33 g/L and 100 +/- 24 g/L respectively. The concentration of total proteins in colostral whey was 134 +/- 30 g/L. The correlations between Brix values and the concentrations of IgG determined with RID and the concentrations of. globulin determined with APE were positive and highly significant (P<0.001 and P<0.01). The concentration of serum proteins of new-born calves was 57.75 +/- 11.8 g/L, the concentration of. globulin was 14.4 +/- 7.8 g/L, and the Brix score was 8.6 +/- 1.0%. FPT (serum. globulin<10 g/L) was detected in 34.5% (10/29) calves. Brix score correlated with the concentration of blood serum. globulins in all examined calves. The results have confirmed that digital Brix refractometry allows the producers to use this technique in order to estimate colostral and calf serum IgG, thereby monitoring both colostrum quality and success of passive transfer.
PB  - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
T2  - Acta Veterinaria-Beograd
T1  - Brix refractometry of colostrum from primiparous dairy cows and new-born calf blood serum in the evaluation of failure of passive transfer
VL  - 67
IS  - 4
SP  - 508
EP  - 524
DO  - 10.1515/acve-2017-0041
ER  - 

@article{
author = "Stojić, Milica and Fratrić, Natalija and Kovacić, Marijana and Ilić, Vesna and Gvozdić, Dragan and Savić, Olivera and Doković, Radojica and Valčić, Olivera",
year = "2017",
abstract = "Failure of passive transfer (FPT) of immunoglobulins (IgG) is associated with increased morbidity and mortality of calves. In this study we evaluated the digital Brix refractometer usefulness for the assessment of FPT. A number of 16 colostrum samples from the first milking (2-3h post-partum) of Holstein-Friesian dairy heifers and 29 blood sera of 3-6 days old calves were analyzed with a digital Brix refractometer. Total proteins were determined by the biuret reaction. Colostral IgG were determined by radial immunodiffusion (RID), and colostral whey and blood serum. globulin (composed almost entirely of IgG) were determined by agarose protein gel electrophoresis (APE) and densitometry. Colostral % Brix score was 25.5 +/- 3.4%. Concentrations of colostrum IgG and colostral whey. globulin were 130 +/- 33 g/L and 100 +/- 24 g/L respectively. The concentration of total proteins in colostral whey was 134 +/- 30 g/L. The correlations between Brix values and the concentrations of IgG determined with RID and the concentrations of. globulin determined with APE were positive and highly significant (P<0.001 and P<0.01). The concentration of serum proteins of new-born calves was 57.75 +/- 11.8 g/L, the concentration of. globulin was 14.4 +/- 7.8 g/L, and the Brix score was 8.6 +/- 1.0%. FPT (serum. globulin<10 g/L) was detected in 34.5% (10/29) calves. Brix score correlated with the concentration of blood serum. globulins in all examined calves. The results have confirmed that digital Brix refractometry allows the producers to use this technique in order to estimate colostral and calf serum IgG, thereby monitoring both colostrum quality and success of passive transfer.",
publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd",
journal = "Acta Veterinaria-Beograd",
title = "Brix refractometry of colostrum from primiparous dairy cows and new-born calf blood serum in the evaluation of failure of passive transfer",
volume = "67",
number = "4",
pages = "508-524",
doi = "10.1515/acve-2017-0041"
}

Stojić, M., Fratrić, N., Kovacić, M., Ilić, V., Gvozdić, D., Savić, O., Doković, R.,& Valčić, O.. (2017). Brix refractometry of colostrum from primiparous dairy cows and new-born calf blood serum in the evaluation of failure of passive transfer. in Acta Veterinaria-Beograd
Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 67(4), 508-524.
https://doi.org/10.1515/acve-2017-0041

Stojić M, Fratrić N, Kovacić M, Ilić V, Gvozdić D, Savić O, Doković R, Valčić O. Brix refractometry of colostrum from primiparous dairy cows and new-born calf blood serum in the evaluation of failure of passive transfer. in Acta Veterinaria-Beograd. 2017;67(4):508-524.
doi:10.1515/acve-2017-0041 .

Stojić, Milica, Fratrić, Natalija, Kovacić, Marijana, Ilić, Vesna, Gvozdić, Dragan, Savić, Olivera, Doković, Radojica, Valčić, Olivera, "Brix refractometry of colostrum from primiparous dairy cows and new-born calf blood serum in the evaluation of failure of passive transfer" in Acta Veterinaria-Beograd, 67, no. 4 (2017):508-524,
https://doi.org/10.1515/acve-2017-0041 . .

TY  - JOUR
AU  - Vuković, Dejan
AU  - Božić, Aleksandar
AU  - Relić, Renata
AU  - Stančić, Blagoje
AU  - Gvozdić, Dragan
AU  - Kucević, Denis
PY  - 2016
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1413
AB  - An experiment was conducted to investigate the effects of hormonal synchronization of ovulation on progesterone concentrations in milk and blood serum and on reproductive performance. Sixty Holstein-Friesian cows averaging 8000 L over 305 days of lactation were divided into 2 groups of 30 animals. One-factor ANOVA and a t-test of progesterone concentrations in venous serum and milk revealed that the lowest concentrations of progesterone in milk (Ovsynch 5.8 + 1.0 ng/mL; control 4.5 + 0.6 ng/mL) and blood serum (Ovsynch 1.3 +/- 0.9 ng/mL; control 1.4 +/- 0.5 ng/mL) in both groups were found on the day of estrus or artificial insemination (AI) (both P < 0.05). Increases in the concentrations of progesterone in milk (Ovsynch 17.6 +/- 4.3 ng/mL; control 10.5 +/- 1.9 ng/mL) and blood serum (Ovsynch 3.6 +/- 1.1 ng/mL; control 4.0 +/- 1.0 ng/mL) were observed on day 7 after AI (both P < 0.05). Concentrations of progesterone in milk and blood serum in nonpregnant cows were reduced on day 21 after AI. Assessment of reproductive performance revealed that the application of treatment shortened the duration of the service period (Ovsynch 76 days; control 83 days) and the calving interval (Ovsynch 376 days; control 382 days).
PB  - Scientific Technical Research Council Turkey-Tubitak, Ankara
T2  - Turkish Journal of Veterinary & Animal Sciences
T1  - Progesterone concentration in milk and blood serum and reproductive efficiency of cows after Ovsynch treatment
VL  - 40
IS  - 1
SP  - 75
EP  - 80
DO  - 10.3906/vet-1505-17
ER  - 

@article{
author = "Vuković, Dejan and Božić, Aleksandar and Relić, Renata and Stančić, Blagoje and Gvozdić, Dragan and Kucević, Denis",
year = "2016",
abstract = "An experiment was conducted to investigate the effects of hormonal synchronization of ovulation on progesterone concentrations in milk and blood serum and on reproductive performance. Sixty Holstein-Friesian cows averaging 8000 L over 305 days of lactation were divided into 2 groups of 30 animals. One-factor ANOVA and a t-test of progesterone concentrations in venous serum and milk revealed that the lowest concentrations of progesterone in milk (Ovsynch 5.8 + 1.0 ng/mL; control 4.5 + 0.6 ng/mL) and blood serum (Ovsynch 1.3 +/- 0.9 ng/mL; control 1.4 +/- 0.5 ng/mL) in both groups were found on the day of estrus or artificial insemination (AI) (both P < 0.05). Increases in the concentrations of progesterone in milk (Ovsynch 17.6 +/- 4.3 ng/mL; control 10.5 +/- 1.9 ng/mL) and blood serum (Ovsynch 3.6 +/- 1.1 ng/mL; control 4.0 +/- 1.0 ng/mL) were observed on day 7 after AI (both P < 0.05). Concentrations of progesterone in milk and blood serum in nonpregnant cows were reduced on day 21 after AI. Assessment of reproductive performance revealed that the application of treatment shortened the duration of the service period (Ovsynch 76 days; control 83 days) and the calving interval (Ovsynch 376 days; control 382 days).",
publisher = "Scientific Technical Research Council Turkey-Tubitak, Ankara",
journal = "Turkish Journal of Veterinary & Animal Sciences",
title = "Progesterone concentration in milk and blood serum and reproductive efficiency of cows after Ovsynch treatment",
volume = "40",
number = "1",
pages = "75-80",
doi = "10.3906/vet-1505-17"
}

Vuković, D., Božić, A., Relić, R., Stančić, B., Gvozdić, D.,& Kucević, D.. (2016). Progesterone concentration in milk and blood serum and reproductive efficiency of cows after Ovsynch treatment. in Turkish Journal of Veterinary & Animal Sciences
Scientific Technical Research Council Turkey-Tubitak, Ankara., 40(1), 75-80.
https://doi.org/10.3906/vet-1505-17

Vuković D, Božić A, Relić R, Stančić B, Gvozdić D, Kucević D. Progesterone concentration in milk and blood serum and reproductive efficiency of cows after Ovsynch treatment. in Turkish Journal of Veterinary & Animal Sciences. 2016;40(1):75-80.
doi:10.3906/vet-1505-17 .

Vuković, Dejan, Božić, Aleksandar, Relić, Renata, Stančić, Blagoje, Gvozdić, Dragan, Kucević, Denis, "Progesterone concentration in milk and blood serum and reproductive efficiency of cows after Ovsynch treatment" in Turkish Journal of Veterinary & Animal Sciences, 40, no. 1 (2016):75-80,
https://doi.org/10.3906/vet-1505-17 . .

TY  - JOUR
AU  - Jovanović, Ivan B.
AU  - Velicković, Miljan
AU  - Milanović, Svetlana
AU  - Valčić, Olivera
AU  - Gvozdić, Dragan
AU  - Vranješ-Đurić, Sanja
PY  - 2015
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1182
AB  - The aim of this investigation was to determine the influence of oxidative stress upon general stress in dairy cows on parturition and whether the indicators of stress can be reduced by selenium (Se) supplementation. A total of 36 animals were divided into 3 groups 21 days prepartum and treated with a single-term intra muscular supplement of sodium selenite: Control group - 0 mg; group Se10 - 10 mg; group Se20 - 20 mg. Se supplementation significantly raised blood Se content and glutathione peroxidase (GPx) activity in groups Se10 and Se20, compared to Control, although there was no marked difference between supplemented groups. Plasma malondialdehyde (MDA) and cortisol concentrations were significantly reduced in supplemented groups Se10 and Se20, compared to Control. A negative correlation was detected between blood GPx activity and plasma MDA, while a positive correlation was determined between plasma MDA and cortisol concentrations. These results indicate that prepartum Se supplementation can be utilized for a partial relief of stress in cows during labor by augmenting the antioxidative action of GPx.
PB  - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
T2  - Acta Veterinaria-Beograd
T1  - Supplemental selenium reduces the levels of biomarkers of oxidative and general stress in peripartum dairy cows
VL  - 65
IS  - 2
SP  - 191
EP  - 201
DO  - 10.1515/acve-2015-0016
ER  - 

@article{
author = "Jovanović, Ivan B. and Velicković, Miljan and Milanović, Svetlana and Valčić, Olivera and Gvozdić, Dragan and Vranješ-Đurić, Sanja",
year = "2015",
abstract = "The aim of this investigation was to determine the influence of oxidative stress upon general stress in dairy cows on parturition and whether the indicators of stress can be reduced by selenium (Se) supplementation. A total of 36 animals were divided into 3 groups 21 days prepartum and treated with a single-term intra muscular supplement of sodium selenite: Control group - 0 mg; group Se10 - 10 mg; group Se20 - 20 mg. Se supplementation significantly raised blood Se content and glutathione peroxidase (GPx) activity in groups Se10 and Se20, compared to Control, although there was no marked difference between supplemented groups. Plasma malondialdehyde (MDA) and cortisol concentrations were significantly reduced in supplemented groups Se10 and Se20, compared to Control. A negative correlation was detected between blood GPx activity and plasma MDA, while a positive correlation was determined between plasma MDA and cortisol concentrations. These results indicate that prepartum Se supplementation can be utilized for a partial relief of stress in cows during labor by augmenting the antioxidative action of GPx.",
publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd",
journal = "Acta Veterinaria-Beograd",
title = "Supplemental selenium reduces the levels of biomarkers of oxidative and general stress in peripartum dairy cows",
volume = "65",
number = "2",
pages = "191-201",
doi = "10.1515/acve-2015-0016"
}

Jovanović, I. B., Velicković, M., Milanović, S., Valčić, O., Gvozdić, D.,& Vranješ-Đurić, S.. (2015). Supplemental selenium reduces the levels of biomarkers of oxidative and general stress in peripartum dairy cows. in Acta Veterinaria-Beograd
Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 65(2), 191-201.
https://doi.org/10.1515/acve-2015-0016

Jovanović IB, Velicković M, Milanović S, Valčić O, Gvozdić D, Vranješ-Đurić S. Supplemental selenium reduces the levels of biomarkers of oxidative and general stress in peripartum dairy cows. in Acta Veterinaria-Beograd. 2015;65(2):191-201.
doi:10.1515/acve-2015-0016 .

Jovanović, Ivan B., Velicković, Miljan, Milanović, Svetlana, Valčić, Olivera, Gvozdić, Dragan, Vranješ-Đurić, Sanja, "Supplemental selenium reduces the levels of biomarkers of oxidative and general stress in peripartum dairy cows" in Acta Veterinaria-Beograd, 65, no. 2 (2015):191-201,
https://doi.org/10.1515/acve-2015-0016 . .

TY  - JOUR
AU  - Milanović, Svetlana
AU  - Jovanović, Ivan B.
AU  - Valčić, Olivera
PY  - 2015
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1202
AB  - Selenium is an essential trace element with multi significant role in the body. In contrast to other trace elements that appear as cofactors of certain enzymes, its physiological role is directly related to functions of proteins in composition of which it is cotranslationally installed by atypical amino acid selenocysteine. The group of proteins, in which composition selenocysteine is an integral functional part of polypeptides, are referred to as selenoproteins. The first enzyme that has been proven to have selenocysteine incorporated in its composition, is glutathione peroxidase (GPx). So far there have been identified 5 isoenzyme forms of GPx which reduce hydrogen peroxide and organic hydroperoxides, protecting cells from oxidative damage. Iodothyronine deiodinases (ID) are among the most important selenopoteins, being responsible for both activation and deactivation of thyroid hormones. So far there have been found over twenty selenoproteins, but only for some of them a physiological role is known.
AB  - Selen je esencijalni mikroelement sa mnogostrukim i vrlo važnim ulogama u organizmu. Za razliku od ostalih mikroelemenata koji figuriraju kao kofaktori pojedinih enzima, njegove fiziološke uloge direktno su povezane sa funkcijama proteina u čiji sastav se kotranslatorno ugrađuje putem netipične aminokiseline selenocisteina. Grupa proteina koja u svom sastavu ima selenocistein kao integralni funkcionalni deo polipeptida nazivaju se selenoproteini. Prvi enzim za koji je dokazano da u svom sastavu ima ugrađen selenocistein je glutation peroksidaza (GPx). Do sada je identifikovano 5 izoenzimskih formi GPx koje redukuju vodonik-peroksid i organske hidroperokside, štiteći ćelije od oksidativnog oštećenja. Među najznačajnijim selenoenzimima su i jodotironin dejodinaze (ID), odgovorne za aktivaciju i deaktivaciju tireoidnih hormona. Do sada je otkriveno preko dvadeset selenoproteina, a samo za neke od njih je poznata fiziološka uloga.
PB  - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
T2  - Veterinarski Glasnik
T1  - Selenoproteins
T1  - Selenoproteini
VL  - 69
IS  - 1-2
SP  - 75
EP  - 89
DO  - 10.2298/VETGL1502075M
ER  - 

@article{
author = "Milanović, Svetlana and Jovanović, Ivan B. and Valčić, Olivera",
year = "2015",
abstract = "Selenium is an essential trace element with multi significant role in the body. In contrast to other trace elements that appear as cofactors of certain enzymes, its physiological role is directly related to functions of proteins in composition of which it is cotranslationally installed by atypical amino acid selenocysteine. The group of proteins, in which composition selenocysteine is an integral functional part of polypeptides, are referred to as selenoproteins. The first enzyme that has been proven to have selenocysteine incorporated in its composition, is glutathione peroxidase (GPx). So far there have been identified 5 isoenzyme forms of GPx which reduce hydrogen peroxide and organic hydroperoxides, protecting cells from oxidative damage. Iodothyronine deiodinases (ID) are among the most important selenopoteins, being responsible for both activation and deactivation of thyroid hormones. So far there have been found over twenty selenoproteins, but only for some of them a physiological role is known., Selen je esencijalni mikroelement sa mnogostrukim i vrlo važnim ulogama u organizmu. Za razliku od ostalih mikroelemenata koji figuriraju kao kofaktori pojedinih enzima, njegove fiziološke uloge direktno su povezane sa funkcijama proteina u čiji sastav se kotranslatorno ugrađuje putem netipične aminokiseline selenocisteina. Grupa proteina koja u svom sastavu ima selenocistein kao integralni funkcionalni deo polipeptida nazivaju se selenoproteini. Prvi enzim za koji je dokazano da u svom sastavu ima ugrađen selenocistein je glutation peroksidaza (GPx). Do sada je identifikovano 5 izoenzimskih formi GPx koje redukuju vodonik-peroksid i organske hidroperokside, štiteći ćelije od oksidativnog oštećenja. Među najznačajnijim selenoenzimima su i jodotironin dejodinaze (ID), odgovorne za aktivaciju i deaktivaciju tireoidnih hormona. Do sada je otkriveno preko dvadeset selenoproteina, a samo za neke od njih je poznata fiziološka uloga.",
publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd",
journal = "Veterinarski Glasnik",
title = "Selenoproteins, Selenoproteini",
volume = "69",
number = "1-2",
pages = "75-89",
doi = "10.2298/VETGL1502075M"
}

Milanović, S., Jovanović, I. B.,& Valčić, O.. (2015). Selenoproteins. in Veterinarski Glasnik
Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 69(1-2), 75-89.
https://doi.org/10.2298/VETGL1502075M

Milanović S, Jovanović IB, Valčić O. Selenoproteins. in Veterinarski Glasnik. 2015;69(1-2):75-89.
doi:10.2298/VETGL1502075M .

Milanović, Svetlana, Jovanović, Ivan B., Valčić, Olivera, "Selenoproteins" in Veterinarski Glasnik, 69, no. 1-2 (2015):75-89,
https://doi.org/10.2298/VETGL1502075M . .

TY  - JOUR
AU  - Milanović, Svetlana
AU  - Jovanović, Ivan B.
AU  - Bjelica, Jelena
AU  - Joksimović, Srđan
AU  - Stefanović, Srđan
AU  - Radović, Magdalena
AU  - Kirovski, Danijela
AU  - Valčić, Olivera
AU  - Gvozdić, Dragan
PY  - 2014
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1121
AB  - In this work there was investigated the influence of selenium and deodinases blockers on juvenile rats body weight during three months. The experiment was carried out on 64 rats divided into eight groups with eight individual animals per group. Following groups were formed: 1. Se+PTU-IA- (control group), 2. Se+PTU+IA+, 3. Se+PTU+IA-, 4. Se+P-TU-IA+, 5. Se-PTU-IA-, 6. Se-PTU+IA+, 7. Se-PTU+IA- and 8. Se-PTU-IA+. The groups labeled (Se+) were selenium adequate and they were fed with food that contained 0.334 mg Se/kg. The groups labeled (Se-) were selenium deficient and obtained food with 0.031 mg Se/kg. As deiodinases blockers there were used propylthiouracil (PTU+) in a dose of 150 mg/L of drinking water and iopanoic acid (IA+) in a dose of 6 mg/100 g TM intraperitoneally. Body weight of experimental rats was measured every seven days. After three weeks of treatment there were taken blood samples of animals from all experimental groups and following parameters were determined: selenium concentration in blood, thyroxine (T4), triiodothyronine (T3) and thyroidstimulating hormone (TSH) in blood plasma. Analysis of the samples showed that the animals from the groups treated with PTU had lower body weight in regard to the control group, as well as lower concentration of T3 and T4 in plasma. Selenium deficient rats had lower average body weight compared to the selenium adequate ones after three weeks, but there were no differences in thyroid hormones concentration. The lowest average body weight was noticed in selenium deficient rats groups treated with PTU.
AB  - U okviru ogleda je ispitivan uticaj selena i blokatora dejodinaza na telesnu masu juvenilnih pacova tokom tri nedelje. Ogled je izveden na 64 pacova podeljenih u osam grupa od po 8 jedinki. Formirane su sledeće grupe: 1. Se+PTU-IA- (kontrolna grupa), 2. Se+PTU+IA+, 3. Se+PTU+IA-, 4. Se+PTU-IA+, 5. Se-PTU-IA-, 6. Se-PTU+IA+, 7. Se-PTU+IA- i 8. Se-PTU-IA+. Grupe sa oznakom (Se+) su bile selenadekvatne i dobijale su hranu koja je sadržala 0,334 mg Se/kg hrane. Grupe sa oznakom (Se-) su bile selendeficitne i dobijale su 0,031 mg mg Se/kg hrane. Kao blokatori dejodinaza su korišćeni propiltiouracil (PTU+) u dozi od 150 mg/L vode za piće i jopanoična kiselina (IA+) u dozi od 6 mg/100g t.m. intraperitonealno. Telesna masa oglednih pacova je merena svakih sedam dana. Nakon tri nedelje tretmana uzeti su uzorci krvi životinja iz svih oglednih grupa i određivani su sledeći parametri: koncentracja selena u punoj krvi, tiroksin (T4), trijodtironin (T3) i tireostimulirajući hormon (TSH) u krvnoj plazmi. Analiza je pokazala da su jedinke iz grupe tretiranih sa PTU imale nižu telesnu masu u odnosu na kontrolnu, kao i nižu koncentraciju T3 i T4 u plazmi. Selendeficitni pacovi su nakon tri nedelje imali nižu prosečnu telesnu masu u odnosu na selenadekvatne, ali nisu uočene razlike u koncentraciji tireoidnih hormona. Najniža prosečna telesna masa zabeležena je kod selendeficitnih grupa pacova tretiranih sa PTU.
PB  - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
T2  - Veterinarski Glasnik
T1  - The influence of selenium and deiodinases blockers on juvenile rats body weight
T1  - Vlijanie selena i blokatorov dejodinazy na ves juvenil'nyh krys
T1  - Uticaj selena i blokatora dejodinaza na telesnu masu juvenilnih pacova
VL  - 68
IS  - 1-2
SP  - 3
EP  - 9
DO  - 10.2298/VETGL1402003M
ER  - 

@article{
author = "Milanović, Svetlana and Jovanović, Ivan B. and Bjelica, Jelena and Joksimović, Srđan and Stefanović, Srđan and Radović, Magdalena and Kirovski, Danijela and Valčić, Olivera and Gvozdić, Dragan",
year = "2014",
abstract = "In this work there was investigated the influence of selenium and deodinases blockers on juvenile rats body weight during three months. The experiment was carried out on 64 rats divided into eight groups with eight individual animals per group. Following groups were formed: 1. Se+PTU-IA- (control group), 2. Se+PTU+IA+, 3. Se+PTU+IA-, 4. Se+P-TU-IA+, 5. Se-PTU-IA-, 6. Se-PTU+IA+, 7. Se-PTU+IA- and 8. Se-PTU-IA+. The groups labeled (Se+) were selenium adequate and they were fed with food that contained 0.334 mg Se/kg. The groups labeled (Se-) were selenium deficient and obtained food with 0.031 mg Se/kg. As deiodinases blockers there were used propylthiouracil (PTU+) in a dose of 150 mg/L of drinking water and iopanoic acid (IA+) in a dose of 6 mg/100 g TM intraperitoneally. Body weight of experimental rats was measured every seven days. After three weeks of treatment there were taken blood samples of animals from all experimental groups and following parameters were determined: selenium concentration in blood, thyroxine (T4), triiodothyronine (T3) and thyroidstimulating hormone (TSH) in blood plasma. Analysis of the samples showed that the animals from the groups treated with PTU had lower body weight in regard to the control group, as well as lower concentration of T3 and T4 in plasma. Selenium deficient rats had lower average body weight compared to the selenium adequate ones after three weeks, but there were no differences in thyroid hormones concentration. The lowest average body weight was noticed in selenium deficient rats groups treated with PTU., U okviru ogleda je ispitivan uticaj selena i blokatora dejodinaza na telesnu masu juvenilnih pacova tokom tri nedelje. Ogled je izveden na 64 pacova podeljenih u osam grupa od po 8 jedinki. Formirane su sledeće grupe: 1. Se+PTU-IA- (kontrolna grupa), 2. Se+PTU+IA+, 3. Se+PTU+IA-, 4. Se+PTU-IA+, 5. Se-PTU-IA-, 6. Se-PTU+IA+, 7. Se-PTU+IA- i 8. Se-PTU-IA+. Grupe sa oznakom (Se+) su bile selenadekvatne i dobijale su hranu koja je sadržala 0,334 mg Se/kg hrane. Grupe sa oznakom (Se-) su bile selendeficitne i dobijale su 0,031 mg mg Se/kg hrane. Kao blokatori dejodinaza su korišćeni propiltiouracil (PTU+) u dozi od 150 mg/L vode za piće i jopanoična kiselina (IA+) u dozi od 6 mg/100g t.m. intraperitonealno. Telesna masa oglednih pacova je merena svakih sedam dana. Nakon tri nedelje tretmana uzeti su uzorci krvi životinja iz svih oglednih grupa i određivani su sledeći parametri: koncentracja selena u punoj krvi, tiroksin (T4), trijodtironin (T3) i tireostimulirajući hormon (TSH) u krvnoj plazmi. Analiza je pokazala da su jedinke iz grupe tretiranih sa PTU imale nižu telesnu masu u odnosu na kontrolnu, kao i nižu koncentraciju T3 i T4 u plazmi. Selendeficitni pacovi su nakon tri nedelje imali nižu prosečnu telesnu masu u odnosu na selenadekvatne, ali nisu uočene razlike u koncentraciji tireoidnih hormona. Najniža prosečna telesna masa zabeležena je kod selendeficitnih grupa pacova tretiranih sa PTU.",
publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd",
journal = "Veterinarski Glasnik",
title = "The influence of selenium and deiodinases blockers on juvenile rats body weight, Vlijanie selena i blokatorov dejodinazy na ves juvenil'nyh krys, Uticaj selena i blokatora dejodinaza na telesnu masu juvenilnih pacova",
volume = "68",
number = "1-2",
pages = "3-9",
doi = "10.2298/VETGL1402003M"
}

Milanović, S., Jovanović, I. B., Bjelica, J., Joksimović, S., Stefanović, S., Radović, M., Kirovski, D., Valčić, O.,& Gvozdić, D.. (2014). The influence of selenium and deiodinases blockers on juvenile rats body weight. in Veterinarski Glasnik
Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 68(1-2), 3-9.
https://doi.org/10.2298/VETGL1402003M

Milanović S, Jovanović IB, Bjelica J, Joksimović S, Stefanović S, Radović M, Kirovski D, Valčić O, Gvozdić D. The influence of selenium and deiodinases blockers on juvenile rats body weight. in Veterinarski Glasnik. 2014;68(1-2):3-9.
doi:10.2298/VETGL1402003M .

Milanović, Svetlana, Jovanović, Ivan B., Bjelica, Jelena, Joksimović, Srđan, Stefanović, Srđan, Radović, Magdalena, Kirovski, Danijela, Valčić, Olivera, Gvozdić, Dragan, "The influence of selenium and deiodinases blockers on juvenile rats body weight" in Veterinarski Glasnik, 68, no. 1-2 (2014):3-9,
https://doi.org/10.2298/VETGL1402003M . .

TY  - JOUR
AU  - Jovanović, Ivan B.
AU  - Veličković, Miljan
AU  - Vuković, Dragan
AU  - Milanović, Svetlana
AU  - Valčić, Olivera
AU  - Gvozdić, Dragan
PY  - 2013
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1831
AB  - The incidence of retained placenta (RP) in cows increases in cases of parturition induced by prostaglandin F2α. We analyzed the effects of different doses of supplemental selenium and vitamin E on the incidence of RP, blood selenium, plasma thyronines, and malondialdehyde concentration. Thirty-three clinically healthy, multiparous Holstein-Frisian cows were assigned to 3 groups and supplemented with a single intramuscular injection of sodium selenite (SS) and tocopherol acetate (TAc) between days 250 to 255 of gestation: control—unsupplemented; group A—10 mg SS + 400 mg TAc; group B—20 mg SS + 800 mg TAc. Parturition was induced using PGF2α not before day 275 of gestation. The RP incidence was reduced from 66.7% in the control to 38.2 and 30.8% in groups A and B, respectively. Blood selenium and glutathione peroxidase activity in treated groups were significantly higher compared to control, with no significant difference between groups A and B. Plasma malondialdehyde in group B was significantly lower than that in control and group A, while thyronines levels were not affected. Comparison of RP and non-RP cows, independently of supplement treatment, revealed higher blood selenium and glutathione peroxidase activity and lower MDA and thyroxine in non-RP animals, while triiodothyronine level did not differ.
PB  - Hindawi
T2  - Journal of Veterinary Medicine
T1  - Effects of Different Amounts of Supplemental Selenium and Vitamin E on the Incidence of Retained Placenta, Selenium, Malondialdehyde, and Thyronines Status in Cows Treated with Prostaglandin F2α for the Induction of Parturition
VL  - 2013
SP  - 867453
DO  - 10.1155/2013/867453
ER  - 

@article{
author = "Jovanović, Ivan B. and Veličković, Miljan and Vuković, Dragan and Milanović, Svetlana and Valčić, Olivera and Gvozdić, Dragan",
year = "2013",
abstract = "The incidence of retained placenta (RP) in cows increases in cases of parturition induced by prostaglandin F2α. We analyzed the effects of different doses of supplemental selenium and vitamin E on the incidence of RP, blood selenium, plasma thyronines, and malondialdehyde concentration. Thirty-three clinically healthy, multiparous Holstein-Frisian cows were assigned to 3 groups and supplemented with a single intramuscular injection of sodium selenite (SS) and tocopherol acetate (TAc) between days 250 to 255 of gestation: control—unsupplemented; group A—10 mg SS + 400 mg TAc; group B—20 mg SS + 800 mg TAc. Parturition was induced using PGF2α not before day 275 of gestation. The RP incidence was reduced from 66.7% in the control to 38.2 and 30.8% in groups A and B, respectively. Blood selenium and glutathione peroxidase activity in treated groups were significantly higher compared to control, with no significant difference between groups A and B. Plasma malondialdehyde in group B was significantly lower than that in control and group A, while thyronines levels were not affected. Comparison of RP and non-RP cows, independently of supplement treatment, revealed higher blood selenium and glutathione peroxidase activity and lower MDA and thyroxine in non-RP animals, while triiodothyronine level did not differ.",
publisher = "Hindawi",
journal = "Journal of Veterinary Medicine",
title = "Effects of Different Amounts of Supplemental Selenium and Vitamin E on the Incidence of Retained Placenta, Selenium, Malondialdehyde, and Thyronines Status in Cows Treated with Prostaglandin F2α for the Induction of Parturition",
volume = "2013",
pages = "867453",
doi = "10.1155/2013/867453"
}

Jovanović, I. B., Veličković, M., Vuković, D., Milanović, S., Valčić, O.,& Gvozdić, D.. (2013). Effects of Different Amounts of Supplemental Selenium and Vitamin E on the Incidence of Retained Placenta, Selenium, Malondialdehyde, and Thyronines Status in Cows Treated with Prostaglandin F2α for the Induction of Parturition. in Journal of Veterinary Medicine
Hindawi., 2013, 867453.
https://doi.org/10.1155/2013/867453

Jovanović IB, Veličković M, Vuković D, Milanović S, Valčić O, Gvozdić D. Effects of Different Amounts of Supplemental Selenium and Vitamin E on the Incidence of Retained Placenta, Selenium, Malondialdehyde, and Thyronines Status in Cows Treated with Prostaglandin F2α for the Induction of Parturition. in Journal of Veterinary Medicine. 2013;2013:867453.
doi:10.1155/2013/867453 .

Jovanović, Ivan B., Veličković, Miljan, Vuković, Dragan, Milanović, Svetlana, Valčić, Olivera, Gvozdić, Dragan, "Effects of Different Amounts of Supplemental Selenium and Vitamin E on the Incidence of Retained Placenta, Selenium, Malondialdehyde, and Thyronines Status in Cows Treated with Prostaglandin F2α for the Induction of Parturition" in Journal of Veterinary Medicine, 2013 (2013):867453,
https://doi.org/10.1155/2013/867453 . .

TY  - JOUR
AU  - Valčić, Olivera
AU  - Jovanović, Ivan B.
AU  - Milanović, Svetlana
AU  - Gvozdić, Dragan
PY  - 2013
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1007
AB  - A total of 221 feedstuff samples (187 grain samples and 34 hay samples) were collected from 13 different locations on the territory of the Republic of Serbia. The results expressed as μg/kg have shown an average selenium content in grain samples of 34.3 ± 17.1 and 53.8 ± 18.7 in hay samples. However, a distinct difference was noted between samples collected from the locations north of the river Danube (52.8 ± 20.0 and 73.4 ± 21.3 for grain and hay samples, respectively) compared to the locations south of the Danube (23.3 ±15.4 and 41.7 ± 17.1 for grain and hay samples, respectively). GPx activity was measured in a total of 58 blood plasma samples collected from ewes grazing on 5 different locations. The average GPx activity was 157.4 ± 61.9 μkat/L and it followed a pattern similar to the distribution of Se in feedstuffs. GPx activity was higher in samples collected north of the Danube (212.8 ± 91.2 μkat/L), compared to ewes south of the Danube (66.9 ± 14.0 μkat/L). According to the obtained results and literature data Serbia can be described as a selenium deficient area, showing a marked deficiency on the locations south of the Danube.
AB  - Ispitano je ukupno 221 uzoraka biljnih hraniva (187 žitarica i 34 uzoraka sena) sakupljenih sa različitih lokacija na području 15 opština Republike Srbije. Rezultati izraženi u μg/kg pokazali su da je prosečan sadržaj selena 34.3 ± 17.1 μg/kg u uzorcima žitarica i 53.8 ± 18.7 μg/kg u uzorcima sena. Međutim, značajna razlika je uočena između uzoraka koji potiču sa područja severno (52.8 ± 20.0 i 73.4 ± 21.3 za uzorke žitarica i sena) u odnosu na uzorke sa južne strane toka Dunava (23.3 ±15.4 i 41.7 ± 17.1 za uzorke žitarica i sena). Aktivnost GPx je merena u ukupno 58 uzoraka krvne plazme ovaca koje su bile na ispaši na 5 različitih lokacija. Prosečna GPx aktivnost je iznosila 157.4 ± 61.9 μkat/L. Aktivnost GPx je pokazala distribuciju po lokalitetima slično kao i ispitivana biljna hraniva. Naime, aktivnost GPx je bila viša (212.8 ± 91.2 μkat/L) u uzorcima krvi ovaca na ispaši severno od Dunava u odnosu na ovce koje su bile na ispaši na južnim lokalitetima (66.9 ± 14.0 μkat/L). U skladu sa postignutim rezultatima, kao i literaturnim podacima, Srbija može da se svrsta u seleno deficitarne regione, pri čemu lokaliteti južno od toka Dunava pokazuju više izražen deficit. .
PB  - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
T2  - Acta Veterinaria-Beograd
T1  - Selenium status of feedstuffs and grazing ewes in Serbia
T1  - Status selena u hranivima za ovce na ispaši u Srbiji
VL  - 63
IS  - 5-6
SP  - 665
EP  - 675
DO  - 10.2298/AVB1306665V
ER  - 

@article{
author = "Valčić, Olivera and Jovanović, Ivan B. and Milanović, Svetlana and Gvozdić, Dragan",
year = "2013",
abstract = "A total of 221 feedstuff samples (187 grain samples and 34 hay samples) were collected from 13 different locations on the territory of the Republic of Serbia. The results expressed as μg/kg have shown an average selenium content in grain samples of 34.3 ± 17.1 and 53.8 ± 18.7 in hay samples. However, a distinct difference was noted between samples collected from the locations north of the river Danube (52.8 ± 20.0 and 73.4 ± 21.3 for grain and hay samples, respectively) compared to the locations south of the Danube (23.3 ±15.4 and 41.7 ± 17.1 for grain and hay samples, respectively). GPx activity was measured in a total of 58 blood plasma samples collected from ewes grazing on 5 different locations. The average GPx activity was 157.4 ± 61.9 μkat/L and it followed a pattern similar to the distribution of Se in feedstuffs. GPx activity was higher in samples collected north of the Danube (212.8 ± 91.2 μkat/L), compared to ewes south of the Danube (66.9 ± 14.0 μkat/L). According to the obtained results and literature data Serbia can be described as a selenium deficient area, showing a marked deficiency on the locations south of the Danube., Ispitano je ukupno 221 uzoraka biljnih hraniva (187 žitarica i 34 uzoraka sena) sakupljenih sa različitih lokacija na području 15 opština Republike Srbije. Rezultati izraženi u μg/kg pokazali su da je prosečan sadržaj selena 34.3 ± 17.1 μg/kg u uzorcima žitarica i 53.8 ± 18.7 μg/kg u uzorcima sena. Međutim, značajna razlika je uočena između uzoraka koji potiču sa područja severno (52.8 ± 20.0 i 73.4 ± 21.3 za uzorke žitarica i sena) u odnosu na uzorke sa južne strane toka Dunava (23.3 ±15.4 i 41.7 ± 17.1 za uzorke žitarica i sena). Aktivnost GPx je merena u ukupno 58 uzoraka krvne plazme ovaca koje su bile na ispaši na 5 različitih lokacija. Prosečna GPx aktivnost je iznosila 157.4 ± 61.9 μkat/L. Aktivnost GPx je pokazala distribuciju po lokalitetima slično kao i ispitivana biljna hraniva. Naime, aktivnost GPx je bila viša (212.8 ± 91.2 μkat/L) u uzorcima krvi ovaca na ispaši severno od Dunava u odnosu na ovce koje su bile na ispaši na južnim lokalitetima (66.9 ± 14.0 μkat/L). U skladu sa postignutim rezultatima, kao i literaturnim podacima, Srbija može da se svrsta u seleno deficitarne regione, pri čemu lokaliteti južno od toka Dunava pokazuju više izražen deficit. .",
publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd",
journal = "Acta Veterinaria-Beograd",
title = "Selenium status of feedstuffs and grazing ewes in Serbia, Status selena u hranivima za ovce na ispaši u Srbiji",
volume = "63",
number = "5-6",
pages = "665-675",
doi = "10.2298/AVB1306665V"
}

Valčić, O., Jovanović, I. B., Milanović, S.,& Gvozdić, D.. (2013). Selenium status of feedstuffs and grazing ewes in Serbia. in Acta Veterinaria-Beograd
Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 63(5-6), 665-675.
https://doi.org/10.2298/AVB1306665V

Valčić O, Jovanović IB, Milanović S, Gvozdić D. Selenium status of feedstuffs and grazing ewes in Serbia. in Acta Veterinaria-Beograd. 2013;63(5-6):665-675.
doi:10.2298/AVB1306665V .

Valčić, Olivera, Jovanović, Ivan B., Milanović, Svetlana, Gvozdić, Dragan, "Selenium status of feedstuffs and grazing ewes in Serbia" in Acta Veterinaria-Beograd, 63, no. 5-6 (2013):665-675,
https://doi.org/10.2298/AVB1306665V . .

TY  - JOUR
AU  - Gvozdić, Dragan
AU  - Dovenski, Toni
AU  - Stančić, Ivan
AU  - Stančić, Blagoje
AU  - Božić, Aleksandar
AU  - Jovanović, Ivan B.
AU  - Atanasov, Branko
AU  - Šuluburić, Adam
PY  - 2013
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/975
AB  - Reproduction efficiency in dairy cows is declining all over the world. Epidemiologic studies suggest that diseases have greater effect on herd fertility compared to the parameters like milk production. Immediate solution to the problem of infertility may be the application of some method of hormonal manipulation of estrous cycle in dairy cows. Reproductive system ultrasound examination enables today's veterinarians to visualize ovarian changes during the estrous cycle, giving them a chance to intervene with exogenous hormonal inhibition and/or stimulation of temporary ovarian structures at the appropriate time. Summarizing possible hormonal methods for estrous cycle manipulation we have analyzed following protocols: prostaglandin based protocols, prostaglandin + progestagensin combination, regimes using prostaglandin + gonadotropin-releasing hormone (GnRH) and prostaglandin + GnRH + estradiol protocols. In dairy herds where estrus detection does not represent a significant problem, prostaglandin based or Select Synch protocols are methods of choice for the hormonal manipulation of estrous cycle. However, if there are problems regarding estrus detection Ovsynch or Presynch + Ovsynch could be an effective alternative for the hormonal manipulation of estrous cycle. Furthermore, fixed time artificial insemination (TAI) could be modified to coincide with the second GnRH injection, thus reducing the time and number of visits. .
AB  - Efikasnost reprodukcije kod mlečnih krava ima tendenciju pogoršanja u svim delovima sveta pa i u Republici Srbiji. Epidemiološka ispitivanja ukazuju da se razlozi za smanjenje reproduktivne efikasnosti pre moraju tražiti u parametrima vezanim za pojavu različitih oboljenja nego u porastu proizvodnje mleka. Međutim, trenutno rešenje za problem smanjene plodnosti mlečnih krava najčešće se traži u primeni različitih hormonalnih metoda za manipulaciju estrusnim ciklusom kod mlečnih krava. Ultrazvučni pregled reproduktivnog trakta kod mlečnih krava je omogućio veterinarima da direktno prate promene na jajnicima i uterusu tokom estrusnog ciklusa, otvarajući prostor za pravovremenu primenu hormona radi inhibicije/stimulacije privremenih endokrinih struktura na jajnicima. U našem pokušaju da sumiramo najznačajnije hormonalne metode za manipulaciju estrusnog ciklusa kod mlečnih krava analizirali smo protokole bazirane isključivo na aplikaciji prostaglandina, metode zasnovane na kombinovanju prostaglandina i progestagena, režime manipulacije bazirane na primeni kombinacije prostaglandina i gonadotropnog oslobađajućeg hormona (GnRH), kao i primenu prostaglandina, GnRH i estradiola. U stadima mlečnih krava gde je optimalna detekcija estrusa metoda izbora za hormonalnu manipulaciju estrusnog ciklusa je tzv. Select Synch protokol. Ukoliko je na farmi ustanovljen prisutan problem detekcija estrusa može se primeniti Ovsynch protokol ili kombinacija Presynch i Ovsynch protokola za hormonalnu manipulaciju estrusnog ciklusa. Fiksno vreme veštačkog osemenjavanja koje se sprovodi u toku Ovsynch protokola može se pomeriti tako da se vrši u vreme druge aplikacije GnRH, čime se smanjuje broj fizičkih intervencija i skraćuje trajanje protokola. .
PB  - Univerzitet u Novom Sadu - Poljoprivredni fakultet, Novi Sad i Naučni institut za ratarstvo i povrtarstvo, Novi Sad
T2  - Savremena poljoprivreda
T1  - Hormonal methods for estrous cycle manipulation in dairy cows
T1  - Hormonalne metode za manipulaciju estrusnim ciklusom kod mlečnih krava
VL  - 62
IS  - 3-4
SP  - 319
EP  - 332
UR  - https://hdl.handle.net/21.15107/rcub_veterinar_975
ER  - 

@article{
author = "Gvozdić, Dragan and Dovenski, Toni and Stančić, Ivan and Stančić, Blagoje and Božić, Aleksandar and Jovanović, Ivan B. and Atanasov, Branko and Šuluburić, Adam",
year = "2013",
abstract = "Reproduction efficiency in dairy cows is declining all over the world. Epidemiologic studies suggest that diseases have greater effect on herd fertility compared to the parameters like milk production. Immediate solution to the problem of infertility may be the application of some method of hormonal manipulation of estrous cycle in dairy cows. Reproductive system ultrasound examination enables today's veterinarians to visualize ovarian changes during the estrous cycle, giving them a chance to intervene with exogenous hormonal inhibition and/or stimulation of temporary ovarian structures at the appropriate time. Summarizing possible hormonal methods for estrous cycle manipulation we have analyzed following protocols: prostaglandin based protocols, prostaglandin + progestagensin combination, regimes using prostaglandin + gonadotropin-releasing hormone (GnRH) and prostaglandin + GnRH + estradiol protocols. In dairy herds where estrus detection does not represent a significant problem, prostaglandin based or Select Synch protocols are methods of choice for the hormonal manipulation of estrous cycle. However, if there are problems regarding estrus detection Ovsynch or Presynch + Ovsynch could be an effective alternative for the hormonal manipulation of estrous cycle. Furthermore, fixed time artificial insemination (TAI) could be modified to coincide with the second GnRH injection, thus reducing the time and number of visits. ., Efikasnost reprodukcije kod mlečnih krava ima tendenciju pogoršanja u svim delovima sveta pa i u Republici Srbiji. Epidemiološka ispitivanja ukazuju da se razlozi za smanjenje reproduktivne efikasnosti pre moraju tražiti u parametrima vezanim za pojavu različitih oboljenja nego u porastu proizvodnje mleka. Međutim, trenutno rešenje za problem smanjene plodnosti mlečnih krava najčešće se traži u primeni različitih hormonalnih metoda za manipulaciju estrusnim ciklusom kod mlečnih krava. Ultrazvučni pregled reproduktivnog trakta kod mlečnih krava je omogućio veterinarima da direktno prate promene na jajnicima i uterusu tokom estrusnog ciklusa, otvarajući prostor za pravovremenu primenu hormona radi inhibicije/stimulacije privremenih endokrinih struktura na jajnicima. U našem pokušaju da sumiramo najznačajnije hormonalne metode za manipulaciju estrusnog ciklusa kod mlečnih krava analizirali smo protokole bazirane isključivo na aplikaciji prostaglandina, metode zasnovane na kombinovanju prostaglandina i progestagena, režime manipulacije bazirane na primeni kombinacije prostaglandina i gonadotropnog oslobađajućeg hormona (GnRH), kao i primenu prostaglandina, GnRH i estradiola. U stadima mlečnih krava gde je optimalna detekcija estrusa metoda izbora za hormonalnu manipulaciju estrusnog ciklusa je tzv. Select Synch protokol. Ukoliko je na farmi ustanovljen prisutan problem detekcija estrusa može se primeniti Ovsynch protokol ili kombinacija Presynch i Ovsynch protokola za hormonalnu manipulaciju estrusnog ciklusa. Fiksno vreme veštačkog osemenjavanja koje se sprovodi u toku Ovsynch protokola može se pomeriti tako da se vrši u vreme druge aplikacije GnRH, čime se smanjuje broj fizičkih intervencija i skraćuje trajanje protokola. .",
publisher = "Univerzitet u Novom Sadu - Poljoprivredni fakultet, Novi Sad i Naučni institut za ratarstvo i povrtarstvo, Novi Sad",
journal = "Savremena poljoprivreda",
title = "Hormonal methods for estrous cycle manipulation in dairy cows, Hormonalne metode za manipulaciju estrusnim ciklusom kod mlečnih krava",
volume = "62",
number = "3-4",
pages = "319-332",
url = "https://hdl.handle.net/21.15107/rcub_veterinar_975"
}

Gvozdić, D., Dovenski, T., Stančić, I., Stančić, B., Božić, A., Jovanović, I. B., Atanasov, B.,& Šuluburić, A.. (2013). Hormonal methods for estrous cycle manipulation in dairy cows. in Savremena poljoprivreda
Univerzitet u Novom Sadu - Poljoprivredni fakultet, Novi Sad i Naučni institut za ratarstvo i povrtarstvo, Novi Sad., 62(3-4), 319-332.
https://hdl.handle.net/21.15107/rcub_veterinar_975

Gvozdić D, Dovenski T, Stančić I, Stančić B, Božić A, Jovanović IB, Atanasov B, Šuluburić A. Hormonal methods for estrous cycle manipulation in dairy cows. in Savremena poljoprivreda. 2013;62(3-4):319-332.
https://hdl.handle.net/21.15107/rcub_veterinar_975 .

Gvozdić, Dragan, Dovenski, Toni, Stančić, Ivan, Stančić, Blagoje, Božić, Aleksandar, Jovanović, Ivan B., Atanasov, Branko, Šuluburić, Adam, "Hormonal methods for estrous cycle manipulation in dairy cows" in Savremena poljoprivreda, 62, no. 3-4 (2013):319-332,
https://hdl.handle.net/21.15107/rcub_veterinar_975 .

TY  - THES
AU  - Milanović, Svetlana
PY  - 2012
UR  - http://vbs.rs/scripts/cobiss?command=DISPLAY&base=70036&RID=42752015
UR  - http://nardus.mpn.gov.rs/123456789/2960
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1826
AB  - The effects of the applied deiodinase blockers on the thyroid status of selenium adequate and selenium deficient juvenile rats were studied. The experiment was carried out on 128 male Wistar rats randomly allotted to 8 groups, 16 rats each. The following groups were formed: Se+PTU-IA- (control group), 2. Se+PTU+IA+, 3. Se+PTU+IA-, 4. Se+PTU-IA+, 5. Se-PTU-IA- , 6. Se-PTU+IA+, 7. Se-PTU+IA- i 8. Se-PTU-IA+. The first four groups were selenium adequate (Se+) and were fed a diet containing 0.334 mg/Se kg feed. Groups five, six, seven and eight were selenium deficient and fed 0.031 mgSe/ kg feed. As deiodinase blockers were used propylthiouracil (PTU+) in a dose of 150 mg/L potable water and iopanoic acid (IA+) in a dose of 6 mg/kg body mass applied intraperitoneally. After 3 and 7 weeks of treatment eight rats from each group were sacrificed and the following parameters were determined: thyroxine (T4), triiodothyronine (T3), Thyroid stimulating hormone (TSH), blood selenium concentration, erythrocyte cytosolic glutathione peroxidase activity (GPx1) and blood plasma glutathione peroxidase activity (GPx3). Selenium deficiency resulted in decreased body mass. Application of propylthiouracil resulted in decreased body mass by 19% in selenium adequate and by 59% in selenium deficient rats. A decrease in T4 and T3 concentration and increased TSH concentration in the blood plasma was recorded in both selenium adequate and selenium deficient groups treated with PTU after three weeks of treatment. After seven weeks T3 concentration in all selenium adequate rats was uniform, and selenium deficient PTU treated rats had decreased blood T3 concentrations. Concurrent use of IA and PTU in selenium deficient animals resulted in increased GPx1 activity after 3 weeks and GPx3 after 7 weeks of treatment. The use of PTU led to the loss of correlation between blood selenium and GPx1 treatment in both selenium adequate and deficient rats after three weeks of treatment. After seven weeks of treatment PTU (with or without the concurrent application of IA) resulted in the loss of correlation between blood selenium concentration and GPx3 activity. A negative correlation between T3 concentration and GPx1 activity in selenium deficient rats was recorded after three weeks of treatment, and between T3 concentration and GPx3 activity after seven weeks.
AB  - U okviru ove doktorske disertacije, ispitivan je uticaj primene blokatora dejodinaza na tireoidni status selenadekvatnih i selendeficitnih juvenilnih pacova. Ogled je izveden na ukupno 128 Wistar pacova muškog pola, podeljenih u osam grupa od po 16 jedinki. Formirane su sledeće grupe: 1. Se+PTU-IA- (kontrolna grupa), 2. Se+PTU+IA+, 3. Se+PTU+IA-, 4. Se+PTUIA+, 5. Se-PTU-IA-, 6. Se-PTU+IA+, 7. Se-PTU+IA- i 8. Se-PTU-IA+. Prve četiri grupe su bile selenadekvatne (Se+) i dobijale su hranu koja je sadržala 0.334 mg selena po kilogramu hrane. Grupe pet, šest, sedam i osam su bile selendeficitne (Se-) i dobijale su 0.031 mg selena po kilogramu hrane. Kao blokatori dejodinaza su korišćeni propiltiouracil (PTU+) u dozi od 150 mg/L vode za piće i jopanoična kiselina (IA+) u dozi od 6 mg/100g TM intraperitonealno. Nakon tri i sedam nedelja tretmana žrtvovano je po 8 jedinki iz svake grupe i određivani su sledeći parametri: tiroksin (T4), trijodtironin (T3), tireostimulirajući hormon (TSH), koncentracija selena u krvi, aktivnost citosolne glutation peroksidaze eritrocita (GPx1) i aktivnost glutation peroksidaze u krvnoj plazmi (GPx3). Deficit selena doveo je do blagog pada telesne mase jedinki. Primena propiltiouracila (PTU) dovela je do značajnog pada telesne mase od 19% kod selenadekvatnih jedinki i 59% kod selendeficitnih jedinki. Pad koncentracije T4 i T3 i porast koncentracije TSH u krvnoj plazmi zabeležen je kod selenadekvatnih i selendeficitnih jedinki tretiranih sa PTU, nakon tri nedelje tretmana. Nakon sedam nedelja, koncentracije T3 u krvi svih selenadekvatnih jedinki su bile ujednačene, a kod selendeficitnih jedinki je pri upotrebi PTU bila smanjena koncentracija T3 u krvi. Istovremena upotreba jopanoične kiseline i propiltiouracila kod selendeficitnih jedinki dovela je do rasta aktivnosti GPx1 nakon tri nedelje i GPx3 nakon sedam nedelja tretmana. Upotreba PTU je dovela do gubitka korelacione zavisnosti između koncentracije selena u krvi i aktivnosti GPx1 kod selenadekvatnih i selendeficitnih jedinki nakon tri nedelje tretmana, a nakon sedam nedelja tretmana, upotreba PTU sa ili bez jopanoične kiseline je dovela do gubitka korelacione zavisnosti između koncentracije selena u krvi i aktivnosti GPx3. Negativna korelaciona zavisnost između koncentracije T3 i aktivnosti GPx1 kod selendeficitnih jedinki uočena je nakon tri nedelje tretmana, a nakon sedam nedelja između koncentracije T3 i aktivnosti GPx3.
PB  - Univerzitet u Beogradu, Fakultet veterinarske medicine
T1  - The influence of propylthiouracil and iopanoic acid on thyroid axis and glutathione peroxidases activities in selenium adequate and selenium deficient juvenile rats
T1  - Uticaj propiltiouracila i jopanoične kiseline na funkciju tireoidne osovine i aktivnost glutation peroksidaza kod selen-deficijentnih i selen-adekvatnih juvenilnih pacova
UR  - https://hdl.handle.net/21.15107/rcub_nardus_2960
ER  - 

@phdthesis{
author = "Milanović, Svetlana",
year = "2012",
abstract = "The effects of the applied deiodinase blockers on the thyroid status of selenium adequate and selenium deficient juvenile rats were studied. The experiment was carried out on 128 male Wistar rats randomly allotted to 8 groups, 16 rats each. The following groups were formed: Se+PTU-IA- (control group), 2. Se+PTU+IA+, 3. Se+PTU+IA-, 4. Se+PTU-IA+, 5. Se-PTU-IA- , 6. Se-PTU+IA+, 7. Se-PTU+IA- i 8. Se-PTU-IA+. The first four groups were selenium adequate (Se+) and were fed a diet containing 0.334 mg/Se kg feed. Groups five, six, seven and eight were selenium deficient and fed 0.031 mgSe/ kg feed. As deiodinase blockers were used propylthiouracil (PTU+) in a dose of 150 mg/L potable water and iopanoic acid (IA+) in a dose of 6 mg/kg body mass applied intraperitoneally. After 3 and 7 weeks of treatment eight rats from each group were sacrificed and the following parameters were determined: thyroxine (T4), triiodothyronine (T3), Thyroid stimulating hormone (TSH), blood selenium concentration, erythrocyte cytosolic glutathione peroxidase activity (GPx1) and blood plasma glutathione peroxidase activity (GPx3). Selenium deficiency resulted in decreased body mass. Application of propylthiouracil resulted in decreased body mass by 19% in selenium adequate and by 59% in selenium deficient rats. A decrease in T4 and T3 concentration and increased TSH concentration in the blood plasma was recorded in both selenium adequate and selenium deficient groups treated with PTU after three weeks of treatment. After seven weeks T3 concentration in all selenium adequate rats was uniform, and selenium deficient PTU treated rats had decreased blood T3 concentrations. Concurrent use of IA and PTU in selenium deficient animals resulted in increased GPx1 activity after 3 weeks and GPx3 after 7 weeks of treatment. The use of PTU led to the loss of correlation between blood selenium and GPx1 treatment in both selenium adequate and deficient rats after three weeks of treatment. After seven weeks of treatment PTU (with or without the concurrent application of IA) resulted in the loss of correlation between blood selenium concentration and GPx3 activity. A negative correlation between T3 concentration and GPx1 activity in selenium deficient rats was recorded after three weeks of treatment, and between T3 concentration and GPx3 activity after seven weeks., U okviru ove doktorske disertacije, ispitivan je uticaj primene blokatora dejodinaza na tireoidni status selenadekvatnih i selendeficitnih juvenilnih pacova. Ogled je izveden na ukupno 128 Wistar pacova muškog pola, podeljenih u osam grupa od po 16 jedinki. Formirane su sledeće grupe: 1. Se+PTU-IA- (kontrolna grupa), 2. Se+PTU+IA+, 3. Se+PTU+IA-, 4. Se+PTUIA+, 5. Se-PTU-IA-, 6. Se-PTU+IA+, 7. Se-PTU+IA- i 8. Se-PTU-IA+. Prve četiri grupe su bile selenadekvatne (Se+) i dobijale su hranu koja je sadržala 0.334 mg selena po kilogramu hrane. Grupe pet, šest, sedam i osam su bile selendeficitne (Se-) i dobijale su 0.031 mg selena po kilogramu hrane. Kao blokatori dejodinaza su korišćeni propiltiouracil (PTU+) u dozi od 150 mg/L vode za piće i jopanoična kiselina (IA+) u dozi od 6 mg/100g TM intraperitonealno. Nakon tri i sedam nedelja tretmana žrtvovano je po 8 jedinki iz svake grupe i određivani su sledeći parametri: tiroksin (T4), trijodtironin (T3), tireostimulirajući hormon (TSH), koncentracija selena u krvi, aktivnost citosolne glutation peroksidaze eritrocita (GPx1) i aktivnost glutation peroksidaze u krvnoj plazmi (GPx3). Deficit selena doveo je do blagog pada telesne mase jedinki. Primena propiltiouracila (PTU) dovela je do značajnog pada telesne mase od 19% kod selenadekvatnih jedinki i 59% kod selendeficitnih jedinki. Pad koncentracije T4 i T3 i porast koncentracije TSH u krvnoj plazmi zabeležen je kod selenadekvatnih i selendeficitnih jedinki tretiranih sa PTU, nakon tri nedelje tretmana. Nakon sedam nedelja, koncentracije T3 u krvi svih selenadekvatnih jedinki su bile ujednačene, a kod selendeficitnih jedinki je pri upotrebi PTU bila smanjena koncentracija T3 u krvi. Istovremena upotreba jopanoične kiseline i propiltiouracila kod selendeficitnih jedinki dovela je do rasta aktivnosti GPx1 nakon tri nedelje i GPx3 nakon sedam nedelja tretmana. Upotreba PTU je dovela do gubitka korelacione zavisnosti između koncentracije selena u krvi i aktivnosti GPx1 kod selenadekvatnih i selendeficitnih jedinki nakon tri nedelje tretmana, a nakon sedam nedelja tretmana, upotreba PTU sa ili bez jopanoične kiseline je dovela do gubitka korelacione zavisnosti između koncentracije selena u krvi i aktivnosti GPx3. Negativna korelaciona zavisnost između koncentracije T3 i aktivnosti GPx1 kod selendeficitnih jedinki uočena je nakon tri nedelje tretmana, a nakon sedam nedelja između koncentracije T3 i aktivnosti GPx3.",
publisher = "Univerzitet u Beogradu, Fakultet veterinarske medicine",
title = "The influence of propylthiouracil and iopanoic acid on thyroid axis and glutathione peroxidases activities in selenium adequate and selenium deficient juvenile rats, Uticaj propiltiouracila i jopanoične kiseline na funkciju tireoidne osovine i aktivnost glutation peroksidaza kod selen-deficijentnih i selen-adekvatnih juvenilnih pacova",
url = "https://hdl.handle.net/21.15107/rcub_nardus_2960"
}

Milanović, S.. (2012). The influence of propylthiouracil and iopanoic acid on thyroid axis and glutathione peroxidases activities in selenium adequate and selenium deficient juvenile rats. 
Univerzitet u Beogradu, Fakultet veterinarske medicine..
https://hdl.handle.net/21.15107/rcub_nardus_2960

Milanović S. The influence of propylthiouracil and iopanoic acid on thyroid axis and glutathione peroxidases activities in selenium adequate and selenium deficient juvenile rats. 2012;.
https://hdl.handle.net/21.15107/rcub_nardus_2960 .

Milanović, Svetlana, "The influence of propylthiouracil and iopanoic acid on thyroid axis and glutathione peroxidases activities in selenium adequate and selenium deficient juvenile rats" (2012),
https://hdl.handle.net/21.15107/rcub_nardus_2960 .

TY  - JOUR
AU  - Fratrić, Natalija
AU  - Gvozdić, Dragan
AU  - Vuković, Dejan
AU  - Savić, Olivera
AU  - Buac, Marijana
AU  - Ilić, Vesna
PY  - 2012
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/933
AB  - Immune complexes (IC) could have an important role in the pathogenesis of pre-ruminant calves bronchopneumonia. IC are potent activators of complement and neutrophils and they might be responsible for immune protection, as well as for pulmonary damage. Immunoglobulin G (IgG), as constituents of IC, initiates the effector phase of immune response through binding of Fc gamma and complement receptors. The oligosaccharide moieties expressed on IgG can modulate their antigen affinity and effector function. Structural characteristics of IgG molecules from IC in the pre-ruminant calves have not been studied in detail. The aim of our study was to determine if the glycosylation profile of IgG from circulating IC (CIC) in calves with bronchopneumonia differed from those of healthy control calves. A total number of 13 Holstein-Friesian calves, at the age of three months were included in the study. All calves were clinically examined by a veterinarian. Calves were classified by signs of respiratory disease in two groups: healthy (n = 6) and diseased (n = 7) calves. The CIC from calves sera were isolated by the polyethylene glycol precipitation (PEG) method. IgG molecules were isolated from PEG precipitates by Protein G affinity method. The level of expression and localization N-acetylglucosamine, galactose, sialic acid, and fucose within the isolated IgG was determined by lectin blot assay. Calves with bronchopneumonia had a statistically significantly increased level of CIC. IgG molecule:, were isolated from CIC of both healthy and diseased calves. Several other proteins in complex with IgG were detected in both groups of animals. The isolated IgG heavy chains of healthy calves expressed N-acetylglucosamine, galactose, sialic acid, and fucose. The light chains of IgG expressed N-acetylglucosamine, sialic acid, and fucose whereas galactose was not detected in healthy calves. In diseased animals, galactose was detected on light chains, and both heavy and light IgG chains were more sialylated. Proteins in complex with IgG were also lectin reactive, and their glycosylation in diseased animals was different compared to healthy controls. Increased sialylation is a characteristic of anti-inflammatory IgG. The increased sialylation of IgG from CIC in bronchopneumonia might be an attempt of immune system of calves to protect lung tissues against damages provoked by activated cells and secreted pro-inflammatory cytokines. At the same time, increased IgG sialylation could explain the inability of calves immune system to initiate the process of antigen elimination by activation of Fc gamma receptors.
PB  - Elsevier, Amsterdam
T2  - Veterinary Immunology and Immunopathology
T1  - Evidence that calf bronchopneumonia may be accompanied by increased sialylation of circulating immune complexes  IgG
VL  - 150
IS  - 3-4
SP  - 161
EP  - 168
DO  - 10.1016/j.vetimm.2012.09.009
ER  - 

@article{
author = "Fratrić, Natalija and Gvozdić, Dragan and Vuković, Dejan and Savić, Olivera and Buac, Marijana and Ilić, Vesna",
year = "2012",
abstract = "Immune complexes (IC) could have an important role in the pathogenesis of pre-ruminant calves bronchopneumonia. IC are potent activators of complement and neutrophils and they might be responsible for immune protection, as well as for pulmonary damage. Immunoglobulin G (IgG), as constituents of IC, initiates the effector phase of immune response through binding of Fc gamma and complement receptors. The oligosaccharide moieties expressed on IgG can modulate their antigen affinity and effector function. Structural characteristics of IgG molecules from IC in the pre-ruminant calves have not been studied in detail. The aim of our study was to determine if the glycosylation profile of IgG from circulating IC (CIC) in calves with bronchopneumonia differed from those of healthy control calves. A total number of 13 Holstein-Friesian calves, at the age of three months were included in the study. All calves were clinically examined by a veterinarian. Calves were classified by signs of respiratory disease in two groups: healthy (n = 6) and diseased (n = 7) calves. The CIC from calves sera were isolated by the polyethylene glycol precipitation (PEG) method. IgG molecules were isolated from PEG precipitates by Protein G affinity method. The level of expression and localization N-acetylglucosamine, galactose, sialic acid, and fucose within the isolated IgG was determined by lectin blot assay. Calves with bronchopneumonia had a statistically significantly increased level of CIC. IgG molecule:, were isolated from CIC of both healthy and diseased calves. Several other proteins in complex with IgG were detected in both groups of animals. The isolated IgG heavy chains of healthy calves expressed N-acetylglucosamine, galactose, sialic acid, and fucose. The light chains of IgG expressed N-acetylglucosamine, sialic acid, and fucose whereas galactose was not detected in healthy calves. In diseased animals, galactose was detected on light chains, and both heavy and light IgG chains were more sialylated. Proteins in complex with IgG were also lectin reactive, and their glycosylation in diseased animals was different compared to healthy controls. Increased sialylation is a characteristic of anti-inflammatory IgG. The increased sialylation of IgG from CIC in bronchopneumonia might be an attempt of immune system of calves to protect lung tissues against damages provoked by activated cells and secreted pro-inflammatory cytokines. At the same time, increased IgG sialylation could explain the inability of calves immune system to initiate the process of antigen elimination by activation of Fc gamma receptors.",
publisher = "Elsevier, Amsterdam",
journal = "Veterinary Immunology and Immunopathology",
title = "Evidence that calf bronchopneumonia may be accompanied by increased sialylation of circulating immune complexes  IgG",
volume = "150",
number = "3-4",
pages = "161-168",
doi = "10.1016/j.vetimm.2012.09.009"
}

Fratrić, N., Gvozdić, D., Vuković, D., Savić, O., Buac, M.,& Ilić, V.. (2012). Evidence that calf bronchopneumonia may be accompanied by increased sialylation of circulating immune complexes  IgG. in Veterinary Immunology and Immunopathology
Elsevier, Amsterdam., 150(3-4), 161-168.
https://doi.org/10.1016/j.vetimm.2012.09.009

Fratrić N, Gvozdić D, Vuković D, Savić O, Buac M, Ilić V. Evidence that calf bronchopneumonia may be accompanied by increased sialylation of circulating immune complexes  IgG. in Veterinary Immunology and Immunopathology. 2012;150(3-4):161-168.
doi:10.1016/j.vetimm.2012.09.009 .

Fratrić, Natalija, Gvozdić, Dragan, Vuković, Dejan, Savić, Olivera, Buac, Marijana, Ilić, Vesna, "Evidence that calf bronchopneumonia may be accompanied by increased sialylation of circulating immune complexes  IgG" in Veterinary Immunology and Immunopathology, 150, no. 3-4 (2012):161-168,
https://doi.org/10.1016/j.vetimm.2012.09.009 . .

TY  - JOUR
AU  - Vakanjac, Slobodanka
AU  - Dražić, M.
AU  - Pavlović, V.
AU  - Gvozdić, Dragan
AU  - Jovičin, Milovan
AU  - Đukić, M.
AU  - Stepanović, P.
PY  - 2012
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/866
AB  - The aim of this work was to investigate the impact of two energy supplements based on propylene glycol in dairy cows diet on ovarian and follicular morphology, conception, insemination index and length of service period. A total number of 60 Holstein Friesian dairy cows, parity between 2-8, with an average milk production of 7000 kg/305 days of lactation were divided into three experimental groups (20 dairy cows per group). The first group of dairy cows was supplemented daily with 'Energy-plus' (O1 group; 200 mL propylene-glycol supplement) and the second group was supplemented with 'Ketal' (O2 group; 160 mL propylene-glycol supplement), two weeks before partus until 30 days post partum. The third experimental group were non supplemented dairy cows (O3, control group). Ultrasound examination of the reproductive system using real time echo camera Falco VET 100 (ESAOTE PieMedical, Holland, B-shaped scan with linear-array endorectal 5-8 MHz probe) was conducted on every animal starting from day 40 postpartum. The diameters of the ovaries (left and right) and of the dominant follicle(s) were recorded. Ultrasound testing was repeated on day 50 and 60 postpartum only in cows which in the meantime were not inseminated. Reproduction efficiency parameters (conception rate, number of inseminations and length of service period) were recorded individually. The statistical significance of the differences between groups was tested using ANOVA with LSD test at the level of significance p lt 0.05, chi-square test and Kaplan-Meier survival analysis (the length of service period). There was no significant impact of the propylene glycol supplementation on the ovarian and follicular morphology at the first ultrasound examination. At the second ultrasound examination there was a significant difference between left ovarian dominant follicle diameter in the control and supplemented dairy cows (1.67±0.53 vs 1.12±0.29 and 1.11±0.35 cm, p lt 0.05, O3 vs O1 and O2, respectively). The cumulative percentage of conception after the first and second insemination was 60%, 81% and 25% in groups O1, O2 and O3, respectively (p lt 0.05, chi-square test). The insemination index was lowest in group O2 and statistically significant differences were found between groups O2 and O3 (1.69±0.79 : 3.38±1.36, respectively, p lt 0,05). The length of the service period was significantly (p lt 0.05, LSD test) shorter in the O2 group (100±35 days) compared to groups O1 and O3 (168±59 and 157±52 days, respectively), that was confirmed by the Kaplan-Meier survival analysis of days open periods. The use of propylene glycol supplement in dairy cows diet during peripartal period induced higher percentage of pregnancy rates after the first and second insemination, significantly shortened the length of the service period and reduced the insemination index.
AB  - Cilj ovog rada je bio da se ispita uticaj primene dva tipa energetskih dodataka u ishrani mlečnih krava na bazi propilen glikola na morfologiju jajnika i folikula, koncepciju, indeks osemenjavanja i dužinu servis perioda. U ogled je bilo uključeno ukupno 60 krava Holštajn Frizijske rase, u toku 2-8 laktacije, sa prosečnom proizvodnjom mleka od 7000 kg/305 dana laktacije, koje su bile podeljene u tri ogledne grupe (20 krava po grupi). Prva grupa mlečnih krava (O1) je svakodnevno suplementirana peroralnom aplikacijom 200 mL 'Energy-plus', druga grupa krava (O2) suplementirana je sa 160 mL 'Ketal-a', počevši od dve nedelje pre partusa do 30 dana nakon partusa. Treću grupu mlečnih krava (O3, kontrola) su predstavljale netretirane životinje. Ultrazvučni pregled reproduktivnog sistema vršen je sa uređajem Falco VET 100 (ESAOTE PieMedical, Holland), linearnom endorektalnom sondom od 5-8 MHz kod svake životinje najmanje dva puta počevši od 40 dana posle partusa. Ultrazvučni pregled je ponovljen sa 50 i/ili 60 dana posle partusa kod krava koje nisu u međuvremenu osemenjene. U toku svakog pregleda su registrovani prečnik oba jajnika i dominantnog folikula. Kod svake ogledne životinje su određeni parametri efikasnosti reprodukcije: stepen koncepcije, indeks osemenjavanja i servis period. Statistička značajnost razlika srednjih vrednosti dobijenih parametara određivana je ANOVA metodom i LSD testom na nivou značajnosti od p lt 0.05, hi-kvadrat testom i Kaplan-Majerovom analizom (dužina servis perioda). Rezultati prvog ultrazvučnog pregleda su ukazali da nema statistički značajnih razlika u morfologiji jajnika i dominantnog folikula između suplementiranih grupa u odnosu na kontrolnu grupu krava. Rezultati drugog ultrazvučnog pregleda su ukazali da postoji statistički značajna razlika između srednjih vrednosti prečnika dominantnog folikula na levom jajniku kod kontrolne grupe krava u odnosu na suplementirane životinje (1,67±0,53:1,12±0,29 i 1,11±0,35 cm, p lt 0.05, O3:O1 i O2). Zbirne vrednosti procenta koncepcije nakon prvog i drugog osemenjavanja bile su statistički značajno više kod suplementiranih krava u odnosu na kontrolnu grupu životinja (60% : 81% : 25%; O1:O2:O3, p lt 0,05, hi-kvadrat test). Najniža vrednost indeksa osemenjavanja je utvrđena kod ogledne grupe krava suplentirane Ketal-om (1.69±0.79), koja je bila značajno viša u odnosu na kontrolnu grupu krava (3.38±1.36, p lt 0,05). Dužina servis perioda je bila najmanja kod grupe krava suplementiranih Ketal-om (100±35 days) i značajno se razlikovala u odnosu na ostale ogledne grupe (168±59 i 157±52 dana, O1 i O2), što je potvrđeno Kaplan Majerovom analizom. Energetska suplementacija mlečnih krava propilen glikolom tokom peripartalnog perioda može dovesti do povećanja procenta gravidnih krava nakon prvog i drugog osemenjavanja, smanjenja vrednosti indeksa osemenjavanja i skraćenja dužine servis perioda.
PB  - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
T2  - Acta Veterinaria-Beograd
T1  - Propylene glycol energy supplementation during peripartal period in dairy cows and reproduction efficiency parameters
T1  - Energetska suplementacija propilen glikolom tokom peripartalnog perioda i parametri efikasnosti reprodukcije kod mlečnih krava
VL  - 62
IS  - 2-3
SP  - 249
EP  - 260
DO  - 10.2298/AVB1203249V
ER  - 

@article{
author = "Vakanjac, Slobodanka and Dražić, M. and Pavlović, V. and Gvozdić, Dragan and Jovičin, Milovan and Đukić, M. and Stepanović, P.",
year = "2012",
abstract = "The aim of this work was to investigate the impact of two energy supplements based on propylene glycol in dairy cows diet on ovarian and follicular morphology, conception, insemination index and length of service period. A total number of 60 Holstein Friesian dairy cows, parity between 2-8, with an average milk production of 7000 kg/305 days of lactation were divided into three experimental groups (20 dairy cows per group). The first group of dairy cows was supplemented daily with 'Energy-plus' (O1 group; 200 mL propylene-glycol supplement) and the second group was supplemented with 'Ketal' (O2 group; 160 mL propylene-glycol supplement), two weeks before partus until 30 days post partum. The third experimental group were non supplemented dairy cows (O3, control group). Ultrasound examination of the reproductive system using real time echo camera Falco VET 100 (ESAOTE PieMedical, Holland, B-shaped scan with linear-array endorectal 5-8 MHz probe) was conducted on every animal starting from day 40 postpartum. The diameters of the ovaries (left and right) and of the dominant follicle(s) were recorded. Ultrasound testing was repeated on day 50 and 60 postpartum only in cows which in the meantime were not inseminated. Reproduction efficiency parameters (conception rate, number of inseminations and length of service period) were recorded individually. The statistical significance of the differences between groups was tested using ANOVA with LSD test at the level of significance p lt 0.05, chi-square test and Kaplan-Meier survival analysis (the length of service period). There was no significant impact of the propylene glycol supplementation on the ovarian and follicular morphology at the first ultrasound examination. At the second ultrasound examination there was a significant difference between left ovarian dominant follicle diameter in the control and supplemented dairy cows (1.67±0.53 vs 1.12±0.29 and 1.11±0.35 cm, p lt 0.05, O3 vs O1 and O2, respectively). The cumulative percentage of conception after the first and second insemination was 60%, 81% and 25% in groups O1, O2 and O3, respectively (p lt 0.05, chi-square test). The insemination index was lowest in group O2 and statistically significant differences were found between groups O2 and O3 (1.69±0.79 : 3.38±1.36, respectively, p lt 0,05). The length of the service period was significantly (p lt 0.05, LSD test) shorter in the O2 group (100±35 days) compared to groups O1 and O3 (168±59 and 157±52 days, respectively), that was confirmed by the Kaplan-Meier survival analysis of days open periods. The use of propylene glycol supplement in dairy cows diet during peripartal period induced higher percentage of pregnancy rates after the first and second insemination, significantly shortened the length of the service period and reduced the insemination index., Cilj ovog rada je bio da se ispita uticaj primene dva tipa energetskih dodataka u ishrani mlečnih krava na bazi propilen glikola na morfologiju jajnika i folikula, koncepciju, indeks osemenjavanja i dužinu servis perioda. U ogled je bilo uključeno ukupno 60 krava Holštajn Frizijske rase, u toku 2-8 laktacije, sa prosečnom proizvodnjom mleka od 7000 kg/305 dana laktacije, koje su bile podeljene u tri ogledne grupe (20 krava po grupi). Prva grupa mlečnih krava (O1) je svakodnevno suplementirana peroralnom aplikacijom 200 mL 'Energy-plus', druga grupa krava (O2) suplementirana je sa 160 mL 'Ketal-a', počevši od dve nedelje pre partusa do 30 dana nakon partusa. Treću grupu mlečnih krava (O3, kontrola) su predstavljale netretirane životinje. Ultrazvučni pregled reproduktivnog sistema vršen je sa uređajem Falco VET 100 (ESAOTE PieMedical, Holland), linearnom endorektalnom sondom od 5-8 MHz kod svake životinje najmanje dva puta počevši od 40 dana posle partusa. Ultrazvučni pregled je ponovljen sa 50 i/ili 60 dana posle partusa kod krava koje nisu u međuvremenu osemenjene. U toku svakog pregleda su registrovani prečnik oba jajnika i dominantnog folikula. Kod svake ogledne životinje su određeni parametri efikasnosti reprodukcije: stepen koncepcije, indeks osemenjavanja i servis period. Statistička značajnost razlika srednjih vrednosti dobijenih parametara određivana je ANOVA metodom i LSD testom na nivou značajnosti od p lt 0.05, hi-kvadrat testom i Kaplan-Majerovom analizom (dužina servis perioda). Rezultati prvog ultrazvučnog pregleda su ukazali da nema statistički značajnih razlika u morfologiji jajnika i dominantnog folikula između suplementiranih grupa u odnosu na kontrolnu grupu krava. Rezultati drugog ultrazvučnog pregleda su ukazali da postoji statistički značajna razlika između srednjih vrednosti prečnika dominantnog folikula na levom jajniku kod kontrolne grupe krava u odnosu na suplementirane životinje (1,67±0,53:1,12±0,29 i 1,11±0,35 cm, p lt 0.05, O3:O1 i O2). Zbirne vrednosti procenta koncepcije nakon prvog i drugog osemenjavanja bile su statistički značajno više kod suplementiranih krava u odnosu na kontrolnu grupu životinja (60% : 81% : 25%; O1:O2:O3, p lt 0,05, hi-kvadrat test). Najniža vrednost indeksa osemenjavanja je utvrđena kod ogledne grupe krava suplentirane Ketal-om (1.69±0.79), koja je bila značajno viša u odnosu na kontrolnu grupu krava (3.38±1.36, p lt 0,05). Dužina servis perioda je bila najmanja kod grupe krava suplementiranih Ketal-om (100±35 days) i značajno se razlikovala u odnosu na ostale ogledne grupe (168±59 i 157±52 dana, O1 i O2), što je potvrđeno Kaplan Majerovom analizom. Energetska suplementacija mlečnih krava propilen glikolom tokom peripartalnog perioda može dovesti do povećanja procenta gravidnih krava nakon prvog i drugog osemenjavanja, smanjenja vrednosti indeksa osemenjavanja i skraćenja dužine servis perioda.",
publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd",
journal = "Acta Veterinaria-Beograd",
title = "Propylene glycol energy supplementation during peripartal period in dairy cows and reproduction efficiency parameters, Energetska suplementacija propilen glikolom tokom peripartalnog perioda i parametri efikasnosti reprodukcije kod mlečnih krava",
volume = "62",
number = "2-3",
pages = "249-260",
doi = "10.2298/AVB1203249V"
}

Vakanjac, S., Dražić, M., Pavlović, V., Gvozdić, D., Jovičin, M., Đukić, M.,& Stepanović, P.. (2012). Propylene glycol energy supplementation during peripartal period in dairy cows and reproduction efficiency parameters. in Acta Veterinaria-Beograd
Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 62(2-3), 249-260.
https://doi.org/10.2298/AVB1203249V

Vakanjac S, Dražić M, Pavlović V, Gvozdić D, Jovičin M, Đukić M, Stepanović P. Propylene glycol energy supplementation during peripartal period in dairy cows and reproduction efficiency parameters. in Acta Veterinaria-Beograd. 2012;62(2-3):249-260.
doi:10.2298/AVB1203249V .

Vakanjac, Slobodanka, Dražić, M., Pavlović, V., Gvozdić, Dragan, Jovičin, Milovan, Đukić, M., Stepanović, P., "Propylene glycol energy supplementation during peripartal period in dairy cows and reproduction efficiency parameters" in Acta Veterinaria-Beograd, 62, no. 2-3 (2012):249-260,
https://doi.org/10.2298/AVB1203249V . .

TY  - JOUR
AU  - Valčić, Olivera
AU  - Jovanović, Ivan B.
AU  - Milanović, Svetlana
AU  - Veličković, Miljan
AU  - Gvozdić, Dragan
PY  - 2011
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/2077
AB  - Vreme oko partusa kod mlečnih krava smatra se najosetljivijim periodom sa više aspekata, među kojima se posebno ističu prestrojavanje metabolizma u pravcu laktacije i posledično povećanje oksidativnog stresa organizma. Osim toga, indukcija porođaja uz pomoć PGF2α dodatno povećava učestalost retencije posteljice.
U sistem odbrane od oksidativnog stresa ukljuceni su neenzimski molekuli (vitamini C i E i glutation) i enzimi: superoksid dismutaza, katalaza i glutation peroksidaza. Selenoenzim glutation peroksidaza redukuje nastale hidroperokside masnih kiselina, čime prekida lančanu reakciju oštećenja lipida ćelijske membrane. malondialdehid (MDA), nastao neenzimskim cepanjem lipidnih hidroperoksida, može ukankrsno da se veže za druge biološke molekule, čime dovodi do citotoksičnosti i mutagenosti. Koncentracija MDA u krvnoj plazmi predstavlja dobar indikator stepena oksidativnog oštećenja lipida u organizmu.
Cilj našeg rada je bio da ustanovimo promene koncentracije MDA u krvnoj plazmi tokom teljenja i u peripartalnom periodu, 12 sati pre i nakon partusa, kao i uspešnost izbacivanja posteljice kod krava čiji je porođaj indukovan prostaglandinom.
Ogled je izvršen na kravama Holštajn-frizijske rase podeljenim u tri grupe: 1) nesumplementirana kontrolna grupa (n=9), 2) grupa tretirana sa 20 ml (n=11) i 3) sa 40 ml (n=13) Promtselena® 30 dana pre partusa. Koncentracija MDA u krvi je određivana spektrofotometrijski.
Koncentracije MDA u plazmi krava suplementiranih sa 20 ml Promtselena 12 časova pre porođaja (4,59 ± 1,20), tokom porođaja (4,44 ± 0,68) i 12 časova nakon porođaja (4,67 ± 0,80), bile su značajno niže u odnosu na kontrolnu grupu. Grupa tretirana sa 40 ml Promtselena je od svih posmatranih životinja imala najizrazitije smanjene vrednosti MDA u plazmi 12 sati pre partusa. Tretmani sa 20 ml i 40 ml Promtselena® rezultirali su značajnim smanjenjem učestalosti retencije posteljice (38,2% i 30,8%) u odnosu na netretiranu grupu (66,67%).
Možemo zaključiti da aplikacija 20 ml i 40 ml Promtselena 30 dana pre indukcije porođaja rezultira statistički značajnim smanjenjem MDA u plazmi tokom peripartalnog perioda, kao i značajnim smanjenjem učestalosti zaostajanja posteljice.
AB  - The time close to calving in dairy cows is considered as the most sensitive period from more aspects, among which most relevant are the metabolic shift due to lactation and subsequently increased oxidative stress. Besides, PGF2 induction of delivery additionally increases the incidence of retained placenta. The oxidative stress defense mechanisms consist of nonenzymatic molecules (vitamins C and E, glutathione) and enzymes: superoxide dismutase, catalase and glutathione peroxidase. 
The selenoenzyme glutathione peroxidase reduces the formed fatty acids hydroperoxides, thus interruptting the chain reaction of damage to the cell membrane lipids. Malondialdehyde (MDA), formed by nonenzymatic fission can cross link to other biological molecules which results in cytotoxicity and mutations. The concentration of MDA in blood plasma is a good indicator of the degree of oxidative damage in the organism. 
The aim of this study was to determine changes in MDA concentration in the blood plasma during calving and in the peripartal period, 12h before and after calving, as well as the success rate in the expulsion of the placenta in cows with prostaglandin induced delivery. 
The experiment was done on dairy Holstein Friesian cows allotted into 3 groups: 1) not supplemented control group (n=9), 2) group treated with 20 mL (n=11) and 3) with 40 mL (n=13) Promtselen® 30 days before calving. MDA plasma concentration was measured spectrophotometrically. 
Plasma MDA concentrations in cows supplemented with 20 mL Promtselen® 12h before calving were (4.59 ± 1.20), at calving (4.44 ± 0.68) and 12h after delivery (4.67 ± 0.80), were significantly lower compared to the control group. The group treated with 40 mL Promtselen® had the lowest MDA results of all groups at 12h after calving. Treatments with 20 mL and 40 mL Promtselen® resulted in a significant decrease in placenta retention (38.2% and 30.8%) compared with the control group (66.67%). 
It can be concluded that application of 20 and 40 mL Promtselen® 30 days before induction of calving resulted in a statistically significant reduction of plasma MDA concentrations during the peripartal period, as well as with a significant reduction in retained placenta.
PB  - Banja Luka : PI Veterinary Institute Republic of Srpska „Dr. Vaso Butozan“
T2  - Veterinarski žurnal Republike Srpske
T1  - Efekat dodavanja selena (Promtselen®) na koncentraciju MDA i učestalost zaostajanja posteljice kod krava kojima je indukovan partus
T1  - Effects of selenium supplementation (Promtselen®) on MDA concentration and frequency of retaind placenta in cows with induced calving
VL  - 11
IS  - 2
SP  - 148
EP  - 154
UR  - https://hdl.handle.net/21.15107/rcub_veterinar_2077
ER  - 

@article{
author = "Valčić, Olivera and Jovanović, Ivan B. and Milanović, Svetlana and Veličković, Miljan and Gvozdić, Dragan",
year = "2011",
abstract = "Vreme oko partusa kod mlečnih krava smatra se najosetljivijim periodom sa više aspekata, među kojima se posebno ističu prestrojavanje metabolizma u pravcu laktacije i posledično povećanje oksidativnog stresa organizma. Osim toga, indukcija porođaja uz pomoć PGF2α dodatno povećava učestalost retencije posteljice.
U sistem odbrane od oksidativnog stresa ukljuceni su neenzimski molekuli (vitamini C i E i glutation) i enzimi: superoksid dismutaza, katalaza i glutation peroksidaza. Selenoenzim glutation peroksidaza redukuje nastale hidroperokside masnih kiselina, čime prekida lančanu reakciju oštećenja lipida ćelijske membrane. malondialdehid (MDA), nastao neenzimskim cepanjem lipidnih hidroperoksida, može ukankrsno da se veže za druge biološke molekule, čime dovodi do citotoksičnosti i mutagenosti. Koncentracija MDA u krvnoj plazmi predstavlja dobar indikator stepena oksidativnog oštećenja lipida u organizmu.
Cilj našeg rada je bio da ustanovimo promene koncentracije MDA u krvnoj plazmi tokom teljenja i u peripartalnom periodu, 12 sati pre i nakon partusa, kao i uspešnost izbacivanja posteljice kod krava čiji je porođaj indukovan prostaglandinom.
Ogled je izvršen na kravama Holštajn-frizijske rase podeljenim u tri grupe: 1) nesumplementirana kontrolna grupa (n=9), 2) grupa tretirana sa 20 ml (n=11) i 3) sa 40 ml (n=13) Promtselena® 30 dana pre partusa. Koncentracija MDA u krvi je određivana spektrofotometrijski.
Koncentracije MDA u plazmi krava suplementiranih sa 20 ml Promtselena 12 časova pre porođaja (4,59 ± 1,20), tokom porođaja (4,44 ± 0,68) i 12 časova nakon porođaja (4,67 ± 0,80), bile su značajno niže u odnosu na kontrolnu grupu. Grupa tretirana sa 40 ml Promtselena je od svih posmatranih životinja imala najizrazitije smanjene vrednosti MDA u plazmi 12 sati pre partusa. Tretmani sa 20 ml i 40 ml Promtselena® rezultirali su značajnim smanjenjem učestalosti retencije posteljice (38,2% i 30,8%) u odnosu na netretiranu grupu (66,67%).
Možemo zaključiti da aplikacija 20 ml i 40 ml Promtselena 30 dana pre indukcije porođaja rezultira statistički značajnim smanjenjem MDA u plazmi tokom peripartalnog perioda, kao i značajnim smanjenjem učestalosti zaostajanja posteljice., The time close to calving in dairy cows is considered as the most sensitive period from more aspects, among which most relevant are the metabolic shift due to lactation and subsequently increased oxidative stress. Besides, PGF2 induction of delivery additionally increases the incidence of retained placenta. The oxidative stress defense mechanisms consist of nonenzymatic molecules (vitamins C and E, glutathione) and enzymes: superoxide dismutase, catalase and glutathione peroxidase. 
The selenoenzyme glutathione peroxidase reduces the formed fatty acids hydroperoxides, thus interruptting the chain reaction of damage to the cell membrane lipids. Malondialdehyde (MDA), formed by nonenzymatic fission can cross link to other biological molecules which results in cytotoxicity and mutations. The concentration of MDA in blood plasma is a good indicator of the degree of oxidative damage in the organism. 
The aim of this study was to determine changes in MDA concentration in the blood plasma during calving and in the peripartal period, 12h before and after calving, as well as the success rate in the expulsion of the placenta in cows with prostaglandin induced delivery. 
The experiment was done on dairy Holstein Friesian cows allotted into 3 groups: 1) not supplemented control group (n=9), 2) group treated with 20 mL (n=11) and 3) with 40 mL (n=13) Promtselen® 30 days before calving. MDA plasma concentration was measured spectrophotometrically. 
Plasma MDA concentrations in cows supplemented with 20 mL Promtselen® 12h before calving were (4.59 ± 1.20), at calving (4.44 ± 0.68) and 12h after delivery (4.67 ± 0.80), were significantly lower compared to the control group. The group treated with 40 mL Promtselen® had the lowest MDA results of all groups at 12h after calving. Treatments with 20 mL and 40 mL Promtselen® resulted in a significant decrease in placenta retention (38.2% and 30.8%) compared with the control group (66.67%). 
It can be concluded that application of 20 and 40 mL Promtselen® 30 days before induction of calving resulted in a statistically significant reduction of plasma MDA concentrations during the peripartal period, as well as with a significant reduction in retained placenta.",
publisher = "Banja Luka : PI Veterinary Institute Republic of Srpska „Dr. Vaso Butozan“",
journal = "Veterinarski žurnal Republike Srpske",
title = "Efekat dodavanja selena (Promtselen®) na koncentraciju MDA i učestalost zaostajanja posteljice kod krava kojima je indukovan partus, Effects of selenium supplementation (Promtselen®) on MDA concentration and frequency of retaind placenta in cows with induced calving",
volume = "11",
number = "2",
pages = "148-154",
url = "https://hdl.handle.net/21.15107/rcub_veterinar_2077"
}

Valčić, O., Jovanović, I. B., Milanović, S., Veličković, M.,& Gvozdić, D.. (2011). Efekat dodavanja selena (Promtselen®) na koncentraciju MDA i učestalost zaostajanja posteljice kod krava kojima je indukovan partus. in Veterinarski žurnal Republike Srpske
Banja Luka : PI Veterinary Institute Republic of Srpska „Dr. Vaso Butozan“., 11(2), 148-154.
https://hdl.handle.net/21.15107/rcub_veterinar_2077

Valčić O, Jovanović IB, Milanović S, Veličković M, Gvozdić D. Efekat dodavanja selena (Promtselen®) na koncentraciju MDA i učestalost zaostajanja posteljice kod krava kojima je indukovan partus. in Veterinarski žurnal Republike Srpske. 2011;11(2):148-154.
https://hdl.handle.net/21.15107/rcub_veterinar_2077 .

Valčić, Olivera, Jovanović, Ivan B., Milanović, Svetlana, Veličković, Miljan, Gvozdić, Dragan, "Efekat dodavanja selena (Promtselen®) na koncentraciju MDA i učestalost zaostajanja posteljice kod krava kojima je indukovan partus" in Veterinarski žurnal Republike Srpske, 11, no. 2 (2011):148-154,
https://hdl.handle.net/21.15107/rcub_veterinar_2077 .

TY  - JOUR
AU  - Gvozdić, Dragan
AU  - Stančić, Ivan
AU  - Savović, Milan
AU  - Stančić, Blagoje
AU  - Božić, Aleksandar
AU  - Milanović, Svetlana
AU  - Jovanović, Ivan B.
AU  - Barna, Tomislav
PY  - 2011
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/845
AB  - The aim of this work was to determine incidence of calving and postcalving reproduction disorders and their effect on the major parameters of cows reproductive efficiency at dairy farm in the R. Serbia. Total number of 1835 high-milking dairy cows (av. milk production >8500L/305d of lactation) records has been reviewed during one year period, at the large dairy farm in area of Vojvodina (R. Serbia). Normal calving and puerperal period without health problems was observed at 583 cows (27,6%), while different abnormalities during and after calving were recorded in 1252 cows (72,4%). The highest percentages of registered peripartal disorders were dystocia and endometritis (62% and 64%, respectively), affecting almost the same percentage of cows. Peripartal disorders had statistically significant influence (P lt 0.05) on the increase of number of services/conception (3,5 vs. 2,7, reproductive disorders vs. healthy cows, respectively), prolongation of the interval from first postpartal insemination till conception (110 vs. 57 days, reproductive disorders vs. healthy cows, respectively), and increase of days open period (214 vs. 146 days, reproductive disorders vs. healthy cows, respectively). This results have confirmed increased incidence of reproduction disorders during calving and postcalving period that significantly reduces reproductive efficiency in high milking dairy cows after parturition.
AB  - Istraživanja u mnogim zemljama, tokom poslednjih decenija, pokazuju permanentan pad reproduktivne efikasnosti krava visoke mlečnosti. Cilj ovog rada je da se utvrdi da li i u kojoj meri, peripartalni poremećaji imaju uticaja na osnovne parametre reproduktivne efikasnosti krava u našim proizvodnim uslovima. Istraživanjem je obuhvaćeno ukupno 1835 krava, tokom jedne godine, na jednoj velikoj farmi sa visokom proizvodnjom mleka (prosečna proizvodnja >8500L/305 dana laktacije) u regionu Vojvodine (Republika Srbija). Od ukupnog broja ispitivanih krava, telenje je prošlo bez poremećaja kod 583 krave (27,6%), a različiti poremećaji tokom i posle telenja su ustanovljeni kod 1.252 krave (72,4%). Najčešće ustanovljeni peripartalni poremećaji kod visoko mlečnih krava su teško teljenje (62%) i endometritis (64%). Peripartalni poremećaji imaju statistički značajan uticaj (P lt 0,05) na povećanje indeksa osemenjavanja (3,5 prema 2,7), produženje intervala od prvog do fertilnog osemenjavanja (57 prema 110 dana), kao i na produženje trajanja servis perioda (146 prema 214 dana), u poređenju sa kravama bez poremećaja. Dobijeni rezultati pokazuju da na farmama visoko mlečnih krava povišena učestalost peripartalnih reproduktivnih poremećaja koji značajno utiču na smanjenje reproduktivne efikasnosti krava nakon partusa.
PB  - Univerzitet u Novom Sadu - Poljoprivredni fakultet, Novi Sad i Naučni institut za ratarstvo i povrtarstvo, Novi Sad
T2  - Savremena poljoprivreda
T1  - Reproductive efficiency in high-milking dairy cows after calving
T1  - Reproduktivna efikasnost visoko-mlečnih krava posle telenja
VL  - 60
IS  - 1-2
SP  - 86
EP  - 97
UR  - https://hdl.handle.net/21.15107/rcub_veterinar_845
ER  - 

@article{
author = "Gvozdić, Dragan and Stančić, Ivan and Savović, Milan and Stančić, Blagoje and Božić, Aleksandar and Milanović, Svetlana and Jovanović, Ivan B. and Barna, Tomislav",
year = "2011",
abstract = "The aim of this work was to determine incidence of calving and postcalving reproduction disorders and their effect on the major parameters of cows reproductive efficiency at dairy farm in the R. Serbia. Total number of 1835 high-milking dairy cows (av. milk production >8500L/305d of lactation) records has been reviewed during one year period, at the large dairy farm in area of Vojvodina (R. Serbia). Normal calving and puerperal period without health problems was observed at 583 cows (27,6%), while different abnormalities during and after calving were recorded in 1252 cows (72,4%). The highest percentages of registered peripartal disorders were dystocia and endometritis (62% and 64%, respectively), affecting almost the same percentage of cows. Peripartal disorders had statistically significant influence (P lt 0.05) on the increase of number of services/conception (3,5 vs. 2,7, reproductive disorders vs. healthy cows, respectively), prolongation of the interval from first postpartal insemination till conception (110 vs. 57 days, reproductive disorders vs. healthy cows, respectively), and increase of days open period (214 vs. 146 days, reproductive disorders vs. healthy cows, respectively). This results have confirmed increased incidence of reproduction disorders during calving and postcalving period that significantly reduces reproductive efficiency in high milking dairy cows after parturition., Istraživanja u mnogim zemljama, tokom poslednjih decenija, pokazuju permanentan pad reproduktivne efikasnosti krava visoke mlečnosti. Cilj ovog rada je da se utvrdi da li i u kojoj meri, peripartalni poremećaji imaju uticaja na osnovne parametre reproduktivne efikasnosti krava u našim proizvodnim uslovima. Istraživanjem je obuhvaćeno ukupno 1835 krava, tokom jedne godine, na jednoj velikoj farmi sa visokom proizvodnjom mleka (prosečna proizvodnja >8500L/305 dana laktacije) u regionu Vojvodine (Republika Srbija). Od ukupnog broja ispitivanih krava, telenje je prošlo bez poremećaja kod 583 krave (27,6%), a različiti poremećaji tokom i posle telenja su ustanovljeni kod 1.252 krave (72,4%). Najčešće ustanovljeni peripartalni poremećaji kod visoko mlečnih krava su teško teljenje (62%) i endometritis (64%). Peripartalni poremećaji imaju statistički značajan uticaj (P lt 0,05) na povećanje indeksa osemenjavanja (3,5 prema 2,7), produženje intervala od prvog do fertilnog osemenjavanja (57 prema 110 dana), kao i na produženje trajanja servis perioda (146 prema 214 dana), u poređenju sa kravama bez poremećaja. Dobijeni rezultati pokazuju da na farmama visoko mlečnih krava povišena učestalost peripartalnih reproduktivnih poremećaja koji značajno utiču na smanjenje reproduktivne efikasnosti krava nakon partusa.",
publisher = "Univerzitet u Novom Sadu - Poljoprivredni fakultet, Novi Sad i Naučni institut za ratarstvo i povrtarstvo, Novi Sad",
journal = "Savremena poljoprivreda",
title = "Reproductive efficiency in high-milking dairy cows after calving, Reproduktivna efikasnost visoko-mlečnih krava posle telenja",
volume = "60",
number = "1-2",
pages = "86-97",
url = "https://hdl.handle.net/21.15107/rcub_veterinar_845"
}

Gvozdić, D., Stančić, I., Savović, M., Stančić, B., Božić, A., Milanović, S., Jovanović, I. B.,& Barna, T.. (2011). Reproductive efficiency in high-milking dairy cows after calving. in Savremena poljoprivreda
Univerzitet u Novom Sadu - Poljoprivredni fakultet, Novi Sad i Naučni institut za ratarstvo i povrtarstvo, Novi Sad., 60(1-2), 86-97.
https://hdl.handle.net/21.15107/rcub_veterinar_845

Gvozdić D, Stančić I, Savović M, Stančić B, Božić A, Milanović S, Jovanović IB, Barna T. Reproductive efficiency in high-milking dairy cows after calving. in Savremena poljoprivreda. 2011;60(1-2):86-97.
https://hdl.handle.net/21.15107/rcub_veterinar_845 .

Gvozdić, Dragan, Stančić, Ivan, Savović, Milan, Stančić, Blagoje, Božić, Aleksandar, Milanović, Svetlana, Jovanović, Ivan B., Barna, Tomislav, "Reproductive efficiency in high-milking dairy cows after calving" in Savremena poljoprivreda, 60, no. 1-2 (2011):86-97,
https://hdl.handle.net/21.15107/rcub_veterinar_845 .

TY  - JOUR
AU  - Valčić, Olivera
AU  - Jovanović, Ivan B.
AU  - Milanović, Svetlana
PY  - 2011
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/764
AB  - The objective of this experiment was to compare the efficiencies of sodium selenite (SS) and selenized yeast (SY) supplemented at different doses (0.05 and 0.30 mg Se/kg feed) with respect to plasma glutathione peroxidase (Gpx) activity, extent of oxidative lipid injury, and thyroid hormone activation in broilers during the first four weeks of growth. Results indicate a significant increase in plasma Gpx activity and reduction in thiobarbituric acid reactive substances (TBARS) in all supplemented groups at 4 weeks of age compared to 2-week-old chicks. Plasma thyronine activation was highest in SY supplemented broilers. It can be concluded that in the first 4 weeks of broiler life selenite has a more efficient antioxidative effect which is reflected in lower plasma and liver TBARS values. However, broiler feed supplementation with selenized yeast results in a more proficient conversion of T4 to T3.
PB  - Hokkaido Univ, Sapporo
T2  - Japanese Journal of Veterinary Research
T1  - Selenium, thiobarbituric acid reactive substances, and thyroid hormone activation in broilers supplemented with selenium as selenized yeast or sodium selenite
VL  - 59
IS  - 2-3
SP  - 69
EP  - 77
UR  - https://hdl.handle.net/21.15107/rcub_veterinar_764
ER  - 

@article{
author = "Valčić, Olivera and Jovanović, Ivan B. and Milanović, Svetlana",
year = "2011",
abstract = "The objective of this experiment was to compare the efficiencies of sodium selenite (SS) and selenized yeast (SY) supplemented at different doses (0.05 and 0.30 mg Se/kg feed) with respect to plasma glutathione peroxidase (Gpx) activity, extent of oxidative lipid injury, and thyroid hormone activation in broilers during the first four weeks of growth. Results indicate a significant increase in plasma Gpx activity and reduction in thiobarbituric acid reactive substances (TBARS) in all supplemented groups at 4 weeks of age compared to 2-week-old chicks. Plasma thyronine activation was highest in SY supplemented broilers. It can be concluded that in the first 4 weeks of broiler life selenite has a more efficient antioxidative effect which is reflected in lower plasma and liver TBARS values. However, broiler feed supplementation with selenized yeast results in a more proficient conversion of T4 to T3.",
publisher = "Hokkaido Univ, Sapporo",
journal = "Japanese Journal of Veterinary Research",
title = "Selenium, thiobarbituric acid reactive substances, and thyroid hormone activation in broilers supplemented with selenium as selenized yeast or sodium selenite",
volume = "59",
number = "2-3",
pages = "69-77",
url = "https://hdl.handle.net/21.15107/rcub_veterinar_764"
}

Valčić, O., Jovanović, I. B.,& Milanović, S.. (2011). Selenium, thiobarbituric acid reactive substances, and thyroid hormone activation in broilers supplemented with selenium as selenized yeast or sodium selenite. in Japanese Journal of Veterinary Research
Hokkaido Univ, Sapporo., 59(2-3), 69-77.
https://hdl.handle.net/21.15107/rcub_veterinar_764

Valčić O, Jovanović IB, Milanović S. Selenium, thiobarbituric acid reactive substances, and thyroid hormone activation in broilers supplemented with selenium as selenized yeast or sodium selenite. in Japanese Journal of Veterinary Research. 2011;59(2-3):69-77.
https://hdl.handle.net/21.15107/rcub_veterinar_764 .

Valčić, Olivera, Jovanović, Ivan B., Milanović, Svetlana, "Selenium, thiobarbituric acid reactive substances, and thyroid hormone activation in broilers supplemented with selenium as selenized yeast or sodium selenite" in Japanese Journal of Veterinary Research, 59, no. 2-3 (2011):69-77,
https://hdl.handle.net/21.15107/rcub_veterinar_764 .