TY  - JOUR
AU  - Čobanović, Nikola
AU  - Čalović, Sara
AU  - Suvajdžić, Branko
AU  - Grković, Nevena
AU  - Stanković, Sanja Dj
AU  - Radaković, Milena
AU  - Spariosu, Kristina
AU  - Karabasil, Nedjeljko
PY  - 2024
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/3494
AB  - This study assessed the influence of transport conditions on welfare indicators of slaughter
pigs with different health status and RYR-1 genotype. The group of pigs, predominantly consisting of
Nn (56.67%) and subclinically diseased (60.00%) individuals, that were exposed to short transportation (<30 min) at high loading density (~235 kg/m2
) had the highest slipping (p < 0.0001), falling
(p = 0.0009), turning back (p < 0.0001), reluctance to move (p < 0.0001), panting (p < 0.0001) and
shivering (p < 0.0001) frequencies at unloading. Subclinically diseased Nn pigs subjected to short
transportation (<30 min) and high loading density (~235 kg/m2
) had the highest lactate (p < 0.0001
and p < 0.0001), glucose (p = 0.0450 and p = 0.0002), CK (p < 0.0001 and p = 0.0010), LDH (p < 0.0001
and p = 0.0484), AST (p = 0.0208 and p = 0.0170), ALT (p = 0.0500 and p = 0.00081), ceruloplasmin
(p = 0.0334 and p < 0.0001) and MDA (p = 0.0048 and p < 0.0001) concentrations, but the lowest
sodium (p < 0.0001 and p < 0.0001), chloride (p = 0.0001 and p = 0.0432), albumin (p < 0.0090 and
p < 0.0001), PON-1 (p = 0.0122 and p = 0.0500) and GSH (p = 0.0042 and p = 0.0340) levels, respectively. In the group consisting of of stress-resistant (100%) and predominantly healthy (60.00%)
pigs subjected to short transportation (<30 min) at high loading density (~235 kg/m2
), none of the
individuals showed irregular behavioural reactions during unloading. Healthy NN pigs that underwent short transportation (<30 min) at high loading density (~235 kg/m2
) had the lowest lactate
(p < 0.0001 and p < 0.0001), glucose (p = 0.0450 and p = 0.0002), CK (p < 0.0001 and p = 0.0010), LDH
(p < 0.0001 and p = 0.0484) and ceruloplasmin (p = 0.0334 and p < 0.0001) levels, but the highest sodium
(p < 0.0001 and p < 0.0001) and chloride (p = 0.0001 and p = 0.0432) concentrations, respectively. Inconclusion, the most compromised welfare was recorded in subclinically diseased Nn pigs exposed
to short transportation (<30 min) and high loading density (~235 kg/m2
), while under the same
conditions, the welfare of healthy NN pigs was not compromised. Therefore, stress-carrier pigs with
subclinical pathological lesions should not be considered fit for transportation, indicating that the
health status and genotype are the key factors for optimising pig welfare
PB  - MDPI
T2  - Animals
T1  - Consequences of transport conditions on the welfare of slaughter pigs with different health status and RYR-1 genotype
VL  - 14
IS  - 2
SP  - 191
DO  - 10.3390/ani14020191
ER  - 

@article{
author = "Čobanović, Nikola and Čalović, Sara and Suvajdžić, Branko and Grković, Nevena and Stanković, Sanja Dj and Radaković, Milena and Spariosu, Kristina and Karabasil, Nedjeljko",
year = "2024",
abstract = "This study assessed the influence of transport conditions on welfare indicators of slaughter
pigs with different health status and RYR-1 genotype. The group of pigs, predominantly consisting of
Nn (56.67%) and subclinically diseased (60.00%) individuals, that were exposed to short transportation (<30 min) at high loading density (~235 kg/m2
) had the highest slipping (p < 0.0001), falling
(p = 0.0009), turning back (p < 0.0001), reluctance to move (p < 0.0001), panting (p < 0.0001) and
shivering (p < 0.0001) frequencies at unloading. Subclinically diseased Nn pigs subjected to short
transportation (<30 min) and high loading density (~235 kg/m2
) had the highest lactate (p < 0.0001
and p < 0.0001), glucose (p = 0.0450 and p = 0.0002), CK (p < 0.0001 and p = 0.0010), LDH (p < 0.0001
and p = 0.0484), AST (p = 0.0208 and p = 0.0170), ALT (p = 0.0500 and p = 0.00081), ceruloplasmin
(p = 0.0334 and p < 0.0001) and MDA (p = 0.0048 and p < 0.0001) concentrations, but the lowest
sodium (p < 0.0001 and p < 0.0001), chloride (p = 0.0001 and p = 0.0432), albumin (p < 0.0090 and
p < 0.0001), PON-1 (p = 0.0122 and p = 0.0500) and GSH (p = 0.0042 and p = 0.0340) levels, respectively. In the group consisting of of stress-resistant (100%) and predominantly healthy (60.00%)
pigs subjected to short transportation (<30 min) at high loading density (~235 kg/m2
), none of the
individuals showed irregular behavioural reactions during unloading. Healthy NN pigs that underwent short transportation (<30 min) at high loading density (~235 kg/m2
) had the lowest lactate
(p < 0.0001 and p < 0.0001), glucose (p = 0.0450 and p = 0.0002), CK (p < 0.0001 and p = 0.0010), LDH
(p < 0.0001 and p = 0.0484) and ceruloplasmin (p = 0.0334 and p < 0.0001) levels, but the highest sodium
(p < 0.0001 and p < 0.0001) and chloride (p = 0.0001 and p = 0.0432) concentrations, respectively. Inconclusion, the most compromised welfare was recorded in subclinically diseased Nn pigs exposed
to short transportation (<30 min) and high loading density (~235 kg/m2
), while under the same
conditions, the welfare of healthy NN pigs was not compromised. Therefore, stress-carrier pigs with
subclinical pathological lesions should not be considered fit for transportation, indicating that the
health status and genotype are the key factors for optimising pig welfare",
publisher = "MDPI",
journal = "Animals",
title = "Consequences of transport conditions on the welfare of slaughter pigs with different health status and RYR-1 genotype",
volume = "14",
number = "2",
pages = "191",
doi = "10.3390/ani14020191"
}

Čobanović, N., Čalović, S., Suvajdžić, B., Grković, N., Stanković, S. D., Radaković, M., Spariosu, K.,& Karabasil, N.. (2024). Consequences of transport conditions on the welfare of slaughter pigs with different health status and RYR-1 genotype. in Animals
MDPI., 14(2), 191.
https://doi.org/10.3390/ani14020191

Čobanović N, Čalović S, Suvajdžić B, Grković N, Stanković SD, Radaković M, Spariosu K, Karabasil N. Consequences of transport conditions on the welfare of slaughter pigs with different health status and RYR-1 genotype. in Animals. 2024;14(2):191.
doi:10.3390/ani14020191 .

Čobanović, Nikola, Čalović, Sara, Suvajdžić, Branko, Grković, Nevena, Stanković, Sanja Dj, Radaković, Milena, Spariosu, Kristina, Karabasil, Nedjeljko, "Consequences of transport conditions on the welfare of slaughter pigs with different health status and RYR-1 genotype" in Animals, 14, no. 2 (2024):191,
https://doi.org/10.3390/ani14020191 . .

TY  - JOUR
AU  - Ilić, Milica
AU  - Ivković, Maša
AU  - Radaković, Milena
AU  - Spariosu, Kristina
AU  - Andrić, Nenad
AU  - Kovačević Filipović, Milica
AU  - Beletić, Anđelo
AU  - Francuski Andrić, Jelena
PY  - 2023
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/3254
AB  - Red blood cell osmotic fragility (RBCOF) refers to susceptibility to hemolysis in
vivo and in vitro. An increase in mean cellular hemoglobin concentration (MCHC)
also reflects in vivo and in vitro hemolysis. Common inflammatory infectious
diseases in dogs are often characterized by an increase in MCHC; however, it is
not known if there is a concomitant increase in RBCOF. The objective of this
study was to determine RBCOF in dogs with babesiosis, dirofilariosis,
parvovirosis, pyometra, and canine distemper and to investigate whether RBCOF
correlates with routine hematologic and biochemical parameters and lipoprotein
fractions. The diagnosis of canine infectious disease was made and complete
blood count, serum biochemical profiles, and lipoprotein electrophoresis were
determined according to current institutional protocols. RBCOF of healthy
control (n=8) and infected dogs (n=73) was measured with a phosphate-buffered
saline dilution test, and mean corpuscular fragility (MCF) was calculated. MCF
was increased in dirofilariosis, pyometra, and distemper; MCHC was increased
in all infected groups; HDL was decreased in babesiosis, pyometra, and
distemper compared with healthy controls. However, no correlation was found
between these parameters. On the other hand, hematological and biochemical
parameters, that are highly predictive of specific infections, correlated with MCF:
ALP for babesiosis (r=0.415, P=0.035), urea (r=-0.488, P=0.034) for
dirofilariosis, and leukocyte count (r=-0.820, P=0.046) for pyometra. Although
elevated MCHC levels in all samples from infected dogs indicate hemolysis,
RBCOF was elevated only in dirofilariosis, pyometra, and canine distemper,
leading to the conclusion that these apparently related phenomena are controlled
by different mechanisms.
PB  - Faculty of Veterinary Science, University of Agriculture, Faisalabad, Pakistan
T2  - Pakistan Veterinary Journal
T1  - Association of increased osmotic fragility of red blood cells with common systemic inflammatory diseases in dogs
VL  - 43
IS  - 3
SP  - 463
EP  - 469
DO  - 10.29261/pakvetj/2023.048
ER  - 

@article{
author = "Ilić, Milica and Ivković, Maša and Radaković, Milena and Spariosu, Kristina and Andrić, Nenad and Kovačević Filipović, Milica and Beletić, Anđelo and Francuski Andrić, Jelena",
year = "2023",
abstract = "Red blood cell osmotic fragility (RBCOF) refers to susceptibility to hemolysis in
vivo and in vitro. An increase in mean cellular hemoglobin concentration (MCHC)
also reflects in vivo and in vitro hemolysis. Common inflammatory infectious
diseases in dogs are often characterized by an increase in MCHC; however, it is
not known if there is a concomitant increase in RBCOF. The objective of this
study was to determine RBCOF in dogs with babesiosis, dirofilariosis,
parvovirosis, pyometra, and canine distemper and to investigate whether RBCOF
correlates with routine hematologic and biochemical parameters and lipoprotein
fractions. The diagnosis of canine infectious disease was made and complete
blood count, serum biochemical profiles, and lipoprotein electrophoresis were
determined according to current institutional protocols. RBCOF of healthy
control (n=8) and infected dogs (n=73) was measured with a phosphate-buffered
saline dilution test, and mean corpuscular fragility (MCF) was calculated. MCF
was increased in dirofilariosis, pyometra, and distemper; MCHC was increased
in all infected groups; HDL was decreased in babesiosis, pyometra, and
distemper compared with healthy controls. However, no correlation was found
between these parameters. On the other hand, hematological and biochemical
parameters, that are highly predictive of specific infections, correlated with MCF:
ALP for babesiosis (r=0.415, P=0.035), urea (r=-0.488, P=0.034) for
dirofilariosis, and leukocyte count (r=-0.820, P=0.046) for pyometra. Although
elevated MCHC levels in all samples from infected dogs indicate hemolysis,
RBCOF was elevated only in dirofilariosis, pyometra, and canine distemper,
leading to the conclusion that these apparently related phenomena are controlled
by different mechanisms.",
publisher = "Faculty of Veterinary Science, University of Agriculture, Faisalabad, Pakistan",
journal = "Pakistan Veterinary Journal",
title = "Association of increased osmotic fragility of red blood cells with common systemic inflammatory diseases in dogs",
volume = "43",
number = "3",
pages = "463-469",
doi = "10.29261/pakvetj/2023.048"
}

Ilić, M., Ivković, M., Radaković, M., Spariosu, K., Andrić, N., Kovačević Filipović, M., Beletić, A.,& Francuski Andrić, J.. (2023). Association of increased osmotic fragility of red blood cells with common systemic inflammatory diseases in dogs. in Pakistan Veterinary Journal
Faculty of Veterinary Science, University of Agriculture, Faisalabad, Pakistan., 43(3), 463-469.
https://doi.org/10.29261/pakvetj/2023.048

Ilić M, Ivković M, Radaković M, Spariosu K, Andrić N, Kovačević Filipović M, Beletić A, Francuski Andrić J. Association of increased osmotic fragility of red blood cells with common systemic inflammatory diseases in dogs. in Pakistan Veterinary Journal. 2023;43(3):463-469.
doi:10.29261/pakvetj/2023.048 .

Ilić, Milica, Ivković, Maša, Radaković, Milena, Spariosu, Kristina, Andrić, Nenad, Kovačević Filipović, Milica, Beletić, Anđelo, Francuski Andrić, Jelena, "Association of increased osmotic fragility of red blood cells with common systemic inflammatory diseases in dogs" in Pakistan Veterinary Journal, 43, no. 3 (2023):463-469,
https://doi.org/10.29261/pakvetj/2023.048 . .

TY  - JOUR
AU  - Radaković, Milena
AU  - Francuski Andrić, Jelena
AU  - Spariosu, Kristina
AU  - Vejnović, Branislav
AU  - Kovačević Filipović, Milica
AU  - Andrić, Nenad
PY  - 2023
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/3391
AB  - Oxidative stress plays an important role in pathogenesis of idiopathic epilepsy (IE). Although IE is the most
common neurological condition, oxidant–antioxidant status in epileptic dogs is still unknown. The aim of this
study is to evaluate the serum oxidant-antioxidant status in dogs with newly diagnosed IE. The status in 15 dogs
with IE and 15 healthy dogs is estimated through spectrophotometric determination of two oxidant markers:
advanced oxidation protein products-albumin index (AOPP) and thiobarbituric acid reactive substances
(TBARS); and three antioxidant markers: total thiols (R-SH) level, glutathione (GSH) level, and paraoxonase-1
(PON-1) activity. Also, butyrylcholinesterase (BChE) activity is assessed in both groups of dogs. Higher AOPP
is observed in the dogs with newly diagnosed IE, while TBARS level shows no difference when compared to the
healthy dogs. In contrast, lower levels of antioxidants (R-SH, GSH, and PON-1) and BChE activity are found in the
dogs with IE. No significant differences are observed in the oxidant and antioxidant markers and BChE activity
across the investigated IE cases with focal and generalized seizures. Our findings provide evidence that dogs with
IE are characterized by an impaired serum oxidant–antioxidant balance and lower BChE activity, which may
contribute to a better understanding of IE pathogenesis.
PB  - Elsevier
T2  - Research in Veterinary Science
T1  - Serum oxidant–antioxidant status and butyrylcholinesterase activity in dogs with idiopathic epilepsy – A pilot study
VL  - 165
SP  - 105076
DO  - 10.1016/j.rvsc.2023.105076
ER  - 

@article{
author = "Radaković, Milena and Francuski Andrić, Jelena and Spariosu, Kristina and Vejnović, Branislav and Kovačević Filipović, Milica and Andrić, Nenad",
year = "2023",
abstract = "Oxidative stress plays an important role in pathogenesis of idiopathic epilepsy (IE). Although IE is the most
common neurological condition, oxidant–antioxidant status in epileptic dogs is still unknown. The aim of this
study is to evaluate the serum oxidant-antioxidant status in dogs with newly diagnosed IE. The status in 15 dogs
with IE and 15 healthy dogs is estimated through spectrophotometric determination of two oxidant markers:
advanced oxidation protein products-albumin index (AOPP) and thiobarbituric acid reactive substances
(TBARS); and three antioxidant markers: total thiols (R-SH) level, glutathione (GSH) level, and paraoxonase-1
(PON-1) activity. Also, butyrylcholinesterase (BChE) activity is assessed in both groups of dogs. Higher AOPP
is observed in the dogs with newly diagnosed IE, while TBARS level shows no difference when compared to the
healthy dogs. In contrast, lower levels of antioxidants (R-SH, GSH, and PON-1) and BChE activity are found in the
dogs with IE. No significant differences are observed in the oxidant and antioxidant markers and BChE activity
across the investigated IE cases with focal and generalized seizures. Our findings provide evidence that dogs with
IE are characterized by an impaired serum oxidant–antioxidant balance and lower BChE activity, which may
contribute to a better understanding of IE pathogenesis.",
publisher = "Elsevier",
journal = "Research in Veterinary Science",
title = "Serum oxidant–antioxidant status and butyrylcholinesterase activity in dogs with idiopathic epilepsy – A pilot study",
volume = "165",
pages = "105076",
doi = "10.1016/j.rvsc.2023.105076"
}

Radaković, M., Francuski Andrić, J., Spariosu, K., Vejnović, B., Kovačević Filipović, M.,& Andrić, N.. (2023). Serum oxidant–antioxidant status and butyrylcholinesterase activity in dogs with idiopathic epilepsy – A pilot study. in Research in Veterinary Science
Elsevier., 165, 105076.
https://doi.org/10.1016/j.rvsc.2023.105076

Radaković M, Francuski Andrić J, Spariosu K, Vejnović B, Kovačević Filipović M, Andrić N. Serum oxidant–antioxidant status and butyrylcholinesterase activity in dogs with idiopathic epilepsy – A pilot study. in Research in Veterinary Science. 2023;165:105076.
doi:10.1016/j.rvsc.2023.105076 .

Radaković, Milena, Francuski Andrić, Jelena, Spariosu, Kristina, Vejnović, Branislav, Kovačević Filipović, Milica, Andrić, Nenad, "Serum oxidant–antioxidant status and butyrylcholinesterase activity in dogs with idiopathic epilepsy – A pilot study" in Research in Veterinary Science, 165 (2023):105076,
https://doi.org/10.1016/j.rvsc.2023.105076 . .

TY  - JOUR
AU  - Kopilović, Aleksandar
AU  - Gvozdić, Dragan
AU  - Radaković, Milena
AU  - Spariosu, Kristina
AU  - Andrić, Nenad
AU  - Francuski Andrić, Jelena
PY  - 2023
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/3442
AB  - In veterinary medicine, knowledge about hematologic ratios (neutrophil-to-lymphocyte
ratio (NLR), platelet-to-lymphocyte ratio (PLR) and mean platelet volume-to-platelet
ratio (MPV/PLT)) is limited, particularly in cats. While the roles of these ratios have
been proven in oncology, systemic inflammation with or without systemic inflammatory
response syndrome (SIRS), and sepsis, information is lacking about their alterations in
non-septic effusions, like feline infectious peritonitis (FIP).
This study aimed to describe whether NLR, PLR, and MPV/PLT were changed and
whether they correlated with routine hematologic and biochemical parameters in 16
cats with non-septic effusions, highly suspected to be the effusive form of FIP without
SIRS, compared to nine clinically healthy cats.
The NLR was calculated as the absolute count of neutrophils divided by the absolute
count of lymphocytes, PLR by calculating the absolute platelet divided by the absolute
lymphocyte count, and MPV/PLT by dividing mean platelet volume by absolute platelet
count.
The NLR, MPV, and MPV/PLT ratios were higher in cats with non-septic effusions
suspected to be FIP, but PLR did not differ, when compared to healthy cats. Correlation analysis did not show any association between the selected ratios and hematological and
biochemical parameters.
In the absence of leukocytosis, increased NLR could help us to confirm the presence
of systemic inflammation in cats with non-septic effusions indicative of FIP. However,
a high MPV/PLT ratio should be interpreted with caution, especially in cats.
PB  - Beograd : Fakultet veterinarske medicine
T2  - Veterinarski Glasnik
T1  - Selected hematology ratios in cats with non-septic effusions highly suspected of feline infectious peritonitis
VL  - 77
IS  - 2
SP  - 164
EP  - 175
DO  - 10.2298/VETGL230710008K
ER  - 

@article{
author = "Kopilović, Aleksandar and Gvozdić, Dragan and Radaković, Milena and Spariosu, Kristina and Andrić, Nenad and Francuski Andrić, Jelena",
year = "2023",
abstract = "In veterinary medicine, knowledge about hematologic ratios (neutrophil-to-lymphocyte
ratio (NLR), platelet-to-lymphocyte ratio (PLR) and mean platelet volume-to-platelet
ratio (MPV/PLT)) is limited, particularly in cats. While the roles of these ratios have
been proven in oncology, systemic inflammation with or without systemic inflammatory
response syndrome (SIRS), and sepsis, information is lacking about their alterations in
non-septic effusions, like feline infectious peritonitis (FIP).
This study aimed to describe whether NLR, PLR, and MPV/PLT were changed and
whether they correlated with routine hematologic and biochemical parameters in 16
cats with non-septic effusions, highly suspected to be the effusive form of FIP without
SIRS, compared to nine clinically healthy cats.
The NLR was calculated as the absolute count of neutrophils divided by the absolute
count of lymphocytes, PLR by calculating the absolute platelet divided by the absolute
lymphocyte count, and MPV/PLT by dividing mean platelet volume by absolute platelet
count.
The NLR, MPV, and MPV/PLT ratios were higher in cats with non-septic effusions
suspected to be FIP, but PLR did not differ, when compared to healthy cats. Correlation analysis did not show any association between the selected ratios and hematological and
biochemical parameters.
In the absence of leukocytosis, increased NLR could help us to confirm the presence
of systemic inflammation in cats with non-septic effusions indicative of FIP. However,
a high MPV/PLT ratio should be interpreted with caution, especially in cats.",
publisher = "Beograd : Fakultet veterinarske medicine",
journal = "Veterinarski Glasnik",
title = "Selected hematology ratios in cats with non-septic effusions highly suspected of feline infectious peritonitis",
volume = "77",
number = "2",
pages = "164-175",
doi = "10.2298/VETGL230710008K"
}

Kopilović, A., Gvozdić, D., Radaković, M., Spariosu, K., Andrić, N.,& Francuski Andrić, J.. (2023). Selected hematology ratios in cats with non-septic effusions highly suspected of feline infectious peritonitis. in Veterinarski Glasnik
Beograd : Fakultet veterinarske medicine., 77(2), 164-175.
https://doi.org/10.2298/VETGL230710008K

Kopilović A, Gvozdić D, Radaković M, Spariosu K, Andrić N, Francuski Andrić J. Selected hematology ratios in cats with non-septic effusions highly suspected of feline infectious peritonitis. in Veterinarski Glasnik. 2023;77(2):164-175.
doi:10.2298/VETGL230710008K .

Kopilović, Aleksandar, Gvozdić, Dragan, Radaković, Milena, Spariosu, Kristina, Andrić, Nenad, Francuski Andrić, Jelena, "Selected hematology ratios in cats with non-septic effusions highly suspected of feline infectious peritonitis" in Veterinarski Glasnik, 77, no. 2 (2023):164-175,
https://doi.org/10.2298/VETGL230710008K . .

TY  - JOUR
AU  - Ilić Božović, Anja
AU  - Đoković, Petar
AU  - Milanović, Zorana
AU  - Janjić, Filip
AU  - Spariosu, Kristina
AU  - Radonjić, Vladimir
AU  - Radaković, Milena
AU  - Magaš, Vladimir
AU  - Filipović, Dimitrije
AU  - Stanković, Sanja
AU  - Kovačević Filipović, Milica
AU  - Beletić, Andelo
PY  - 2023
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/2934
AB  - Homocysteine (Hcy) was investigated as the biomarker of cardiac, renal, and gastrointestinal disorders
in dogs. Data about low Hcy concentrations in the systemic inflammatory response syndrome raised a hypothesis that
Hcy in dogs could be a negative acute-phase reactant. This survey compared Hcy concentrations, serum amyloid A
(SAA), and the routine laboratory parameters between healthy (HD, N=6) and dogs with inflammation of different
extent: mild (dirofilariosis (DIR), N=31), moderate (babesiosis (BAB), N=12), and severe (pyometra (PYO), N=8).
The BAB and PYO groups had lower Hcy er than HD. Also, the levels in the PYO group were below those in the
DIRO group. SAA had the inverse pattern. Across the groups, Hcy and SAA levels correlated negatively (ρ = -0.502,
P<0.001). Hcy and SAA correlated with the erythrocyte count, hematocrit, hemoglobin and mean cellular hemoglobin
concentrations, and neutrophil count, with correlations being positive for Hcy and negative for SAA. Among all dogs,
hemoglobin was the only independent predictor of Hcy concentration. Hcy levels in canine infections, decreased as
acute-phase reaction (APR) intensified. Also, they were related with the hematology changes accompanying the APR.
Further studies will establish the clinical potential of these alterations.
PB  - Hellenic Veterinary Medical Society
T2  - Journal of the Hellenic Veterinary Medical Society
T1  - Could homocysteine represent a negative acute phase reactant in canine infections-a pilot study?
VL  - 74
IS  - 1
SP  - 5463
EP  - 5470
DO  - 10.12681/jhvms.29529
ER  - 

@article{
author = "Ilić Božović, Anja and Đoković, Petar and Milanović, Zorana and Janjić, Filip and Spariosu, Kristina and Radonjić, Vladimir and Radaković, Milena and Magaš, Vladimir and Filipović, Dimitrije and Stanković, Sanja and Kovačević Filipović, Milica and Beletić, Andelo",
year = "2023",
abstract = "Homocysteine (Hcy) was investigated as the biomarker of cardiac, renal, and gastrointestinal disorders
in dogs. Data about low Hcy concentrations in the systemic inflammatory response syndrome raised a hypothesis that
Hcy in dogs could be a negative acute-phase reactant. This survey compared Hcy concentrations, serum amyloid A
(SAA), and the routine laboratory parameters between healthy (HD, N=6) and dogs with inflammation of different
extent: mild (dirofilariosis (DIR), N=31), moderate (babesiosis (BAB), N=12), and severe (pyometra (PYO), N=8).
The BAB and PYO groups had lower Hcy er than HD. Also, the levels in the PYO group were below those in the
DIRO group. SAA had the inverse pattern. Across the groups, Hcy and SAA levels correlated negatively (ρ = -0.502,
P<0.001). Hcy and SAA correlated with the erythrocyte count, hematocrit, hemoglobin and mean cellular hemoglobin
concentrations, and neutrophil count, with correlations being positive for Hcy and negative for SAA. Among all dogs,
hemoglobin was the only independent predictor of Hcy concentration. Hcy levels in canine infections, decreased as
acute-phase reaction (APR) intensified. Also, they were related with the hematology changes accompanying the APR.
Further studies will establish the clinical potential of these alterations.",
publisher = "Hellenic Veterinary Medical Society",
journal = "Journal of the Hellenic Veterinary Medical Society",
title = "Could homocysteine represent a negative acute phase reactant in canine infections-a pilot study?",
volume = "74",
number = "1",
pages = "5463-5470",
doi = "10.12681/jhvms.29529"
}

Ilić Božović, A., Đoković, P., Milanović, Z., Janjić, F., Spariosu, K., Radonjić, V., Radaković, M., Magaš, V., Filipović, D., Stanković, S., Kovačević Filipović, M.,& Beletić, A.. (2023). Could homocysteine represent a negative acute phase reactant in canine infections-a pilot study?. in Journal of the Hellenic Veterinary Medical Society
Hellenic Veterinary Medical Society., 74(1), 5463-5470.
https://doi.org/10.12681/jhvms.29529

Ilić Božović A, Đoković P, Milanović Z, Janjić F, Spariosu K, Radonjić V, Radaković M, Magaš V, Filipović D, Stanković S, Kovačević Filipović M, Beletić A. Could homocysteine represent a negative acute phase reactant in canine infections-a pilot study?. in Journal of the Hellenic Veterinary Medical Society. 2023;74(1):5463-5470.
doi:10.12681/jhvms.29529 .

Ilić Božović, Anja, Đoković, Petar, Milanović, Zorana, Janjić, Filip, Spariosu, Kristina, Radonjić, Vladimir, Radaković, Milena, Magaš, Vladimir, Filipović, Dimitrije, Stanković, Sanja, Kovačević Filipović, Milica, Beletić, Andelo, "Could homocysteine represent a negative acute phase reactant in canine infections-a pilot study?" in Journal of the Hellenic Veterinary Medical Society, 74, no. 1 (2023):5463-5470,
https://doi.org/10.12681/jhvms.29529 . .

TY  - CONF
AU  - Kovačević-Filipović, Milica
AU  - Spariosu, Kristina
AU  - Janjić, Filip
AU  - Radaković, Milena
AU  - Ilić Božović, Anja
AU  - Davitkov, Darko
AU  - Francuski Andrić, Jelena
PY  - 2022
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/2501
AB  - Prema mehanizmu nastanka, anemije se klasifikuju na
hemoličke i hemoragijske i anemije koje nastaju usled
poremećaja na nivou kostne srži. Hemoličke i hemoragijske
anemije su najčešće praćene ubrzanom eritropoezom i jakim
regenerativnim odgovorom, koji se ogleda u značajnom
porastu broja retikulocita. Suprotno, poremećaji na nivou
kostne srži, koji najčešće uključuju različite oblike
imunosupresije, inhibiciju proliferacije eritroidnih progenitora
i/ili nedostatak nutritivnih faktora, dijagnostikuju se kao
neregenerativne anemije, koje se analizom krvne slike
prepoznaju na osnovu relativno malog broja retikulocita.
PB  - Fakultet veterinarske medicine Univerziteta u Beogradu
C3  - Clinica veterinaria zbornik predavanja Dvadeset trećeg regionalnog savetovanja iz kliničke patologije i terapije malih životinja, Fruška gora, 09-11. jun
T1  - Kliničko-patološki pristup dijagnostici anemija različite etiologije
SP  - 27
SP  - 29
EP  - 31
UR  - https://hdl.handle.net/21.15107/rcub_veterinar_2501
ER  - 

@conference{
author = "Kovačević-Filipović, Milica and Spariosu, Kristina and Janjić, Filip and Radaković, Milena and Ilić Božović, Anja and Davitkov, Darko and Francuski Andrić, Jelena",
year = "2022",
abstract = "Prema mehanizmu nastanka, anemije se klasifikuju na
hemoličke i hemoragijske i anemije koje nastaju usled
poremećaja na nivou kostne srži. Hemoličke i hemoragijske
anemije su najčešće praćene ubrzanom eritropoezom i jakim
regenerativnim odgovorom, koji se ogleda u značajnom
porastu broja retikulocita. Suprotno, poremećaji na nivou
kostne srži, koji najčešće uključuju različite oblike
imunosupresije, inhibiciju proliferacije eritroidnih progenitora
i/ili nedostatak nutritivnih faktora, dijagnostikuju se kao
neregenerativne anemije, koje se analizom krvne slike
prepoznaju na osnovu relativno malog broja retikulocita.",
publisher = "Fakultet veterinarske medicine Univerziteta u Beogradu",
journal = "Clinica veterinaria zbornik predavanja Dvadeset trećeg regionalnog savetovanja iz kliničke patologije i terapije malih životinja, Fruška gora, 09-11. jun",
title = "Kliničko-patološki pristup dijagnostici anemija različite etiologije",
pages = "27-29-31",
url = "https://hdl.handle.net/21.15107/rcub_veterinar_2501"
}

Kovačević-Filipović, M., Spariosu, K., Janjić, F., Radaković, M., Ilić Božović, A., Davitkov, D.,& Francuski Andrić, J.. (2022). Kliničko-patološki pristup dijagnostici anemija različite etiologije. in Clinica veterinaria zbornik predavanja Dvadeset trećeg regionalnog savetovanja iz kliničke patologije i terapije malih životinja, Fruška gora, 09-11. jun
Fakultet veterinarske medicine Univerziteta u Beogradu., 27-31.
https://hdl.handle.net/21.15107/rcub_veterinar_2501

Kovačević-Filipović M, Spariosu K, Janjić F, Radaković M, Ilić Božović A, Davitkov D, Francuski Andrić J. Kliničko-patološki pristup dijagnostici anemija različite etiologije. in Clinica veterinaria zbornik predavanja Dvadeset trećeg regionalnog savetovanja iz kliničke patologije i terapije malih životinja, Fruška gora, 09-11. jun. 2022;:27-31.
https://hdl.handle.net/21.15107/rcub_veterinar_2501 .

Kovačević-Filipović, Milica, Spariosu, Kristina, Janjić, Filip, Radaković, Milena, Ilić Božović, Anja, Davitkov, Darko, Francuski Andrić, Jelena, "Kliničko-patološki pristup dijagnostici anemija različite etiologije" in Clinica veterinaria zbornik predavanja Dvadeset trećeg regionalnog savetovanja iz kliničke patologije i terapije malih životinja, Fruška gora, 09-11. jun (2022):27-31,
https://hdl.handle.net/21.15107/rcub_veterinar_2501 .

TY  - CONF
AU  - Radaković, Milena
AU  - Spariosu, Kristina
AU  - Janjić, Filip
AU  - Francuski Andrić, Jelena
AU  - Beletić, Anđelo
AU  - Milanović, Svetlana
AU  - Kovačević Filipović, Milica
PY  - 2022
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/2612
C3  - 24th Annual Congress of the European Society of Veterinary Clinical Pathology, Belgrade, Serbia, October 5-8, 2022
T1  - Oxidative stress in canine babesiosis
SP  - 80
EP  - 81
UR  - https://hdl.handle.net/21.15107/rcub_veterinar_2612
ER  - 

@conference{
author = "Radaković, Milena and Spariosu, Kristina and Janjić, Filip and Francuski Andrić, Jelena and Beletić, Anđelo and Milanović, Svetlana and Kovačević Filipović, Milica",
year = "2022",
journal = "24th Annual Congress of the European Society of Veterinary Clinical Pathology, Belgrade, Serbia, October 5-8, 2022",
title = "Oxidative stress in canine babesiosis",
pages = "80-81",
url = "https://hdl.handle.net/21.15107/rcub_veterinar_2612"
}

Radaković, M., Spariosu, K., Janjić, F., Francuski Andrić, J., Beletić, A., Milanović, S.,& Kovačević Filipović, M.. (2022). Oxidative stress in canine babesiosis. in 24th Annual Congress of the European Society of Veterinary Clinical Pathology, Belgrade, Serbia, October 5-8, 2022, 80-81.
https://hdl.handle.net/21.15107/rcub_veterinar_2612

Radaković M, Spariosu K, Janjić F, Francuski Andrić J, Beletić A, Milanović S, Kovačević Filipović M. Oxidative stress in canine babesiosis. in 24th Annual Congress of the European Society of Veterinary Clinical Pathology, Belgrade, Serbia, October 5-8, 2022. 2022;:80-81.
https://hdl.handle.net/21.15107/rcub_veterinar_2612 .

Radaković, Milena, Spariosu, Kristina, Janjić, Filip, Francuski Andrić, Jelena, Beletić, Anđelo, Milanović, Svetlana, Kovačević Filipović, Milica, "Oxidative stress in canine babesiosis" in 24th Annual Congress of the European Society of Veterinary Clinical Pathology, Belgrade, Serbia, October 5-8, 2022 (2022):80-81,
https://hdl.handle.net/21.15107/rcub_veterinar_2612 .

TY  - JOUR
AU  - Marković, Aleksandra
AU  - Tubić Vukajlović, Jovana
AU  - Grujičić, Darko
AU  - Radović Jakovljević, Marina
AU  - Stanković, Milan
AU  - Djordjević, Katarina
AU  - Đelić, Ninoslav
AU  - Radaković, Milena
AU  - Milošević-Djordjević, Olivera
PY  - 2022
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/2244
AB  - The study was designed to evaluate antigenotoxic effect of methanol Teucrium arduini and Teucrium flavum extracts against mitomycin C (MMC)-induced chromosome and DNA damage in vitro. Cytokinesis-block micronucleus (CBMN) and comet assays were used to investigate effect of plant extracts in different concentrations (125, 250, 500 and 1000 µg/mL) on human peripheral blood lymphocytes (PBLs). The obtained results showed that the all tested concentrations of T. arduini and the highest concentration of T. flavum significantly reduced the MMC-induced micronucleus (MN) frequency in comparison to positive control (only MMC). There were significantly negative correlations between the extracts concentrations and MN frequencies (Pearson, r = −0.905, p = 0.0001 for T. arduini; r = −0.861, p = 0.0001 for T. flavum). The extracts of both plants further lowered the MMC-decreased nuclear division index (NDI) in a dose dependent-manner (Pearson, r = −0.837, p = 0.001 for T. arduini; r = −0.598, p = 0.040 for T. flavum), but significantly only in the highest concentration (1000 µg/mL). Comet assay showed that extracts reduced MMC-increased genetic damage index (GDI), significantly in the concentrations of 500 and 1000 μg/mL, in comparison with positive control. Based on our results, it can be concluded that methanol T. arduini and T. flavum extracts possess protective proapoptotic and antigenotoxic effect which is indication of their medicinal relevance and use in treatment.
AB  - The study was designed to evaluate antigenotoxic effect of methanol Teucrium arduini and Teucrium flavum extracts against mitomycin C (MMC)-induced chromosome and DNA damage in vitro. Cytokinesis-block micronucleus (CBMN) and comet assays were used to investigate effect of plant extracts in different concentrations (125, 250, 500 and 1000 µg/mL) on human peripheral blood lymphocytes (PBLs). The obtained results showed that the all tested concentrations of T. arduini and the highest concentration of T. flavum significantly reduced the MMC-induced micronucleus (MN) frequency in comparison to positive control (only MMC). There were significantly negative correlations between the extracts concentrations and MN frequencies (Pearson, r = −0.905, p = 0.0001 for T. arduini; r = −0.861, p = 0.0001 for T. flavum). The extracts of both plants further lowered the MMC-decreased nuclear division index (NDI) in a dose dependent-manner (Pearson, r = −0.837, p = 0.001 for T. arduini; r = −0.598, p = 0.040 for T. flavum), but significantly only in the highest concentration (1000 µg/mL). Comet assay showed that extracts reduced MMC-increased genetic damage index (GDI), significantly in the concentrations of 500 and 1000 μg/mL, in comparison with positive control. Based on our results, it can be concluded that methanol T. arduini and T. flavum extracts possess protective proapoptotic and antigenotoxic effect which is indication of their medicinal relevance and use in treatment.
PB  - Taylor and Francis
T2  - Drug and Chemical Toxicology
T1  - Methanol extracts of Teucrium arduini L. and Teucrium flavum L. induce protective effect against mitomycin C in human lymphocytes in vitro
VL  - 45
IS  - 2
SP  - 940
EP  - 945
DO  - 10.1080/01480545.2020.1802477
ER  - 

@article{
author = "Marković, Aleksandra and Tubić Vukajlović, Jovana and Grujičić, Darko and Radović Jakovljević, Marina and Stanković, Milan and Djordjević, Katarina and Đelić, Ninoslav and Radaković, Milena and Milošević-Djordjević, Olivera",
year = "2022",
abstract = "The study was designed to evaluate antigenotoxic effect of methanol Teucrium arduini and Teucrium flavum extracts against mitomycin C (MMC)-induced chromosome and DNA damage in vitro. Cytokinesis-block micronucleus (CBMN) and comet assays were used to investigate effect of plant extracts in different concentrations (125, 250, 500 and 1000 µg/mL) on human peripheral blood lymphocytes (PBLs). The obtained results showed that the all tested concentrations of T. arduini and the highest concentration of T. flavum significantly reduced the MMC-induced micronucleus (MN) frequency in comparison to positive control (only MMC). There were significantly negative correlations between the extracts concentrations and MN frequencies (Pearson, r = −0.905, p = 0.0001 for T. arduini; r = −0.861, p = 0.0001 for T. flavum). The extracts of both plants further lowered the MMC-decreased nuclear division index (NDI) in a dose dependent-manner (Pearson, r = −0.837, p = 0.001 for T. arduini; r = −0.598, p = 0.040 for T. flavum), but significantly only in the highest concentration (1000 µg/mL). Comet assay showed that extracts reduced MMC-increased genetic damage index (GDI), significantly in the concentrations of 500 and 1000 μg/mL, in comparison with positive control. Based on our results, it can be concluded that methanol T. arduini and T. flavum extracts possess protective proapoptotic and antigenotoxic effect which is indication of their medicinal relevance and use in treatment., The study was designed to evaluate antigenotoxic effect of methanol Teucrium arduini and Teucrium flavum extracts against mitomycin C (MMC)-induced chromosome and DNA damage in vitro. Cytokinesis-block micronucleus (CBMN) and comet assays were used to investigate effect of plant extracts in different concentrations (125, 250, 500 and 1000 µg/mL) on human peripheral blood lymphocytes (PBLs). The obtained results showed that the all tested concentrations of T. arduini and the highest concentration of T. flavum significantly reduced the MMC-induced micronucleus (MN) frequency in comparison to positive control (only MMC). There were significantly negative correlations between the extracts concentrations and MN frequencies (Pearson, r = −0.905, p = 0.0001 for T. arduini; r = −0.861, p = 0.0001 for T. flavum). The extracts of both plants further lowered the MMC-decreased nuclear division index (NDI) in a dose dependent-manner (Pearson, r = −0.837, p = 0.001 for T. arduini; r = −0.598, p = 0.040 for T. flavum), but significantly only in the highest concentration (1000 µg/mL). Comet assay showed that extracts reduced MMC-increased genetic damage index (GDI), significantly in the concentrations of 500 and 1000 μg/mL, in comparison with positive control. Based on our results, it can be concluded that methanol T. arduini and T. flavum extracts possess protective proapoptotic and antigenotoxic effect which is indication of their medicinal relevance and use in treatment.",
publisher = "Taylor and Francis",
journal = "Drug and Chemical Toxicology",
title = "Methanol extracts of Teucrium arduini L. and Teucrium flavum L. induce protective effect against mitomycin C in human lymphocytes in vitro",
volume = "45",
number = "2",
pages = "940-945",
doi = "10.1080/01480545.2020.1802477"
}

Marković, A., Tubić Vukajlović, J., Grujičić, D., Radović Jakovljević, M., Stanković, M., Djordjević, K., Đelić, N., Radaković, M.,& Milošević-Djordjević, O.. (2022). Methanol extracts of Teucrium arduini L. and Teucrium flavum L. induce protective effect against mitomycin C in human lymphocytes in vitro. in Drug and Chemical Toxicology
Taylor and Francis., 45(2), 940-945.
https://doi.org/10.1080/01480545.2020.1802477

Marković A, Tubić Vukajlović J, Grujičić D, Radović Jakovljević M, Stanković M, Djordjević K, Đelić N, Radaković M, Milošević-Djordjević O. Methanol extracts of Teucrium arduini L. and Teucrium flavum L. induce protective effect against mitomycin C in human lymphocytes in vitro. in Drug and Chemical Toxicology. 2022;45(2):940-945.
doi:10.1080/01480545.2020.1802477 .

Marković, Aleksandra, Tubić Vukajlović, Jovana, Grujičić, Darko, Radović Jakovljević, Marina, Stanković, Milan, Djordjević, Katarina, Đelić, Ninoslav, Radaković, Milena, Milošević-Djordjević, Olivera, "Methanol extracts of Teucrium arduini L. and Teucrium flavum L. induce protective effect against mitomycin C in human lymphocytes in vitro" in Drug and Chemical Toxicology, 45, no. 2 (2022):940-945,
https://doi.org/10.1080/01480545.2020.1802477 . .

TY  - JOUR
AU  - Janjić, Filip
AU  - Beletić, Anđelo
AU  - Radaković, Milena
AU  - Spariosu, Kristina
AU  - Diklić, Miloš
AU  - Francuski Andrić, Jelena
AU  - Radonjić, Vladimir
AU  - Ajtić, Jelena
AU  - Kovačević-Filipović, Milica
PY  - 2022
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/2338
AB  - The highest number of acute Babesia canis cases in dogs is recorded over the February-May (Feb-May) period, which also represents the optimal climate conditions for tick activity in Belgrade, Serbia. A possibility that the acute phase response is more intense in dogs developing the disease in the Feb-May period compared with the response in other time periods of the year was tested. A total of 63 client-owned dogs with acute B. canis infection were enrolled and the routine hematology and biochemistry parameters-serum amyloid A (SAA), IgG against B. canis, level of parasitemia, ceruloplasmin (CER), paraoxonase-1 (PON-1), and fibrinogen-were measured. Acute phase indexes (API) were calculated as (SAA×CER)/(Iron×PON-1) and (SAA×CER)/(Albumin×Iron). Statistics included Kruskal-Wallis test and logistic regression analysis. The results showed that in the Feb-May period, the following parameters were lower: creatinine, albumin, iron, and level of parasitemia. Furthermore, increased API values were more probable in the Feb-May than in the other periods. Together, higher acute phase response intensity and presumptive hemodilution in the Feb-May period indicate a more acute course of B. canis infection than in other time periods of the year.
PB  - Springer
T2  - International Journal of Biometeorology
T1  - Seasonal differences in the intensity of acute phase response in dogs infected with Babesia canis
DO  - 10.1007/s00484-021-02228-4
ER  - 

@article{
author = "Janjić, Filip and Beletić, Anđelo and Radaković, Milena and Spariosu, Kristina and Diklić, Miloš and Francuski Andrić, Jelena and Radonjić, Vladimir and Ajtić, Jelena and Kovačević-Filipović, Milica",
year = "2022",
abstract = "The highest number of acute Babesia canis cases in dogs is recorded over the February-May (Feb-May) period, which also represents the optimal climate conditions for tick activity in Belgrade, Serbia. A possibility that the acute phase response is more intense in dogs developing the disease in the Feb-May period compared with the response in other time periods of the year was tested. A total of 63 client-owned dogs with acute B. canis infection were enrolled and the routine hematology and biochemistry parameters-serum amyloid A (SAA), IgG against B. canis, level of parasitemia, ceruloplasmin (CER), paraoxonase-1 (PON-1), and fibrinogen-were measured. Acute phase indexes (API) were calculated as (SAA×CER)/(Iron×PON-1) and (SAA×CER)/(Albumin×Iron). Statistics included Kruskal-Wallis test and logistic regression analysis. The results showed that in the Feb-May period, the following parameters were lower: creatinine, albumin, iron, and level of parasitemia. Furthermore, increased API values were more probable in the Feb-May than in the other periods. Together, higher acute phase response intensity and presumptive hemodilution in the Feb-May period indicate a more acute course of B. canis infection than in other time periods of the year.",
publisher = "Springer",
journal = "International Journal of Biometeorology",
title = "Seasonal differences in the intensity of acute phase response in dogs infected with Babesia canis",
doi = "10.1007/s00484-021-02228-4"
}

Janjić, F., Beletić, A., Radaković, M., Spariosu, K., Diklić, M., Francuski Andrić, J., Radonjić, V., Ajtić, J.,& Kovačević-Filipović, M.. (2022). Seasonal differences in the intensity of acute phase response in dogs infected with Babesia canis. in International Journal of Biometeorology
Springer..
https://doi.org/10.1007/s00484-021-02228-4

Janjić F, Beletić A, Radaković M, Spariosu K, Diklić M, Francuski Andrić J, Radonjić V, Ajtić J, Kovačević-Filipović M. Seasonal differences in the intensity of acute phase response in dogs infected with Babesia canis. in International Journal of Biometeorology. 2022;.
doi:10.1007/s00484-021-02228-4 .

Janjić, Filip, Beletić, Anđelo, Radaković, Milena, Spariosu, Kristina, Diklić, Miloš, Francuski Andrić, Jelena, Radonjić, Vladimir, Ajtić, Jelena, Kovačević-Filipović, Milica, "Seasonal differences in the intensity of acute phase response in dogs infected with Babesia canis" in International Journal of Biometeorology (2022),
https://doi.org/10.1007/s00484-021-02228-4 . .

TY  - CONF
AU  - Kovačević-Filipović, Milica
AU  - Francuski Andrić, Jelena
AU  - Radaković, Milena
AU  - Spariosu, Kristina
PY  - 2022
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/2429
AB  - Procenjuje se da prevalenca bubrežnih bolesti u ukupnoj populaciji pasa i mačka iznosi oko 0,5% do 3%, ali da u gerijatrijskoj populaciji prevalenca hronične bubrežne bolesti dostiže čak 80%. Osim
rasne predispozije i starosti, kao faktori rizika navode se hiperkalcemija, bolesti srca, cistitis, urolitijaza, hipertireoidizam, periodontalni i
metabolički poremećaji i hronične ili perzistentne infekcije. Stalni monitoring funkcije bubrega je neophodan da bi se uvela odgovarajuća
terapija, koja može značajno da uspori progresivan tok gubitka funkcije bubrega koji prati bubrežne bolesti. Klasični markeri gubitka funkcije bubrega su koncentracija uree i kreatinina u serumu. Njihova koncentracija raste tek kada je rezervni kapacitet bubrega potrošen, odnosno kada propadne 75% svih nefrona. Na radionici će biti objašnjen
i demonstriran značaj 1) simetričnog dimetilarginina (SDMA) kao novog, osetljivijeg markera premećaja funkcije bubrega, potom 2) značaj
određivanja odnosa proteina i kreatinina u mokraći, kao i 3) potencijal
primene elektroforeze na gelu poliakrilamida za detekciju proteina u
urinu sa ciljem diferencijalne dijagnostike poremećaja funkcije glomerula, odnosno tubula.
AB  - It is estimated that the prevalence of kidney disease in the total population of dogs
and cats is about 0.5% to 3%, but in the geriatric population the prevalence of chronic
kidney disease reaches as much as 80%. In addition to breed predisposition and age,
hypercalcemia, heart disease, periodontal problems, cystitis, urolithiasis, hyperthyroidism,
metabolic disorders, and chronic or persistent infections are listed as risk factors.
Continuous monitoring of the renal function is important for timely and appropriate therapy
managment. Appropriate therapy can significantly slow down the progressive course of
renal disease. The classic markers to test the loss of kidney function are concentration
of urea and creatinine in the serum. Their concentration increases only when the reserve
capacity of the kidneys is lost, ie. when 75% of all nephrons fail. The workshop will explain
and demonstrate the importance of 1) symmetric dimethylarginine (SDMA) as a new, more
sensitive marker of renal dysfunction, 2) determining the urine protein-creatinine ratio, as
well as 3) differential diagnosis of glomerular or tubular proteinuria using polyacrilamid gel
electrophoresis.
PB  - Fakultet veterinarske medicine, Centar za izdavačku delatnost i promet učila
C3  - Zbornik radova - XLIII seminar inovacija znanja veterinara
T1  - Novi laboratorijski parametri dijagnostike poremećaja funkcije bubrega kod pasa i mačaka
T1  - New laboratory parameters for the diagnostic algorithm of kidney function disorders in dogs and cats
SP  - 191
EP  - 202
UR  - https://hdl.handle.net/21.15107/rcub_veterinar_2429
ER  - 

@conference{
author = "Kovačević-Filipović, Milica and Francuski Andrić, Jelena and Radaković, Milena and Spariosu, Kristina",
year = "2022",
abstract = "Procenjuje se da prevalenca bubrežnih bolesti u ukupnoj populaciji pasa i mačka iznosi oko 0,5% do 3%, ali da u gerijatrijskoj populaciji prevalenca hronične bubrežne bolesti dostiže čak 80%. Osim
rasne predispozije i starosti, kao faktori rizika navode se hiperkalcemija, bolesti srca, cistitis, urolitijaza, hipertireoidizam, periodontalni i
metabolički poremećaji i hronične ili perzistentne infekcije. Stalni monitoring funkcije bubrega je neophodan da bi se uvela odgovarajuća
terapija, koja može značajno da uspori progresivan tok gubitka funkcije bubrega koji prati bubrežne bolesti. Klasični markeri gubitka funkcije bubrega su koncentracija uree i kreatinina u serumu. Njihova koncentracija raste tek kada je rezervni kapacitet bubrega potrošen, odnosno kada propadne 75% svih nefrona. Na radionici će biti objašnjen
i demonstriran značaj 1) simetričnog dimetilarginina (SDMA) kao novog, osetljivijeg markera premećaja funkcije bubrega, potom 2) značaj
određivanja odnosa proteina i kreatinina u mokraći, kao i 3) potencijal
primene elektroforeze na gelu poliakrilamida za detekciju proteina u
urinu sa ciljem diferencijalne dijagnostike poremećaja funkcije glomerula, odnosno tubula., It is estimated that the prevalence of kidney disease in the total population of dogs
and cats is about 0.5% to 3%, but in the geriatric population the prevalence of chronic
kidney disease reaches as much as 80%. In addition to breed predisposition and age,
hypercalcemia, heart disease, periodontal problems, cystitis, urolithiasis, hyperthyroidism,
metabolic disorders, and chronic or persistent infections are listed as risk factors.
Continuous monitoring of the renal function is important for timely and appropriate therapy
managment. Appropriate therapy can significantly slow down the progressive course of
renal disease. The classic markers to test the loss of kidney function are concentration
of urea and creatinine in the serum. Their concentration increases only when the reserve
capacity of the kidneys is lost, ie. when 75% of all nephrons fail. The workshop will explain
and demonstrate the importance of 1) symmetric dimethylarginine (SDMA) as a new, more
sensitive marker of renal dysfunction, 2) determining the urine protein-creatinine ratio, as
well as 3) differential diagnosis of glomerular or tubular proteinuria using polyacrilamid gel
electrophoresis.",
publisher = "Fakultet veterinarske medicine, Centar za izdavačku delatnost i promet učila",
journal = "Zbornik radova - XLIII seminar inovacija znanja veterinara",
title = "Novi laboratorijski parametri dijagnostike poremećaja funkcije bubrega kod pasa i mačaka, New laboratory parameters for the diagnostic algorithm of kidney function disorders in dogs and cats",
pages = "191-202",
url = "https://hdl.handle.net/21.15107/rcub_veterinar_2429"
}

Kovačević-Filipović, M., Francuski Andrić, J., Radaković, M.,& Spariosu, K.. (2022). Novi laboratorijski parametri dijagnostike poremećaja funkcije bubrega kod pasa i mačaka. in Zbornik radova - XLIII seminar inovacija znanja veterinara
Fakultet veterinarske medicine, Centar za izdavačku delatnost i promet učila., 191-202.
https://hdl.handle.net/21.15107/rcub_veterinar_2429

Kovačević-Filipović M, Francuski Andrić J, Radaković M, Spariosu K. Novi laboratorijski parametri dijagnostike poremećaja funkcije bubrega kod pasa i mačaka. in Zbornik radova - XLIII seminar inovacija znanja veterinara. 2022;:191-202.
https://hdl.handle.net/21.15107/rcub_veterinar_2429 .

Kovačević-Filipović, Milica, Francuski Andrić, Jelena, Radaković, Milena, Spariosu, Kristina, "Novi laboratorijski parametri dijagnostike poremećaja funkcije bubrega kod pasa i mačaka" in Zbornik radova - XLIII seminar inovacija znanja veterinara (2022):191-202,
https://hdl.handle.net/21.15107/rcub_veterinar_2429 .

TY  - CONF
AU  - Janjić, Filip
AU  - Beletić, Anđelo
AU  - Radaković, Milena
AU  - Spariosu, Kristina
AU  - Francuski Andrić, Jelena
AU  - Ajtić, Jelena
AU  - Kovačević-Filipović, Milica
PY  - 2022
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/2488
AB  - Background: Canine babesiosis is a disease with a seasonal character. We have
previously observed that in Belgrade, the capital of the Republic of Serbia, 60% of
cases with the acute-phase response (APR) give a notable maximum between mid-
February and May, the so-called “high season”. The other two peak seasons with
less pronounced maxima are in winter, from January to mid-February, and in
autumn, from October to December. Objectives: Based on clinical observations, we
postulate that dogs infected with B. canis in the “high season” develop a more
intense APR than dogs in the other two seasons. Material and Methods: To test this
hypothesis, we compare the relative parasite load and the level of acute-phase
proteins and reactants, their indexes (calculated as a combination of
concentrations of fast and slow positive, and fast and slow negative acute phase
reactants), as well as the concentration of coagulation factors, complete blood
count, and biochemistry among dogs that developed the disease in the autumn,
winter, and “high season”. Results: The relative parasite load is the lowest, and APR
Indexes are the highest in dogs infected in “high season”. These findings are
accompanied by relatively low creatinine and urea, implying that dogs in “high
season” had hemodilution, thus further suggesting short incubation. Unlike other
acute-phase proteins, fibrinogen showed the lowest concentration in “high
season”. Conclusion: Future research will help unveil the connection between
more intense APR and relatively low parasite load and fibrinogen concentration.
C3  - 24th Annual Congress of the European Society of Veterinary Clinical Pathology, Belgrade, Serbia, October 5-8
T1  - Canine babesiosis in different seasons - a fertile ground for multiple questions
SP  - 78
EP  - 79
UR  - https://hdl.handle.net/21.15107/rcub_veterinar_2488
ER  - 

@conference{
author = "Janjić, Filip and Beletić, Anđelo and Radaković, Milena and Spariosu, Kristina and Francuski Andrić, Jelena and Ajtić, Jelena and Kovačević-Filipović, Milica",
year = "2022",
abstract = "Background: Canine babesiosis is a disease with a seasonal character. We have
previously observed that in Belgrade, the capital of the Republic of Serbia, 60% of
cases with the acute-phase response (APR) give a notable maximum between mid-
February and May, the so-called “high season”. The other two peak seasons with
less pronounced maxima are in winter, from January to mid-February, and in
autumn, from October to December. Objectives: Based on clinical observations, we
postulate that dogs infected with B. canis in the “high season” develop a more
intense APR than dogs in the other two seasons. Material and Methods: To test this
hypothesis, we compare the relative parasite load and the level of acute-phase
proteins and reactants, their indexes (calculated as a combination of
concentrations of fast and slow positive, and fast and slow negative acute phase
reactants), as well as the concentration of coagulation factors, complete blood
count, and biochemistry among dogs that developed the disease in the autumn,
winter, and “high season”. Results: The relative parasite load is the lowest, and APR
Indexes are the highest in dogs infected in “high season”. These findings are
accompanied by relatively low creatinine and urea, implying that dogs in “high
season” had hemodilution, thus further suggesting short incubation. Unlike other
acute-phase proteins, fibrinogen showed the lowest concentration in “high
season”. Conclusion: Future research will help unveil the connection between
more intense APR and relatively low parasite load and fibrinogen concentration.",
journal = "24th Annual Congress of the European Society of Veterinary Clinical Pathology, Belgrade, Serbia, October 5-8",
title = "Canine babesiosis in different seasons - a fertile ground for multiple questions",
pages = "78-79",
url = "https://hdl.handle.net/21.15107/rcub_veterinar_2488"
}

Janjić, F., Beletić, A., Radaković, M., Spariosu, K., Francuski Andrić, J., Ajtić, J.,& Kovačević-Filipović, M.. (2022). Canine babesiosis in different seasons - a fertile ground for multiple questions. in 24th Annual Congress of the European Society of Veterinary Clinical Pathology, Belgrade, Serbia, October 5-8, 78-79.
https://hdl.handle.net/21.15107/rcub_veterinar_2488

Janjić F, Beletić A, Radaković M, Spariosu K, Francuski Andrić J, Ajtić J, Kovačević-Filipović M. Canine babesiosis in different seasons - a fertile ground for multiple questions. in 24th Annual Congress of the European Society of Veterinary Clinical Pathology, Belgrade, Serbia, October 5-8. 2022;:78-79.
https://hdl.handle.net/21.15107/rcub_veterinar_2488 .

Janjić, Filip, Beletić, Anđelo, Radaković, Milena, Spariosu, Kristina, Francuski Andrić, Jelena, Ajtić, Jelena, Kovačević-Filipović, Milica, "Canine babesiosis in different seasons - a fertile ground for multiple questions" in 24th Annual Congress of the European Society of Veterinary Clinical Pathology, Belgrade, Serbia, October 5-8 (2022):78-79,
https://hdl.handle.net/21.15107/rcub_veterinar_2488 .

TY  - CONF
AU  - Marković, Lazar
AU  - Đoković, Stefan
AU  - Radaković, Milena
AU  - Francuski Andrić, Jelena
AU  - Milošević, Ivan
AU  - Beletić, Anđelo
AU  - Kovačević Filipović, Milica
PY  - 2022
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/2590
AB  - Inflamatorni i degenerativni procesi na zglobovima konja se mogu postepeno razvijati,
pri čemu klinički znaci patoloških promena često nisu vidljivi. Cilj ove studije je
bio da se na osnovu rutinskog pregleda sinovijalne tečnosti (ST) poreklom iz metakarpo/
metatarzofalangealnih (MCP/MTP) zglobova radnih konja, koji su bili upućeni na
klanje i njenih biohemijskih karakteristika utvrdi da li je postojala lokalna inflamacija.
Studija je sprovedena na 6 konja starosti 3 do 12 godina (medijana 8), odnosno 24
MCP/MTP zgloba. Post mortem, iz svakog zgloba je uzorkovana ST. Kliničkim pregledom
pre klanja, nisu uočene promene u izgledu i funkciji mišićno-skeletnog sistema.
Urađen je rutinski pregled ST kojim je opisana boja, prozirnost, viskoznost i broj ćelija.
Određena je koncentracija sledećih biohemijskih parametara: ukupnih proteina,
albumina, aktivnost alkalne fosfataze (ALP), aspartat aminotransferaze (AST), kreatin
kinaze (CK), kao i koncentracije haptoglobina (Hp) i ceruloplazmina (Cp). Kod svih
uzoraka, ST je bila bistra, providna, viskozna i blede do bledo žute boje. Najmlađi konj,
star tri godine, je u sva četiri pregledana zgloba imao ukupan broj ćelija 200-890/μL,
što odgovara fiziološkim vrednostima. Dva konja su imala povećan broj ćelija na jednom,
odnosno dva zgloba (1 400-2 560/μL), dok su tri konja imala promene na sva četiri
zgloba (1 100-2 200/μL). Ispitivani biohemijski parametri se nisu razlikovali u uzorcima
ST iz zglobova sa ukupnim brojem ćelija u okviru fizioloških vrednosti i onih kod
kojih je broj ćelija bio povećan. Pozitivne, umerene korelacije su postojale između koncentracije
proteina i aktivnosti ALP, koncentracije proteina i albumina, aktivnosti AST
i CK. Ispitivanjem ST radnih konja, dokazano je da inflamatorne promene u MCP/MTP
zglobovima nisu prisutne. Nalaz povećanog broja ćelija u ST bez inflamatornih promena
zahteva dodatna ispitivanja.
PB  - Beograd : Srpsko veterinarsko društvo
C3  - 33. Savetovanje Veterinara Srbije, Zlatibor, 08 - 11. septembra, 2022
T1  - Laboratorijski profil sinovijalne tečnosti kod šest radnih konja različite starosti
SP  - 294
EP  - 300
UR  - https://hdl.handle.net/21.15107/rcub_veterinar_2590
ER  - 

@conference{
author = "Marković, Lazar and Đoković, Stefan and Radaković, Milena and Francuski Andrić, Jelena and Milošević, Ivan and Beletić, Anđelo and Kovačević Filipović, Milica",
year = "2022",
abstract = "Inflamatorni i degenerativni procesi na zglobovima konja se mogu postepeno razvijati,
pri čemu klinički znaci patoloških promena često nisu vidljivi. Cilj ove studije je
bio da se na osnovu rutinskog pregleda sinovijalne tečnosti (ST) poreklom iz metakarpo/
metatarzofalangealnih (MCP/MTP) zglobova radnih konja, koji su bili upućeni na
klanje i njenih biohemijskih karakteristika utvrdi da li je postojala lokalna inflamacija.
Studija je sprovedena na 6 konja starosti 3 do 12 godina (medijana 8), odnosno 24
MCP/MTP zgloba. Post mortem, iz svakog zgloba je uzorkovana ST. Kliničkim pregledom
pre klanja, nisu uočene promene u izgledu i funkciji mišićno-skeletnog sistema.
Urađen je rutinski pregled ST kojim je opisana boja, prozirnost, viskoznost i broj ćelija.
Određena je koncentracija sledećih biohemijskih parametara: ukupnih proteina,
albumina, aktivnost alkalne fosfataze (ALP), aspartat aminotransferaze (AST), kreatin
kinaze (CK), kao i koncentracije haptoglobina (Hp) i ceruloplazmina (Cp). Kod svih
uzoraka, ST je bila bistra, providna, viskozna i blede do bledo žute boje. Najmlađi konj,
star tri godine, je u sva četiri pregledana zgloba imao ukupan broj ćelija 200-890/μL,
što odgovara fiziološkim vrednostima. Dva konja su imala povećan broj ćelija na jednom,
odnosno dva zgloba (1 400-2 560/μL), dok su tri konja imala promene na sva četiri
zgloba (1 100-2 200/μL). Ispitivani biohemijski parametri se nisu razlikovali u uzorcima
ST iz zglobova sa ukupnim brojem ćelija u okviru fizioloških vrednosti i onih kod
kojih je broj ćelija bio povećan. Pozitivne, umerene korelacije su postojale između koncentracije
proteina i aktivnosti ALP, koncentracije proteina i albumina, aktivnosti AST
i CK. Ispitivanjem ST radnih konja, dokazano je da inflamatorne promene u MCP/MTP
zglobovima nisu prisutne. Nalaz povećanog broja ćelija u ST bez inflamatornih promena
zahteva dodatna ispitivanja.",
publisher = "Beograd : Srpsko veterinarsko društvo",
journal = "33. Savetovanje Veterinara Srbije, Zlatibor, 08 - 11. septembra, 2022",
title = "Laboratorijski profil sinovijalne tečnosti kod šest radnih konja različite starosti",
pages = "294-300",
url = "https://hdl.handle.net/21.15107/rcub_veterinar_2590"
}

Marković, L., Đoković, S., Radaković, M., Francuski Andrić, J., Milošević, I., Beletić, A.,& Kovačević Filipović, M.. (2022). Laboratorijski profil sinovijalne tečnosti kod šest radnih konja različite starosti. in 33. Savetovanje Veterinara Srbije, Zlatibor, 08 - 11. septembra, 2022
Beograd : Srpsko veterinarsko društvo., 294-300.
https://hdl.handle.net/21.15107/rcub_veterinar_2590

Marković L, Đoković S, Radaković M, Francuski Andrić J, Milošević I, Beletić A, Kovačević Filipović M. Laboratorijski profil sinovijalne tečnosti kod šest radnih konja različite starosti. in 33. Savetovanje Veterinara Srbije, Zlatibor, 08 - 11. septembra, 2022. 2022;:294-300.
https://hdl.handle.net/21.15107/rcub_veterinar_2590 .

Marković, Lazar, Đoković, Stefan, Radaković, Milena, Francuski Andrić, Jelena, Milošević, Ivan, Beletić, Anđelo, Kovačević Filipović, Milica, "Laboratorijski profil sinovijalne tečnosti kod šest radnih konja različite starosti" in 33. Savetovanje Veterinara Srbije, Zlatibor, 08 - 11. septembra, 2022 (2022):294-300,
https://hdl.handle.net/21.15107/rcub_veterinar_2590 .

TY  - CONF
AU  - Kovandžić, Marija
AU  - Janjić, Filip
AU  - Spariosu, Kristina
AU  - Radaković, Milena
AU  - Francuski Andrić, Jelena
AU  - Beletić, Anđelo
AU  - Kovačević Filipović, Milica
PY  - 2022
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/2588
PB  - Beograd : Srpsko veterinarsko društvo
C3  - 33. Savetovanje Veterinara Srbije, Zlatibor, 08 - 11. Septembar 2022
T1  - Analiza krvne slike magaraca na velikim i malim farmama – implikacije u vezi sa eozinofilijom
IS  - 310
EP  - 311
UR  - https://hdl.handle.net/21.15107/rcub_veterinar_2588
ER  - 

@conference{
author = "Kovandžić, Marija and Janjić, Filip and Spariosu, Kristina and Radaković, Milena and Francuski Andrić, Jelena and Beletić, Anđelo and Kovačević Filipović, Milica",
year = "2022",
publisher = "Beograd : Srpsko veterinarsko društvo",
journal = "33. Savetovanje Veterinara Srbije, Zlatibor, 08 - 11. Septembar 2022",
title = "Analiza krvne slike magaraca na velikim i malim farmama – implikacije u vezi sa eozinofilijom",
number = "310",
pages = "311",
url = "https://hdl.handle.net/21.15107/rcub_veterinar_2588"
}

Kovandžić, M., Janjić, F., Spariosu, K., Radaković, M., Francuski Andrić, J., Beletić, A.,& Kovačević Filipović, M.. (2022). Analiza krvne slike magaraca na velikim i malim farmama – implikacije u vezi sa eozinofilijom. in 33. Savetovanje Veterinara Srbije, Zlatibor, 08 - 11. Septembar 2022
Beograd : Srpsko veterinarsko društvo.(310).
https://hdl.handle.net/21.15107/rcub_veterinar_2588

Kovandžić M, Janjić F, Spariosu K, Radaković M, Francuski Andrić J, Beletić A, Kovačević Filipović M. Analiza krvne slike magaraca na velikim i malim farmama – implikacije u vezi sa eozinofilijom. in 33. Savetovanje Veterinara Srbije, Zlatibor, 08 - 11. Septembar 2022. 2022;(310):null-311.
https://hdl.handle.net/21.15107/rcub_veterinar_2588 .

Kovandžić, Marija, Janjić, Filip, Spariosu, Kristina, Radaković, Milena, Francuski Andrić, Jelena, Beletić, Anđelo, Kovačević Filipović, Milica, "Analiza krvne slike magaraca na velikim i malim farmama – implikacije u vezi sa eozinofilijom" in 33. Savetovanje Veterinara Srbije, Zlatibor, 08 - 11. Septembar 2022, no. 310 (2022),
https://hdl.handle.net/21.15107/rcub_veterinar_2588 .

TY  - CONF
AU  - Janjić, Filip
AU  - Spariosu, Kristina
AU  - Kitanović, Sara
AU  - Radaković, Milena
AU  - Francuski Andrić, Jelena
AU  - Beletić, Anđelo
AU  - Kovačević Filipović, Milica
PY  - 2022
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/2586
PB  - Beograd : Srpsko veterinarsko društvo
C3  - 33. Savetovanje Veterinara Srbije, Zlatibor, 08 - 11. Septembar 2022
T1  - Retrospektivna analiza prevalence anemija i faktori rizika kod pasa i mačaka u toku 2021–2022. godine na klinici za male životinje Fakulteta Veterinarske Medicine Univerziteta u Beogradu
SP  - 312
EP  - 313
UR  - https://hdl.handle.net/21.15107/rcub_veterinar_2586
ER  - 

@conference{
author = "Janjić, Filip and Spariosu, Kristina and Kitanović, Sara and Radaković, Milena and Francuski Andrić, Jelena and Beletić, Anđelo and Kovačević Filipović, Milica",
year = "2022",
publisher = "Beograd : Srpsko veterinarsko društvo",
journal = "33. Savetovanje Veterinara Srbije, Zlatibor, 08 - 11. Septembar 2022",
title = "Retrospektivna analiza prevalence anemija i faktori rizika kod pasa i mačaka u toku 2021–2022. godine na klinici za male životinje Fakulteta Veterinarske Medicine Univerziteta u Beogradu",
pages = "312-313",
url = "https://hdl.handle.net/21.15107/rcub_veterinar_2586"
}

Janjić, F., Spariosu, K., Kitanović, S., Radaković, M., Francuski Andrić, J., Beletić, A.,& Kovačević Filipović, M.. (2022). Retrospektivna analiza prevalence anemija i faktori rizika kod pasa i mačaka u toku 2021–2022. godine na klinici za male životinje Fakulteta Veterinarske Medicine Univerziteta u Beogradu. in 33. Savetovanje Veterinara Srbije, Zlatibor, 08 - 11. Septembar 2022
Beograd : Srpsko veterinarsko društvo., 312-313.
https://hdl.handle.net/21.15107/rcub_veterinar_2586

Janjić F, Spariosu K, Kitanović S, Radaković M, Francuski Andrić J, Beletić A, Kovačević Filipović M. Retrospektivna analiza prevalence anemija i faktori rizika kod pasa i mačaka u toku 2021–2022. godine na klinici za male životinje Fakulteta Veterinarske Medicine Univerziteta u Beogradu. in 33. Savetovanje Veterinara Srbije, Zlatibor, 08 - 11. Septembar 2022. 2022;:312-313.
https://hdl.handle.net/21.15107/rcub_veterinar_2586 .

Janjić, Filip, Spariosu, Kristina, Kitanović, Sara, Radaković, Milena, Francuski Andrić, Jelena, Beletić, Anđelo, Kovačević Filipović, Milica, "Retrospektivna analiza prevalence anemija i faktori rizika kod pasa i mačaka u toku 2021–2022. godine na klinici za male životinje Fakulteta Veterinarske Medicine Univerziteta u Beogradu" in 33. Savetovanje Veterinara Srbije, Zlatibor, 08 - 11. Septembar 2022 (2022):312-313,
https://hdl.handle.net/21.15107/rcub_veterinar_2586 .

TY  - CONF
AU  - Nikolić, Milica
AU  - Radaković, Milena
AU  - Spariosu, Kristina
AU  - Kovačević Filipović, Milica
AU  - Francuski Andrić, Jelena
PY  - 2022
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/2587
PB  - Beograd : Srpsko veterinarsko društvo
C3  - 33. Savetovanje Veterinara Srbije, Zlatibor, 08 - 11. Septembar 2022
T1  - Značaj indeksa anizocitoze u dijagnostici najčešćih infektivnih anemija mačaka
SP  - 322
EP  - 323
UR  - https://hdl.handle.net/21.15107/rcub_veterinar_2587
ER  - 

@conference{
author = "Nikolić, Milica and Radaković, Milena and Spariosu, Kristina and Kovačević Filipović, Milica and Francuski Andrić, Jelena",
year = "2022",
publisher = "Beograd : Srpsko veterinarsko društvo",
journal = "33. Savetovanje Veterinara Srbije, Zlatibor, 08 - 11. Septembar 2022",
title = "Značaj indeksa anizocitoze u dijagnostici najčešćih infektivnih anemija mačaka",
pages = "322-323",
url = "https://hdl.handle.net/21.15107/rcub_veterinar_2587"
}

Nikolić, M., Radaković, M., Spariosu, K., Kovačević Filipović, M.,& Francuski Andrić, J.. (2022). Značaj indeksa anizocitoze u dijagnostici najčešćih infektivnih anemija mačaka. in 33. Savetovanje Veterinara Srbije, Zlatibor, 08 - 11. Septembar 2022
Beograd : Srpsko veterinarsko društvo., 322-323.
https://hdl.handle.net/21.15107/rcub_veterinar_2587

Nikolić M, Radaković M, Spariosu K, Kovačević Filipović M, Francuski Andrić J. Značaj indeksa anizocitoze u dijagnostici najčešćih infektivnih anemija mačaka. in 33. Savetovanje Veterinara Srbije, Zlatibor, 08 - 11. Septembar 2022. 2022;:322-323.
https://hdl.handle.net/21.15107/rcub_veterinar_2587 .

Nikolić, Milica, Radaković, Milena, Spariosu, Kristina, Kovačević Filipović, Milica, Francuski Andrić, Jelena, "Značaj indeksa anizocitoze u dijagnostici najčešćih infektivnih anemija mačaka" in 33. Savetovanje Veterinara Srbije, Zlatibor, 08 - 11. Septembar 2022 (2022):322-323,
https://hdl.handle.net/21.15107/rcub_veterinar_2587 .

TY  - CONF
AU  - Beletić, Anđelo
AU  - Kuleš, Josipa
AU  - Farkaš, Vladimir
AU  - Radaković, Milena
AU  - Rešetar Maslov, Dina
AU  - Francuski Andrić, Jelena
AU  - Spariosu, Kristina
AU  - Janjić, Filip
AU  - Rubić, Ivana
AU  - Kovačević Filipović, Milica
AU  - Mrljak, Vladimir
PY  - 2022
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/2615
C3  - 24th Annual Congress of the European Society of Veterinary Clinical Pathology, Belgrade, Serbia, October 5-8, 2022
T1  - Canine babesiosis through the eyes of proteomics and metabolomics
SP  - 72
EP  - 73
UR  - https://hdl.handle.net/21.15107/rcub_veterinar_2615
ER  - 

@conference{
author = "Beletić, Anđelo and Kuleš, Josipa and Farkaš, Vladimir and Radaković, Milena and Rešetar Maslov, Dina and Francuski Andrić, Jelena and Spariosu, Kristina and Janjić, Filip and Rubić, Ivana and Kovačević Filipović, Milica and Mrljak, Vladimir",
year = "2022",
journal = "24th Annual Congress of the European Society of Veterinary Clinical Pathology, Belgrade, Serbia, October 5-8, 2022",
title = "Canine babesiosis through the eyes of proteomics and metabolomics",
pages = "72-73",
url = "https://hdl.handle.net/21.15107/rcub_veterinar_2615"
}

Beletić, A., Kuleš, J., Farkaš, V., Radaković, M., Rešetar Maslov, D., Francuski Andrić, J., Spariosu, K., Janjić, F., Rubić, I., Kovačević Filipović, M.,& Mrljak, V.. (2022). Canine babesiosis through the eyes of proteomics and metabolomics. in 24th Annual Congress of the European Society of Veterinary Clinical Pathology, Belgrade, Serbia, October 5-8, 2022, 72-73.
https://hdl.handle.net/21.15107/rcub_veterinar_2615

Beletić A, Kuleš J, Farkaš V, Radaković M, Rešetar Maslov D, Francuski Andrić J, Spariosu K, Janjić F, Rubić I, Kovačević Filipović M, Mrljak V. Canine babesiosis through the eyes of proteomics and metabolomics. in 24th Annual Congress of the European Society of Veterinary Clinical Pathology, Belgrade, Serbia, October 5-8, 2022. 2022;:72-73.
https://hdl.handle.net/21.15107/rcub_veterinar_2615 .

Beletić, Anđelo, Kuleš, Josipa, Farkaš, Vladimir, Radaković, Milena, Rešetar Maslov, Dina, Francuski Andrić, Jelena, Spariosu, Kristina, Janjić, Filip, Rubić, Ivana, Kovačević Filipović, Milica, Mrljak, Vladimir, "Canine babesiosis through the eyes of proteomics and metabolomics" in 24th Annual Congress of the European Society of Veterinary Clinical Pathology, Belgrade, Serbia, October 5-8, 2022 (2022):72-73,
https://hdl.handle.net/21.15107/rcub_veterinar_2615 .

TY  - CONF
AU  - Francuski Andrić, Jelena
AU  - Magaš, Vladimir
AU  - Ilić Božović, Anja
AU  - Spariosu, Kristina
AU  - Radaković, Milena
AU  - Sukara, Ratko
AU  - Tomanović, Snežana
AU  - Kovačević Filipović, Milica
PY  - 2022
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/2614
C3  - 24th Annual Congress of the European Society of Veterinary Clinical Pathology, Belgrade, Serbia, October 5-8, 2022
T1  - Three clinical cases of Babesia gibsoni infection in Serbia should we worry?
SP  - 74
EP  - 75
UR  - https://hdl.handle.net/21.15107/rcub_veterinar_2614
ER  - 

@conference{
author = "Francuski Andrić, Jelena and Magaš, Vladimir and Ilić Božović, Anja and Spariosu, Kristina and Radaković, Milena and Sukara, Ratko and Tomanović, Snežana and Kovačević Filipović, Milica",
year = "2022",
journal = "24th Annual Congress of the European Society of Veterinary Clinical Pathology, Belgrade, Serbia, October 5-8, 2022",
title = "Three clinical cases of Babesia gibsoni infection in Serbia should we worry?",
pages = "74-75",
url = "https://hdl.handle.net/21.15107/rcub_veterinar_2614"
}

Francuski Andrić, J., Magaš, V., Ilić Božović, A., Spariosu, K., Radaković, M., Sukara, R., Tomanović, S.,& Kovačević Filipović, M.. (2022). Three clinical cases of Babesia gibsoni infection in Serbia should we worry?. in 24th Annual Congress of the European Society of Veterinary Clinical Pathology, Belgrade, Serbia, October 5-8, 2022, 74-75.
https://hdl.handle.net/21.15107/rcub_veterinar_2614

Francuski Andrić J, Magaš V, Ilić Božović A, Spariosu K, Radaković M, Sukara R, Tomanović S, Kovačević Filipović M. Three clinical cases of Babesia gibsoni infection in Serbia should we worry?. in 24th Annual Congress of the European Society of Veterinary Clinical Pathology, Belgrade, Serbia, October 5-8, 2022. 2022;:74-75.
https://hdl.handle.net/21.15107/rcub_veterinar_2614 .

Francuski Andrić, Jelena, Magaš, Vladimir, Ilić Božović, Anja, Spariosu, Kristina, Radaković, Milena, Sukara, Ratko, Tomanović, Snežana, Kovačević Filipović, Milica, "Three clinical cases of Babesia gibsoni infection in Serbia should we worry?" in 24th Annual Congress of the European Society of Veterinary Clinical Pathology, Belgrade, Serbia, October 5-8, 2022 (2022):74-75,
https://hdl.handle.net/21.15107/rcub_veterinar_2614 .

TY  - CONF
AU  - Spariosu, Kristina
AU  - Marković, Lazar
AU  - Radaković, Milena
AU  - Francuski Andrić, Jelena
AU  - Beletić, Anđelo
AU  - Kovačević Filipović, Milica
PY  - 2022
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/2613
C3  - 24th Annual Congress of the European Society of Veterinary Clinical Pathology, Belgrade, Serbia, October 5-8, 2022
T1  - Septic versus non-septic canine babesiosis: is there a difference in leukocyte function?
SP  - 70
EP  - 71
UR  - https://hdl.handle.net/21.15107/rcub_veterinar_2613
ER  - 

@conference{
author = "Spariosu, Kristina and Marković, Lazar and Radaković, Milena and Francuski Andrić, Jelena and Beletić, Anđelo and Kovačević Filipović, Milica",
year = "2022",
journal = "24th Annual Congress of the European Society of Veterinary Clinical Pathology, Belgrade, Serbia, October 5-8, 2022",
title = "Septic versus non-septic canine babesiosis: is there a difference in leukocyte function?",
pages = "70-71",
url = "https://hdl.handle.net/21.15107/rcub_veterinar_2613"
}

Spariosu, K., Marković, L., Radaković, M., Francuski Andrić, J., Beletić, A.,& Kovačević Filipović, M.. (2022). Septic versus non-septic canine babesiosis: is there a difference in leukocyte function?. in 24th Annual Congress of the European Society of Veterinary Clinical Pathology, Belgrade, Serbia, October 5-8, 2022, 70-71.
https://hdl.handle.net/21.15107/rcub_veterinar_2613

Spariosu K, Marković L, Radaković M, Francuski Andrić J, Beletić A, Kovačević Filipović M. Septic versus non-septic canine babesiosis: is there a difference in leukocyte function?. in 24th Annual Congress of the European Society of Veterinary Clinical Pathology, Belgrade, Serbia, October 5-8, 2022. 2022;:70-71.
https://hdl.handle.net/21.15107/rcub_veterinar_2613 .

Spariosu, Kristina, Marković, Lazar, Radaković, Milena, Francuski Andrić, Jelena, Beletić, Anđelo, Kovačević Filipović, Milica, "Septic versus non-septic canine babesiosis: is there a difference in leukocyte function?" in 24th Annual Congress of the European Society of Veterinary Clinical Pathology, Belgrade, Serbia, October 5-8, 2022 (2022):70-71,
https://hdl.handle.net/21.15107/rcub_veterinar_2613 .

TY  - CONF
AU  - Milanović, Zorana
AU  - Ilić Božović, Anja
AU  - Beletić, Anđelo
AU  - Radaković, Milena
AU  - Kovačević Filipović, Milica
PY  - 2022
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/2611
C3  - 24th Annual Congress of the European Society of Veterinary Clinical Pathology, Belgrade, Serbia, October 5-8, 2022.
T1  - Inflammation in canine babesiosis: what to expect in asymptomatic dogs and dogs with coinfections?
SP  - 76
SP  - 77
UR  - https://hdl.handle.net/21.15107/rcub_veterinar_2611
ER  - 

@conference{
author = "Milanović, Zorana and Ilić Božović, Anja and Beletić, Anđelo and Radaković, Milena and Kovačević Filipović, Milica",
year = "2022",
journal = "24th Annual Congress of the European Society of Veterinary Clinical Pathology, Belgrade, Serbia, October 5-8, 2022.",
title = "Inflammation in canine babesiosis: what to expect in asymptomatic dogs and dogs with coinfections?",
pages = "76-77",
url = "https://hdl.handle.net/21.15107/rcub_veterinar_2611"
}

Milanović, Z., Ilić Božović, A., Beletić, A., Radaković, M.,& Kovačević Filipović, M.. (2022). Inflammation in canine babesiosis: what to expect in asymptomatic dogs and dogs with coinfections?. in 24th Annual Congress of the European Society of Veterinary Clinical Pathology, Belgrade, Serbia, October 5-8, 2022., 76.
https://hdl.handle.net/21.15107/rcub_veterinar_2611

Milanović Z, Ilić Božović A, Beletić A, Radaković M, Kovačević Filipović M. Inflammation in canine babesiosis: what to expect in asymptomatic dogs and dogs with coinfections?. in 24th Annual Congress of the European Society of Veterinary Clinical Pathology, Belgrade, Serbia, October 5-8, 2022.. 2022;:76.
https://hdl.handle.net/21.15107/rcub_veterinar_2611 .

Milanović, Zorana, Ilić Božović, Anja, Beletić, Anđelo, Radaković, Milena, Kovačević Filipović, Milica, "Inflammation in canine babesiosis: what to expect in asymptomatic dogs and dogs with coinfections?" in 24th Annual Congress of the European Society of Veterinary Clinical Pathology, Belgrade, Serbia, October 5-8, 2022. (2022):76,
https://hdl.handle.net/21.15107/rcub_veterinar_2611 .

TY  - CONF
AU  - Spariosu, Kristina
AU  - Antić, Milutin
AU  - Radaković, Milena
AU  - Beletić, Anđelo
AU  - Kovačević Filipović, Milica
PY  - 2022
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/2589
PB  - Beograd : Srpsko veterinarsko društvo
C3  - 33. Savetovanje Veterinara Srbije, Zlatibor, 08 - 11. Septembar 2022
T1  - Razlike u nivou matriks metaloproteinaza 2 i 9 u serumu pasa sa blagom i umerenom formom lajšmanioze
SP  - 307
EP  - 309
UR  - https://hdl.handle.net/21.15107/rcub_veterinar_2589
ER  - 

@conference{
author = "Spariosu, Kristina and Antić, Milutin and Radaković, Milena and Beletić, Anđelo and Kovačević Filipović, Milica",
year = "2022",
publisher = "Beograd : Srpsko veterinarsko društvo",
journal = "33. Savetovanje Veterinara Srbije, Zlatibor, 08 - 11. Septembar 2022",
title = "Razlike u nivou matriks metaloproteinaza 2 i 9 u serumu pasa sa blagom i umerenom formom lajšmanioze",
pages = "307-309",
url = "https://hdl.handle.net/21.15107/rcub_veterinar_2589"
}

Spariosu, K., Antić, M., Radaković, M., Beletić, A.,& Kovačević Filipović, M.. (2022). Razlike u nivou matriks metaloproteinaza 2 i 9 u serumu pasa sa blagom i umerenom formom lajšmanioze. in 33. Savetovanje Veterinara Srbije, Zlatibor, 08 - 11. Septembar 2022
Beograd : Srpsko veterinarsko društvo., 307-309.
https://hdl.handle.net/21.15107/rcub_veterinar_2589

Spariosu K, Antić M, Radaković M, Beletić A, Kovačević Filipović M. Razlike u nivou matriks metaloproteinaza 2 i 9 u serumu pasa sa blagom i umerenom formom lajšmanioze. in 33. Savetovanje Veterinara Srbije, Zlatibor, 08 - 11. Septembar 2022. 2022;:307-309.
https://hdl.handle.net/21.15107/rcub_veterinar_2589 .

Spariosu, Kristina, Antić, Milutin, Radaković, Milena, Beletić, Anđelo, Kovačević Filipović, Milica, "Razlike u nivou matriks metaloproteinaza 2 i 9 u serumu pasa sa blagom i umerenom formom lajšmanioze" in 33. Savetovanje Veterinara Srbije, Zlatibor, 08 - 11. Septembar 2022 (2022):307-309,
https://hdl.handle.net/21.15107/rcub_veterinar_2589 .

TY  - JOUR
AU  - Antić, Milutin
AU  - Beletić, Anđelo
AU  - Radaković, Milena
AU  - Spariosu, Kristina
AU  - Stanković, Sanja
AU  - Trailović, Dragiša
AU  - Kovačević Filipović, Milica
PY  - 2022
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/2718
AB  - Progressive tissue injury in canine leishmaniosis (CL) is related to the deposition of
immune complexes, which induces vasculitis and leads to endothelial dysfunction.
Homocysteine (Hcy) increase may worsen endothelial dysfunction, but data concerning
its concentration in different CL stages and links to the acute phase response and
oxidative stress are missing. We compared Hcy levels between dogs with mild (N=24)
and moderate CL without treatment (N=17) and treated with anti-Leishmania drugs
and vitamin B supplements (N=9). Dogs with moderate CL, regardless of therapy
administration, had more distinct clinical signs, lower erythron values, and a higher level
of acute-phase proteins (APPs), IgG against Leishmania spp., urea and creatinine, than
dogs with mild CL. Hcy values did not differ between stages, but treated dogs had the
lowest levels of Hcy. An inverse relationship existed between Hcy and the CL stage,
therapy, levels of IgG, and clinical pathology data. The only positive relationship existed
between Hcy and the erythron state. The disease stage and therapeutic intervention
were not related to the oxidative stress level, except in the case of paraoxonase-1/
Hcy ratio, indicating favorable conditions for antioxidative defense in treated dogs. In
conclusion, changes in Hcy levels indicated its possible involvement with endothelial
dysfunction and inverse relationship to tissue injury evaluated by APPs. Finally, Hcy
might be an early marker of favorable conditions for endothelium recovery in CL
PB  - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
T2  - Acta Veterinaria
T1  - Homocysteine concentration in the serum of dogs naturally infected with Leishmania spp. – association with the stage of the disease, therapy, and clinical pathology data
VL  - 72
IS  - 3
SP  - 309
EP  - 323
DO  - 10.2478/acve-2022-0025
ER  - 

@article{
author = "Antić, Milutin and Beletić, Anđelo and Radaković, Milena and Spariosu, Kristina and Stanković, Sanja and Trailović, Dragiša and Kovačević Filipović, Milica",
year = "2022",
abstract = "Progressive tissue injury in canine leishmaniosis (CL) is related to the deposition of
immune complexes, which induces vasculitis and leads to endothelial dysfunction.
Homocysteine (Hcy) increase may worsen endothelial dysfunction, but data concerning
its concentration in different CL stages and links to the acute phase response and
oxidative stress are missing. We compared Hcy levels between dogs with mild (N=24)
and moderate CL without treatment (N=17) and treated with anti-Leishmania drugs
and vitamin B supplements (N=9). Dogs with moderate CL, regardless of therapy
administration, had more distinct clinical signs, lower erythron values, and a higher level
of acute-phase proteins (APPs), IgG against Leishmania spp., urea and creatinine, than
dogs with mild CL. Hcy values did not differ between stages, but treated dogs had the
lowest levels of Hcy. An inverse relationship existed between Hcy and the CL stage,
therapy, levels of IgG, and clinical pathology data. The only positive relationship existed
between Hcy and the erythron state. The disease stage and therapeutic intervention
were not related to the oxidative stress level, except in the case of paraoxonase-1/
Hcy ratio, indicating favorable conditions for antioxidative defense in treated dogs. In
conclusion, changes in Hcy levels indicated its possible involvement with endothelial
dysfunction and inverse relationship to tissue injury evaluated by APPs. Finally, Hcy
might be an early marker of favorable conditions for endothelium recovery in CL",
publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd",
journal = "Acta Veterinaria",
title = "Homocysteine concentration in the serum of dogs naturally infected with Leishmania spp. – association with the stage of the disease, therapy, and clinical pathology data",
volume = "72",
number = "3",
pages = "309-323",
doi = "10.2478/acve-2022-0025"
}

Antić, M., Beletić, A., Radaković, M., Spariosu, K., Stanković, S., Trailović, D.,& Kovačević Filipović, M.. (2022). Homocysteine concentration in the serum of dogs naturally infected with Leishmania spp. – association with the stage of the disease, therapy, and clinical pathology data. in Acta Veterinaria
Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 72(3), 309-323.
https://doi.org/10.2478/acve-2022-0025

Antić M, Beletić A, Radaković M, Spariosu K, Stanković S, Trailović D, Kovačević Filipović M. Homocysteine concentration in the serum of dogs naturally infected with Leishmania spp. – association with the stage of the disease, therapy, and clinical pathology data. in Acta Veterinaria. 2022;72(3):309-323.
doi:10.2478/acve-2022-0025 .

Antić, Milutin, Beletić, Anđelo, Radaković, Milena, Spariosu, Kristina, Stanković, Sanja, Trailović, Dragiša, Kovačević Filipović, Milica, "Homocysteine concentration in the serum of dogs naturally infected with Leishmania spp. – association with the stage of the disease, therapy, and clinical pathology data" in Acta Veterinaria, 72, no. 3 (2022):309-323,
https://doi.org/10.2478/acve-2022-0025 . .

TY  - JOUR
AU  - Spariosu, Kristina
AU  - Janjić, Filip
AU  - Francuski Andrić, Jelena
AU  - Radaković, Milena
AU  - Beletić, Anđelo
AU  - Kovačević-Filipović, Milica
AU  - Milanović, Svetlana
PY  - 2021
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/2132
AB  - Hemolysis and systemic acute inflammation characterize canine babesiosis caused by the intraerythrocytic protozoan parasite Babesia canis. Our hypothesis was that blood redox homeostasis of patients that suffered acute B. canis infection might be disturbed even after treatment with imidocarb-dipropionate and successful clinical recovery. Eight owner dogs with acute B. canis infection were used for this study. We analyzed the complete blood count, acute phase proteins (ceruloplasmin, haptoglobin, paraoxonase-1) in the serum, antioxidant enzymes (catalase and glutathione peroxidase) in the erythrocytes, and oxidative stress markers (malondialdehyde in erythrocytes and thiol groups in serum) at presentation and 15 days after treatment. Results were evaluated by corresponding statistical tests. At presentation, anemia, low/normal leukocyte count and severe thrombocytopenia occurred together with increased ceruloplasmin, haptoglobin levels within the reference interval, decreased paraoxonase-1 and compromised antioxidant defense in the red blood cells. After treatment and successful clinical recovery, hematological values generally fitted within the reference intervals, acute phase proteins were within the physiological levels in the majority of cases and the activities of the antioxidant enzymes were increased. However, elevated malondialdehyde levels indicated increased oxidative damage of erythrocytes that remained as a deleterious sequel despite a successful clinical recovery of the dogs.
AB  - Babezioza pasa, koju izaziva protozoa Babesia canis, praćena je hemolizom i sistemskom akutnom infl amacijom. Naša hipoteza je da kod pasa sa akutnom B. canis infekcijom, čak i nakon terapije imidokarb-dipropionatom i uspešnog kliničkog oporavka, postoji poremećaj redoks homeostaze. Studija uključuje osam vlasničkih pasa akutno infi ciranih babezijom. Analizirani su kompletna krvna slika, proteini akutne faze (ceruloplazmin, haptoglobin i paraoksonaza-1) u serumu, antioksidativni enzimi (katalaza i glutation peroksidaza) u eritrocitima i markeri oksidativnog stresa (malondialdehid u eritrocitima, tiolne grupe u serumu) na prezentaciji i 15 dana nakon terapije. Za procenu značajnosti rezultata primenjeni su odgovarajući statistički testovi. Anemija, nizak/normalan broj leukocita i teška trombocitopenija praćeni povišenom koncentracijom ceruloplazmina, haptoglobinom u fi ziološkim intervalima i sniženim nivoom paraoksonaze-1, kao i kompromitovana antioksidativna zaštita, uočeni su na prezentaciji. Nakon terapije i uspešnog kliničkog oporavka, hematološke vrednosti su bile u fi ziološkom opsegu, kao i proteini akutne faze kod većine pacijenata, a aktivnost antioksidativnih enzima je pojačana. Međutim, povišena koncentracija malondialdehida ukazuje na povećano oštećenje eritrocita koje je zaostalo uprkos uspešnom kliničkom oporavku pasa.
PB  - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
T2  - Acta Veterinaria-Beograd
T1  - Relationship between changes in hematological parameters, levels of acute phase proteins and redox homeostasis during acute Babesia canis infection in dogs
T1  - Povezanost promena hematoloških parametara, nivoa proteina akutne faze i redoks homeostaze tokom akutne infekcije pasa sa babesia canis
VL  - 71
IS  - 2
SP  - 158
EP  - 169
DO  - 10.2478/acve-2021-0014
ER  - 

@article{
author = "Spariosu, Kristina and Janjić, Filip and Francuski Andrić, Jelena and Radaković, Milena and Beletić, Anđelo and Kovačević-Filipović, Milica and Milanović, Svetlana",
year = "2021",
abstract = "Hemolysis and systemic acute inflammation characterize canine babesiosis caused by the intraerythrocytic protozoan parasite Babesia canis. Our hypothesis was that blood redox homeostasis of patients that suffered acute B. canis infection might be disturbed even after treatment with imidocarb-dipropionate and successful clinical recovery. Eight owner dogs with acute B. canis infection were used for this study. We analyzed the complete blood count, acute phase proteins (ceruloplasmin, haptoglobin, paraoxonase-1) in the serum, antioxidant enzymes (catalase and glutathione peroxidase) in the erythrocytes, and oxidative stress markers (malondialdehyde in erythrocytes and thiol groups in serum) at presentation and 15 days after treatment. Results were evaluated by corresponding statistical tests. At presentation, anemia, low/normal leukocyte count and severe thrombocytopenia occurred together with increased ceruloplasmin, haptoglobin levels within the reference interval, decreased paraoxonase-1 and compromised antioxidant defense in the red blood cells. After treatment and successful clinical recovery, hematological values generally fitted within the reference intervals, acute phase proteins were within the physiological levels in the majority of cases and the activities of the antioxidant enzymes were increased. However, elevated malondialdehyde levels indicated increased oxidative damage of erythrocytes that remained as a deleterious sequel despite a successful clinical recovery of the dogs., Babezioza pasa, koju izaziva protozoa Babesia canis, praćena je hemolizom i sistemskom akutnom infl amacijom. Naša hipoteza je da kod pasa sa akutnom B. canis infekcijom, čak i nakon terapije imidokarb-dipropionatom i uspešnog kliničkog oporavka, postoji poremećaj redoks homeostaze. Studija uključuje osam vlasničkih pasa akutno infi ciranih babezijom. Analizirani su kompletna krvna slika, proteini akutne faze (ceruloplazmin, haptoglobin i paraoksonaza-1) u serumu, antioksidativni enzimi (katalaza i glutation peroksidaza) u eritrocitima i markeri oksidativnog stresa (malondialdehid u eritrocitima, tiolne grupe u serumu) na prezentaciji i 15 dana nakon terapije. Za procenu značajnosti rezultata primenjeni su odgovarajući statistički testovi. Anemija, nizak/normalan broj leukocita i teška trombocitopenija praćeni povišenom koncentracijom ceruloplazmina, haptoglobinom u fi ziološkim intervalima i sniženim nivoom paraoksonaze-1, kao i kompromitovana antioksidativna zaštita, uočeni su na prezentaciji. Nakon terapije i uspešnog kliničkog oporavka, hematološke vrednosti su bile u fi ziološkom opsegu, kao i proteini akutne faze kod većine pacijenata, a aktivnost antioksidativnih enzima je pojačana. Međutim, povišena koncentracija malondialdehida ukazuje na povećano oštećenje eritrocita koje je zaostalo uprkos uspešnom kliničkom oporavku pasa.",
publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd",
journal = "Acta Veterinaria-Beograd",
title = "Relationship between changes in hematological parameters, levels of acute phase proteins and redox homeostasis during acute Babesia canis infection in dogs, Povezanost promena hematoloških parametara, nivoa proteina akutne faze i redoks homeostaze tokom akutne infekcije pasa sa babesia canis",
volume = "71",
number = "2",
pages = "158-169",
doi = "10.2478/acve-2021-0014"
}

Spariosu, K., Janjić, F., Francuski Andrić, J., Radaković, M., Beletić, A., Kovačević-Filipović, M.,& Milanović, S.. (2021). Relationship between changes in hematological parameters, levels of acute phase proteins and redox homeostasis during acute Babesia canis infection in dogs. in Acta Veterinaria-Beograd
Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 71(2), 158-169.
https://doi.org/10.2478/acve-2021-0014

Spariosu K, Janjić F, Francuski Andrić J, Radaković M, Beletić A, Kovačević-Filipović M, Milanović S. Relationship between changes in hematological parameters, levels of acute phase proteins and redox homeostasis during acute Babesia canis infection in dogs. in Acta Veterinaria-Beograd. 2021;71(2):158-169.
doi:10.2478/acve-2021-0014 .

Spariosu, Kristina, Janjić, Filip, Francuski Andrić, Jelena, Radaković, Milena, Beletić, Anđelo, Kovačević-Filipović, Milica, Milanović, Svetlana, "Relationship between changes in hematological parameters, levels of acute phase proteins and redox homeostasis during acute Babesia canis infection in dogs" in Acta Veterinaria-Beograd, 71, no. 2 (2021):158-169,
https://doi.org/10.2478/acve-2021-0014 . .

TY  - JOUR
AU  - Valčić, Olivera
AU  - Milanović, Svetlana
AU  - Došenović, Milan
AU  - Özvegy, József
AU  - Radaković, Milena
AU  - Vejnović, Branislav
AU  - Vučićević, Miloš
PY  - 2021
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/2215
AB  - Introduction. Glutathione peroxidases are selenoenzymes which have a crucial role in the protection of animals against oxidative stress. 
Materials and Methods. From September 2017 to April 2018, a group of eight red-eared sliders were admitted at the Clinic for Small Animals, Faculty of Veterinary Medicine, University of Belgrade for elective diagnostic celioscopy. The turtles were of unknown age, weight from 1.20 kg to 1.86 kg. The anesthesia protocol involved using ketamine and medetomidine, both at a low dosage (10 mg kg-1 and 0.1 mg kg-1, respectively) as induction, after which anesthesia was maintained using isoflurane at 3% (vapor setting) in 100% oxygen (0.5 L min-1). Medetomidine was reversed with atipamezole (0.2 mg kg-1), given intramuscularly. The elective celioscopy was performed according to standard protocols. One day prior to anesthesia, heparinized blood samples were taken using the subcarapacial venous plexus for venipuncture. The second sampling took place three hours after the anesthetics were administered. 
Results and Conclusions. GPx3 activity in the blood plasmas (n=8) was measured by the coupled test as described by Günzler et al. (1974). Data were tested for normality by the Shapiro-Wilk normality test and the groups were compared using a paired t-test. 
Blood plasma GPx3 activity was significantly higher (p=0.009) after a three-hour recovery period from inhalation anesthesia performed for elective diagnostic celioscopy, than before anesthesia. The measured post-anesthesia GPx3 activities were, on average, 
80% higher than the measurements prior to anesthesia. It can be concluded that the statistically significant increase in the activity of plasma GPx3 from 91.02±36.05 mKat L-1 prior to anesthesia to 160.21±58.94 mKat L-1 three hours after anesthesia is due to the change in oxygen saturation. This is increased to 100% during the procedure, thus exposing the turtles to conditions of high oxygen saturation.
AB  - Uvod. Glutation peroksidaze su selenoenzimi koji igraju ključnu ulogu u zaštiti životinja od oksidativnog stresa. 
Materijal i metode. Od septembra 2017. do aprila 2018. godine, grupa od osam crvenouhih kornjača je primljena na Kliniku za male životinje, Fakulteta Veterinarske Medicine, Univerziteta u Beogradu zbog izvođenja elektivne dijagnostičke celioskopije. Kornjače su bile nepoznate starosti, mase između 1,20 kg i 1,86 kg. Anastetički protokol je uključivao primenu ketamina (10 mg kg-1) i medetomidina (0.1 mg kg-1) za indukciju, oba u niskim dozama, nakon čega je anestezija održavana primenom izoflurana u koncentraciji od 3% (podešen na isparavanje) u 100% kiseoniku (0.5 L min-1). Dejstvo medetomidina je neutralizovano atipamezolom (0.2 mg kg-1), aplikovanim intramuskularno. Elektivna celioskopija je izvedena u skladu sa standardnim protokolima. Heparinizovani uzorci krvi su uzeti jedan dan pre uvođenja u anesteziju venepunkcijom iz subkarapacijalnog venskog pleksusa. Drugo uzorkovanje krvi je uzvršeno tri sata nakon administracije anestetika. 
Rezultati i zaključak. GPx3 aktivnost u krvnoj plazmi (n=8) je izmerena primenom kuplovane reakcije, kao što su opisali Günzler i sar. (1974). Normalna distribucija podataka je testirana pomoću Shapiro - Wilk testa normalnosti (p>0,05), a grupe su poređene koristeći t test za zavisne uzorke. 
Aktivnost GPx3 u krvnoj plazmi je bila značajno viša (p=0.009) u uzorcima uzetim nakon trosatnog perioda oporavka od inhalacione anestezije aplikovane radi izvođenja elektivne celioskopije, nego u uzorcima uzetim pre aplikovanja anestezije. Vrednosti GPx3 izmerene nakon anestezije bile su u proseku 80% više od vrednosti pre anestezije. Može se zaključiti da je statistički značajan porast u aktivnosti GPx3 u plazmi od 91.02±36.05 mKat L-1, pre anestezije do 160.21±58.94 mKat L-1, tri sata nakon anestezije uzrokovan promenom u saturaciji kiseonika. Tokom intervencije saturacija kiseonika se povećava i do 100% čime se kornjače uvode u uslove visoke saturacije kiseonikom.
PB  - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
T2  - Veterinarski Glasnik
T1  - Plasma glutathione peroxidase (GPx 3) activity in the freshwater turtle trachemys scripta elegans after isoflurane inhalation anesthesia
T1  - Aktivnost glutation peroksidaze (GPx 3) u plazmi semiakvatičnih kornjača trachemys scripta elegans nakon inhalacione anestezije izofluranom
VL  - 75
IS  - 1
SP  - 76
EP  - 82
DO  - 10.2298/VETGL181208005V
ER  - 

@article{
author = "Valčić, Olivera and Milanović, Svetlana and Došenović, Milan and Özvegy, József and Radaković, Milena and Vejnović, Branislav and Vučićević, Miloš",
year = "2021",
abstract = "Introduction. Glutathione peroxidases are selenoenzymes which have a crucial role in the protection of animals against oxidative stress. 
Materials and Methods. From September 2017 to April 2018, a group of eight red-eared sliders were admitted at the Clinic for Small Animals, Faculty of Veterinary Medicine, University of Belgrade for elective diagnostic celioscopy. The turtles were of unknown age, weight from 1.20 kg to 1.86 kg. The anesthesia protocol involved using ketamine and medetomidine, both at a low dosage (10 mg kg-1 and 0.1 mg kg-1, respectively) as induction, after which anesthesia was maintained using isoflurane at 3% (vapor setting) in 100% oxygen (0.5 L min-1). Medetomidine was reversed with atipamezole (0.2 mg kg-1), given intramuscularly. The elective celioscopy was performed according to standard protocols. One day prior to anesthesia, heparinized blood samples were taken using the subcarapacial venous plexus for venipuncture. The second sampling took place three hours after the anesthetics were administered. 
Results and Conclusions. GPx3 activity in the blood plasmas (n=8) was measured by the coupled test as described by Günzler et al. (1974). Data were tested for normality by the Shapiro-Wilk normality test and the groups were compared using a paired t-test. 
Blood plasma GPx3 activity was significantly higher (p=0.009) after a three-hour recovery period from inhalation anesthesia performed for elective diagnostic celioscopy, than before anesthesia. The measured post-anesthesia GPx3 activities were, on average, 
80% higher than the measurements prior to anesthesia. It can be concluded that the statistically significant increase in the activity of plasma GPx3 from 91.02±36.05 mKat L-1 prior to anesthesia to 160.21±58.94 mKat L-1 three hours after anesthesia is due to the change in oxygen saturation. This is increased to 100% during the procedure, thus exposing the turtles to conditions of high oxygen saturation., Uvod. Glutation peroksidaze su selenoenzimi koji igraju ključnu ulogu u zaštiti životinja od oksidativnog stresa. 
Materijal i metode. Od septembra 2017. do aprila 2018. godine, grupa od osam crvenouhih kornjača je primljena na Kliniku za male životinje, Fakulteta Veterinarske Medicine, Univerziteta u Beogradu zbog izvođenja elektivne dijagnostičke celioskopije. Kornjače su bile nepoznate starosti, mase između 1,20 kg i 1,86 kg. Anastetički protokol je uključivao primenu ketamina (10 mg kg-1) i medetomidina (0.1 mg kg-1) za indukciju, oba u niskim dozama, nakon čega je anestezija održavana primenom izoflurana u koncentraciji od 3% (podešen na isparavanje) u 100% kiseoniku (0.5 L min-1). Dejstvo medetomidina je neutralizovano atipamezolom (0.2 mg kg-1), aplikovanim intramuskularno. Elektivna celioskopija je izvedena u skladu sa standardnim protokolima. Heparinizovani uzorci krvi su uzeti jedan dan pre uvođenja u anesteziju venepunkcijom iz subkarapacijalnog venskog pleksusa. Drugo uzorkovanje krvi je uzvršeno tri sata nakon administracije anestetika. 
Rezultati i zaključak. GPx3 aktivnost u krvnoj plazmi (n=8) je izmerena primenom kuplovane reakcije, kao što su opisali Günzler i sar. (1974). Normalna distribucija podataka je testirana pomoću Shapiro - Wilk testa normalnosti (p>0,05), a grupe su poređene koristeći t test za zavisne uzorke. 
Aktivnost GPx3 u krvnoj plazmi je bila značajno viša (p=0.009) u uzorcima uzetim nakon trosatnog perioda oporavka od inhalacione anestezije aplikovane radi izvođenja elektivne celioskopije, nego u uzorcima uzetim pre aplikovanja anestezije. Vrednosti GPx3 izmerene nakon anestezije bile su u proseku 80% više od vrednosti pre anestezije. Može se zaključiti da je statistički značajan porast u aktivnosti GPx3 u plazmi od 91.02±36.05 mKat L-1, pre anestezije do 160.21±58.94 mKat L-1, tri sata nakon anestezije uzrokovan promenom u saturaciji kiseonika. Tokom intervencije saturacija kiseonika se povećava i do 100% čime se kornjače uvode u uslove visoke saturacije kiseonikom.",
publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd",
journal = "Veterinarski Glasnik",
title = "Plasma glutathione peroxidase (GPx 3) activity in the freshwater turtle trachemys scripta elegans after isoflurane inhalation anesthesia, Aktivnost glutation peroksidaze (GPx 3) u plazmi semiakvatičnih kornjača trachemys scripta elegans nakon inhalacione anestezije izofluranom",
volume = "75",
number = "1",
pages = "76-82",
doi = "10.2298/VETGL181208005V"
}

Valčić, O., Milanović, S., Došenović, M., Özvegy, J., Radaković, M., Vejnović, B.,& Vučićević, M.. (2021). Plasma glutathione peroxidase (GPx 3) activity in the freshwater turtle trachemys scripta elegans after isoflurane inhalation anesthesia. in Veterinarski Glasnik
Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 75(1), 76-82.
https://doi.org/10.2298/VETGL181208005V

Valčić O, Milanović S, Došenović M, Özvegy J, Radaković M, Vejnović B, Vučićević M. Plasma glutathione peroxidase (GPx 3) activity in the freshwater turtle trachemys scripta elegans after isoflurane inhalation anesthesia. in Veterinarski Glasnik. 2021;75(1):76-82.
doi:10.2298/VETGL181208005V .

Valčić, Olivera, Milanović, Svetlana, Došenović, Milan, Özvegy, József, Radaković, Milena, Vejnović, Branislav, Vučićević, Miloš, "Plasma glutathione peroxidase (GPx 3) activity in the freshwater turtle trachemys scripta elegans after isoflurane inhalation anesthesia" in Veterinarski Glasnik, 75, no. 1 (2021):76-82,
https://doi.org/10.2298/VETGL181208005V . .

TY  - JOUR
AU  - Tubić Vukajlović, Jovana
AU  - Kosanić, Marijana
AU  - Ranković, Branislav
AU  - Stanojković, Tatjana
AU  - Marković, Aleksandra
AU  - Grujičić, Darko
AU  - Đelić, Ninoslav
AU  - Radaković, Milena
AU  - Milošević-Djordjević, Olivera
PY  - 2021
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/2318
AB  - Bioactivity of acetone extract of Leccinum scabrum was evaluated. Antioxidant activity was evaluated by free radical scavenging activity, reducing power and determination of total phenolic content. The microdilution plate method was used to detect antimicrobial activity. Cytotoxic activity was tested by MTT assay. Genotoxic potential was evaluated by comet assay. Results showed a stronger free radical scavenging activity, but the reducing power was less pronounced. The total content of phenols in the extract was 14.91 µg PE/mg. The minimum inhibitory concentration related to the tested microorganisms fluctuated in the range 0.039-10 mg/mL. The most sensitive was Bacillus cereus. A strong cytotoxic activity was revealed with IC50 values ranging between 73.64 and 200.00 µg/mL, among which HeLa was the most sensitive. Results showed that the extract was not genotoxic and it decreased the H2O2-induced GDI values in comparison to the positive control. L. scabrum possesses bioactivities such as antioxidant, antimicrobial, cytotoxic, no genotoxic and protective against H2O2, and in the highest tested concentration it showed a synergistic activity.
AB  - Studiul prezintă evaluarea activității biologice a extractului în acetonă obținut din Leccinum scabrum. Activitatea antioxidantă a fost evaluată prin determinarea capacității de chelatare a radicalilor liberi, a capacității reducătoare și a conținutului total în fenoli. Activitatea antimicrobiană a fost testată prin metoda microdiluției, activitatea citotoxică prin metoda MTT, iar potențialul genotoxic a fost determinat prin calcularea indexului de deteriorare genetică. Conținutul total de fenoli a fost 14,91 μg PE/mg. Concentrația minimă inhibitorie a variat în intervalul 0,039 - 10 mg/mL. Activitatea citotoxică pronunțată a fost corelată cu valorile IC50 în domeniul 73,64 - 200,00 μg/mL. Rezultatele au arătat că extractul nu este genotoxic și au scăzut valorile indexului de deteriorare genetică-indus de H2O2 , în comparație cu controlul pozitiv. L. scabrum posedă activități antioxidantă, antimicrobiană, citotoxică șı protectoare împotriva H2O2.
PB  - Societatea de Științe Farmaceutice din România
T2  - Farmacia
T1  - Evaluation of biological activities of acetone extract of the mushroom leccinum scabrum
VL  - 69
IS  - 5
SP  - 974
EP  - 979
DO  - 10.31925/FARMACIA.2021.5.22
ER  - 

@article{
author = "Tubić Vukajlović, Jovana and Kosanić, Marijana and Ranković, Branislav and Stanojković, Tatjana and Marković, Aleksandra and Grujičić, Darko and Đelić, Ninoslav and Radaković, Milena and Milošević-Djordjević, Olivera",
year = "2021",
abstract = "Bioactivity of acetone extract of Leccinum scabrum was evaluated. Antioxidant activity was evaluated by free radical scavenging activity, reducing power and determination of total phenolic content. The microdilution plate method was used to detect antimicrobial activity. Cytotoxic activity was tested by MTT assay. Genotoxic potential was evaluated by comet assay. Results showed a stronger free radical scavenging activity, but the reducing power was less pronounced. The total content of phenols in the extract was 14.91 µg PE/mg. The minimum inhibitory concentration related to the tested microorganisms fluctuated in the range 0.039-10 mg/mL. The most sensitive was Bacillus cereus. A strong cytotoxic activity was revealed with IC50 values ranging between 73.64 and 200.00 µg/mL, among which HeLa was the most sensitive. Results showed that the extract was not genotoxic and it decreased the H2O2-induced GDI values in comparison to the positive control. L. scabrum possesses bioactivities such as antioxidant, antimicrobial, cytotoxic, no genotoxic and protective against H2O2, and in the highest tested concentration it showed a synergistic activity., Studiul prezintă evaluarea activității biologice a extractului în acetonă obținut din Leccinum scabrum. Activitatea antioxidantă a fost evaluată prin determinarea capacității de chelatare a radicalilor liberi, a capacității reducătoare și a conținutului total în fenoli. Activitatea antimicrobiană a fost testată prin metoda microdiluției, activitatea citotoxică prin metoda MTT, iar potențialul genotoxic a fost determinat prin calcularea indexului de deteriorare genetică. Conținutul total de fenoli a fost 14,91 μg PE/mg. Concentrația minimă inhibitorie a variat în intervalul 0,039 - 10 mg/mL. Activitatea citotoxică pronunțată a fost corelată cu valorile IC50 în domeniul 73,64 - 200,00 μg/mL. Rezultatele au arătat că extractul nu este genotoxic și au scăzut valorile indexului de deteriorare genetică-indus de H2O2 , în comparație cu controlul pozitiv. L. scabrum posedă activități antioxidantă, antimicrobiană, citotoxică șı protectoare împotriva H2O2.",
publisher = "Societatea de Științe Farmaceutice din România",
journal = "Farmacia",
title = "Evaluation of biological activities of acetone extract of the mushroom leccinum scabrum",
volume = "69",
number = "5",
pages = "974-979",
doi = "10.31925/FARMACIA.2021.5.22"
}

Tubić Vukajlović, J., Kosanić, M., Ranković, B., Stanojković, T., Marković, A., Grujičić, D., Đelić, N., Radaković, M.,& Milošević-Djordjević, O.. (2021). Evaluation of biological activities of acetone extract of the mushroom leccinum scabrum. in Farmacia
Societatea de Științe Farmaceutice din România., 69(5), 974-979.
https://doi.org/10.31925/FARMACIA.2021.5.22

Tubić Vukajlović J, Kosanić M, Ranković B, Stanojković T, Marković A, Grujičić D, Đelić N, Radaković M, Milošević-Djordjević O. Evaluation of biological activities of acetone extract of the mushroom leccinum scabrum. in Farmacia. 2021;69(5):974-979.
doi:10.31925/FARMACIA.2021.5.22 .

Tubić Vukajlović, Jovana, Kosanić, Marijana, Ranković, Branislav, Stanojković, Tatjana, Marković, Aleksandra, Grujičić, Darko, Đelić, Ninoslav, Radaković, Milena, Milošević-Djordjević, Olivera, "Evaluation of biological activities of acetone extract of the mushroom leccinum scabrum" in Farmacia, 69, no. 5 (2021):974-979,
https://doi.org/10.31925/FARMACIA.2021.5.22 . .

TY  - JOUR
AU  - Beletić, Anđelo
AU  - Janjić, Filip
AU  - Radaković, Milena
AU  - Spariosu, Kristina
AU  - Francuski Andrić, Jelena
AU  - Chandrashekar, Ramaswamy
AU  - Tyrrell, Phyllis
AU  - Radonjić, Vladimir
AU  - Balint, Bela
AU  - Ajtić, Jelena
AU  - Kovačević-Filipović, Milica
PY  - 2021
UR  - https://vet-erinar.vet.bg.ac.rs/handle/123456789/2015
AB  - The common signs of canine babesiosis caused by an infection with Babesia canis are fever, anorexia, lethargy, pulse alterations, anemia, and occasionally mild icterus. Dogs with these clinical signs can be divided into two groups: those with acute-phase reaction and those with systemic inflammatory response syndrome (SIRS). Factors associated with the occurrence of SIRS in canine babesiosis have not been thoroughly researched. This article outlines a cross-sectional study of 54 client-owned dogs with an acute B. canis infection, and evaluates the differences in age, gender, laboratory findings, parasite load, and seroreactivity against B. canis between the SIRS and the SIRS-free dogs. We have analyzed a complete blood count, serum biochemistry, serum amyloid A, ceruloplasmin, paraoxonase-1, serology, and PCR testing using standard methodologies. The frequency of SIRS among the investigated dogs reached 0.59. Male dogs and those seronegative against B. canis, were more frequent in the SIRS group, whilst age and parasite load could not be associated with the presence of SIRS. Dogs with SIRS had a lower count of total leukocytes, neutrophils, lymphocytes, and monocytes, and a lower concentration of iron and bilirubin compared with SIRS-free dogs. No significant differences in the concentration of acute-phase proteins have been noticed to exist between the groups of dogs. Further, the seronegative dogs had a lower count of lymphocytes and monocytes and a higher parasite load than the seroreactive dogs. Multivariate logistic regression analysis has identified leukopenia (<6 × 109/L) and monocytopenia (<0.2 × 109/L) as independent associates of SIRS in the investigated dogs, thus implying that these routine tests could be used as reliable markers for SIRS.
PB  - Elsevier
T2  - Veterinary Parasitology
T1  - Systemic inflammatory response syndrome in dogs naturally infected with Babesia canis: Association with the parasite load and host factors
VL  - 291
DO  - 10.1016/j.vetpar.2021.109366
ER  - 

@article{
author = "Beletić, Anđelo and Janjić, Filip and Radaković, Milena and Spariosu, Kristina and Francuski Andrić, Jelena and Chandrashekar, Ramaswamy and Tyrrell, Phyllis and Radonjić, Vladimir and Balint, Bela and Ajtić, Jelena and Kovačević-Filipović, Milica",
year = "2021",
abstract = "The common signs of canine babesiosis caused by an infection with Babesia canis are fever, anorexia, lethargy, pulse alterations, anemia, and occasionally mild icterus. Dogs with these clinical signs can be divided into two groups: those with acute-phase reaction and those with systemic inflammatory response syndrome (SIRS). Factors associated with the occurrence of SIRS in canine babesiosis have not been thoroughly researched. This article outlines a cross-sectional study of 54 client-owned dogs with an acute B. canis infection, and evaluates the differences in age, gender, laboratory findings, parasite load, and seroreactivity against B. canis between the SIRS and the SIRS-free dogs. We have analyzed a complete blood count, serum biochemistry, serum amyloid A, ceruloplasmin, paraoxonase-1, serology, and PCR testing using standard methodologies. The frequency of SIRS among the investigated dogs reached 0.59. Male dogs and those seronegative against B. canis, were more frequent in the SIRS group, whilst age and parasite load could not be associated with the presence of SIRS. Dogs with SIRS had a lower count of total leukocytes, neutrophils, lymphocytes, and monocytes, and a lower concentration of iron and bilirubin compared with SIRS-free dogs. No significant differences in the concentration of acute-phase proteins have been noticed to exist between the groups of dogs. Further, the seronegative dogs had a lower count of lymphocytes and monocytes and a higher parasite load than the seroreactive dogs. Multivariate logistic regression analysis has identified leukopenia (<6 × 109/L) and monocytopenia (<0.2 × 109/L) as independent associates of SIRS in the investigated dogs, thus implying that these routine tests could be used as reliable markers for SIRS.",
publisher = "Elsevier",
journal = "Veterinary Parasitology",
title = "Systemic inflammatory response syndrome in dogs naturally infected with Babesia canis: Association with the parasite load and host factors",
volume = "291",
doi = "10.1016/j.vetpar.2021.109366"
}

Beletić, A., Janjić, F., Radaković, M., Spariosu, K., Francuski Andrić, J., Chandrashekar, R., Tyrrell, P., Radonjić, V., Balint, B., Ajtić, J.,& Kovačević-Filipović, M.. (2021). Systemic inflammatory response syndrome in dogs naturally infected with Babesia canis: Association with the parasite load and host factors. in Veterinary Parasitology
Elsevier., 291.
https://doi.org/10.1016/j.vetpar.2021.109366

Beletić A, Janjić F, Radaković M, Spariosu K, Francuski Andrić J, Chandrashekar R, Tyrrell P, Radonjić V, Balint B, Ajtić J, Kovačević-Filipović M. Systemic inflammatory response syndrome in dogs naturally infected with Babesia canis: Association with the parasite load and host factors. in Veterinary Parasitology. 2021;291.
doi:10.1016/j.vetpar.2021.109366 .

Beletić, Anđelo, Janjić, Filip, Radaković, Milena, Spariosu, Kristina, Francuski Andrić, Jelena, Chandrashekar, Ramaswamy, Tyrrell, Phyllis, Radonjić, Vladimir, Balint, Bela, Ajtić, Jelena, Kovačević-Filipović, Milica, "Systemic inflammatory response syndrome in dogs naturally infected with Babesia canis: Association with the parasite load and host factors" in Veterinary Parasitology, 291 (2021),
https://doi.org/10.1016/j.vetpar.2021.109366 . .